RPS28 | ENSG00000233927 | NCBI 6234

Details for: RPS28

Gene ID: 6234

Symbol: RPS28

Ensembl ID: ENSG00000233927

Description: ribosomal protein S28

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 modulates host translation machinery
(R-HSA-9735869)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates host translation machinery
(R-HSA-9754678)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Translation initiation complex formation
(R-HSA-72649)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic side of rough endoplasmic reticulum membrane
(GO:0098556)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic small ribosomal subunit
(GO:0022627)
Extracellular exosome
(GO:0070062)
Maturation of ssu-rrna
(GO:0030490)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Protein binding
(GO:0005515)
Ribosomal small subunit assembly
(GO:0000028)
Ribosomal small subunit biogenesis
(GO:0042274)
Ribosome
(GO:0005840)
Ribosome biogenesis
(GO:0042254)
Rna binding
(GO:0003723)
Rrna processing
(GO:0006364)
Small-subunit processome
(GO:0032040)
Small ribosomal subunit
(GO:0015935)
Structural constituent of ribosome
(GO:0003735)
Synapse
(GO:0045202)
Translation
(GO:0006412)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: embryonic stem cell (CL0002322)
Fold Change: 757.8634
Cell Significance Index: -312.2000
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 700.0493
Cell Significance Index: -284.4000
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 621.1945
Cell Significance Index: -293.2800
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 610.9818
Cell Significance Index: -314.2800
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 438.7188
Cell Significance Index: -294.3900
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 302.3327
Cell Significance Index: -288.6500
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 52.5391
Cell Significance Index: -140.7500
Cell Name: abnormal cell (CL0001061)
Fold Change: 16.7960
Cell Significance Index: 1715.7100
Cell Name: pro-T cell (CL0000827)
Fold Change: 15.4094
Cell Significance Index: 393.6600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 14.7038
Cell Significance Index: 691.0700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 12.8810
Cell Significance Index: 344.5600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 12.8558
Cell Significance Index: 368.5200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 12.5382
Cell Significance Index: 231.7400
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 11.7858
Cell Significance Index: 208.2700
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 11.7757
Cell Significance Index: 72.4700
Cell Name: granulosa cell (CL0000501)
Fold Change: 11.4425
Cell Significance Index: 300.8800
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 10.2637
Cell Significance Index: 116.6000
Cell Name: lactocyte (CL0002325)
Fold Change: 10.0793
Cell Significance Index: 1302.1700
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 10.0694
Cell Significance Index: 128.9600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 9.9054
Cell Significance Index: 1785.6400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 9.8218
Cell Significance Index: 1207.6800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 9.7496
Cell Significance Index: 689.5300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 8.9353
Cell Significance Index: 1227.0600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 8.5007
Cell Significance Index: 3758.3800
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 8.4401
Cell Significance Index: 995.3500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 8.3335
Cell Significance Index: 621.0900
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 7.7481
Cell Significance Index: 162.1800
Cell Name: cell in vitro (CL0001034)
Fold Change: 7.6943
Cell Significance Index: 4202.0200
Cell Name: odontoblast (CL0000060)
Fold Change: 7.4039
Cell Significance Index: 949.1400
Cell Name: theca cell (CL0000503)
Fold Change: 7.2459
Cell Significance Index: 42.5700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 6.5785
Cell Significance Index: 306.7200
Cell Name: early pro-B cell (CL0002046)
Fold Change: 6.3054
Cell Significance Index: 406.8000
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 6.2279
Cell Significance Index: 182.9100
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 6.1746
Cell Significance Index: 56.8600
Cell Name: peg cell (CL4033014)
Fold Change: 5.9082
Cell Significance Index: 136.5000
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 5.7981
Cell Significance Index: 15.5300
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 5.6951
Cell Significance Index: 60.5100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 5.5662
Cell Significance Index: 4213.1300
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 5.4729
Cell Significance Index: 287.3500
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 5.2514
Cell Significance Index: 57.0900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 5.0707
Cell Significance Index: 138.0200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 4.9314
Cell Significance Index: 842.0600
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 4.8691
Cell Significance Index: 41.8400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 3.4871
Cell Significance Index: 121.1800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 3.0840
Cell Significance Index: 2784.6600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.5960
Cell Significance Index: 135.2200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.2026
Cell Significance Index: 99.8400
Cell Name: kidney cell (CL1000497)
Fold Change: 1.9576
Cell Significance Index: 15.6300
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 1.7241
Cell Significance Index: 1264.1100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.6827
Cell Significance Index: 44.9300
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 1.6321
Cell Significance Index: 129.2600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.9585
Cell Significance Index: 182.4100
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: 0.6334
Cell Significance Index: 13.2100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1848
Cell Significance Index: 66.2800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1401
Cell Significance Index: 7.2800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0438
Cell Significance Index: -82.3900
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0889
Cell Significance Index: -17.6500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1108
Cell Significance Index: -82.0700
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.1517
Cell Significance Index: -279.7600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.1848
Cell Significance Index: -284.5000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.1889
Cell Significance Index: -30.7200
Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.2144
Cell Significance Index: -21.2100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.2338
Cell Significance Index: -317.9600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.2494
Cell Significance Index: -140.6800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.2733
Cell Significance Index: -170.6400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.3888
Cell Significance Index: -246.9600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.5730
Cell Significance Index: -114.9400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.5939
Cell Significance Index: -269.5500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.5991
Cell Significance Index: -126.1800
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.8110
Cell Significance Index: -49.8500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.8929
Cell Significance Index: -256.9200
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -1.2420
Cell Significance Index: -21.4100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -1.2797
Cell Significance Index: -146.6200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.2832
Cell Significance Index: -41.1000
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.6633
Cell Significance Index: -104.8300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -1.6762
Cell Significance Index: -115.9200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -1.8183
Cell Significance Index: -264.3100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -2.0148
Cell Significance Index: -33.7200
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -2.1965
Cell Significance Index: -250.7300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -2.4197
Cell Significance Index: -135.7800
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -2.4463
Cell Significance Index: -14.7800
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -2.6213
Cell Significance Index: -92.1100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -2.7291
Cell Significance Index: -284.1600
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -3.2415
Cell Significance Index: -194.6000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -3.4357
Cell Significance Index: -98.9900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -3.4614
Cell Significance Index: -265.6200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -3.7532
Cell Significance Index: -93.8200
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -3.9381
Cell Significance Index: -53.7300
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -3.9902
Cell Significance Index: -59.7900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -4.0149
Cell Significance Index: -246.1500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -4.0217
Cell Significance Index: -87.1300
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -4.3262
Cell Significance Index: -23.5900
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -4.3315
Cell Significance Index: -291.2500
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -5.5949
Cell Significance Index: -95.8800
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -5.9068
Cell Significance Index: -173.9800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -6.3246
Cell Significance Index: -279.7500
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -7.1261
Cell Significance Index: -91.7700
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -7.4402
Cell Significance Index: -273.1300
Cell Name: retinal rod cell (CL0000604)
Fold Change: -7.5055
Cell Significance Index: -89.4700
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -7.5329
Cell Significance Index: -285.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** RPS28 is a 28-kDa protein that belongs to the ribosomal protein S family. It is a component of the 40S small subunit of the eukaryotic ribosome, which is responsible for the initiation of translation. RPS28 is highly conserved across species, with its sequence showing high similarity to other ribosomal proteins. The protein is characterized by its ability to bind to mRNA and participate in the initiation of translation, as well as its involvement in regulating protein synthesis in response to stress and starvation. **Pathways and Functions** RPS28 is involved in several key pathways and processes, including: 1. **Translation Initiation**: RPS28 plays a crucial role in the initiation of translation, where it binds to mRNA and participates in the recruitment of the 40S small subunit to the mRNA. 2. **Stress Response**: RPS28 is involved in the regulation of protein synthesis in response to stress and starvation. It is activated by the eIF2α kinase, GCN2, in response to amino acid deficiency. 3. **Viral Infection**: RPS28 is involved in the translation of viral mRNAs, including those of the influenza virus. 4. **Immune Response**: RPS28 is expressed in immune cells, such as T cells and natural killer cells, where it plays a role in regulating protein synthesis in response to viral infections. 5. **Cellular Response to Stimuli**: RPS28 is involved in the regulation of protein synthesis in response to various cellular stimuli, including growth factors and cytokines. **Clinical Significance** RPS28 has been implicated in several diseases, including: 1. **Influenza**: RPS28 is involved in the translation of influenza viral mRNAs, making it a potential target for therapeutic intervention. 2. **Cancer**: RPS28 is overexpressed in various types of cancer, including breast and pancreatic cancer, where it may contribute to tumorigenesis. 3. **Neurological Disorders**: RPS28 has been implicated in neurological disorders, including amyotrophic lateral sclerosis (ALS) and Alzheimer's disease, where it may contribute to protein misfolding and aggregation. 4. **Immune-Mediated Diseases**: RPS28 is involved in the regulation of protein synthesis in immune cells, where it may contribute to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In summary, RPS28 is a critical component of the eukaryotic ribosome, involved in translation initiation, stress response, and viral infection. Its dysregulation has been implicated in various diseases, highlighting its importance as a therapeutic target.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

