STAT3 | ENSG00000168610 | NCBI 6774

Details for: STAT3

Gene ID: 6774

Symbol: STAT3

Ensembl ID: ENSG00000168610

Description: signal transducer and activator of transcription 3

Associated with

Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Apoptosis
(R-HSA-109581)
Association of tric/cct with target proteins during biosynthesis
(R-HSA-390471)
Bh3-only proteins associate with and inactivate anti-apoptotic bcl-2 members
(R-HSA-111453)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular senescence
(R-HSA-2559583)
Chaperonin-mediated protein folding
(R-HSA-390466)
Cytokine signaling in immune system
(R-HSA-1280215)
Cytoprotection by hmox1
(R-HSA-9707564)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signal transduction
(R-HSA-186763)
Fgfr1 mutant receptor activation
(R-HSA-1839124)
Growth hormone receptor signaling
(R-HSA-982772)
Immune system
(R-HSA-168256)
Inactivation of csf3 (g-csf) signaling
(R-HSA-9705462)
Interferon signaling
(R-HSA-913531)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-2 family signaling
(R-HSA-451927)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Interleukin-6 family signaling
(R-HSA-6783589)
Interleukin-6 signaling
(R-HSA-1059683)
Interleukin-7 signaling
(R-HSA-1266695)
Interleukin-9 signaling
(R-HSA-8985947)
Interleukin-10 signaling
(R-HSA-6783783)
Interleukin-12 family signaling
(R-HSA-447115)
Interleukin-15 signaling
(R-HSA-8983432)
Interleukin-20 family signaling
(R-HSA-8854691)
Interleukin-21 signaling
(R-HSA-9020958)
Interleukin-23 signaling
(R-HSA-9020933)
Interleukin-27 signaling
(R-HSA-9020956)
Interleukin-35 signalling
(R-HSA-8984722)
Interleukin-37 signaling
(R-HSA-9008059)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Metabolism of proteins
(R-HSA-392499)
Met activates stat3
(R-HSA-8875791)
Nuclear events stimulated by alk signaling in cancer
(R-HSA-9725371)
Pkr-mediated signaling
(R-HSA-9833482)
Pou5f1 (oct4), sox2, nanog activate genes related to proliferation
(R-HSA-2892247)
Programmed cell death
(R-HSA-5357801)
Protein folding
(R-HSA-391251)
Ptk6 activates stat3
(R-HSA-8849474)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by alk
(R-HSA-201556)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by csf1 (m-csf) in myeloid cells
(R-HSA-9680350)
Signaling by csf3 (g-csf)
(R-HSA-9674555)
Signaling by cytosolic fgfr1 fusion mutants
(R-HSA-1839117)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by interleukins
(R-HSA-449147)
Signaling by kit in disease
(R-HSA-9669938)
Signaling by leptin
(R-HSA-2586552)
Signaling by met
(R-HSA-6806834)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by pdgf
(R-HSA-186797)
Signaling by pdgfra extracellular domain mutants
(R-HSA-9673770)
Signaling by pdgfra transmembrane, juxtamembrane and kinase domain mutants
(R-HSA-9673767)
Signaling by pdgfr in disease
(R-HSA-9671555)
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain kit mutants
(R-HSA-9670439)
Signaling by ptk6
(R-HSA-8848021)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by scf-kit
(R-HSA-1433557)
Signalling to stat3
(R-HSA-198745)
Signal transduction
(R-HSA-162582)
Stat3 nuclear events downstream of alk signaling
(R-HSA-9701898)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Transcriptional regulation of pluripotent stem cells
(R-HSA-452723)
Chromatin dna binding
(GO:0031490)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription factor binding
(GO:0140297)
Dna binding
(GO:0003677)
Identical protein binding
(GO:0042802)
Lncrna binding
(GO:0106222)
Nuclear receptor activity
(GO:0004879)
Primary mirna binding
(GO:0070878)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Protein phosphatase binding
(GO:0019903)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Signaling adaptor activity
(GO:0035591)
Signaling receptor binding
(GO:0005102)
Transcription cis-regulatory region binding
(GO:0000976)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 617.6982
Cell Significance Index: -96.0800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 345.6822
Cell Significance Index: -87.6800
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 225.0043
Cell Significance Index: -92.6900
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 208.3145
Cell Significance Index: -98.3500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 207.9964
Cell Significance Index: -84.5000
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 185.9404
Cell Significance Index: -95.6500
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 146.8208
Cell Significance Index: -98.5200
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 88.9349
Cell Significance Index: -84.9100
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 79.2243
Cell Significance Index: -97.6800
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 32.5325
Cell Significance Index: -87.1500
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 28.2968
Cell Significance Index: -61.9300
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 24.9667
Cell Significance Index: -98.5200
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 24.7830
Cell Significance Index: -76.1200
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 4.1380
Cell Significance Index: 69.7100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 3.1909
Cell Significance Index: 244.8700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.7968
Cell Significance Index: 145.6800
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.1954
Cell Significance Index: 38.8000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.9078
Cell Significance Index: 262.0000
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.9068
Cell Significance Index: 27.4300
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.7781
Cell Significance Index: 24.2600
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.7607
Cell Significance Index: 131.2300
Cell Name: peg cell (CL4033014)
Fold Change: 1.7270
Cell Significance Index: 39.9000
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.5964
Cell Significance Index: 316.8200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.5410
Cell Significance Index: 72.4300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.5399
Cell Significance Index: 41.9200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.2522
Cell Significance Index: 136.2100
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.2196
Cell Significance Index: 34.9600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 1.1593
Cell Significance Index: 28.9800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.1095
Cell Significance Index: 66.6100
Cell Name: preadipocyte (CL0002334)
Fold Change: 1.1093
Cell Significance Index: 21.6500
Cell Name: lactocyte (CL0002325)
Fold Change: 1.0190
Cell Significance Index: 131.6500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0151
Cell Significance Index: 203.6300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.0090
Cell Significance Index: 124.0600
Cell Name: odontoblast (CL0000060)
Fold Change: 1.0027
Cell Significance Index: 128.5500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.9684
Cell Significance Index: 45.1500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.9608
Cell Significance Index: 173.2000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.9421
Cell Significance Index: 416.5200
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.9307
Cell Significance Index: 508.2900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.8897
Cell Significance Index: 25.6400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8830
Cell Significance Index: 797.3100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.7622
Cell Significance Index: 21.3000
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.6778
Cell Significance Index: 8.0800
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.6285
Cell Significance Index: 21.8400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5624
Cell Significance Index: 201.7300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.5286
Cell Significance Index: 335.6900
