Details for: SNAPC2

Gene ID: 6618

Symbol: SNAPC2

Ensembl ID: ENSG00000104976

Description: small nuclear RNA activating complex polypeptide 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 122.9224
    Cell Significance Index: -19.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 72.2274
    Cell Significance Index: -18.3200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 40.5403
    Cell Significance Index: -19.1400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 38.1778
    Cell Significance Index: -15.5100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 35.5376
    Cell Significance Index: -18.2800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.3915
    Cell Significance Index: -20.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2305
    Cell Significance Index: -20.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.2369
    Cell Significance Index: -11.3500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.5162
    Cell Significance Index: -10.8000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.2885
    Cell Significance Index: 54.1900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.6858
    Cell Significance Index: 14.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3557
    Cell Significance Index: 157.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7854
    Cell Significance Index: 47.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7532
    Cell Significance Index: 81.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6955
    Cell Significance Index: 36.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6452
    Cell Significance Index: 104.9400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6384
    Cell Significance Index: 6.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6243
    Cell Significance Index: 85.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5974
    Cell Significance Index: 16.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5204
    Cell Significance Index: 7.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5026
    Cell Significance Index: 49.7200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4849
    Cell Significance Index: 10.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3961
    Cell Significance Index: 27.4000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3807
    Cell Significance Index: 11.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3660
    Cell Significance Index: 16.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3223
    Cell Significance Index: 175.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3204
    Cell Significance Index: 15.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3179
    Cell Significance Index: 14.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2978
    Cell Significance Index: 38.1800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2931
    Cell Significance Index: 3.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2732
    Cell Significance Index: 7.8700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2691
    Cell Significance Index: 118.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2672
    Cell Significance Index: 32.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2668
    Cell Significance Index: 5.7800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2569
    Cell Significance Index: 3.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2430
    Cell Significance Index: 18.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2295
    Cell Significance Index: 16.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2247
    Cell Significance Index: 29.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1979
    Cell Significance Index: 12.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1973
    Cell Significance Index: 35.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1954
    Cell Significance Index: 5.2400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1746
    Cell Significance Index: 4.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1551
    Cell Significance Index: 140.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0831
    Cell Significance Index: 16.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0702
    Cell Significance Index: 8.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0657
    Cell Significance Index: 3.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0627
    Cell Significance Index: 2.1800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0533
    Cell Significance Index: 10.1400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0356
    Cell Significance Index: 1.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0193
    Cell Significance Index: 3.8300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0057
    Cell Significance Index: 0.1000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0094
    Cell Significance Index: -6.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0094
    Cell Significance Index: -17.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0105
    Cell Significance Index: -7.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0151
    Cell Significance Index: -27.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0180
    Cell Significance Index: -27.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0188
    Cell Significance Index: -1.9200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0190
    Cell Significance Index: -13.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0190
    Cell Significance Index: -6.8300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0198
    Cell Significance Index: -0.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0205
    Cell Significance Index: -27.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0245
    Cell Significance Index: -18.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0254
    Cell Significance Index: -16.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0312
    Cell Significance Index: -17.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0370
    Cell Significance Index: -10.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0372
    Cell Significance Index: -23.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0378
    Cell Significance Index: -17.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0385
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0477
    Cell Significance Index: -8.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0573
    Cell Significance Index: -6.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0709
    Cell Significance Index: -2.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0768
    Cell Significance Index: -2.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0897
    Cell Significance Index: -4.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1002
    Cell Significance Index: -2.8000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1010
    Cell Significance Index: -2.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1101
    Cell Significance Index: -23.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1178
    Cell Significance Index: -17.1200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1279
    Cell Significance Index: -2.2600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1612
    Cell Significance Index: -2.9800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1738
    Cell Significance Index: -1.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1745
    Cell Significance Index: -6.1300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1790
    Cell Significance Index: -1.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1804
    Cell Significance Index: -11.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1921
    Cell Significance Index: -20.0100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2016
    Cell Significance Index: -1.6100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2115
    Cell Significance Index: -16.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2128
    Cell Significance Index: -14.3100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2236
    Cell Significance Index: -2.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2342
    Cell Significance Index: -14.3600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2353
    Cell Significance Index: -3.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2364
    Cell Significance Index: -14.5300
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.2437
    Cell Significance Index: -1.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2609
    Cell Significance Index: -7.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2665
    Cell Significance Index: -20.4500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2773
    Cell Significance Index: -3.9400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3175
    Cell Significance Index: -16.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3502
    Cell Significance Index: -19.6500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3530
    Cell Significance Index: -5.3200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3726
    Cell Significance Index: -15.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3937
    Cell Significance Index: -10.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SNAPC2 exhibits several distinct characteristics that make it an essential player in gene expression regulation. These include: 1. **Subunit of the spliceosome**: SNAPC2 is a subunit of the small nuclear RNA activating complex, a key component of the spliceosome, which is responsible for the splicing of pre-mRNA. 2. **Significant expression in germ cells**: SNAPC2 is highly expressed in germ cells, suggesting its importance in reproductive processes. 3. **Expression in neural progenitor cells**: SNAPC2 is also expressed in neural progenitor cells, highlighting its potential role in neuronal development and function. 4. **Variety of cell types**: SNAPC2 is expressed in a range of cell types, including B-2 B cells, kidney proximal straight tubule epithelial cells, and primordial germ cells, underscoring its broad functional significance. **Pathways and Functions** SNAPC2 is involved in various pathways and functions, including: 1. **Gene expression regulation**: SNAPC2 plays a critical role in the regulation of gene expression through its involvement in the spliceosome, which facilitates the splicing of pre-mRNA. 2. **Splicing of pre-mRNA**: SNAPC2 is essential for the splicing of pre-mRNA, a process that removes introns and joins exons to form mature mRNA. 3. **RNA polymerase II transcription**: SNAPC2 is involved in the transcription of snRNA genes by RNA polymerase II, a key transcription factor. 4. **Nucleus and nucleoplasm**: SNAPC2 is localized to the nucleus and nucleoplasm, highlighting its role in nuclear processes. **Clinical Significance** The clinical significance of SNAPC2 is an area of ongoing research. However, its expression in various cell types and its involvement in gene expression regulation suggest potential implications for: 1. **Reproductive disorders**: SNAPC2's expression in germ cells and primordial germ cells may be relevant to reproductive disorders, such as infertility or testicular cancer. 2. **Neurological disorders**: SNAPC2's expression in neural progenitor cells and its involvement in RNA polymerase II transcription may be relevant to neurological disorders, such as Alzheimer's disease or Parkinson's disease. 3. **Cancer**: SNAPC2's expression in various cell types and its role in gene expression regulation may be relevant to cancer development and progression. In conclusion, SNAPC2 is a critical component of the spliceosome, involved in gene expression regulation through its role in the splicing of pre-mRNA. Its significant expression in various cell types and its involvement in RNA polymerase II transcription highlight its broad functional significance. Further research is needed to fully elucidate the clinical significance of SNAPC2 and its implications for human disease.

