Details for: SMARCC1

Gene ID: 6599

Symbol: SMARCC1

Ensembl ID: ENSG00000173473

Description: SWI/SNF related BAF chromatin remodeling complex subunit C1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 378.7644
    Cell Significance Index: -58.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 206.6287
    Cell Significance Index: -52.4100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 143.3102
    Cell Significance Index: -67.6600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 141.9052
    Cell Significance Index: -57.6500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 126.3644
    Cell Significance Index: -65.0000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 100.8909
    Cell Significance Index: -67.7000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 60.9798
    Cell Significance Index: -58.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 51.0116
    Cell Significance Index: -62.9000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 23.4241
    Cell Significance Index: -62.7500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.1771
    Cell Significance Index: -55.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.1668
    Cell Significance Index: -63.8000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.0045
    Cell Significance Index: -30.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 4.5993
    Cell Significance Index: 258.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.8863
    Cell Significance Index: 39.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.7681
    Cell Significance Index: 549.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.7515
    Cell Significance Index: 73.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.4391
    Cell Significance Index: 68.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.2043
    Cell Significance Index: 239.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.2017
    Cell Significance Index: 58.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.1068
    Cell Significance Index: 73.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7734
    Cell Significance Index: 355.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.6078
    Cell Significance Index: 98.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.4182
    Cell Significance Index: 36.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2290
    Cell Significance Index: 221.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1066
    Cell Significance Index: 136.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0985
    Cell Significance Index: 394.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0881
    Cell Significance Index: 594.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0193
    Cell Significance Index: 78.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0145
    Cell Significance Index: 65.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9609
    Cell Significance Index: 50.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8476
    Cell Significance Index: 44.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7873
    Cell Significance Index: 22.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7775
    Cell Significance Index: 537.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7390
    Cell Significance Index: 101.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.6152
    Cell Significance Index: 14.7600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6077
    Cell Significance Index: 548.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6032
    Cell Significance Index: 15.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5514
    Cell Significance Index: 25.9200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5426
    Cell Significance Index: 63.9900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.4986
    Cell Significance Index: 8.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4392
    Cell Significance Index: 827.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4081
    Cell Significance Index: 180.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4031
    Cell Significance Index: 18.2700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3736
    Cell Significance Index: 10.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2812
    Cell Significance Index: 432.8900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2763
    Cell Significance Index: 52.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2651
    Cell Significance Index: 5.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2563
    Cell Significance Index: 11.9500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2264
    Cell Significance Index: 417.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2245
    Cell Significance Index: 38.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2113
    Cell Significance Index: 27.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2104
    Cell Significance Index: 133.6100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1973
    Cell Significance Index: 19.5200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1839
    Cell Significance Index: 3.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1522
    Cell Significance Index: 206.9400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1185
    Cell Significance Index: 5.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0880
    Cell Significance Index: 39.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0572
    Cell Significance Index: 9.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0566
    Cell Significance Index: 0.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0535
    Cell Significance Index: 3.9900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.0050
    Cell Significance Index: 0.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0143
    Cell Significance Index: -0.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0329
