Details for: SGCB

Gene ID: 6443

Symbol: SGCB

Ensembl ID: ENSG00000163069

Description: sarcoglycan beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 239.2873
    Cell Significance Index: -37.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 147.3328
    Cell Significance Index: -37.3700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 89.2104
    Cell Significance Index: -36.7500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 76.2726
    Cell Significance Index: -36.0100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.2201
    Cell Significance Index: -37.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.1287
    Cell Significance Index: -35.1700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.3942
    Cell Significance Index: -37.0700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 3.3406
    Cell Significance Index: 28.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.9648
    Cell Significance Index: 135.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.8729
    Cell Significance Index: 185.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3711
    Cell Significance Index: 159.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9340
    Cell Significance Index: 56.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.8513
    Cell Significance Index: 244.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8312
    Cell Significance Index: 135.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8003
    Cell Significance Index: 102.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7389
    Cell Significance Index: 148.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6975
    Cell Significance Index: 14.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6898
    Cell Significance Index: 94.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4746
    Cell Significance Index: 259.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4210
    Cell Significance Index: 151.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3974
    Cell Significance Index: 8.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3865
    Cell Significance Index: 11.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3711
    Cell Significance Index: 22.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3578
    Cell Significance Index: 16.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3053
    Cell Significance Index: 8.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2266
    Cell Significance Index: 14.2900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2207
    Cell Significance Index: 152.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2073
    Cell Significance Index: 91.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1407
    Cell Significance Index: 16.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1312
    Cell Significance Index: 10.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1225
    Cell Significance Index: 3.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0902
    Cell Significance Index: 5.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0646
    Cell Significance Index: 1.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0403
    Cell Significance Index: 7.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0275
    Cell Significance Index: 4.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0246
    Cell Significance Index: 3.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0013
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0031
    Cell Significance Index: -5.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0047
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0071
    Cell Significance Index: -4.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0076
    Cell Significance Index: -11.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0114
    Cell Significance Index: -0.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0128
    Cell Significance Index: -9.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0139
    Cell Significance Index: -10.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0167
    Cell Significance Index: -30.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0218
    Cell Significance Index: -0.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0235
    Cell Significance Index: -32.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0243
    Cell Significance Index: -13.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0297
    Cell Significance Index: -13.5000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0297
    Cell Significance Index: -2.1000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0331
    Cell Significance Index: -0.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0336
    Cell Significance Index: -21.3600
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0364
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0390
    Cell Significance Index: -6.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0398
    Cell Significance Index: -30.1400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0403
    Cell Significance Index: -0.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0423
    Cell Significance Index: -8.4000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0680
    Cell Significance Index: -1.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0863
    Cell Significance Index: -18.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0914
    Cell Significance Index: -9.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0941
    Cell Significance Index: -6.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0950
    Cell Significance Index: -12.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1095
    Cell Significance Index: -12.9100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1195
    Cell Significance Index: -2.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1600
    Cell Significance Index: -7.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1640
    Cell Significance Index: -5.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1658
    Cell Significance Index: -8.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1796
    Cell Significance Index: -26.1000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2276
    Cell Significance Index: -25.9800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2346
    Cell Significance Index: -5.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2708
    Cell Significance Index: -7.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3061
    Cell Significance Index: -15.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3353
    Cell Significance Index: -24.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3429
    Cell Significance Index: -35.7100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3637
    Cell Significance Index: -5.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3821
    Cell Significance Index: -24.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3878
    Cell Significance Index: -12.4200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3908
    Cell Significance Index: -30.9500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4084
    Cell Significance Index: -7.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4251
    Cell Significance Index: -11.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4886
    Cell Significance Index: -21.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5851
    Cell Significance Index: -35.8800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5915
    Cell Significance Index: -7.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5931
    Cell Significance Index: -22.4600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5969
    Cell Significance Index: -14.5700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6662
    Cell Significance Index: -9.8400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.7078
    Cell Significance Index: -10.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7741
    Cell Significance Index: -25.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7912
    Cell Significance Index: -25.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8070
    Cell Significance Index: -23.7000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8384
    Cell Significance Index: -29.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8512
    Cell Significance Index: -24.2900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8561
    Cell Significance Index: -31.4300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.8684
    Cell Significance Index: -12.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8710
    Cell Significance Index: -23.3400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8858
    Cell Significance Index: -26.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.9052
    Cell Significance Index: -24.1700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.9218
    Cell Significance Index: -15.1900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.9425
    Cell Significance Index: -47.6300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.9489
    Cell Significance Index: -13.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SGCB is a transmembrane protein that is significantly expressed in skeletal muscle satellite stem cells, peripheral nervous system neurons, and other cell types involved in muscle development and maintenance. Its expression is critical for the proper functioning of the DAGC, which is composed of multiple subunits, including dystrophin, alpha-dystroglycan, beta-dystroglycan, and sarcoglycans. The SGCB gene is predominantly found in muscle tissues, where it plays a key role in maintaining muscle cell integrity and function. **Pathways and Functions:** The SGCB gene is involved in various cellular pathways, including: 1. **Cardiac muscle cell development:** SGCB is essential for the proper development and maturation of cardiac muscle cells, where it helps to maintain the structural integrity of the myocardium. 2. **Cytoskeleton organization:** SGCB plays a crucial role in maintaining the organization and stability of the cytoskeleton, which is essential for muscle contraction and relaxation. 3. **Dystrophin-associated glycoprotein complex formation:** SGCB is a critical component of the DAGC, which is essential for anchoring dystrophin to the plasma membrane and maintaining muscle cell integrity. 4. **Glucose homeostasis:** SGCB has been implicated in glucose homeostasis, where it plays a role in regulating insulin sensitivity and glucose uptake in muscle tissues. **Clinical Significance:** Dysregulation of the SGCB gene has been implicated in various muscular dystrophies, including Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). Mutations in the SGCB gene can lead to impaired formation of the DAGC, resulting in muscle cell damage and progressive muscle weakness. Furthermore, SGCB has been implicated in other diseases, including: 1. **Muscular dystrophy:** SGCB mutations can lead to impaired muscle function and weakness, which can be life-threatening. 2. **Cardiac arrhythmias:** Impaired SGCB function can contribute to the development of cardiac arrhythmias, which can be life-threatening. 3. **Diabetes:** SGCB has been implicated in glucose homeostasis, where impaired function can contribute to the development of diabetes. In conclusion, the SGCB gene plays a critical role in maintaining muscle function and homeostasis. Its dysregulation can lead to various muscular dystrophies and other diseases, highlighting the importance of further research into the molecular mechanisms underlying SGCB function.

