Details for: SNX2

Gene ID: 6643

Symbol: SNX2

Ensembl ID: ENSG00000205302

Description: sorting nexin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 336.2366
    Cell Significance Index: -52.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 192.2778
    Cell Significance Index: -48.7700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 146.5963
    Cell Significance Index: -60.3900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 132.7361
    Cell Significance Index: -53.9300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 131.0676
    Cell Significance Index: -61.8800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 114.9722
    Cell Significance Index: -59.1400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 92.5007
    Cell Significance Index: -62.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 57.0494
    Cell Significance Index: -54.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 46.2060
    Cell Significance Index: -56.9700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.2806
    Cell Significance Index: -51.6500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.1139
    Cell Significance Index: -59.6400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.5864
    Cell Significance Index: -41.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.7930
    Cell Significance Index: -25.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.6819
    Cell Significance Index: 545.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.3549
    Cell Significance Index: 89.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.5671
    Cell Significance Index: 165.6200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.2277
    Cell Significance Index: 2011.4400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.7338
    Cell Significance Index: 104.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4087
    Cell Significance Index: 282.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1164
    Cell Significance Index: 609.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1119
    Cell Significance Index: 136.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0862
    Cell Significance Index: 195.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0654
    Cell Significance Index: 125.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9790
    Cell Significance Index: 194.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8580
    Cell Significance Index: 117.8300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.8527
    Cell Significance Index: 15.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7854
    Cell Significance Index: 281.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7850
    Cell Significance Index: 100.6300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7166
    Cell Significance Index: 15.0000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.6617
    Cell Significance Index: 17.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5677
    Cell Significance Index: 250.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3695
    Cell Significance Index: 22.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3563
    Cell Significance Index: 18.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3314
    Cell Significance Index: 15.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3209
    Cell Significance Index: 18.0100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3102
    Cell Significance Index: 214.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3092
    Cell Significance Index: 21.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2867
    Cell Significance Index: 15.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2190
    Cell Significance Index: 15.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1547
    Cell Significance Index: 7.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1543
    Cell Significance Index: 29.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1368
    Cell Significance Index: 10.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1282
    Cell Significance Index: 21.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0987
    Cell Significance Index: 5.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0873
    Cell Significance Index: 8.6400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0852
    Cell Significance Index: 0.7800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0682
    Cell Significance Index: 8.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0669
    Cell Significance Index: 125.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0404
    Cell Significance Index: 25.6700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0390
    Cell Significance Index: 0.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0182
    Cell Significance Index: 8.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0073
    Cell Significance Index: 13.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0062
    Cell Significance Index: 9.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0008
    Cell Significance Index: 0.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0045
    Cell Significance Index: -6.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0129
    Cell Significance Index: -9.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0318
    Cell Significance Index: -3.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0343
    Cell Significance Index: -26.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0534
    Cell Significance Index: -0.9200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0596
    Cell Significance Index: -37.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0769
    Cell Significance Index: -5.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0783
    Cell Significance Index: -44.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0944
    Cell Significance Index: -5.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1114
    Cell Significance Index: -2.9300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1165
    Cell Significance Index: -1.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1496
    Cell Significance Index: -11.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1545
    Cell Significance Index: -5.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1607
    Cell Significance Index: -33.8500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1755
    Cell Significance Index: -3.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1822
    Cell Significance Index: -52.4400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.2060
    Cell Significance Index: -1.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2108
    Cell Significance Index: -30.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2546
    Cell Significance Index: -7.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2908
    Cell Significance Index: -13.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3138
    Cell Significance Index: -10.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3175
    Cell Significance Index: -36.3700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3410
    Cell Significance Index: -38.9200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3495
    Cell Significance Index: -4.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3592
    Cell Significance Index: -15.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4120
    Cell Significance Index: -15.6000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.4158
    Cell Significance Index: -3.3200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4471
    Cell Significance Index: -5.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4829
    Cell Significance Index: -50.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5158
    Cell Significance Index: -40.8500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5342
    Cell Significance Index: -14.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6310
    Cell Significance Index: -18.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6388
    Cell Significance Index: -18.7600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7403
    Cell Significance Index: -17.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7469
    Cell Significance Index: -19.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7877
    Cell Significance Index: -22.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8180
    Cell Significance Index: -11.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8259
    Cell Significance Index: -17.5900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8635
    Cell Significance Index: -22.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8640
    Cell Significance Index: -52.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8702
    Cell Significance Index: -25.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.0448
    Cell Significance Index: -29.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0556
    Cell Significance Index: -28.2900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.0873
    Cell Significance Index: -11.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.1409
    Cell Significance Index: -28.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNX2 is a small GTPase-binding protein that belongs to the sorting nexin family, characterized by its ability to interact with phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3-phosphate (PI3P) on the plasma membrane. This interaction enables SNX2 to regulate the trafficking of proteins and lipids through the formation of specific membrane domains, such as the early endosome and the trans-Golgi network. SNX2 also exhibits homodimerization and heterodimerization activities, allowing it to interact with other proteins and modulate its activity. **Pathways and Functions:** SNX2 is involved in several key pathways, including: 1. **Retromer complex formation:** SNX2 interacts with other components of the retromer complex, such as Vps35 and Vps4, to regulate the retrograde transport of proteins and lipids. 2. **Endosome-to-Golgi trafficking:** SNX2 facilitates the transport of proteins and lipids from endosomes to the Golgi apparatus. 3. **Endosome-to-plasma membrane trafficking:** SNX2 regulates the transport of proteins and lipids from endosomes to the plasma membrane. 4. **Lysosomal trafficking:** SNX2 interacts with lysosomal proteins to regulate the trafficking of lysosomal enzymes and other components. 5. **Cytoskeletal organization:** SNX2 regulates the organization of the cytoskeleton, particularly the actin cytoskeleton, through its interaction with actin-binding proteins. **Clinical Significance:** Dysregulation of SNX2 has been implicated in various immune-mediated diseases, including: 1. **Autoimmune disorders:** SNX2 dysfunction has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, where immune cell trafficking and signaling are disrupted. 2. **Cancer:** SNX2 overexpression has been observed in certain types of cancer, including breast and lung cancer, where it promotes tumor growth and metastasis. 3. **Infectious diseases:** SNX2 plays a crucial role in the regulation of immune cell trafficking in response to infection, and its dysfunction can contribute to the development of severe infections. 4. **Immunodeficiency disorders:** SNX2 mutations have been identified in individuals with immunodeficiency disorders, such as chronic granulomatous disease, where immune cell trafficking and signaling are impaired. In conclusion, SNX2 is a vital component of the immune system, regulating membrane trafficking and endocytic pathways in immune cells. Its dysregulation has been implicated in various immune-mediated diseases, highlighting the importance of SNX2 in maintaining immune homeostasis and regulating immune cell function. Further research is needed to fully elucidate the functional significance of SNX2 and its role in disease pathology.

