Details for: SNRPE
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 347.6159
Cell Significance Index: -54.0700 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 190.3640
Cell Significance Index: -78.4200 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 164.8724
Cell Significance Index: -77.8400 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 164.4829
Cell Significance Index: -41.7200 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 156.1573
Cell Significance Index: -63.4400 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 141.0421
Cell Significance Index: -72.5500 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 116.6280
Cell Significance Index: -78.2600 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 67.2642
Cell Significance Index: -64.2200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 59.3371
Cell Significance Index: -73.1600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 22.8045
Cell Significance Index: -61.0900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 20.3419
Cell Significance Index: -80.2700 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 13.8794
Cell Significance Index: -42.6300 - Cell Name: kidney cell (CL1000497)
Fold Change: 8.4122
Cell Significance Index: 67.1700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 7.2924
Cell Significance Index: -15.9600 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 7.0120
Cell Significance Index: 76.2300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 6.3808
Cell Significance Index: 133.5600 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 5.3702
Cell Significance Index: 143.6500 - Cell Name: granulosa cell (CL0000501)
Fold Change: 4.5880
Cell Significance Index: 120.6400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 4.4389
Cell Significance Index: 154.2500 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 2.6566
Cell Significance Index: 30.1800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 2.5877
Cell Significance Index: 1413.2000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.5857
Cell Significance Index: 70.3800 - Cell Name: lactocyte (CL0002325)
Fold Change: 2.5811
Cell Significance Index: 333.4700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 2.5424
Cell Significance Index: 179.8100 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.5215
Cell Significance Index: 23.2200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.4982
Cell Significance Index: 450.3500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.4754
Cell Significance Index: 184.4900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.4476
Cell Significance Index: 336.1300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 2.3399
Cell Significance Index: 109.9800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.3374
Cell Significance Index: 287.4100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.1011
Cell Significance Index: 247.7800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.0849
Cell Significance Index: 921.7900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.0132
Cell Significance Index: 129.8800 - Cell Name: peg cell (CL4033014)
Fold Change: 1.9802
Cell Significance Index: 45.7500 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 1.7257
Cell Significance Index: 10.6200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.6233
Cell Significance Index: 75.6900 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.5089
Cell Significance Index: 26.6700 - Cell Name: odontoblast (CL0000060)
Fold Change: 1.3934
Cell Significance Index: 178.6200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.3480
Cell Significance Index: 38.6400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.2946
Cell Significance Index: 67.2500 - Cell Name: sensory neuron (CL0000101)
Fold Change: 1.2860
Cell Significance Index: 7.3100 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.2181
Cell Significance Index: 15.6000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.9417
Cell Significance Index: 65.1200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6371
Cell Significance Index: 103.6200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.6080
Cell Significance Index: 120.6600 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.5558
Cell Significance Index: 14.8400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5050
Cell Significance Index: 10.9400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3901
Cell Significance Index: 352.2500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3771
Cell Significance Index: 10.8700 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.3660
Cell Significance Index: 10.7500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3401
Cell Significance Index: 58.0700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.3375
Cell Significance Index: 17.7200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3124
Cell Significance Index: 14.1600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3023
Cell Significance Index: 57.5300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2879
Cell Significance Index: 28.4800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.2259
Cell Significance Index: 171.0000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1802
Cell Significance Index: 3.0200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1632
Cell Significance Index: 32.7400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.1532
Cell Significance Index: 7.9800 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.1186
Cell Significance Index: 3.8000 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0462
Cell Significance Index: 33.8400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0019
Cell Significance Index: -0.6800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0035
Cell Significance Index: -2.5900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0055
Cell Significance Index: -0.2000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0298
Cell Significance Index: -56.1100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0388
Cell Significance Index: -24.2500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0464
Cell Significance Index: -85.6600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0533
Cell Significance Index: -1.4900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0559
Cell Significance Index: -86.0900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0613
Cell Significance Index: -6.2600 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0658
Cell Significance Index: -4.1500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0660
Cell Significance Index: -89.6900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0797
Cell Significance Index: -44.9700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0895
Cell Significance Index: -56.8300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1289
Cell Significance Index: -27.1400 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1327
Cell Significance Index: -3.3900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1506
Cell Significance Index: -68.3700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1682
Cell Significance Index: -48.4100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1686
Cell Significance Index: -9.4600 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -0.1693
Cell Significance Index: -1.4600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2301
Cell Significance Index: -14.1400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2306
Cell Significance Index: -26.8700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2600
Cell Significance Index: -29.7900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.4481
Cell Significance Index: -65.1300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4828
Cell Significance Index: -38.2400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.5024
Cell Significance Index: -10.7000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.5177
Cell Significance Index: -59.1000 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.5581
Cell Significance Index: -10.3200 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.6720
Cell Significance Index: -4.0600 - Cell Name: chondroblast (CL0000058)
Fold Change: -0.6746
Cell Significance Index: -3.9600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.7659
Cell Significance Index: -79.7500 - Cell Name: theca cell (CL0000503)
Fold Change: -0.7915
Cell Significance Index: -4.6500 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.8588
Cell Significance Index: -8.8900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.8590
Cell Significance Index: -11.7200 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.8758
Cell Significance Index: -10.4400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.9747
Cell Significance Index: -74.8000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.0870
Cell Significance Index: -73.0900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -1.1081
Cell Significance Index: -66.5300 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.1862
Cell Significance Index: -34.9400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.2421
Cell Significance Index: -76.1500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1682296630
Symbol: RUXE_HUMAN
Name: Small nuclear ribonucleoprotein E
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2974536
Title: The complete primary structure of the human snRNP E protein.
