Details for: SRSF4

Gene ID: 6429

Symbol: SRSF4

Ensembl ID: ENSG00000116350

Description: serine and arginine rich splicing factor 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 428.4927
    Cell Significance Index: -66.6500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 286.5046
    Cell Significance Index: -72.6700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 186.8684
    Cell Significance Index: -76.9800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 174.3477
    Cell Significance Index: -70.8300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 173.7155
    Cell Significance Index: -82.0200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 154.1841
    Cell Significance Index: -79.3100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 122.5816
    Cell Significance Index: -82.2600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 74.4860
    Cell Significance Index: -71.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 64.2683
    Cell Significance Index: -79.2400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 26.3097
    Cell Significance Index: -70.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.4914
    Cell Significance Index: -80.8600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.2933
    Cell Significance Index: -62.3300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 19.1676
    Cell Significance Index: -41.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 5.3847
    Cell Significance Index: 143.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.8462
    Cell Significance Index: 77.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.0294
    Cell Significance Index: 56.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9473
    Cell Significance Index: 386.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.8034
    Cell Significance Index: 221.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.7106
    Cell Significance Index: 95.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6770
    Cell Significance Index: 302.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4548
    Cell Significance Index: 199.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4062
    Cell Significance Index: 767.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3893
    Cell Significance Index: 106.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2098
    Cell Significance Index: 78.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1720
    Cell Significance Index: 420.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1382
    Cell Significance Index: 51.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1058
    Cell Significance Index: 31.8600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.9412
    Cell Significance Index: 18.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9380
    Cell Significance Index: 32.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8973
    Cell Significance Index: 19.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8734
    Cell Significance Index: 175.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8391
    Cell Significance Index: 98.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8379
    Cell Significance Index: 39.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7395
    Cell Significance Index: 326.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7192
    Cell Significance Index: 37.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6397
    Cell Significance Index: 82.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5898
    Cell Significance Index: 27.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5875
    Cell Significance Index: 30.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4674
    Cell Significance Index: 422.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3823
    Cell Significance Index: 28.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3511
    Cell Significance Index: 45.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3422
    Cell Significance Index: 236.6500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3345
    Cell Significance Index: 9.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3177
    Cell Significance Index: 6.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2297
    Cell Significance Index: 432.5800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2036
    Cell Significance Index: 3.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2008
    Cell Significance Index: 127.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1958
    Cell Significance Index: 88.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1869
    Cell Significance Index: 11.4900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1621
    Cell Significance Index: 2.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1507
    Cell Significance Index: 25.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1496
    Cell Significance Index: 10.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1473
    Cell Significance Index: 200.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1468
    Cell Significance Index: 9.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1369
    Cell Significance Index: 210.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1169
    Cell Significance Index: 215.5100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1128
    Cell Significance Index: 2.9000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1026
    Cell Significance Index: 0.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0501
    Cell Significance Index: 9.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0224
    Cell Significance Index: 2.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0244
    Cell Significance Index: -18.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0254
    Cell Significance Index: -18.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0459
    Cell Significance Index: -33.9900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0762
    Cell Significance Index: -47.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0828
    Cell Significance Index: -13.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1094
    Cell Significance Index: -4.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1108
    Cell Significance Index: -11.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1161
    Cell Significance Index: -65.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1437
    Cell Significance Index: -2.4100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1594
    Cell Significance Index: -4.6800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1620
    Cell Significance Index: -2.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2031
    Cell Significance Index: -10.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2339
    Cell Significance Index: -15.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2445
    Cell Significance Index: -35.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2496
    Cell Significance Index: -71.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2649
    Cell Significance Index: -55.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2911
    Cell Significance Index: -11.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3042
    Cell Significance Index: -10.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3750
    Cell Significance Index: -9.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4144
    Cell Significance Index: -47.4800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4402
    Cell Significance Index: -11.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5177
    Cell Significance Index: -60.3300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5326
    Cell Significance Index: -4.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5575
    Cell Significance Index: -58.0500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5600
    Cell Significance Index: -7.6400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6001
    Cell Significance Index: -19.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6045
    Cell Significance Index: -12.8800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6518
    Cell Significance Index: -11.1700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6572
    Cell Significance Index: -9.7000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.6696
    Cell Significance Index: -5.4600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6974
    Cell Significance Index: -12.8900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.7333
    Cell Significance Index: -83.7100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8157
    Cell Significance Index: -12.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8929
    Cell Significance Index: -70.7200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.0205
    Cell Significance Index: -26.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0520
    Cell Significance Index: -64.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.0923
    Cell Significance Index: -75.5400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.2193
    Cell Significance Index: -29.7500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.2756
    Cell Significance Index: -29.4700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.3170
    Cell Significance Index: -31.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SRSF4 is a 79-kDa protein that contains a characteristic serine/arginine-rich domain, which is essential for its interactions with other RNA-binding proteins and the spliceosome. The protein's ability to bind to specific RNA sequences allows it to regulate the splicing of pre-mRNA, a critical step in the processing of messenger RNA (mRNA) from its precursor form. SRSF4's role in splicing is mediated through its interaction with other components of the spliceosome, including the U1 small nuclear ribonucleoprotein (snRNP) and the U2AF65 protein. Additionally, SRSF4 has been shown to interact with various transcription factors and other RNA-binding proteins, suggesting its involvement in broader regulatory networks. **Pathways and Functions** SRSF4 is involved in several key pathways, including: 1. **RNA Splicing**: SRSF4 plays a central role in the splicing of pre-mRNA, which is essential for the production of mature mRNA. By binding to specific RNA sequences, SRSF4 regulates the inclusion or exclusion of splice sites, thereby controlling the final structure of the mature mRNA. 2. **Gene Expression**: SRSF4's involvement in splicing and transcriptional regulation makes it a key player in gene expression. By controlling the processing of pre-mRNA, SRSF4 influences the translation of mRNA into protein. 3. **Metabolism of RNA**: SRSF4 is also involved in the metabolism of RNA, including the regulation of RNA stability and degradation. Its interactions with other RNA-binding proteins and the spliceosome suggest its role in the broader context of RNA metabolism. 4. **Cellular Processes**: SRSF4's expression in various cell types, including those of the cardiovascular, epithelial, and hematopoietic lineages, suggests its involvement in a range of cellular processes, including differentiation, proliferation, and survival. **Clinical Significance** Dysregulation of SRSF4 has been implicated in various diseases, including: 1. **Cancer**: Alterations in SRSF4 expression have been observed in several types of cancer, including breast, lung, and colon cancer. These changes can lead to the dysregulation of splicing and the production of aberrant mRNAs. 2. **Neurodegenerative Diseases**: SRSF4 has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and amyotrophic lateral sclerosis (ALS). Dysregulation of SRSF4 has been shown to contribute to the production of aberrant mRNAs and the disruption of normal RNA processing. 3. **Cardiovascular Disease**: SRSF4's expression in cardiac cells suggests its involvement in the regulation of cardiac gene expression. Alterations in SRSF4 expression have been observed in cardiac diseases, including heart failure and arrhythmias. In conclusion, SRSF4 is a multifunctional protein that plays a critical role in the regulation of RNA processing, particularly in the splicing of pre-mRNA. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining normal cellular function and preventing disease.

