RPS27A | ENSG00000143947 | NCBI 6233

Details for: RPS27A

Gene ID: 6233

Symbol: RPS27A

Ensembl ID: ENSG00000143947

Description: ribosomal protein S27a

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Adaptive immune system
(R-HSA-1280218)
Aerobic respiration and respiratory electron transport
(R-HSA-1428517)
Amyloid fiber formation
(R-HSA-977225)
Apoptosis
(R-HSA-109581)
Asparagine n-linked glycosylation
(R-HSA-446203)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Autophagy
(R-HSA-9612973)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to hypoxia
(R-HSA-1234174)
Cellular senescence
(R-HSA-2559583)
Chaperone mediated autophagy
(R-HSA-9613829)
Circadian clock
(R-HSA-400253)
Cytokine signaling in immune system
(R-HSA-1280215)
Cytosolic sensors of pathogen-associated dna
(R-HSA-1834949)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-HSA-168928)
Death receptor signaling
(R-HSA-73887)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of metabolism
(R-HSA-5668914)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna damage bypass
(R-HSA-73893)
Dna double-strand break repair
(R-HSA-5693532)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Eukaryotic translation elongation
(R-HSA-156842)
Fanconi anemia pathway
(R-HSA-6783310)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Intracellular signaling by second messengers
(R-HSA-9006925)
Ion channel transport
(R-HSA-983712)
Iron uptake and transport
(R-HSA-917937)
Late endosomal microautophagy
(R-HSA-9615710)
Macroautophagy
(R-HSA-1632852)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of carbohydrates
(R-HSA-71387)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g2-g2/m phases
(R-HSA-453274)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Nucleotide excision repair
(R-HSA-5696398)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
Peroxisomal protein import
(R-HSA-9033241)
Pip3 activates akt signaling
(R-HSA-1257604)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Protein localization
(R-HSA-9609507)
Recognition of dna damage by pcna-containing replication complex
(R-HSA-110314)
Regulated necrosis
(R-HSA-5218859)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Rna polymerase ii transcription
(R-HSA-73857)
Rrna processing
(R-HSA-72312)
Selenoamino acid metabolism
(R-HSA-2408522)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb4
(R-HSA-1236394)
Signaling by fgfr
(R-HSA-190236)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch2
(R-HSA-1980145)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Stimuli-sensing channels
(R-HSA-2672351)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Toll-like receptor cascades
(R-HSA-168898)
Translation
(R-HSA-72766)
Translesion synthesis by y family dna polymerases bypasses lesions on dna template
(R-HSA-110313)
Transport of small molecules
(R-HSA-382551)
Vesicle-mediated transport
(R-HSA-5653656)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: embryonic stem cell (CL0002322)
Fold Change: 879.0924
Cell Significance Index: -362.1400
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 771.6049
Cell Significance Index: -313.4700
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 698.8438
Cell Significance Index: -329.9400
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 673.0170
Cell Significance Index: -346.1900
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 494.0373
Cell Significance Index: -331.5100
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 335.1269
Cell Significance Index: -319.9600
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 41.4019
Cell Significance Index: -110.9100
Cell Name: abnormal cell (CL0001061)
Fold Change: 18.1437
Cell Significance Index: 1853.3700
Cell Name: pro-T cell (CL0000827)
Fold Change: 17.8191
Cell Significance Index: 455.2200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 14.7555
Cell Significance Index: 693.5000
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 14.7476
Cell Significance Index: 394.4900
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 12.5383
Cell Significance Index: 359.4200
Cell Name: granulosa cell (CL0000501)
Fold Change: 11.2830
Cell Significance Index: 296.6900
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 10.6418
Cell Significance Index: 188.0600
Cell Name: lactocyte (CL0002325)
Fold Change: 10.4262
Cell Significance Index: 1346.9900
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 10.0742
Cell Significance Index: 210.8700
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 9.8790
Cell Significance Index: 112.2300
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 9.7324
Cell Significance Index: 124.6400
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 9.5170
Cell Significance Index: 25.5000
Cell Name: theca cell (CL0000503)
Fold Change: 9.4076
Cell Significance Index: 55.2700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 9.2240
Cell Significance Index: 652.3600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 9.1212
Cell Significance Index: 316.9600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 9.0412
Cell Significance Index: 1241.6100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 9.0324
Cell Significance Index: 1110.6200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 8.7857
Cell Significance Index: 654.7900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 8.7828
Cell Significance Index: 1583.2700
Cell Name: peg cell (CL4033014)
Fold Change: 8.7684
Cell Significance Index: 202.5800
Cell Name: cell in vitro (CL0001034)
Fold Change: 8.7527
Cell Significance Index: 4780.0800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 8.6813
Cell Significance Index: 3838.2200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 8.0744
Cell Significance Index: 952.2200
Cell Name: odontoblast (CL0000060)
Fold Change: 7.5061
Cell Significance Index: 962.2400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 7.0698
Cell Significance Index: 371.1900
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 6.6462
Cell Significance Index: 122.8400
Cell Name: early pro-B cell (CL0002046)
Fold Change: 6.5681
Cell Significance Index: 423.7400
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 6.0545
Cell Significance Index: 65.8200
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 5.6586
Cell Significance Index: 294.7500
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 5.6151
Cell Significance Index: 164.9100
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 5.6056
Cell Significance Index: 152.5800
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 5.0112
Cell Significance Index: 30.8400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.2398
Cell Significance Index: 197.6800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 4.0506
Cell Significance Index: 691.6600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 3.9112
Cell Significance Index: 2960.4300
Cell Name: colon goblet cell (CL0009039)
Fold Change: 3.0361
Cell Significance Index: 300.3400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.9036
Cell Significance Index: 77.5300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.8833
Cell Significance Index: 572.2000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 2.4575
Cell Significance Index: 2218.9100
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.3717
Cell Significance Index: 21.8400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 1.8957
Cell Significance Index: 1389.9100
