Details for: SNRPE

Gene ID: 6635

Symbol: SNRPE

Ensembl ID: ENSG00000182004

Description: small nuclear ribonucleoprotein polypeptide E

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 347.6159
    Cell Significance Index: -54.0700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 190.3640
    Cell Significance Index: -78.4200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 164.8724
    Cell Significance Index: -77.8400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 164.4829
    Cell Significance Index: -41.7200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 156.1573
    Cell Significance Index: -63.4400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 141.0421
    Cell Significance Index: -72.5500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 116.6280
    Cell Significance Index: -78.2600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 67.2642
    Cell Significance Index: -64.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 59.3371
    Cell Significance Index: -73.1600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.8045
    Cell Significance Index: -61.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.3419
    Cell Significance Index: -80.2700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.8794
    Cell Significance Index: -42.6300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 8.4122
    Cell Significance Index: 67.1700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.2924
    Cell Significance Index: -15.9600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 7.0120
    Cell Significance Index: 76.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 6.3808
    Cell Significance Index: 133.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 5.3702
    Cell Significance Index: 143.6500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.5880
    Cell Significance Index: 120.6400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.4389
    Cell Significance Index: 154.2500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.6566
    Cell Significance Index: 30.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.5877
    Cell Significance Index: 1413.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.5857
    Cell Significance Index: 70.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.5811
    Cell Significance Index: 333.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.5424
    Cell Significance Index: 179.8100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.5215
    Cell Significance Index: 23.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.4982
    Cell Significance Index: 450.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.4754
    Cell Significance Index: 184.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.4476
    Cell Significance Index: 336.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.3399
    Cell Significance Index: 109.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.3374
    Cell Significance Index: 287.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.1011
    Cell Significance Index: 247.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.0849
    Cell Significance Index: 921.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.0132
    Cell Significance Index: 129.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.9802
    Cell Significance Index: 45.7500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.7257
    Cell Significance Index: 10.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.6233
    Cell Significance Index: 75.6900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.5089
    Cell Significance Index: 26.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.3934
    Cell Significance Index: 178.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.3480
    Cell Significance Index: 38.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2946
    Cell Significance Index: 67.2500
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 1.2860
    Cell Significance Index: 7.3100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.2181
    Cell Significance Index: 15.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9417
    Cell Significance Index: 65.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6371
    Cell Significance Index: 103.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6080
    Cell Significance Index: 120.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5558
    Cell Significance Index: 14.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5050
    Cell Significance Index: 10.9400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3901
    Cell Significance Index: 352.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3771
    Cell Significance Index: 10.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3660
    Cell Significance Index: 10.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3401
    Cell Significance Index: 58.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3375
    Cell Significance Index: 17.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3124
    Cell Significance Index: 14.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3023
    Cell Significance Index: 57.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2879
    Cell Significance Index: 28.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2259
    Cell Significance Index: 171.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1802
    Cell Significance Index: 3.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1632
    Cell Significance Index: 32.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1532
    Cell Significance Index: 7.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1186
    Cell Significance Index: 3.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0462
    Cell Significance Index: 33.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0019
    Cell Significance Index: -0.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0035
    Cell Significance Index: -2.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0055
    Cell Significance Index: -0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0298
    Cell Significance Index: -56.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0388
    Cell Significance Index: -24.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0464
    Cell Significance Index: -85.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0533
    Cell Significance Index: -1.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0559
    Cell Significance Index: -86.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0613
    Cell Significance Index: -6.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0658
    Cell Significance Index: -4.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0660
    Cell Significance Index: -89.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0797
    Cell Significance Index: -44.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0895
    Cell Significance Index: -56.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1289
    Cell Significance Index: -27.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1327
    Cell Significance Index: -3.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1506
    Cell Significance Index: -68.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1682
    Cell Significance Index: -48.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1686
    Cell Significance Index: -9.4600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.1693
    Cell Significance Index: -1.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2301
    Cell Significance Index: -14.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2306
    Cell Significance Index: -26.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2600
    Cell Significance Index: -29.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4481
    Cell Significance Index: -65.1300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4828
    Cell Significance Index: -38.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5024
    Cell Significance Index: -10.7000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5177
    Cell Significance Index: -59.1000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5581
    Cell Significance Index: -10.3200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6720
    Cell Significance Index: -4.0600
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.6746
    Cell Significance Index: -3.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7659
    Cell Significance Index: -79.7500
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.7915
    Cell Significance Index: -4.6500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.8588
    Cell Significance Index: -8.8900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8590
    Cell Significance Index: -11.7200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.8758
    Cell Significance Index: -10.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.9747
    Cell Significance Index: -74.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.0870
    Cell Significance Index: -73.0900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.1081
    Cell Significance Index: -66.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.1862
    Cell Significance Index: -34.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2421
    Cell Significance Index: -76.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Location**: The SNRPE gene is located on chromosome 1q21.3, a region known for its involvement in various diseases, including cancer and neurological disorders. 2. **Function**: SNRPE is a component of the spliceosome complex, which is responsible for removing introns from pre-mRNA and joining exons to form mature mRNA. This process is essential for protein synthesis and gene expression. 3. **Expression**: SNRPE is widely expressed in various cell types, including hematopoietic stem cells, erythroid progenitor cells, and epithelial cells. 4. **Protein**: The SNRPE protein, also known as RUXE_HUMAN, is a small nuclear ribonucleoprotein that interacts with other spliceosomal components to facilitate RNA processing. **Pathways and Functions** 1. **Spliceosome Complex**: SNRPE is a key component of the spliceosome complex, which is responsible for RNA processing and splicing. The spliceosome complex consists of various proteins and RNAs that work together to remove introns and join exons to form mature mRNA. 2. **RNA Binding**: SNRPE interacts with various RNAs, including pre-mRNA, snRNA, and miRNA, to facilitate RNA processing and splicing. 3. **Protein Synthesis**: SNRPE is involved in protein synthesis by ensuring that mature mRNA is available for translation. 4. **Gene Expression**: SNRPE regulates gene expression by controlling the splicing of pre-mRNA, which affects the levels and types of proteins produced. 5. **Viral Infections**: SNRPE has been implicated in SARS-CoV-2 infection, where it interacts with the viral RNA-dependent RNA polymerase (RdRp) to modulate host translation machinery. **Clinical Significance** 1. **Disease Association**: SNRPE has been associated with various diseases, including cancer, neurological disorders, and infectious diseases. 2. **Viral Infections**: SNRPE's involvement in SARS-CoV-2 infection highlights its importance in understanding the mechanisms of viral infections and developing novel therapeutic strategies. 3. **Cancer**: SNRPE has been implicated in cancer development and progression, where it may play a role in regulating gene expression and promoting tumorigenesis. 4. **Neurological Disorders**: SNRPE has been associated with various neurological disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 5. **Immunology**: SNRPE's involvement in immune responses, including the regulation of gene expression and protein synthesis, highlights its importance in maintaining immune homeostasis. In conclusion, the SNRPE gene plays a crucial role in RNA processing and splicing, and its involvement in disease and viral infections highlights its importance in maintaining cellular homeostasis and immune function. Further research is needed to fully understand the mechanisms of SNRPE and its role in various diseases and viral infections.

