Details for: SLC3A2

Gene ID: 6520

Symbol: SLC3A2

Ensembl ID: ENSG00000168003

Description: solute carrier family 3 member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 366.4850
    Cell Significance Index: -57.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 240.1009
    Cell Significance Index: -60.9000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 161.6225
    Cell Significance Index: -66.5800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 151.1973
    Cell Significance Index: -61.4300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 149.2621
    Cell Significance Index: -70.4700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 134.6559
    Cell Significance Index: -69.2700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 65.1170
    Cell Significance Index: -62.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 54.8073
    Cell Significance Index: -67.5800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.2433
    Cell Significance Index: -51.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.9724
    Cell Significance Index: -70.9200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.3250
    Cell Significance Index: -47.0700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 9.2515
    Cell Significance Index: 247.0300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.8367
    Cell Significance Index: -19.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 8.1132
    Cell Significance Index: 232.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.1327
    Cell Significance Index: 112.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.2280
    Cell Significance Index: 151.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.3750
    Cell Significance Index: 167.9700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.3258
    Cell Significance Index: 41.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.1228
    Cell Significance Index: 274.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.9489
    Cell Significance Index: 145.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9042
    Cell Significance Index: 25.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.8694
    Cell Significance Index: 826.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.5507
    Cell Significance Index: 212.9500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.5326
    Cell Significance Index: 32.0800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3820
    Cell Significance Index: 82.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0711
    Cell Significance Index: 55.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0091
    Cell Significance Index: 47.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9869
    Cell Significance Index: 538.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8895
    Cell Significance Index: 144.6800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.8706
    Cell Significance Index: 9.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8330
    Cell Significance Index: 106.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8239
    Cell Significance Index: 101.3100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7409
    Cell Significance Index: 38.5900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7202
    Cell Significance Index: 46.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7003
    Cell Significance Index: 18.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6898
    Cell Significance Index: 124.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6372
    Cell Significance Index: 127.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5747
    Cell Significance Index: 15.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5703
    Cell Significance Index: 25.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5517
    Cell Significance Index: 38.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5150
    Cell Significance Index: 102.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5142
    Cell Significance Index: 11.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4677
    Cell Significance Index: 89.0000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4626
    Cell Significance Index: 319.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3536
    Cell Significance Index: 126.8200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.3388
    Cell Significance Index: 2.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2131
    Cell Significance Index: 192.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1937
    Cell Significance Index: 22.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1772
    Cell Significance Index: 6.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1628
    Cell Significance Index: 4.5500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1164
    Cell Significance Index: 2.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1021
    Cell Significance Index: 5.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0443
    Cell Significance Index: 83.4400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0436
    Cell Significance Index: 0.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0340
    Cell Significance Index: 24.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0042
    Cell Significance Index: 3.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0129
    Cell Significance Index: -23.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0282
    Cell Significance Index: -2.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0291
    Cell Significance Index: -2.8800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0309
    Cell Significance Index: -47.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0521
    Cell Significance Index: -33.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0532
    Cell Significance Index: -72.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0569
    Cell Significance Index: -9.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0724
    Cell Significance Index: -53.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0791
    Cell Significance Index: -2.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1070
    Cell Significance Index: -48.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1109
    Cell Significance Index: -62.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1280
    Cell Significance Index: -79.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1884
    Cell Significance Index: -21.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2079
    Cell Significance Index: -59.8100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2466
    Cell Significance Index: -1.4900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3110
    Cell Significance Index: -8.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3314
    Cell Significance Index: -48.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3343
    Cell Significance Index: -38.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3451
    Cell Significance Index: -5.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3475
    Cell Significance Index: -11.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3529
    Cell Significance Index: -74.3200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3572
    Cell Significance Index: -10.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3696
    Cell Significance Index: -22.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4125
    Cell Significance Index: -11.8900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4774
    Cell Significance Index: -5.1900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5176
    Cell Significance Index: -12.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6051
    Cell Significance Index: -38.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6084
    Cell Significance Index: -34.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6192
    Cell Significance Index: -64.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7089
    Cell Significance Index: -54.4000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7479
    Cell Significance Index: -59.2300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8003
    Cell Significance Index: -20.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8702
    Cell Significance Index: -58.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9661
    Cell Significance Index: -59.2300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.0863
    Cell Significance Index: -54.9000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -1.1491
    Cell Significance Index: -7.1400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.2376
    Cell Significance Index: -15.8500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.2792
    Cell Significance Index: -46.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.3037
    Cell Significance Index: -57.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.3884
    Cell Significance Index: -29.5700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.4071
    Cell Significance Index: -29.1900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.4178
    Cell Significance Index: -11.3200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.5114
    Cell Significance Index: -38.8500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.5387
    Cell Significance Index: -45.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Neutral Amino Acid Transporter:** SLC3A2 is a neutral amino acid transporter that facilitates the transport of large neutral amino acids, such as leucine, isoleucine, and valine, across cell membranes. 2. **Heterodimerization:** SLC3A2 forms a heterodimer with SLC3A1, which is essential for the transport of amino acids. 3. **Widespread Expression:** SLC3A2 is expressed in various tissues, including the mammary gland, pancreas, and endothelial cells. 4. **Disease Association:** Mutations in the SLC3A2 gene have been linked to lysinuric protein intolerance (LPI), a rare genetic disorder characterized by impaired amino acid transport. **Pathways and Functions:** 1. **Amino Acid Transport:** SLC3A2 is involved in the transport of essential amino acids across cell membranes, which is essential for protein synthesis, growth, and development. 2. **Endothelial Function:** SLC3A2 is expressed in endothelial cells, where it plays a role in the transport of amino acids and other small molecules across the cell membrane. 3. **Metabolism:** SLC3A2 is involved in the metabolism of amino acids, including the transport of amino acids into lysosomes and peroxisomes. 4. **Cell Signaling:** SLC3A2 may also play a role in cell signaling pathways, including the regulation of calcium and sodium ion transport. **Clinical Significance:** 1. **Lysinuric Protein Intolerance (LPI):** Mutations in the SLC3A2 gene are the primary cause of LPI, a rare genetic disorder characterized by impaired amino acid transport. 2. **Amino Acid Transport Disorders:** SLC3A2 mutations can also lead to other amino acid transport disorders, including cystinuria and hereditary amino acid transport disorders. 3. **Cancer Research:** SLC3A2 may play a role in cancer development and progression, particularly in the transport of amino acids across the blood-brain barrier. 4. **Therapeutic Applications:** Understanding the role of SLC3A2 in amino acid transport and its implications in human disease may lead to the development of new therapeutic strategies for the treatment of amino acid transport disorders. In conclusion, the SLC3A2 gene plays a critical role in the transport of essential amino acids across cell membranes, and its dysfunction has been linked to various human diseases, including lysinuric protein intolerance. Further research is needed to fully understand the role of SLC3A2 in human disease and to develop effective therapeutic strategies for the treatment of amino acid transport disorders.