    Cell Significance Index: -20.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0354
    Cell Significance Index: -1.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0364
    Cell Significance Index: -26.7100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0379
    Cell Significance Index: -0.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0466
    Cell Significance Index: -6.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0474
    Cell Significance Index: -35.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0573
    Cell Significance Index: -43.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0859
    Cell Significance Index: -48.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1113
    Cell Significance Index: -2.3700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1545
    Cell Significance Index: -1.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1551
    Cell Significance Index: -5.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1758
    Cell Significance Index: -22.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2030
    Cell Significance Index: -58.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2107
    Cell Significance Index: -14.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2154
    Cell Significance Index: -45.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2184
    Cell Significance Index: -22.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2964
    Cell Significance Index: -4.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3230
    Cell Significance Index: -10.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3408
    Cell Significance Index: -39.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3539
    Cell Significance Index: -40.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3568
    Cell Significance Index: -37.1500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3894
    Cell Significance Index: -5.6000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4673
    Cell Significance Index: -53.3400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4818
    Cell Significance Index: -10.0000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4832
    Cell Significance Index: -4.4500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4990
    Cell Significance Index: -3.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.5405
    Cell Significance Index: -37.3800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5699
    Cell Significance Index: -14.5600
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.5914
    Cell Significance Index: -5.2500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6026
    Cell Significance Index: -10.1500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6034
    Cell Significance Index: -13.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6294
    Cell Significance Index: -16.8700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6508
    Cell Significance Index: -15.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6575
    Cell Significance Index: -41.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6960
    Cell Significance Index: -55.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8903
    Cell Significance Index: -25.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8960
    Cell Significance Index: -54.9400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.9189
    Cell Significance Index: -20.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Chromatin Remodeling**: SMARCC1 is a key component of the SWI/SNF complex, which regulates chromatin structure and transcription by modifying nucleosome positioning and histone modifications. 2. **Gene Regulation**: SMARCC1 is involved in the regulation of gene expression through its interaction with transcription factors and other regulatory proteins. 3. **Cellular Localization**: SMARCC1 is widely expressed in various cell types, including epithelial cells, neurons, and stem cells. 4. **Protein-Protein Interactions**: SMARCC1 interacts with other proteins, including histone-modifying enzymes, transcription factors, and chromatin remodeling complexes. **Pathways and Functions** 1. **Chromatin Remodeling**: SMARCC1 regulates chromatin structure and transcription by modifying nucleosome positioning and histone modifications. 2. **Gene Expression**: SMARCC1 is involved in the regulation of gene expression through its interaction with transcription factors and other regulatory proteins. 3. **Cell Cycle Regulation**: SMARCC1 regulates cell cycle progression by controlling the transition from G1 to S phase. 4. **Developmental Processes**: SMARCC1 is involved in various developmental processes, including nervous system development, prostate gland development, and male germ cell nucleus formation. 5. **Stem Cell Maintenance**: SMARCC1 is involved in the maintenance of stem cell populations by regulating their self-renewal and differentiation. **Clinical Significance** 1. **Cancer**: SMARCC1 has been identified as a tumor suppressor gene in various cancers, including prostate cancer, breast cancer, and leukemia. 2. **Neurological Disorders**: SMARCC1 has been implicated in the pathogenesis of neurological disorders, including autism spectrum disorder, schizophrenia, and neurodegenerative diseases. 3. **Immunological Disorders**: SMARCC1 has been linked to immunological disorders, including rheumatoid arthritis and lupus. 4. **Developmental Delays**: SMARCC1 mutations have been associated with developmental delays and intellectual disability. In conclusion, SMARCC1 is a critical gene that regulates chromatin structure and transcription, and is involved in various cellular processes, including development, differentiation, and cell cycle regulation. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and immunological disorders. Further research is needed to fully understand the role of SMARCC1 in human disease and to develop targeted therapies for its dysregulation.