Genular Protein ID: 3246891404

Symbol: SNX2_HUMAN

Name: Sorting nexin-2

UniProtKB Accession Codes:

O60749 B3KN44 B4DEK4 B7Z408 O43650 P82862 Q53XK8 Q597H6 Q9BTS8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 4 ChiTaRS 1 ComplexPortal 3 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 2 ExpressionAtlas 1 GO 24 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9819414

Title: Identification of a family of sorting nexin molecules and characterization of their association with receptors.

PubMed ID: 9819414

DOI: 10.1128/mcb.18.12.7278

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11102511

Title: Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes.

PubMed ID: 11102511

DOI: 10.1091/mbc.11.12.4105

PubMed ID: 11438682

Title: The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia.

PubMed ID: 11438682

DOI: 10.1073/pnas.121433898

PubMed ID: 14596906

Title: The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance.

PubMed ID: 14596906

DOI: 10.1016/s0014-5793(03)01063-9

PubMed ID: 16179610

Title: Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport.

PubMed ID: 16179610

DOI: 10.1242/jcs.02568

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17101778

Title: Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors.

PubMed ID: 17101778

DOI: 10.1128/mcb.00156-06

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18088323

Title: SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors.

PubMed ID: 18088323

DOI: 10.1111/j.1600-0854.2007.00686.x

PubMed ID: 19935774

Title: The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport.

PubMed ID: 19935774

DOI: 10.1038/cr.2009.130

PubMed ID: 19619496

Title: The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network.

PubMed ID: 19619496

DOI: 10.1016/j.devcel.2009.04.016

PubMed ID: 19816406

Title: Amphipathic motifs in BAR domains are essential for membrane curvature sensing.

PubMed ID: 19816406

DOI: 10.1038/emboj.2009.261

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20138391

Title: Identification of different itineraries and retromer components for endosome-to-Golgi transport of TGN38 and Shiga toxin.

PubMed ID: 20138391

DOI: 10.1016/j.ejcb.2009.10.021

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 20604901

Title: A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling.

PubMed ID: 20604901

DOI: 10.1111/j.1600-0854.2010.01100.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23085988

Title: Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules.

PubMed ID: 23085988

DOI: 10.1038/emboj.2012.283

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 519
  • Mass: 58471
  • Checksum: 7DC07DFA523312B5
  • Sequence:
    • MAAEREPPPL GDGKPTDFED LEDGEDLFTS TVSTLESSPS SPEPASLPAE DISANSNGPK 
PTEVVLDDDR EDLFAEATEE VSLDSPEREP ILSSEPSPAV TPVTPTTLIA PRIESKSMSA 
PVIFDRSREE IEEEANGDIF DIEIGVSDPE KVGDGMNAYM AYRVTTKTSL SMFSKSEFSV 
KRRFSDFLGL HSKLASKYLH VGYIVPPAPE KSIVGMTKVK VGKEDSSSTE FVEKRRAALE 
RYLQRTVKHP TLLQDPDLRQ FLESSELPRA VNTQALSGAG ILRMVNKAAD AVNKMTIKMN 
ESDAWFEEKQ QQFENLDQQL RKLHVSVEAL VCHRKELSAN TAAFAKSAAM LGNSEDHTAL 
SRALSQLAEV EEKIDQLHQE QAFADFYMFS ELLSDYIRLI AAVKGVFDHR MKCWQKWEDA 
QITLLKKREA EAKMMVANKP DKIQQAKNEI REWEAKVQQG ERDFEQISKT IRKEVGRFEK 
ERVKDFKTVI IKYLESLVQT QQQLIKYWEA FLPEAKAIA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.