Genular Protein ID: 3469053263

Symbol: 4F2_HUMAN

Name: N/A

UniProtKB Accession Codes:

P08195 J3KPF3 Q13543

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 4 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 6 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 EMDB 22 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 44 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 25 PDBsum 25 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 4 RefSeq 4 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3476959

Title: Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth.

PubMed ID: 3476959

DOI: 10.1073/pnas.84.18.6526

PubMed ID: 3036867

Title: Primary structure of the human 4F2 antigen heavy chain predicts a transmembrane protein with a cytoplasmic NH2 terminus.

PubMed ID: 3036867

DOI: 10.1016/s0021-9258(18)47972-0

PubMed ID: 3480538

Title: Cloning, sequence analysis, and expression of the large subunit of the human lymphocyte activation antigen 4F2.

PubMed ID: 3480538

DOI: 10.1073/pnas.84.24.9204

PubMed ID: 3265470

Title: Isolation and structural characterization of the human 4F2 heavy-chain gene, an inducible gene involved in T-lymphocyte activation.

PubMed ID: 3265470

DOI: 10.1128/mcb.8.9.3809-3819.1988

PubMed ID: 11557028

Title: Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines.

PubMed ID: 11557028

DOI: 10.1016/s0005-2736(01)00384-4

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9829974

Title: Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance.