Genular Protein ID: 1682296630

Symbol: RUXE_HUMAN

Name: Small nuclear ribonucleoprotein E

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2974536

Title: The complete primary structure of the human snRNP E protein.

PubMed ID: 2974536

DOI: 10.1093/nar/16.22.10593

PubMed ID: 2972723

Title: The small nuclear ribonucleoprotein E protein gene contains four introns and has upstream similarities to genes for ribosomal proteins.

PubMed ID: 2972723

DOI: 10.1016/s0021-9258(19)77902-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2440864

Title: DNA sequence of a human Sm autoimmune antigen. The multigene family contains a processed pseudogene.

PubMed ID: 2440864

DOI: 10.1016/s0021-9258(18)61052-x

PubMed ID: 10500148

Title: SMN mutants of spinal muscular atrophy patients are defective in binding to snRNP proteins.

PubMed ID: 10500148

DOI: 10.1073/pnas.96.20.11167

PubMed ID: 11574479

Title: Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein.

PubMed ID: 11574479

DOI: 10.1093/emboj/20.19.5470

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 12975319

Title: Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing.

PubMed ID: 12975319

DOI: 10.1101/gad.274403

PubMed ID: 15146077

Title: The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.

PubMed ID: 15146077

DOI: 10.1261/rna.7320604

PubMed ID: 16314521

Title: Specific sequence features, recognized by the SMN complex, identify snRNAs and determine their fate as snRNPs.

PubMed ID: 16314521

DOI: 10.1128/mcb.25.24.10989-11004.2005

PubMed ID: 18984161

Title: An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.

PubMed ID: 18984161

DOI: 10.1016/j.cell.2008.09.020

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23246290

Title: Mutations in SNRPE, which encodes a core protein of the spliceosome, cause autosomal-dominant hypotrichosis simplex.

PubMed ID: 23246290

DOI: 10.1016/j.ajhg.2012.10.022

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 19325628

Title: Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution.

PubMed ID: 19325628

DOI: 10.1038/nature07851

PubMed ID: 21816274

Title: Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly.

PubMed ID: 21816274

DOI: 10.1016/j.cell.2011.06.043

PubMed ID: 21516107

Title: Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis.

PubMed ID: 21516107

DOI: 10.1038/nature09956

PubMed ID: 23333303

Title: Structural basis of assembly chaperone-mediated snRNP formation.

PubMed ID: 23333303

DOI: 10.1016/j.molcel.2012.12.009

PubMed ID: 25555158

Title: Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.

PubMed ID: 25555158

DOI: 10.7554/elife.04986

PubMed ID: 26912367

Title: Molecular architecture of the human U4/U6.U5 tri-snRNP.

PubMed ID: 26912367

DOI: 10.1126/science.aad2085

PubMed ID: 28502770

Title: An Atomic Structure of the Human Spliceosome.

PubMed ID: 28502770

DOI: 10.1016/j.cell.2017.04.033

PubMed ID: 28781166

Title: Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.

PubMed ID: 28781166

DOI: 10.1016/j.cell.2017.07.011

PubMed ID: 28076346

Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

PubMed ID: 28076346

DOI: 10.1038/nature21079

PubMed ID: 31799625

Title: Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assembly.

PubMed ID: 31799625

DOI: 10.1093/nar/gkz1135

PubMed ID: 32494006

Title: Molecular architecture of the human 17S U2 snRNP.

PubMed ID: 32494006

DOI: 10.1038/s41586-020-2344-3

PubMed ID: 33509932

Title: Structure of the activated human minor spliceosome.

PubMed ID: 33509932

DOI: 10.1126/science.abg0879

PubMed ID: 36797247

Title: Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly.

PubMed ID: 36797247

DOI: 10.1038/s41467-023-36489-x

Sequence Information:

  • Length: 92
  • Mass: 10804
  • Checksum: 7D8881CE1F4FA2FD
  • Sequence:
  • MAYRGQGQKV QKVMVQPINL IFRYLQNRSR IQVWLYEQVN MRIEGCIIGF DEYMNLVLDD 
    AEEIHSKTKS RKQLGRIMLK GDNITLLQSV SN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.