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5097
Cell Significance Index: 35.2500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4999
Cell Significance Index: 58.9500
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.3822
Cell Significance Index: 704.8100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.3642
Cell Significance Index: 685.6700
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3332
Cell Significance Index: 230.4700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.3266
Cell Significance Index: 148.2200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.3190
Cell Significance Index: 16.7500
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.3132
Cell Significance Index: 482.1400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2133
Cell Significance Index: 9.6700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2110
Cell Significance Index: 40.1600
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1774
Cell Significance Index: 11.4500
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.1395
Cell Significance Index: 2.9200
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0801
Cell Significance Index: 7.9200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0378
Cell Significance Index: 28.5900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0273
Cell Significance Index: 1.4200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0165
Cell Significance Index: 0.5800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0101
Cell Significance Index: 13.7100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0006
Cell Significance Index: 0.4400
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.0169
Cell Significance Index: -0.2500
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0325
Cell Significance Index: -2.3000
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0405
Cell Significance Index: -1.0700
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0554
Cell Significance Index: -9.4600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1067
Cell Significance Index: -79.0700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1147
Cell Significance Index: -11.7200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1589
Cell Significance Index: -89.6200
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1784
Cell Significance Index: -111.3900
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1945
Cell Significance Index: -2.2100
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2510
Cell Significance Index: -72.2200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2778
Cell Significance Index: -40.3800
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.3144
Cell Significance Index: -15.8900
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.3718
Cell Significance Index: -60.4700
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.4275
Cell Significance Index: -10.9900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.4738
Cell Significance Index: -12.6500
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.4742
Cell Significance Index: -11.5700
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4932
Cell Significance Index: -57.4800
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.5017
Cell Significance Index: -105.6800
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.5579
Cell Significance Index: -34.2900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5836
Cell Significance Index: -60.7700
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.6273
Cell Significance Index: -3.7900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.6306
Cell Significance Index: -72.2400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.6438
Cell Significance Index: -10.7800
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.6503
Cell Significance Index: -12.0200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.8011
Cell Significance Index: -50.4900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.8285
Cell Significance Index: -17.9500
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.0085
Cell Significance Index: -79.8800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.0159
Cell Significance Index: -57.0100
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -1.0410
Cell Significance Index: -15.8100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.1777
Cell Significance Index: -79.1900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.2163
Cell Significance Index: -74.5700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -1.2280
Cell Significance Index: -36.0700
Cell Name: adipocyte of breast (CL0002617)
Fold Change: -1.2595
Cell Significance Index: -15.8600
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -1.3248
Cell Significance Index: -19.0300
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -1.5000
Cell Significance Index: -22.1500
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.5769
Cell Significance Index: -69.7500
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -1.6428
Cell Significance Index: -10.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** STAT3 is a member of the STAT protein family, which consists of seven transcription factors that regulate gene expression in response to cytokines and growth factors. STAT3 is activated through phosphorylation and dimerization, allowing it to bind to specific DNA sequences and regulate the transcription of target genes. STAT3 is highly conserved across species and is expressed in various cell types, including immune cells, epithelial cells, and stem cells. **Pathways and Functions** STAT3 is involved in multiple signaling pathways, including: 1. **JAK/STAT pathway**: STAT3 is activated by the Janus kinase (JAK) family of tyrosine kinases, which phosphorylate and activate STAT3. 2. **Cytokine signaling**: STAT3 mediates the transcriptional response to various cytokines, including interleukins (IL), interferons (IFN), and growth factors. 3. **Apoptosis**: STAT3 can regulate apoptosis by modulating the expression of anti-apoptotic and pro-apoptotic genes. 4. **Cell growth and differentiation**: STAT3 is involved in the regulation of cell growth, differentiation, and survival by controlling the expression of target genes. 5. **Immune responses**: STAT3 plays a critical role in regulating immune responses, including inflammation, immune cell development, and function. **Clinical Significance** Dysregulation of STAT3 has been implicated in various diseases, including: 1. **Cancer**: STAT3 is often overexpressed in cancer cells, contributing to tumorigenesis and tumor progression. 2. **Autoimmune diseases**: STAT3 can contribute to the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Infectious diseases**: STAT3 plays a role in regulating the immune response to infections, including viral and bacterial infections. 4. **Neurological disorders**: STAT3 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, STAT3 is a critical transcription factor that regulates various cellular processes, including cell growth, differentiation, survival, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding STAT3 signaling pathways and their clinical significance. **Implications for Immunology** The study of STAT3 has significant implications for immunology, particularly in the context of: 1. **Immunotherapy**: Targeting STAT3 may provide a novel therapeutic strategy for cancer and autoimmune diseases. 2. **Immunomodulation**: Understanding STAT3 signaling pathways can inform strategies for modulating the immune response in various diseases. 3. **Vaccine development**: STAT3 may play a role in the regulation of immune responses to vaccines, highlighting the importance of considering STAT3 in vaccine development and efficacy. In summary, STAT3 is a critical transcription factor that regulates various cellular processes, including cell growth, differentiation, survival, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding STAT3 signaling pathways and their clinical significance.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

