Details for: ZNF862

Gene ID: 643641

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ZNF862

Ensembl ID: ENSG00000106479

Description: zinc finger protein 862

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • cardiac muscle cell CL0000746
    CSI 8.37
    rCSI 12.01%
    PRS 79.4
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 7.28
    rCSI 6.63%
    PRS 95.8
  • interstitial cell of Cajal CL0002088
    CSI 6.58
    rCSI 8.38%
    PRS 91.9
  • glioblast CL0000030
    CSI 5.04
    rCSI 8.04%
    PRS 80.19
  • renal alpha-intercalated cell CL0005011
    CSI 3.72
    rCSI 4.97%
    PRS 91.8
  • ependymal cell CL0000065
    CSI 3.46
    rCSI 7.03%
    PRS 69.17
  • melanocyte CL0000148
    CSI 3.14
    rCSI 2.33%
    PRS 83.38
  • pulmonary alveolar type 1 cell CL0002062
    CSI 3.14
    rCSI 18.1%
    PRS 84.64
  • naive T cell CL0000898
    CSI 3.02
    rCSI 2.1%
    PRS 96.83
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 2.89
    rCSI 8.28%
    PRS 97.78
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 2.85
    rCSI 3.55%
    PRS 71.19
  • retinal rod cell CL0000604
    CSI 2.85
    rCSI 5.02%
    PRS 83.56
  • regular ventricular cardiac myocyte CL0002131
    CSI 2.7
    rCSI 16.86%
    PRS 81.07
  • mesodermal cell CL0000222
    CSI 2.66
    rCSI 3.19%
    PRS 86.68
  • cardiac endothelial cell CL0010008
    CSI 2.65
    rCSI 10.69%
    PRS 88.41
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 2.64
    rCSI 4.8%
    PRS 80.89
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 2.51
    rCSI 9.04%
    PRS 71.36
  • choroid plexus epithelial cell CL0000706
    CSI 2.46
    rCSI 4.03%
    PRS 79.81
  • vascular leptomeningeal cell CL4023051
    CSI 2.46
    rCSI 4.31%
    PRS 83.64
  • naive B cell CL0000788
    CSI 2.3
    rCSI 1.97%
    PRS 91.7
  • sst GABAergic cortical interneuron CL4023017
    CSI 2.28
    rCSI 2.94%
    PRS 74.47
  • Mueller cell CL0000636
    CSI 2.27
    rCSI 5.18%
    PRS 80.83
  • retinal bipolar neuron CL0000748
    CSI 2.22
    rCSI 4.15%
    PRS 78.47
  • BEST4+ enteroycte CL4030026
    CSI 2.18
    rCSI 2.72%
    PRS 87.79
  • fibroblast of cardiac tissue CL0002548
    CSI 2.17
    rCSI 10.38%
    PRS 88.42
  • cardiac neuron CL0010022
    CSI 2.16
    rCSI 6.9%
    PRS 86.01
  • hepatic stellate cell CL0000632
    CSI 2.01
    rCSI 7.52%
    PRS 82.45
  • inhibitory interneuron CL0000498
    CSI 1.99
    rCSI 4.59%
    PRS 78.04
  • mesothelial cell CL0000077