PubMed ID: 9829974

DOI: 10.1074/jbc.273.49.32437

PubMed ID: 9751058

Title: Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family.

PubMed ID: 9751058

DOI: 10.1038/26246

PubMed ID: 9878049

Title: Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family.

PubMed ID: 9878049

DOI: 10.1093/emboj/18.1.49

PubMed ID: 10391915

Title: Identification of a membrane protein, LAT-2, that co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids.

PubMed ID: 10391915

DOI: 10.1074/jbc.274.28.19738

PubMed ID: 10574970

Title: LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine.

PubMed ID: 10574970

DOI: 10.1074/jbc.274.49.34948

PubMed ID: 10903140

Title: The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine.

PubMed ID: 10903140

DOI: 10.1042/bj3490787

PubMed ID: 11311135

Title: Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains.

PubMed ID: 11311135

DOI: 10.1042/bj3550725

PubMed ID: 11389679

Title: Role of the System L permease LAT1 in amino acid and iodothyronine transport in placenta.

PubMed ID: 11389679

DOI: 10.1042/0264-6021:3560719

PubMed ID: 11696247

Title: Beta1 integrins show specific association with CD98 protein in low density membranes.

PubMed ID: 11696247

DOI: 10.1186/1471-2091-2-10

PubMed ID: 11564694

Title: Thyroid hormone transport by the heterodimeric human system L amino acid transporter.

PubMed ID: 11564694

DOI: 10.1210/endo.142.10.8418

PubMed ID: 11121428

Title: Distinct domains of CD98hc regulate integrins and amino acid transport.

PubMed ID: 11121428

DOI: 10.1074/jbc.m011239200

PubMed ID: 11742812

Title: Expression and regulation of 4F2hc and hLAT1 in human trophoblasts.

PubMed ID: 11742812

DOI: 10.1152/ajpcell.2002.282.1.c196

PubMed ID: 12270127

Title: Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism.

PubMed ID: 12270127

DOI: 10.1016/s0006-291x(02)02227-1

PubMed ID: 12117417

Title: Transport of a neurotoxicant by molecular mimicry: the methylmercury-L-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT) 1 and LAT2.

PubMed ID: 12117417

DOI: 10.1042/bj20020841

PubMed ID: 12225859

Title: Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells.

PubMed ID: 12225859

DOI: 10.1016/s0005-2736(02)00516-3

PubMed ID: 11840567

Title: Cluster analysis of an extensive human breast cancer cell line protein expression map database.

PubMed ID: 11840567

DOI: 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h

PubMed ID: 14603368

Title: Nitric oxide synthesis requires activity of the cationic and neutral amino acid transport system y+L in human umbilical vein endothelium.

PubMed ID: 14603368

DOI: 10.1113/eph8802647

PubMed ID: 12716892

Title: CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia.

PubMed ID: 12716892

DOI: 10.1074/jbc.m302777200

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 15980244

Title: L-type amino acid transporter 1-mediated L-leucine transport at the inner blood-retinal barrier.

PubMed ID: 15980244

DOI: 10.1167/iovs.04-1175

PubMed ID: 15769744

Title: Identification of stereoselective transporters for S-nitroso-L-cysteine: role of LAT1 and LAT2 in biological activity of S-nitrosothiols.

PubMed ID: 15769744

DOI: 10.1074/jbc.m413164200

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 15625115

Title: CD98hc (SLC3A2) mediates integrin signaling.

PubMed ID: 15625115

DOI: 10.1073/pnas.0404852102

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16496379

Title: L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors.

PubMed ID: 16496379

DOI: 10.1002/ijc.21866

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 19065266

Title: Ecto-phosphorylation of CD98 regulates cell-cell interactions.

PubMed ID: 19065266

DOI: 10.1371/journal.pone.0003895

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19292886

Title: CD98hc (SLC3A2), a novel marker in renal cell cancer.

PubMed ID: 19292886

DOI: 10.1111/j.1365-2362.2009.02096.x

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23116296

Title: Discovery of SLC3A2 cell membrane protein as a potential gastric cancer biomarker: implications in molecular imaging.