PubMed ID: 2974536
PubMed ID: 2972723
Title: The small nuclear ribonucleoprotein E protein gene contains four introns and has upstream similarities to genes for ribosomal proteins.
PubMed ID: 2972723
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2440864
Title: DNA sequence of a human Sm autoimmune antigen. The multigene family contains a processed pseudogene.
PubMed ID: 2440864
PubMed ID: 10500148
Title: SMN mutants of spinal muscular atrophy patients are defective in binding to snRNP proteins.
PubMed ID: 10500148
PubMed ID: 11574479
Title: Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein.
PubMed ID: 11574479
PubMed ID: 11991638
Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
PubMed ID: 11991638
PubMed ID: 12975319
Title: Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing.
PubMed ID: 12975319
DOI: 10.1101/gad.274403
PubMed ID: 15146077
Title: The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.
PubMed ID: 15146077
DOI: 10.1261/rna.7320604
PubMed ID: 16314521
Title: Specific sequence features, recognized by the SMN complex, identify snRNAs and determine their fate as snRNPs.
PubMed ID: 16314521
PubMed ID: 18984161
Title: An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.
PubMed ID: 18984161
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23246290
Title: Mutations in SNRPE, which encodes a core protein of the spliceosome, cause autosomal-dominant hypotrichosis simplex.
PubMed ID: 23246290
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 19325628
Title: Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution.
PubMed ID: 19325628
DOI: 10.1038/nature07851
PubMed ID: 21816274
Title: Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly.
PubMed ID: 21816274
PubMed ID: 21516107
Title: Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis.
PubMed ID: 21516107
DOI: 10.1038/nature09956
PubMed ID: 23333303
Title: Structural basis of assembly chaperone-mediated snRNP formation.
PubMed ID: 23333303
PubMed ID: 25555158
Title: Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.
PubMed ID: 25555158
DOI: 10.7554/elife.04986
PubMed ID: 26912367
Title: Molecular architecture of the human U4/U6.U5 tri-snRNP.
PubMed ID: 26912367
PubMed ID: 28502770
Title: An Atomic Structure of the Human Spliceosome.
PubMed ID: 28502770
PubMed ID: 28781166
Title: Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
PubMed ID: 28781166
PubMed ID: 28076346
Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
PubMed ID: 28076346
DOI: 10.1038/nature21079
PubMed ID: 31799625
Title: Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assembly.
PubMed ID: 31799625
DOI: 10.1093/nar/gkz1135
PubMed ID: 32494006
Title: Molecular architecture of the human 17S U2 snRNP.
PubMed ID: 32494006
PubMed ID: 33509932
Title: Structure of the activated human minor spliceosome.
PubMed ID: 33509932
PubMed ID: 36797247
Title: Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly.
PubMed ID: 36797247
Sequence Information:
- Length: 92
- Mass: 10804
- Checksum: 7D8881CE1F4FA2FD
- Sequence:
MAYRGQGQKV QKVMVQPINL IFRYLQNRSR IQVWLYEQVN MRIEGCIIGF DEYMNLVLDD AEEIHSKTKS RKQLGRIMLK GDNITLLQSV SN
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.