Gene RPS27A - ENSG00000143947 | NCBI Gene ID: 6233

Details for: RPS27A

Gene ID: 6233

Symbol: RPS27A

Ensembl ID: ENSG00000143947

Description: ribosomal protein S27a

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Adaptive immune system
(R-HSA-1280218)
Amyloid fiber formation
(R-HSA-977225)
Apoptosis
(R-HSA-109581)
Asparagine n-linked glycosylation
(R-HSA-446203)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Autophagy
(R-HSA-9612973)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to hypoxia
(R-HSA-1234174)
Cellular senescence
(R-HSA-2559583)
Chaperone mediated autophagy
(R-HSA-9613829)
Circadian clock
(R-HSA-400253)
Cytokine signaling in immune system
(R-HSA-1280215)
Cytosolic sensors of pathogen-associated dna
(R-HSA-1834949)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-HSA-168928)
Death receptor signaling
(R-HSA-73887)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of metabolism
(R-HSA-5668914)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna damage bypass
(R-HSA-73893)
Dna double-strand break repair
(R-HSA-5693532)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Eukaryotic translation elongation
(R-HSA-156842)
Fanconi anemia pathway
(R-HSA-6783310)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Intracellular signaling by second messengers
(R-HSA-9006925)
Ion channel transport
(R-HSA-983712)
Iron uptake and transport
(R-HSA-917937)
Late endosomal microautophagy
(R-HSA-9615710)
Macroautophagy
(R-HSA-1632852)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of carbohydrates
(R-HSA-71387)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Nucleotide excision repair
(R-HSA-5696398)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
Peroxisomal protein import
(R-HSA-9033241)
Pip3 activates akt signaling
(R-HSA-1257604)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Protein localization
(R-HSA-9609507)
Recognition of dna damage by pcna-containing replication complex
(R-HSA-110314)
Regulated necrosis
(R-HSA-5218859)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Rna polymerase ii transcription
(R-HSA-73857)
Rrna processing
(R-HSA-72312)
Selenoamino acid metabolism
(R-HSA-2408522)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb4
(R-HSA-1236394)
Signaling by fgfr
(R-HSA-190236)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch2
(R-HSA-1980145)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Stimuli-sensing channels
(R-HSA-2672351)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Toll-like receptor cascades
(R-HSA-168898)
Translation
(R-HSA-72766)
Translesion synthesis by y family dna polymerases bypasses lesions on dna template
(R-HSA-110313)
Transport of small molecules
(R-HSA-382551)
Vesicle-mediated transport
(R-HSA-5653656)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 8.15
Marker Score: 4592
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 6.3
Marker Score: 30926
Cell Name: malignant cell (CL0001064)
Fold Change: 5.85
Marker Score: 78640
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 5.79
Marker Score: 12130
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 5.78
Marker Score: 4194
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 5.58
Marker Score: 2878
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 5.57
Marker Score: 2864
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 5.48
Marker Score: 15997
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 5.46
Marker Score: 7111
Cell Name: mature T cell (CL0002419)
Fold Change: 5.36
Marker Score: 53057
Cell Name: radial glial cell (CL0000681)
Fold Change: 5.31
Marker Score: 1956
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 5.21
Marker Score: 3935
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 5.19
Marker Score: 13184
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 5.18
Marker Score: 8885
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 5.14
Marker Score: 4376
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 5.1
Marker Score: 173604
Cell Name: theca cell (CL0000503)
Fold Change: 5.07
Marker Score: 3635
Cell Name: naive B cell (CL0000788)
Fold Change: 4.97
Marker Score: 4433.5
Cell Name: naive T cell (CL0000898)
Fold Change: 4.93
Marker Score: 3175
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.87
Marker Score: 15366.5
Cell Name: memory T cell (CL0000813)
Fold Change: 4.79
Marker Score: 2059
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.77
Marker Score: 252325.5
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 4.74
Marker Score: 24937
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 4.73
Marker Score: 7288.5
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 4.67
Marker Score: 1115
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 4.59
Marker Score: 5097
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 4.56
Marker Score: 1482
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 4.55
Marker Score: 12183
Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.51
Marker Score: 59486
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.5
Marker Score: 251682
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 4.45
Marker Score: 15788
Cell Name: granulocyte (CL0000094)
Fold Change: 4.4
Marker Score: 1974
Cell Name: germinal center B cell (CL0000844)
Fold Change: 4.4
Marker Score: 2677
Cell Name: blood cell (CL0000081)
Fold Change: 4.39
Marker Score: 50975
Cell Name: elicited macrophage (CL0000861)
Fold Change: 4.38
Marker Score: 26592
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 4.35
Marker Score: 5248
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.32
Marker Score: 11943
Cell Name: acinar cell (CL0000622)
Fold Change: 4.32
Marker Score: 3045.5
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 4.31
Marker Score: 3066
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 4.31
Marker Score: 4067.5
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.25
Marker Score: 11913
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 4.25
Marker Score: 4104
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 4.23
Marker Score: 37120
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.21
Marker Score: 10290
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 4.21
Marker Score: 2468
Cell Name: club cell (CL0000158)
Fold Change: 4.18
Marker Score: 4882
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.16
Marker Score: 9473
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 4.14
Marker Score: 10448
Cell Name: endothelial cell (CL0000115)
Fold Change: 4.14
Marker Score: 3711
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 4.13
Marker Score: 947
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 4.13
Marker Score: 30731
Cell Name: type I NK T cell (CL0000921)
Fold Change: 4.12
Marker Score: 3234
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 4.1
Marker Score: 10008
Cell Name: supporting cell (CL0000630)
Fold Change: 4.09
Marker Score: 7692.5
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 4.09
Marker Score: 4402
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 4.09
Marker Score: 17518
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 4.08
Marker Score: 6015
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 4.08
Marker Score: 3480
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 4.06
Marker Score: 5015
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 4.05
Marker Score: 2162
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 4.04
Marker Score: 26307.5
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 4.03
Marker Score: 4300
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 4.01
Marker Score: 1832
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 4
Marker Score: 3939
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 3.99
Marker Score: 3435
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 3.99
Marker Score: 5795
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 3.99
Marker Score: 9927
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.98
Marker Score: 25419
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 3.96
Marker Score: 1116
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 3.95
Marker Score: 1122
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 3.94
Marker Score: 5710
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 3.93
Marker Score: 1075
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 3.93
Marker Score: 1035
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.93
Marker Score: 3451
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 3.92
Marker Score: 3215
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 3.92
Marker Score: 2031
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 3.91
Marker Score: 3446
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 3.89
Marker Score: 2943
Cell Name: paneth cell (CL0000510)
Fold Change: 3.88
Marker Score: 2701
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 3.87
Marker Score: 4662
Cell Name: reticular cell (CL0000432)
Fold Change: 3.86
Marker Score: 1408
Cell Name: fibroblast (CL0000057)
Fold Change: 3.84
Marker Score: 3712
Cell Name: regulatory T cell (CL0000815)
Fold Change: 3.84
Marker Score: 4247
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 3.84
Marker Score: 3609
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 3.82
Marker Score: 2572.5
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 3.82
Marker Score: 1012
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.82
Marker Score: 1257
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 3.81
Marker Score: 1088
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3.8
Marker Score: 3393.5
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.8
Marker Score: 3380
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 3.8
Marker Score: 3154
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: 3.8
Marker Score: 944
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 3.78
Marker Score: 880
Cell Name: stromal cell (CL0000499)
Fold Change: 3.78
Marker Score: 4427.5
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 3.77
Marker Score: 3823
Cell Name: exhausted T cell (CL0011025)
Fold Change: 3.77
Marker Score: 2168
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.77
Marker Score: 4311
Cell Name: mesothelial fibroblast (CL4023054)
Fold Change: 3.76
Marker Score: 1113
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 3.76
Marker Score: 1207
Cell Name: S cone cell (CL0003050)
Fold Change: 3.76
Marker Score: 1130