Genular Protein ID: 3189052472

Symbol: SMRC1_HUMAN

Name: BRG1-associated factor 155

UniProtKB Accession Codes:

Q92922 Q17RS0 Q6P172 Q8IWH2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 35 DIP 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 39 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8804307

Title: Diversity and specialization of mammalian SWI/SNF complexes.

PubMed ID: 8804307

DOI: 10.1101/gad.10.17.2117

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9744861

Title: Mitotic inactivation of a human SWI/SNF chromatin remodeling complex.

PubMed ID: 9744861

DOI: 10.1101/gad.12.18.2842

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20111005

Title: Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code.

PubMed ID: 20111005

DOI: 10.1038/emboj.2010.3

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 10078207

Title: Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits.

PubMed ID: 10078207

DOI: 10.1016/s1097-2765(00)80315-9

PubMed ID: 9891079

Title: Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest.

PubMed ID: 9891079

DOI: 10.1128/mcb.19.2.1460

PubMed ID: 11018012

Title: Functional selectivity of recombinant mammalian SWI/SNF subunits.

PubMed ID: 11018012

DOI: 10.1101/gad.828000

PubMed ID: 11238380

Title: Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes.

PubMed ID: 11238380

DOI: 10.1101/gad.872801

PubMed ID: 12917342

Title: BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation.

PubMed ID: 12917342

DOI: 10.1128/mcb.23.17.6210-6220.2003

PubMed ID: 18765789

Title: Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.

PubMed ID: 18765789

DOI: 10.1101/gad.471408

PubMed ID: 20829358

Title: Ubiquitin-dependent and ubiquitin-independent control of subunit stoichiometry in the SWI/SNF complex.

PubMed ID: 20829358

DOI: 10.1074/jbc.m110.173997

PubMed ID: 22952240

Title: SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functions.

PubMed ID: 22952240

DOI: 10.1074/jbc.r111.309302

PubMed ID: 26601204

Title: Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics.

PubMed ID: 26601204

DOI: 10.1126/sciadv.1500447

PubMed ID: 28753627

Title: Nuclear/cytoplasmic transport defects in BBS6 underlie congenital heart disease through perturbation of a chromatin remodeling protein.

PubMed ID: 28753627

DOI: 10.1371/journal.pgen.1006936

PubMed ID: 28533407

Title: Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.

PubMed ID: 28533407

DOI: 10.1073/pnas.1700328114

PubMed ID: 29374058

Title: Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.

PubMed ID: 29374058

DOI: 10.1074/jbc.ra117.001065

PubMed ID: 32417234

Title: LDB1 and the SWI/SNF complex participate in both transcriptional activation and repression by Caenorhabditis elegans BLIMP1/PRDM1.

PubMed ID: 32417234

DOI: 10.1016/j.bbagrm.2020.194577

PubMed ID: 32459350

Title: HRP2-DPF3a-BAF complex coordinates histone modification and chromatin remodeling to regulate myogenic gene transcription.

PubMed ID: 32459350

DOI: 10.1093/nar/gkaa441

PubMed ID: 29983323

Title: De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus.

PubMed ID: 29983323

DOI: 10.1016/j.neuron.2018.06.019

PubMed ID: 33077954

Title: Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus.

PubMed ID: 33077954

DOI: 10.1038/s41591-020-1090-2

Sequence Information:

  • Length: 1105
  • Mass: 122867
  • Checksum: EDA6FF5B0472AEA9
  • Sequence:
    • MAAAAGGGGP GTAVGATGSG IAAAAAGLAV YRRKDGGPAT KFWESPETVS QLDSVRVWLG 
KHYKKYVHAD APTNKTLAGL VVQLLQFQED AFGKHVTNPA FTKLPAKCFM DFKAGGALCH 
ILGAAYKYKN EQGWRRFDLQ NPSRMDRNVE MFMNIEKTLV QNNCLTRPNI YLIPDIDLKL 
ANKLKDIIKR HQGTFTDEKS KASHHIYPYS SSQDDEEWLR PVMRKEKQVL VHWGFYPDSY 
DTWVHSNDVD AEIEDPPIPE KPWKVHVKWI LDTDIFNEWM NEEDYEVDEN RKPVSFRQRI 
STKNEEPVRS PERRDRKASA NARKRKHSPS PPPPTPTESR KKSGKKGQAS LYGKRRSQKE 
EDEQEDLTKD MEDPTPVPNI EEVVLPKNVN LKKDSENTPV KGGTVADLDE QDEETVTAGG 
KEDEDPAKGD QSRSVDLGED NVTEQTNHII IPSYASWFDY NCIHVIERRA LPEFFNGKNK 
SKTPEIYLAY RNFMIDTYRL NPQEYLTSTA CRRNLTGDVC AVMRVHAFLE QWGLVNYQVD 
PESRPMAMGP PPTPHFNVLA DTPSGLVPLH LRSPQVPAAQ QMLNFPEKNK EKPVDLQNFG 
LRTDIYSKKT LAKSKGASAG REWTEQETLL LLEALEMYKD DWNKVSEHVG SRTQDECILH 
FLRLPIEDPY LENSDASLGP LAYQPVPFSQ SGNPVMSTVA FLASVVDPRV ASAAAKAALE 
EFSRVREEVP LELVEAHVKK VQEAARASGK VDPTYGLESS CIAGTGPDEP EKLEGAEEEK 
MEADPDGQQP EKAENKVENE TDEGDKAQDG ENEKNSEKEQ DSEVSEDTKS EEKETEENKE 
LTDTCKERES DTGKKKVEHE ISEGNVATAA AAALASAATK AKHLAAVEER KIKSLVALLV 
ETQMKKLEIK LRHFEELETI MDREKEALEQ QRQQLLTERQ NFHMEQLKYA ELRARQQMEQ 
QQHGQNPQQA HQHSGGPGLA PLGAAGHPGM MPHQQPPPYP LMHHQMPPPH PPQPGQIPGP 
GSMMPGQHMP GRMIPTVAAN IHPSGSGPTP PGMPPMPGNI LGPRVPLTAP NGMYPPPPQQ 
QPPPPPPADG VPPPPAPGPP ASAAP