Genular Protein ID: 3036330996

Symbol: SRSF4_HUMAN

Name: Serine/arginine-rich splicing factor 4

UniProtKB Accession Codes:

Q08170 Q5VXP1 Q9BUA4 Q9UEB5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8321209

Title: Human SR proteins and isolation of a cDNA encoding SRp75.

PubMed ID: 8321209

DOI: 10.1128/mcb.13.7.4023-4028.1993

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1577277

Title: SR proteins: a conserved family of pre-mRNA splicing factors.

PubMed ID: 1577277

DOI: 10.1101/gad.6.5.837

PubMed ID: 9531537

Title: A coactivator of pre-mRNA splicing.

PubMed ID: 9531537

DOI: 10.1101/gad.12.7.996

PubMed ID: 15009664

Title: Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors.

PubMed ID: 15009664

DOI: 10.1046/j.1471-4159.2003.02232.x

PubMed ID: 14578391

Title: Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells.

PubMed ID: 14578391

DOI: 10.1167/iovs.03-0240

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 494
  • Mass: 56678
  • Checksum: 5BBAB917C218C20A
  • Sequence:
    • MPRVYIGRLS YQARERDVER FFKGYGKILE VDLKNGYGFV EFDDLRDADD AVYELNGKDL 
CGERVIVEHA RGPRRDGSYG SGRSGYGYRR SGRDKYGPPT RTEYRLIVEN LSSRCSWQDL 
KDYMRQAGEV TYADAHKGRK NEGVIEFVSY SDMKRALEKL DGTEVNGRKI RLVEDKPGSR 
RRRSYSRSRS HSRSRSRSRH SRKSRSRSGS SKSSHSKSRS RSRSGSRSRS KSRSRSQSRS 
RSKKEKSRSP SKEKSRSRSH SAGKSRSKSK DQAEEKIQNN DNVGKPKSRS PSRHKSKSKS 
RSRSQERRVE EEKRGSVSRG RSQEKSLRQS RSRSRSKGGS RSRSRSRSKS KDKRKGRKRS 
REESRSRSRS RSKSERSRKR GSKRDSKAGS SKKKKKEDTD RSQSRSPSRS VSKEREHAKS 
ESSQREGRGE SENAGTNQET RSRSRSNSKS KPNLPSESRS RSKSASKTRS RSKSRSRSAS 
RSPSRSRSRS HSRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.