Hover over a box to see details here...

**Key characteristics:** * The gene is located on chromosome 10 and is approximately 10.5 kb in length. * It encodes a protein of 80 amino acids. * RS27A is a ubiquitin carboxyl extension protein, which is responsible for the addition of ubiquitin molecules to proteins, marking them for degradation. * It is highly expressed in epithelial cells of the exocrine pancreas, myoepithelial cells of the mammary gland, and malignant cells. * It is also expressed in a variety of immune cells, including natural killer cells, activated CD8+ T cells, and regulatory T cells. **Pathways and functions:** * RS27A is involved in the regulation of apoptosis, autophagy, and cell cycle progression. * It is a key regulator of epithelial cell differentiation and function. * It is also involved in the regulation of immune responses, as it is expressed in immune cells and is involved in the regulation of inflammation and immune cell activation. * It is also involved in the regulation of protein degradation. **Clinical significance:** * Mutations in the RPS27A gene have been linked to a number of human diseases, including cancer and inflammatory bowel disease. * Studies of the role of RS27A in cancer have shown that it is a key oncogene, and that mutations in the gene can lead to the development of tumors. * Targeting RS27A with small molecule inhibitors is a promising strategy for the treatment of cancer and other diseases that are characterized by abnormal cell death.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Ubiquitin carboxyl extension protein 80

Genular Protein ID: 3162624145

Symbol: RS27A_HUMAN

Name: Ubiquitin carboxyl extension protein 80

UniProtKB Accession Codes:

P62979 P02248 P02249 P02250 P14798 P62988 Q29120 Q6LBL4 Q6LDU5 Q8WYN8 Q91887 Q91888 Q9BQ77 Q9BWD6 Q9BX98 Q9UEF2 Q9UEG1 Q9UEK8 Q9UPK7

Database IDs:

Citations:

PubMed ID: 1657614

Title: Effect of ubiquitin on platelet functions: possible identity with platelet activity suppressive lymphokine (PASL).

PubMed ID: 1657614

DOI: 10.1002/eji.1830211113

PubMed ID: 1370760

Title: Differential expression of translation-associated genes in benign and malignant human breast tumours.