Genular Protein ID: 20067056

Symbol: Q58EY4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q58EY4

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 2 IntAct 1 InterPro 11 KEGG 1 MINT 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 8 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 RefSeq 1 SAM 2 SMART 2 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1105
  • Mass: 122911
  • Checksum: 86BB4F0F1572AFE9
  • Sequence:
    • MAAAAGGGGP GTAVGATGSG IAAAAAGLAV YRRKDGGPDT KFWESPETVS QLDSVRVWLG 
KHYKKYVHAD APTNKTLAGL VVQLLQFQED AFGKHVTNPA FTKLPAKCFM DFKAGGALCH 
ILGAAYKYKN EQGWRRFDLQ NPSRMDRNVE MFMNIEKTLV QNNCLTRPNI YLIPDIDLKL 
ANKLKDIIKR HQGTFTDEKS KASHHIYPYS SSQDDEEWLR PVMRKEKQVL VHWGFYPDSY 
DTWVHSNDVD AEIEDPPIPE KPWKVHVKWI LDTDIFNEWM NEEDYEVDEN RKPVSFRQRI 
STKNEEPVRS PERRDRKASA NARKRKHSPS PPPPTPTESR KKSGKKGQAS LYGKRRSQKE 
EDEQEDLTKD MEDPTPVPNI EEVVLPKNVN LKKDSENTPV KGGTVADLDE QDEETVTAGG 
KEDEDPAKGD QSRSVDLGED NVTEQTNHII IPSYASWFDY NCIHVIERRA LPEFFNGKNK 
SKTPEIYLAY RNFMIDTYRL NPQEYLTSTA CRRNLTGDVC AVMRVHAFLE QWGLVNYQVD 
PESRPMAMGP PPTPHFNVLA DTPSGLVPLH LRSPQVPAAQ QMLNFPEKNK EKPVDLQNFG 
LRTDIYSKKT LAKSKGASAG REWTEQETLL LLEALEMYKD DWNKVSEHVG SRTQDECILH 
FLRLPIEDPY LENSDASLGP LAYQPVPFSQ SGNPVMSTVA FLASVVDPRV ASAAAKAALE 
EFSRVREEVP LELVEAHVKK VQEAARASGK VDPTYGLESS CIAGTGPDEP EKLEGAEEEK 
MEADPDGQQP EKAENKVENE TDEGDKAQDG ENEKNSEKEQ DSEVSEDTKS EEKETEENKE 
LTDTCKERES DTGKKKVEHE ISEGNVATAA AAALASAATK AKHLAAVEER KIKSLVALLV 
ETQMKKLEIK LRHFEELETI MDREKEALEQ QRQQLLTERQ NFHMEQLKYA ELRARQQMEQ 
QQHGQNPQQA HQHSGGPGLA PLGAAGHPGM MPHQQPPPYP LMHHQMPPPH PPQPGQIPGP 
GSMMPGQHMP GRMIPTVAAN IHPSGSGPTP PGMPPMPGNI LGPRVPLTAP NGMYPPPPQQ 
QPPPPPPADG VPPPPAPGPP ASAAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.