40S ribosomal protein S28

Genular Protein ID: 3572985535

Symbol: RS28_HUMAN

Name: 40S ribosomal protein S28

UniProtKB Accession Codes:

P62857 P25112

Database IDs:

Citations:

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24942156

Title: Diamond-Blackfan anemia with mandibulofacial dystostosis is heterogeneous, including the novel DBA genes TSR2 and RPS28.

PubMed ID: 24942156

DOI: 10.1002/ajmg.a.36633

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 25957688

Title: Structural snapshots of actively translating human ribosomes.

PubMed ID: 25957688

DOI: 10.1016/j.cell.2015.03.052

PubMed ID: 25901680

Title: Structure of the human 80S ribosome.

PubMed ID: 25901680

DOI: 10.1038/nature14427

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

Length: 69
Mass: 7841
Checksum: 49902FE9376EB74F
Sequence:

MDTSRVQPIK LARVTKVLGR TGSQGQCTQV RVEFMDDTSR SIIRNVKGPV REGDVLTLLE 
SEREARRLR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RPS28

Associated with

Cells (max top 100)

Other Information

The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. PubMed ID: 11875025

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. PubMed ID: 8706699

A map of 75 human ribosomal protein genes. PubMed ID: 9582194

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Diamond-Blackfan anemia with mandibulofacial dystostosis is heterogeneous, including the novel DBA genes TSR2 and RPS28. PubMed ID: 24942156

A new system for naming ribosomal proteins. PubMed ID: 24524803

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Structural snapshots of actively translating human ribosomes. PubMed ID: 25957688

Structure of the human 80S ribosome. PubMed ID: 25901680

Nucleolar maturation of the human small subunit processome. PubMed ID: 34516797