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 1.8154
Cell Significance Index: 15.6000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 1.2277
Cell Significance Index: 97.2400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.0062
Cell Significance Index: 191.4800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.7422
Cell Significance Index: 33.6400
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.5341
Cell Significance Index: 32.8300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0545
Cell Significance Index: -10.9300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0589
Cell Significance Index: -110.9800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1308
Cell Significance Index: -96.9100
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.1717
Cell Significance Index: -316.7200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.2085
Cell Significance Index: -320.9600
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.2863
Cell Significance Index: -389.3100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.2913
Cell Significance Index: -164.2700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.2932
Cell Significance Index: -183.1100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.3587
Cell Significance Index: -227.8200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.4484
Cell Significance Index: -160.8500
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.6012
Cell Significance Index: -31.2300
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.6214
Cell Significance Index: -178.8100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.6480
Cell Significance Index: -294.0900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.6881
Cell Significance Index: -144.9300
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.7168
Cell Significance Index: -81.8200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -1.0089
Cell Significance Index: -164.0800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -1.5163
Cell Significance Index: -173.7200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.5379
Cell Significance Index: -86.3000
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -1.5825
Cell Significance Index: -27.2800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -1.9307
Cell Significance Index: -280.6600
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -2.0582
Cell Significance Index: -65.9200
Cell Name: kidney cell (CL1000497)
Fold Change: -2.1843
Cell Significance Index: -17.4400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -2.3879
Cell Significance Index: -150.5000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -2.4899
Cell Significance Index: -41.6700
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -2.6175
Cell Significance Index: -54.5900
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -2.6598
Cell Significance Index: -16.0700
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -2.9832
Cell Significance Index: -104.8300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -3.0863
Cell Significance Index: -213.4300
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -3.0907
Cell Significance Index: -185.5500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -3.1354
Cell Significance Index: -326.4700
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -4.1086
Cell Significance Index: -102.7100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -4.2961
Cell Significance Index: -329.6800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -4.6194
Cell Significance Index: -310.6100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -4.6239
Cell Significance Index: -283.4900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -5.0031
Cell Significance Index: -108.3900
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -5.2296
Cell Significance Index: -89.6200
Cell Name: retinal rod cell (CL0000604)
Fold Change: -6.1075
Cell Significance Index: -72.8100
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -6.1325
Cell Significance Index: -91.8900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -6.1574
Cell Significance Index: -84.0100
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -6.3517
Cell Significance Index: -34.6400
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -6.8112
Cell Significance Index: -200.6200
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -6.9611
Cell Significance Index: -104.9000
Cell Name: perivascular cell (CL4033054)
Fold Change: -7.1125
Cell Significance Index: -32.8400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -7.6528
Cell Significance Index: -338.5000
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -8.0824
Cell Significance Index: -296.7000
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -8.7428
Cell Significance Index: -224.7300
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -8.8197
Cell Significance Index: -113.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** RPS27A is a small protein with a molecular weight of approximately 27 kDa. It is highly conserved across species, with a high degree of sequence similarity to other ribosomal proteins. RPS27A is a ubiquitin carboxyl extension protein, which suggests its role in post-translational modifications and protein stability. The protein is highly phosphorylated, which may regulate its activity and interactions with other proteins. **Pathways and Functions** RPS27A is involved in various cellular processes, including: 1. **Protein Synthesis**: RPS27A is a component of the 40S ribosomal subunit, which is responsible for translating mRNA into proteins. RPS27A plays a crucial role in the initiation of translation, binding to initiator tRNA and positioning the mRNA for translation. 2. **Cell Cycle Regulation**: RPS27A is involved in the regulation of the cell cycle, particularly in the G1 phase. It interacts with other proteins, such as p53 and p21, to regulate cell cycle progression. 3. **Immune Responses**: RPS27A is expressed in immune cells, where it plays a role in the recognition and processing of pathogens. It interacts with other immune proteins, such as MHC class I and TLRs, to regulate immune responses. 4. **Autophagy**: RPS27A is involved in the regulation of autophagy, a process by which cells recycle damaged or dysfunctional proteins and organelles. RPS27A interacts with other autophagy-related proteins to regulate autophagy. **Clinical Significance** RPS27A has been implicated in various diseases, including: 1. **Cancer**: RPS27A is overexpressed in several types of cancer, including breast, lung, and colon cancer. It is involved in the regulation of cell proliferation and survival, and may serve as a prognostic marker. 2. **Autoimmune Diseases**: RPS27A is involved in the regulation of immune responses, and may contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Neurological Disorders**: RPS27A has been implicated in the regulation of protein synthesis and autophagy in the brain, and may contribute to the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, RPS27A is a critical component of the 40S ribosomal subunit, involved in protein synthesis, cell cycle regulation, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of RPS27A in maintaining cellular homeostasis. Further research is needed to fully understand the role of RPS27A in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Ubiquitin carboxyl extension protein 80

