Details for: SNRNP70
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 553.5368
Cell Significance Index: -86.1000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 343.3561
Cell Significance Index: -87.0900 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 207.7532
Cell Significance Index: -98.0900 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 200.2919
Cell Significance Index: -81.3700 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 179.9041
Cell Significance Index: -92.5400 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 146.3066
Cell Significance Index: -98.1800 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 85.6042
Cell Significance Index: -81.7300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 77.4075
Cell Significance Index: -95.4400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 30.9759
Cell Significance Index: -82.9800 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 25.4114
Cell Significance Index: -78.0500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 24.9110
Cell Significance Index: -98.3000 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 21.0867
Cell Significance Index: -46.1500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.2142
Cell Significance Index: 444.1700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.1354
Cell Significance Index: 423.7800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 2.1342
Cell Significance Index: 1476.1100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.0327
Cell Significance Index: 279.1400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.9472
Cell Significance Index: 88.2600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.8691
Cell Significance Index: 120.5900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.8166
Cell Significance Index: 52.3400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.6793
Cell Significance Index: 46.9300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.6751
Cell Significance Index: 600.8400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.6644
Cell Significance Index: 300.0500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.6172
Cell Significance Index: 84.2400 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.5732
Cell Significance Index: 42.8200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.5593
Cell Significance Index: 21.2800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.5556
Cell Significance Index: 73.1100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.5325
Cell Significance Index: 188.4400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.3816
Cell Significance Index: 754.5500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.2853
Cell Significance Index: 98.6300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.2747
Cell Significance Index: 66.9300 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.1991
Cell Significance Index: 25.6300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1684
Cell Significance Index: 190.0400 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.1074
Cell Significance Index: 66.4800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.9987
Cell Significance Index: 441.5700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.9302
Cell Significance Index: 43.3700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.8994
Cell Significance Index: 67.0300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.8169
Cell Significance Index: 17.1000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.7983
Cell Significance Index: 49.0700 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.7819
Cell Significance Index: 100.2300 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.6486
Cell Significance Index: 83.8000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.6320
Cell Significance Index: 74.5300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.5956
Cell Significance Index: 30.9400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.5574
Cell Significance Index: 19.3700 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.5449
Cell Significance Index: 15.6200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.4479
Cell Significance Index: 25.1400 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.4195
Cell Significance Index: 11.0300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3363
Cell Significance Index: 57.4200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3125
Cell Significance Index: 282.1500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2662
Cell Significance Index: 18.8300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2353
Cell Significance Index: 443.0800 - Cell Name: peg cell (CL4033014)
Fold Change: 0.1679
Cell Significance Index: 3.8800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1625
Cell Significance Index: 103.2000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1084
Cell Significance Index: 3.8100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0949
Cell Significance Index: 43.0800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0843
Cell Significance Index: 129.7700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0627
Cell Significance Index: 115.5800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0622
Cell Significance Index: 4.1800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0577
Cell Significance Index: 78.4400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0492
Cell Significance Index: 9.3600 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0243
Cell Significance Index: 0.6500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0377
Cell Significance Index: -28.5500 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0391
Cell Significance Index: -0.6700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0416
Cell Significance Index: -30.5100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0514
Cell Significance Index: -0.8600 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0584
Cell Significance Index: -1.5700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0614
Cell Significance Index: -45.4600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0900
Cell Significance Index: -56.2100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1124
Cell Significance Index: -11.4800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1300
Cell Significance Index: -73.3200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2689
Cell Significance Index: -56.6400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.2926
Cell Significance Index: -28.9400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2947
Cell Significance Index: -84.7800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2956
Cell Significance Index: -42.9700 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.3229
Cell Significance Index: -3.5100 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.3984
Cell Significance Index: -9.7200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4567
Cell Significance Index: -20.2000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4770
Cell Significance Index: -55.5900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.5315
Cell Significance Index: -33.5000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.5377
Cell Significance Index: -61.6000 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.5505
Cell Significance Index: -13.2000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.6106
Cell Significance Index: -69.7000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.7006
Cell Significance Index: -26.5300 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.7410
Cell Significance Index: -18.9300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.7425
Cell Significance Index: -77.3100 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.7957
Cell Significance Index: -15.5300 - Cell Name: kidney cell (CL1000497)
Fold Change: -0.8924
Cell Significance Index: -7.1300 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.9540
Cell Significance Index: -16.0700 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.9844
Cell Significance Index: -9.0700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.0369
Cell Significance Index: -82.1200 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -1.0586
Cell Significance Index: -30.2100 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.0771
Cell Significance Index: -16.1400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.1198
Cell Significance Index: -28.7900 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -1.1332
Cell Significance Index: -33.2800 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -1.1945
Cell Significance Index: -17.6300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.2860
Cell Significance Index: -27.8600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -1.2957
Cell Significance Index: -89.6100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.3926
Cell Significance Index: -85.3800 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -1.3980
Cell Significance Index: -20.6400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.4269
Cell Significance Index: -45.7000 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.5743
Cell Significance Index: -46.3700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 220868807
Symbol: RU17_HUMAN
Name: U1 small nuclear ribonucleoprotein 70 kDa
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3028775
Title: Cloning of the human cDNA for the U1 RNA-associated 70K protein.