    CSI 1.93
    rCSI 7.54%
    PRS 69.27
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 1.91
    rCSI 2.71%
    PRS 85.35
  • adipocyte CL0000136
    CSI 1.91
    rCSI 2.45%
    PRS 78.99
  • lung secretory cell CL1000272
    CSI 1.89
    rCSI 4.67%
    PRS 88.22
  • type B pancreatic cell CL0000169
    CSI 1.83
    rCSI 4.04%
    PRS 87.88
  • VIP GABAergic cortical interneuron CL4023016
    CSI 1.82
    rCSI 2.17%
    PRS 73.52
  • cerebral cortex endothelial cell CL1001602
    CSI 1.79
    rCSI 3.1%
    PRS 81.64
  • Bergmann glial cell CL0000644
    CSI 1.75
    rCSI 2.39%
    PRS 79.9
  • astrocyte of the cerebral cortex CL0002605
    CSI 1.67
    rCSI 3.75%
    PRS 74.04
  • chondrocyte CL0000138
    CSI 1.66
    rCSI 2.64%
    PRS 82.58
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.54
    rCSI 2.71%
    PRS 72.84
  • glial cell CL0000125
    CSI 1.52
    rCSI 5.78%
    PRS 80.72
  • retinal cone cell CL0000573
    CSI 1.52
    rCSI 2.44%
    PRS 79.64
  • sncg GABAergic cortical interneuron CL4023015
    CSI 1.35
    rCSI 2.18%
    PRS 74.48
  • retinal pigment epithelial cell CL0002586
    CSI 1.3
    rCSI 2.57%
    PRS 84.11
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 1.29
    rCSI 3.14%
    PRS 71.12
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 1.18
    rCSI 1.98%
    PRS 73.36
  • retinal ganglion cell CL0000740
    CSI 1.07
    rCSI 2.36%
    PRS 76.27
  • GABAergic neuron CL0000617
    CSI 1.04
    rCSI 3.49%
    PRS 73.66
  • kidney connecting tubule epithelial cell CL1000768
    CSI 1.01
    rCSI 2.55%
    PRS 80.64
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 0.94
    rCSI 2.93%
    PRS 76.77
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 0.86
    rCSI 3.24%
    PRS 73.64
  • L6b glutamatergic cortical neuron CL4023038
    CSI 0.8
    rCSI 2.49%
    PRS 74.8
  • OFF midget ganglion cell CL4033047
    CSI 0.57
    rCSI 11.51%
    PRS 79.47
  • ON midget ganglion cell CL4033046
    CSI 0.56
    rCSI 11.39%
    PRS 78.68
  • blood vessel smooth muscle cell CL0019018
    CSI 0.55
    rCSI 4.5%
    PRS 84.03
  • ON parasol ganglion cell CL4033052
    CSI 0.41
    rCSI 5.87%
    PRS 80.04
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 0.4
    rCSI 2.35%
    PRS 73.86
  • direct pathway medium spiny neuron CL4023026
    CSI 0.31
    rCSI 7.47%
    PRS 70.95
  • indirect pathway medium spiny neuron CL4023029
    CSI 0.29
    rCSI 6.89%
    PRS 71.38