Genular Protein ID: 574340603

Symbol: SNPC2_HUMAN

Name: snRNA-activating protein complex subunit 2

UniProtKB Accession Codes:

Q13487 B2RBZ6 D6W663 Q13486

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 8 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8633057

Title: The SNAP45 subunit of the small nuclear RNA (snRNA) activating protein complex is required for RNA polymerase II and III snRNA gene transcription and interacts with the TATA box binding protein.

PubMed ID: 8633057

DOI: 10.1073/pnas.93.9.4289

PubMed ID: 8524284

Title: Cloning of two proximal sequence element-binding transcription factor subunits (gamma and delta) that are required for transcription of small nuclear RNA genes by RNA polymerases II and III and interact with the TATA-binding protein.

PubMed ID: 8524284

DOI: 10.1128/mcb.16.1.1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9418884

Title: The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1.

PubMed ID: 9418884

DOI: 10.1128/mcb.18.1.368

PubMed ID: 12621023

Title: The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition.

PubMed ID: 12621023

DOI: 10.1074/jbc.m204247200

Sequence Information:

  • Length: 334
  • Mass: 35556
  • Checksum: 441894AF6E1F4083
  • Sequence:
    • MKPPPRRRAA PARYLGEVTG PATWSAREKR QLVRLLQARQ GQPEPDATEL ARELRGRSEA 
EIRVFLQQLK GRVAREAIQK VHPGGLQGPR RREAQPPAPI EVWTDLAEKI TGPLEEALAV 
AFSQVLTIAA TEPVTLLHSK PPKPTQARGK PLLLSAPGGQ EDPAPEIPSS APAAPSSAPR 
TPDPAPEKPS ESSAGPSTEE DFAVDFEKIY KYLSSVSRSG RSPELSAAES AVVLDLLMSL 
PEELPLLPCT ALVEHMTETY LRLTAPQPIP AGGSLGPAAE GDGAGSKAPE ETPPATEKAE 
HSELKSPWQA AGICPLNPFL VPLELLGRAA TPAR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.