PubMed ID: 3028775
PubMed ID: 2447561
Title: The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding.
PubMed ID: 2447561
PubMed ID: 2467746
Title: A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein.
PubMed ID: 2467746
PubMed ID: 2147422
Title: Human U1-70K ribonucleoprotein antigen gene: organization, nucleotide sequence, and mapping to locus 19q13.3.
PubMed ID: 2147422
PubMed ID: 8746626
Title: Identification of an inhibitory element within the human 68-kDa (U1) ribonucleoprotein antigen.
PubMed ID: 8746626
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8332490
Title: Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors.
PubMed ID: 8332490
PubMed ID: 9531537
PubMed ID: 9447963
Title: Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing.
PubMed ID: 9447963
DOI: 10.1128/mcb.18.2.676
PubMed ID: 10339552
Title: The SRm160/300 splicing coactivator is required for exon-enhancer function.
PubMed ID: 10339552
PubMed ID: 11448987
Title: ZNF265 -- a novel spliceosomal protein able to induce alternative splicing.
PubMed ID: 11448987
PubMed ID: 11514619
Title: Nuclear relocalization of the pre-mRNA splicing factor PSF during apoptosis involves hyperphosphorylation, masking of antigenic epitopes, and changes in protein interactions.
PubMed ID: 11514619
PubMed ID: 14561889
Title: Association of polyadenylation cleavage factor I with U1 snRNP.
PubMed ID: 14561889
DOI: 10.1261/rna.5104603
PubMed ID: 15144186
Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
PubMed ID: 15144186
DOI: 10.1021/ac035352d
PubMed ID: 14765198
Title: Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock.
PubMed ID: 14765198
DOI: 10.1038/nature02288
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17656373
Title: Evidence for a direct role of the disease modifier SCNM1 in splicing.
PubMed ID: 17656373
DOI: 10.1093/hmg/ddm206
PubMed ID: 17924679
Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
PubMed ID: 17924679
DOI: 10.1021/pr070152u
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25911097
Title: Gemin5 binds to the survival motor neuron mRNA to regulate SMN expression.
PubMed ID: 25911097
PubMed ID: 26124092
Title: FUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNP.
PubMed ID: 26124092
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 19325628
Title: Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution.
PubMed ID: 19325628
DOI: 10.1038/nature07851
PubMed ID: 21113136
Title: Functional organization of the Sm core in the crystal structure of human U1 snRNP.
PubMed ID: 21113136
PubMed ID: 25555158
Title: Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.
PubMed ID: 25555158
DOI: 10.7554/elife.04986
Sequence Information:
- Length: 437
- Mass: 51557
- Checksum: F1020BF5C40CF97D
- Sequence:
MTQFLPPNLL ALFAPRDPIP YLPPLEKLPH EKHHNQPYCG IAPYIREFED PRDAPPPTRA ETREERMERK RREKIERRQQ EVETELKMWD PHNDPNAQGD AFKTLFVARV NYDTTESKLR REFEVYGPIK RIHMVYSKRS GKPRGYAFIE YEHERDMHSA YKHADGKKID GRRVLVDVER GRTVKGWRPR RLGGGLGGTR RGGADVNIRH SGRDDTSRYD ERPGPSPLPH RDRDRDRERE RRERSRERDK ERERRRSRSR DRRRRSRSRD KEERRRSRER SKDKDRDRKR RSSRSRERAR RERERKEELR GGGGDMAEPS EAGDAPPDDG PPGELGPDGP DGPEEKGRDR DRERRRSHRS ERERRRDRDR DRDRDREHKR GERGSERGRD EARGGGGGQD NGLEGLGNDS RDMYMESEGG DGYLAPENGY LMEAAPE
Genular Protein ID: 4025054881
Symbol: Q9UFS1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 122
- Mass: 13562
- Checksum: C64A153AE2018BDB
- Sequence:
MAEPSEAGDA PPDDGPPGEL GPDGPDGPEE KGRDRDRERR RSHRSERERR RDRDRDRDRD REHKRGERGS ERGRDEARGG GGGQDNGLEG LGNDSRDMYM ESEGGDGYLA PENGYLMEAA PE
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.