STAT3_HUMAN
A0A7I2V395_HUMAN

Genular Protein ID: 1668924148

Symbol: STAT3_HUMAN

Name: N/A

UniProtKB Accession Codes:

P40763 A8K7B8 K7ENL3 O14916 Q9BW54

Database IDs:

Citations:

PubMed ID: 7512451

Title: Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway.

PubMed ID: 7512451

DOI: 10.1016/0092-8674(94)90235-6

PubMed ID: 9630560

Title: Highly conserved amino-acid sequence between murine STAT3 and a revised human STAT3 sequence.

PubMed ID: 9630560

DOI: 10.1016/s0378-1119(98)00185-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7701321

Title: Requirement of serine phosphorylation for formation of STAT-promoter complexes.

PubMed ID: 7701321

DOI: 10.1126/science.7701321

PubMed ID: 9388184

Title: Specific inhibition of Stat3 signal transduction by PIAS3.

PubMed ID: 9388184

DOI: 10.1126/science.278.5344.1803

PubMed ID: 10688651

Title: Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation.

PubMed ID: 10688651

DOI: 10.1128/mcb.20.6.2043-2054.2000

PubMed ID: 12359225

Title: The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation.

PubMed ID: 12359225

DOI: 10.1016/s0006-291x(02)02291-x

PubMed ID: 11773079

Title: Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a.

PubMed ID: 11773079

DOI: 10.1074/jbc.m111486200

PubMed ID: 12208879

Title: Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation.

PubMed ID: 12208879

DOI: 10.1084/jem.20012127

PubMed ID: 12023369

Title: A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.

PubMed ID: 12023369

DOI: 10.4049/jimmunol.168.11.5699

PubMed ID: 12873986

Title: Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor.

PubMed ID: 12873986

PubMed ID: 12763138

Title: Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway.

PubMed ID: 12763138

DOI: 10.1016/s0301-472x(03)00045-6

PubMed ID: 15194700

Title: Characterization of the signaling capacities of the novel gp130-like cytokine receptor.

PubMed ID: 15194700

DOI: 10.1074/jbc.m401122200

PubMed ID: 15465816

Title: IRAK1 serves as a novel regulator essential for lipopolysaccharide-induced interleukin-10 gene expression.

PubMed ID: 15465816

DOI: 10.1074/jbc.m410369200

PubMed ID: 15467733

Title: TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3.

PubMed ID: 15467733

DOI: 10.1038/sj.onc.1208149

PubMed ID: 15994929

Title: Proline-, glutamic acid-, and leucine-rich protein-1 is essential in growth factor regulation of signal transducers and activators of transcription 3 activation.