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary Analyzed for its expression specificity (CSI Z-Score), [ZNF862](/details-gene/643641) is a zinc finger protein that demonstrates a notably broad and non-specific expression pattern across a diverse array of human cell types. Its lack of cell-type-specific expression, underscored by consistently low and statistically non-significant specificity scores, suggests it is not a defining cellular marker. Instead, its molecular function annotations point towards a potential general role in the regulation of DNA-templated transcription within the nucleus, consistent with a ubiquitously expressed transcriptional regulator. ## Cellular Roles and Expression Landscape The expression profile of [ZNF862](/details-gene/643641), when evaluated for specificity, reveals a striking lack of cellular restriction. Within the **Overall** context, the Cell Significance Index (CSI Z-SCORE) is consistently 0.00 across all top cell types, with corresponding p-values being non-significant (p > 0.4). This profile strongly indicates that [ZNF862](/details-gene/643641) is not a specific marker for any particular cell lineage. The gene's expression is detected in functionally and developmentally distinct cell populations, including: * **Muscular tissues**: [cardiac muscle cell](/details-cell/CL0000746) and [regular ventricular cardiac myocyte](/details-cell/CL0002131) * **Immune cells**: [effector memory CD8-positive, alpha-beta T cell](/details-cell/CL0000913), [naive T cell](/details-cell/CL0000898), and [effector CD4-positive, alpha-beta T cell](/details-cell/CL0001044) * **Neural and glial cells**: [interstitial cell of Cajal](/details-cell/CL0002088), [glioblast](/details-cell/CL0000030), [ependymal cell](/details-cell/CL0000065), and [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) * **Epithelial and other cells**: [renal alpha-intercalated cell](/details-cell/CL0005011), [pulmonary alveolar type 1 cell](/details-cell/CL0002062), and [melanocyte](/details-cell/CL0000148) This widespread expression across ectodermal, mesodermal, and endodermal derivatives reinforces the conclusion that [ZNF862](/details-gene/643641) likely participates in fundamental cellular processes common to most cells, rather than driving a specialized cellular identity. The discovery and sequencing of this gene were part of large-scale genome and cDNA collection projects that characterized the foundational components of the human genome (PubMed: [12853948](https://pubmed.ncbi.nlm.nih.gov/12853948), [15489334](https://pubmed.ncbi.nlm.nih.gov/15489334), [9628581](https://pubmed.ncbi.nlm.nih.gov/9628581)). ## Pathways and Molecular Function The functional annotations for [ZNF862](/details-gene/643641) are consistent with its ubiquitous expression pattern and presumed role as a general transcription factor. The gene is associated with fundamental molecular processes rather than specialized pathways. * **Molecular Function:** Key annotations include [Metal ion binding](/details-go/GO:0046872), characteristic of zinc finger proteins, and a general role in [Molecular_function](/details-go/GO:0003674). The potential for [Protein dimerization activity](/details-go/GO:0046983) suggests it may function as part of a larger protein complex. * **Biological Process:** It is implicated in the core process of [Regulation of dna-templated transcription](/details-go/GO:0006355), which is essential for all cell types. * **Cellular Component:** As expected for a transcription factor, it is localized to the [Nucleus](/details-go/GO:0005634). Collectively, these annotations portray [ZNF862](/details-gene/643641) as a canonical zinc finger transcription factor involved in basal gene regulation, which aligns perfectly with its broad, non-specific expression across the cellular landscape. ## Research Directions The data's primary insight is the pronounced lack of cell-type specificity for [ZNF862](/details-gene/643641), which itself generates compelling avenues for future research focused on understanding the roles of such ubiquitously expressed transcription factors. ### Testable Hypotheses 1. **[ZNF862](/details-gene/643641) functions as a regulator of a core set of housekeeping genes.** Its broad expression suggests it may be involved in maintaining basal transcription of genes essential for cell survival and general function across diverse lineages. * **Experimental Approach:** Perform chromatin immunoprecipitation followed by sequencing (ChIP-seq) for ZNF862 in two or more distinct cell types, such as primary T cells and cardiac fibroblasts. A significant overlap in binding sites at the promoters of known housekeeping genes (e.g., those involved in glycolysis or ribosomal biogenesis) would support this hypothesis. 2. **The regulatory activity of [ZNF862](/details-gene/643641) is determined by cell-type-specific protein interactors, not by its expression level.** While the gene is ubiquitously expressed, its functional output could be tailored by the specific co-factors available in different cellular contexts. * **Experimental Approach:** Conduct co-immunoprecipitation of endogenous ZNF862 followed by mass spectrometry (Co-IP/MS) in disparate cell lines (e.g., a neuronal line like SH-SY5Y and an endothelial line like HUVEC). Identification of different sets of interacting proteins would indicate that its function is context-dependent and post-translationally regulated. 3. **[ZNF862](/details-gene/643641) expression is stable under homeostatic conditions but is modulated in response to generalized cellular stress.** Its role may not be in defining cell identity but in orchestrating a common transcriptional response to stressors like DNA damage, oxidative stress, or viral infection. * **Experimental Approach:** Expose multiple cell types ([pulmonary alveolar type 1 cell](/details-cell/CL0002062), [cardiac endothelial cell](/details-cell/CL0010008)) to a common stressor (e.g., sodium arsenite for oxidative stress). Monitor [ZNF862](/details-gene/643641) mRNA and protein levels using RT-qPCR and Western blotting. A consistent upregulation or downregulation across cell types would suggest a role in a conserved stress response pathway. ### Therapeutic Potential Based on its ubiquitous expression pattern and likely role in fundamental transcriptional regulation, [ZNF862](/details-gene/643641) is a poor candidate for a therapeutic target. Systemic inhibition or activation would be expected to have widespread and unpredictable effects across nearly all tissues, leading to a high risk of off-target toxicity. Therapeutic strategies should instead focus on genes with highly cell-type-specific roles.