Genular Protein ID: 3162624145

Symbol: RS27A_HUMAN

Name: Ubiquitin carboxyl extension protein 80

UniProtKB Accession Codes:

P62979 P02248 P02249 P02250 P14798 P62988 Q29120 Q6LBL4 Q6LDU5 Q8WYN8 Q91887 Q91888 Q9BQ77 Q9BWD6 Q9BX98 Q9UEF2 Q9UEG1 Q9UEK8 Q9UPK7

Database IDs:

Citations:

PubMed ID: 1657614

Title: Effect of ubiquitin on platelet functions: possible identity with platelet activity suppressive lymphokine (PASL).

PubMed ID: 1657614

DOI: 10.1002/eji.1830211113

PubMed ID: 1370760

Title: Differential expression of translation-associated genes in benign and malignant human breast tumours.

PubMed ID: 1370760

DOI: 10.1038/bjc.1992.12

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 1128706

Title: Molecular conservation of 74 amino acid sequence of ubiquitin between cattle and man.

PubMed ID: 1128706

DOI: 10.1038/255423a0

PubMed ID: 16443603

Title: Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.

PubMed ID: 16443603

DOI: 10.1074/jbc.m512786200

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 2581967

Title: Nucleotide sequence analysis of a cDNA encoding human ubiquitin reveals that ubiquitin is synthesized as a precursor.

PubMed ID: 2581967

DOI: 10.1016/s0021-9258(17)39652-7

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 16543144

Title: Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain.

PubMed ID: 16543144

DOI: 10.1016/j.molcel.2006.02.018

PubMed ID: 15466860

Title: Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis.