PubMed ID: 1370760

DOI: 10.1038/bjc.1992.12

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 1128706

Title: Molecular conservation of 74 amino acid sequence of ubiquitin between cattle and man.

PubMed ID: 1128706

DOI: 10.1038/255423a0

PubMed ID: 16443603

Title: Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.

PubMed ID: 16443603

DOI: 10.1074/jbc.m512786200

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 2581967

Title: Nucleotide sequence analysis of a cDNA encoding human ubiquitin reveals that ubiquitin is synthesized as a precursor.

PubMed ID: 2581967

DOI: 10.1016/s0021-9258(17)39652-7

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 16543144

Title: Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain.

PubMed ID: 16543144

DOI: 10.1016/j.molcel.2006.02.018

PubMed ID: 15466860

Title: Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis.

PubMed ID: 15466860

DOI: 10.1074/jbc.m402916200

PubMed ID: 18719106

Title: Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks.

PubMed ID: 18719106

DOI: 10.1073/pnas.0805685105

PubMed ID: 19754430

Title: The emerging complexity of protein ubiquitination.

PubMed ID: 19754430

DOI: 10.1042/bst0370937

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24660806

Title: Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.

PubMed ID: 24660806

DOI: 10.1042/bj20140334

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24751536

Title: PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.

PubMed ID: 24751536

DOI: 10.1083/jcb.201402104

PubMed ID: 24784582

Title: Ubiquitin is phosphorylated by PINK1 to activate parkin.

PubMed ID: 24784582

DOI: 10.1038/nature13392

PubMed ID: 25474007

Title: Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering.

PubMed ID: 25474007

DOI: 10.1371/journal.pgen.1004861

PubMed ID: 25527291

Title: Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis.

PubMed ID: 25527291

DOI: 10.15252/embj.201489847

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28525742

Title: Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9.

PubMed ID: 28525742

DOI: 10.1016/j.molcel.2017.04.028

PubMed ID: 32330457

Title: Threonine ADP-ribosylation of ubiquitin by a bacterial effector family blocks host ubiquitination.

PubMed ID: 32330457

DOI: 10.1016/j.molcel.2020.03.016

PubMed ID: 32129764

Title: USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit.

PubMed ID: 32129764

DOI: 10.7554/elife.54435

PubMed ID: 34239127

Title: K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle.

PubMed ID: 34239127

DOI: 10.1038/s41589-021-00823-5

PubMed ID: 36638793

Title: An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes.

PubMed ID: 36638793

DOI: 10.1016/j.cell.2022.12.025

PubMed ID: 25752573

Title: K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of K29 polyubiquitin.

PubMed ID: 25752573

DOI: 10.1016/j.molcel.2015.01.041

PubMed ID: 25752577

Title: Assembly and specific recognition of K29- and K33-linked polyubiquitin.

PubMed ID: 25752577

DOI: 10.1016/j.molcel.2015.01.042

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

Length: 156
Mass: 17965
Checksum: 617BC63DF3A904F7
Sequence:

MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN 
IQKESTLHLV LRLRGGAKKR KKKSYTTPKK NKHKRKKVKL AVLKYYKVDE NGKISRLRRE 
CPSDECGAGV FMASHFDRHY CGKCCLTYCF NKPEDK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: RPS27A

Associated with

Cells (max top 100)

Other Information

Effect of ubiquitin on platelet functions: possible identity with platelet activity suppressive lymphokine (PASL). PubMed ID: 1657614

Differential expression of translation-associated genes in benign and malignant human breast tumours. PubMed ID: 1370760

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. PubMed ID: 8706699

Molecular conservation of 74 amino acid sequence of ubiquitin between cattle and man. PubMed ID: 1128706

Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation. PubMed ID: 16443603

The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. PubMed ID: 11875025

Nucleotide sequence analysis of a cDNA encoding human ubiquitin reveals that ubiquitin is synthesized as a precursor. PubMed ID: 2581967

A map of 75 human ribosomal protein genes. PubMed ID: 9582194

Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. PubMed ID: 16543144

Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis. PubMed ID: 15466860

Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. PubMed ID: 18719106

The emerging complexity of protein ubiquitination. PubMed ID: 19754430

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65. PubMed ID: 24660806

A new system for naming ribosomal proteins. PubMed ID: 24524803

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. PubMed ID: 24751536

Ubiquitin is phosphorylated by PINK1 to activate parkin. PubMed ID: 24784582

Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering. PubMed ID: 25474007

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis. PubMed ID: 25527291

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9. PubMed ID: 28525742

Threonine ADP-ribosylation of ubiquitin by a bacterial effector family blocks host ubiquitination. PubMed ID: 32330457

USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit. PubMed ID: 32129764

K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle. PubMed ID: 34239127

An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes. PubMed ID: 36638793

K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of K29 polyubiquitin. PubMed ID: 25752573

Assembly and specific recognition of K29- and K33-linked polyubiquitin. PubMed ID: 25752577

Nucleolar maturation of the human small subunit processome. PubMed ID: 34516797