Genular Protein ID: 943725576

Symbol: ZN862_HUMAN

Name: Zinc finger protein 862

UniProtKB Accession Codes:

O60290 A0AUL8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 2 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

Sequence Information:

  • Length: 1169
  • Mass: 131654
  • Checksum: 76367C6AE1E3C60A
  • Sequence:
    • MEPRESGKAP VTFDDITVYL LQEEWVLLSQ QQKELCGSNK LVAPLGPTVA NPELFRKFGR 
GPEPWLGSVQ GQRSLLEHHP GKKQMGYMGE MEVQGPTRES GQSLPPQKKA YLSHLSTGSG 
HIEGDWAGRN RKLLKPRSIQ KSWFVQFPWL IMNEEQTALF CSACREYPSI RDKRSRLIEG 
YTGPFKVETL KYHAKSKAHM FCVNALAARD PIWAARFRSI RDPPGDVLAS PEPLFTADCP 
IFYPPGPLGG FDSMAELLPS SRAELEDPGG DGAIPAMYLD CISDLRQKEI TDGIHSSSDI 
NILYNDAVES CIQDPSAEGL SEEVPVVFEE LPVVFEDVAV YFTREEWGML DKRQKELYRD 
VMRMNYELLA SLGPAAAKPD LISKLERRAA PWIKDPNGPK WGKGRPPGNK KMVAVREADT 
QASAADSALL PGSPVEARAS CCSSSICEEG DGPRRIKRTY RPRSIQRSWF GQFPWLVIDP 
KETKLFCSAC IERPNLHDKS SRLVRGYTGP FKVETLKYHE VSKAHRLCVN TVEIKEDTPH 
TALVPEISSD LMANMEHFFN AAYSIAYHSR PLNDFEKILQ LLQSTGTVIL GKYRNRTACT 
QFIKYISETL KREILEDVRN SPCVSVLLDS STDASEQACV GIYIRYFKQM EVKESYITLA 
PLYSETADGY FETIVSALDE LDIPFRKPGW VVGLGTDGSA MLSCRGGLVE KFQEVIPQLL 
PVHCVAHRLH LAVVDACGSI DLVKKCDRHI RTVFKFYQSS NKRLNELQEG AAPLEQEIIR 
LKDLNAVRWV ASRRRTLHAL LVSWPALARH LQRVAEAGGQ IGHRAKGMLK LMRGFHFVKF 
CHFLLDFLSI YRPLSEVCQK EIVLITEVNA TLGRAYVALE SLRHQAGPKE EEFNASFKDG 
RLHGICLDKL EVAEQRFQAD RERTVLTGIE YLQQRFDADR PPQLKNMEVF DTMAWPSGIE 
LASFGNDDIL NLARYFECSL PTGYSEEALL EEWLGLKTIA QHLPFSMLCK NALAQHCRFP 
LLSKLMAVVV CVPISTSCCE RGFKAMNRIR TDERTKLSNE VLNMLMMTAV NGVAVTEYDP 
QPAIQHWYLT SSGRRFSHVY TCAQVPARSP ASARLRKEEM GALYVEEPRT QKPPILPSRE 
AAEVLKDCIM EPPERLLYPH TSQEAPGMS