PubMed ID: 23116296

DOI: 10.1021/pr300555y

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25998567

Title: LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation.

PubMed ID: 25998567

DOI: 10.1038/ncomms8250

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28350098

Title: SLC3A2 is upregulated in human osteosarcoma and promotes tumor growth through the PI3K/Akt signaling pathway.

PubMed ID: 28350098

DOI: 10.3892/or.2017.5530

PubMed ID: 30341327

Title: Hepatitis C Virus Modulates Solute carrier family 3 member 2 for Viral Propagation.

PubMed ID: 30341327

DOI: 10.1038/s41598-018-33861-6

PubMed ID: 33066406

Title: The Heavy Chain 4F2hc Modulates the Substrate Affinity and Specificity of the Light Chains LAT1 and LAT2.

PubMed ID: 33066406

DOI: 10.3390/ijms21207573

PubMed ID: 34294905

Title: Plasmodium vivax binds host CD98hc (SLC3A2) to enter immature red blood cells.

PubMed ID: 34294905

DOI: 10.1038/s41564-021-00939-3

PubMed ID: 36028562

Title: N-glycosylation is crucial for trafficking and stability of SLC3A2 (CD98).

PubMed ID: 36028562

DOI: 10.1038/s41598-022-18779-4

PubMed ID: 17724034

Title: The structure of human 4F2hc ectodomain provides a model for homodimerization and electrostatic interaction with plasma membrane.

PubMed ID: 17724034

DOI: 10.1074/jbc.m704524200

PubMed ID: 30867591

Title: Structure of the human LAT1-4F2hc heteromeric amino acid transporter complex.

PubMed ID: 30867591

DOI: 10.1038/s41586-019-1011-z

PubMed ID: 33298890

Title: Structural insight into the substrate recognition and transport mechanism of the human LAT2-4F2hc complex.

PubMed ID: 33298890

DOI: 10.1038/s41421-020-00207-4

PubMed ID: 33758168

Title: Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter.

PubMed ID: 33758168

DOI: 10.1038/s41421-021-00247-4

PubMed ID: 34880232

Title: Molecular basis for redox control by the human cystine/glutamate antiporter system xc.

PubMed ID: 34880232

DOI: 10.1038/s41467-021-27414-1

PubMed ID: 35352032

Title: The structure of erastin-bound xCT-4F2hc complexreveals molecular mechanisms underlying erastin-induced ferroptosis.

PubMed ID: 35352032

DOI: 10.1038/s41422-022-00642-w

Sequence Information:

  • Length: 630
  • Mass: 67994
  • Checksum: AE427F8204CC10B0
  • Sequence:
    • MELQPPEASI AVVSIPRQLP GSHSEAGVQG LSAGDDSELG SHCVAQTGLE LLASGDPLPS 
ASQNAEMIET GSDCVTQAGL QLLASSDPPA LASKNAEVTG TMSQDTEVDM KEVELNELEP 
EKQPMNAASG AAMSLAGAEK NGLVKIKVAE DEAEAAAAAK FTGLSKEELL KVAGSPGWVR 
TRWALLLLFW LGWLGMLAGA VVIIVRAPRC RELPAQKWWH TGALYRIGDL QAFQGHGAGN 
LAGLKGRLDY LSSLKVKGLV LGPIHKNQKD DVAQTDLLQI DPNFGSKEDF DSLLQSAKKK 
SIRVILDLTP NYRGENSWFS TQVDTVATKV KDALEFWLQA GVDGFQVRDI ENLKDASSFL 
AEWQNITKGF SEDRLLIAGT NSSDLQQILS LLESNKDLLL TSSYLSDSGS TGEHTKSLVT 
QYLNATGNRW CSWSLSQARL LTSFLPAQLL RLYQLMLFTL PGTPVFSYGD EIGLDAAALP 
GQPMEAPVML WDESSFPDIP GAVSANMTVK GQSEDPGSLL SLFRRLSDQR SKERSLLHGD 
FHAFSAGPGL FSYIRHWDQN ERFLVVLNFG DVGLSAGLQA SDLPASASLP AKADLLLSTQ 
PGREEGSPLE LERLKLEPHE GLLLRFPYAA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.