PubMed ID: 15466860

DOI: 10.1074/jbc.m402916200

PubMed ID: 18719106

Title: Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks.

PubMed ID: 18719106

DOI: 10.1073/pnas.0805685105

PubMed ID: 19754430

Title: The emerging complexity of protein ubiquitination.

PubMed ID: 19754430

DOI: 10.1042/bst0370937

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24660806

Title: Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.

PubMed ID: 24660806

DOI: 10.1042/bj20140334

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24751536

Title: PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.

PubMed ID: 24751536

DOI: 10.1083/jcb.201402104

PubMed ID: 24784582

Title: Ubiquitin is phosphorylated by PINK1 to activate parkin.

PubMed ID: 24784582

DOI: 10.1038/nature13392

PubMed ID: 25474007

Title: Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering.

PubMed ID: 25474007

DOI: 10.1371/journal.pgen.1004861

PubMed ID: 25527291

Title: Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis.

PubMed ID: 25527291

DOI: 10.15252/embj.201489847

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28525742

Title: Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9.

PubMed ID: 28525742

DOI: 10.1016/j.molcel.2017.04.028

PubMed ID: 32330457

Title: Threonine ADP-ribosylation of ubiquitin by a bacterial effector family blocks host ubiquitination.

PubMed ID: 32330457

DOI: 10.1016/j.molcel.2020.03.016

PubMed ID: 32129764

Title: USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit.

PubMed ID: 32129764

DOI: 10.7554/elife.54435

PubMed ID: 34239127

Title: K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle.

PubMed ID: 34239127

DOI: 10.1038/s41589-021-00823-5

PubMed ID: 36638793

Title: An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes.

PubMed ID: 36638793

DOI: 10.1016/j.cell.2022.12.025

PubMed ID: 25752573

Title: K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of K29 polyubiquitin.

PubMed ID: 25752573

DOI: 10.1016/j.molcel.2015.01.041

PubMed ID: 25752577

Title: Assembly and specific recognition of K29- and K33-linked polyubiquitin.

PubMed ID: 25752577

DOI: 10.1016/j.molcel.2015.01.042

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

Length: 156
Mass: 17965
Checksum: 617BC63DF3A904F7
Sequence:

MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN 
IQKESTLHLV LRLRGGAKKR KKKSYTTPKK NKHKRKKVKL AVLKYYKVDE NGKISRLRRE 
CPSDECGAGV FMASHFDRHY CGKCCLTYCF NKPEDK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RPS27A

Associated with

Cells (max top 100)

Other Information

Effect of ubiquitin on platelet functions: possible identity with platelet activity suppressive lymphokine (PASL). PubMed ID: 1657614

Differential expression of translation-associated genes in benign and malignant human breast tumours. PubMed ID: 1370760

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. PubMed ID: 8706699

Molecular conservation of 74 amino acid sequence of ubiquitin between cattle and man. PubMed ID: 1128706

Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation. PubMed ID: 16443603

The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. PubMed ID: 11875025

Nucleotide sequence analysis of a cDNA encoding human ubiquitin reveals that ubiquitin is synthesized as a precursor. PubMed ID: 2581967

A map of 75 human ribosomal protein genes. PubMed ID: 9582194

Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. PubMed ID: 16543144

Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis. PubMed ID: 15466860

Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. PubMed ID: 18719106

The emerging complexity of protein ubiquitination. PubMed ID: 19754430

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65. PubMed ID: 24660806

A new system for naming ribosomal proteins. PubMed ID: 24524803

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. PubMed ID: 24751536

Ubiquitin is phosphorylated by PINK1 to activate parkin. PubMed ID: 24784582

Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering. PubMed ID: 25474007

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis. PubMed ID: 25527291

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9. PubMed ID: 28525742

Threonine ADP-ribosylation of ubiquitin by a bacterial effector family blocks host ubiquitination. PubMed ID: 32330457

USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit. PubMed ID: 32129764

K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle. PubMed ID: 34239127

An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes. PubMed ID: 36638793

K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of K29 polyubiquitin. PubMed ID: 25752573

Assembly and specific recognition of K29- and K33-linked polyubiquitin. PubMed ID: 25752577

Nucleolar maturation of the human small subunit processome. PubMed ID: 34516797

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399