Genular Protein ID: 2563605048

Symbol: SGCB_HUMAN

Name: Beta-sarcoglycan

UniProtKB Accession Codes:

Q16585 B7Z635 O00661

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 4 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 1 ExpressionAtlas 1 GO 13 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7581449

Title: Beta-sarcoglycan (A3b) mutations cause autosomal recessive muscular dystrophy with loss of the sarcoglycan complex.

PubMed ID: 7581449

DOI: 10.1038/ng1195-266

PubMed ID: 7581448

Title: Beta-sarcoglycan: characterization and role in limb-girdle muscular dystrophy linked to 4q12.

PubMed ID: 7581448

DOI: 10.1038/ng1195-257

PubMed ID: 8968749

Title: Genomic screening for beta-sarcoglycan gene mutations: missense mutations may cause severe limb-girdle muscular dystrophy type 2E (LGMD 2E).

PubMed ID: 8968749

DOI: 10.1093/hmg/5.12.1953

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 9631401

Title: LGMD 2E in Tunisia is caused by a homozygous missense mutation in beta-sarcoglycan exon 3.

PubMed ID: 9631401

DOI: 10.1016/s0960-8966(98)00014-5

PubMed ID: 9032047

Title: Mutations in the sarcoglycan genes in patients with myopathy.

PubMed ID: 9032047

DOI: 10.1056/nejm199702273360904

PubMed ID: 10660328

Title: Novel mutation (Y184C) in exon 4 of the beta-sarcoglycan gene identified in a Portuguese patient.

PubMed ID: 10660328

PubMed ID: 9565988

Title: Beta-sarcoglycan: genomic analysis and identification of a novel missense mutation in the LGMD2E Amish isolate.

PubMed ID: 9565988

DOI: 10.1016/s0960-8966(97)00135-1

PubMed ID: 30345904

Title: The impact of PYROXD1 deficiency on cellular respiration and correlations with genetic analyses of limb-girdle muscular dystrophy in Saudi Arabia and Sudan.

PubMed ID: 30345904

DOI: 10.1152/physiolgenomics.00036.2018

Sequence Information:

  • Length: 318
  • Mass: 34777
  • Checksum: DAC5E93D1AB6C80C
  • Sequence:
    • MAAAAAAAAE QQSSNGPVKK SMREKAVERR SVNKEHNSNF KAGYIPIDED RLHKTGLRGR 
KGNLAICVII LLFILAVINL IITLVIWAVI RIGPNGCDSM EFHESGLLRF KQVSDMGVIH 
PLYKSTVGGR RNENLVITGN NQPIVFQQGT TKLSVENNKT SITSDIGMQF FDPRTQNILF 
STDYETHEFH LPSGVKSLNV QKASTERITS NATSDLNIKV DGRAIVRGNE GVFIMGKTIE 
FHMGGNMELK AENSIILNGS VMVSTTRLPS SSSGDQLGSG DWVRYKLCMC ADGTLFKVQV 
TSQNMGCQIS DNPCGNTH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.