PubMed ID: 15994929

DOI: 10.1158/0008-5472.can-04-4664

PubMed ID: 16285960

Title: STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen.

PubMed ID: 16285960

DOI: 10.1053/j.gastro.2005.07.055

PubMed ID: 16219639

Title: Physical and functional interactions between STAT3 and ZIP kinase.

PubMed ID: 16219639

DOI: 10.1093/intimm/dxh331

PubMed ID: 15677474

Title: Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation.

PubMed ID: 15677474

DOI: 10.1074/jbc.m411596200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 15919823

Title: STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3.

PubMed ID: 15919823

DOI: 10.1073/pnas.0501643102

PubMed ID: 15653507

Title: Stat3 dimerization regulated by reversible acetylation of a single lysine residue.

PubMed ID: 15653507

DOI: 10.1126/science.1105166

PubMed ID: 16568091

Title: Identification of STAT3 as a specific substrate of breast tumor kinase.

PubMed ID: 16568091

DOI: 10.1038/sj.onc.1209501

PubMed ID: 17875724

Title: Protein kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer.

PubMed ID: 17875724

DOI: 10.1158/0008-5472.can-07-1604

PubMed ID: 17344214

Title: leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3.

PubMed ID: 17344214

DOI: 10.1074/jbc.m609798200

PubMed ID: 17956865

Title: The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression.

PubMed ID: 17956865

DOI: 10.1074/jbc.m706458200

PubMed ID: 18242580

Title: up-regulation of survivin by leptin/STAT3 signaling in MCF-7 cells.

PubMed ID: 18242580

DOI: 10.1016/j.bbrc.2007.04.004

PubMed ID: 18599021

Title: Role for DYRK family kinases on regulation of apoptosis.

PubMed ID: 18599021

DOI: 10.1016/j.bcp.2008.05.021

PubMed ID: 18070987

Title: Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts.

PubMed ID: 18070987

DOI: 10.1182/blood-2007-05-090985

PubMed ID: 18234692

Title: BART is essential for nuclear retention of STAT3.

PubMed ID: 18234692

DOI: 10.1093/intimm/dxm154

PubMed ID: 18782771

Title: The STAT3 NH2-terminal domain stabilizes enhanceosome assembly by interacting with the p300 bromodomain.

PubMed ID: 18782771

DOI: 10.1074/jbc.m805941200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19147545

Title: The Fer tyrosine kinase cooperates with interleukin-6 to activate signal transducer and activator of transcription 3 and promote human prostate cancer cell growth.

PubMed ID: 19147545

DOI: 10.1158/1541-7786.mcr-08-0117

PubMed ID: 20826784

Title: Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity.

PubMed ID: 20826784

DOI: 10.1074/jbc.m110.152777

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21135090

Title: Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells.

PubMed ID: 21135090

DOI: 10.1074/jbc.m110.182642

PubMed ID: 22306293

Title: Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase.

PubMed ID: 22306293

DOI: 10.1016/j.molcel.2012.01.001

PubMed ID: 23084476

Title: Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity.

PubMed ID: 23084476

DOI: 10.1016/j.molcel.2012.09.013

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25476455

Title: Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity.

PubMed ID: 25476455

DOI: 10.1038/srep07330

PubMed ID: 26675719

Title: Germline variant FGFR4 p.G388R exposes a membrane-proximal STAT3 binding site.

PubMed ID: 26675719

DOI: 10.1038/nature16449

PubMed ID: 27387064

Title: Human Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFNgamma-Like Response.

PubMed ID: 27387064

DOI: 10.1371/journal.ppat.1005748

PubMed ID: 28065600

Title: Lysyl oxidase 3 is a dual-specificity enzyme involved in STAT3 deacetylation and deacetylimination modulation.

PubMed ID: 28065600

DOI: 10.1016/j.molcel.2016.12.002

PubMed ID: 28262505

Title: Distinct roles of Brd2 and Brd4 in potentiating the transcriptional program for th17 cell differentiation.

PubMed ID: 28262505

DOI: 10.1016/j.molcel.2016.12.022

PubMed ID: 29924996

Title: Salmonella Activation of STAT3 Signaling by SarA Effector Promotes Intracellular Replication and Production of IL-10.

PubMed ID: 29924996

DOI: 10.1016/j.celrep.2018.05.072

PubMed ID: 31462771

Title: Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation.

PubMed ID: 31462771

DOI: 10.1038/s41586-019-1511-x

PubMed ID: 32555452

Title:

PubMed ID: 32555452

DOI: 10.1038/s41586-020-2414-6

PubMed ID: 32929201

Title: PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.

PubMed ID: 32929201

DOI: 10.1038/s41556-020-0575-z

PubMed ID: 31899195

Title: Prohibitin 1 interacts with signal transducer and activator of transcription 3 in T-helper 17 cells.

PubMed ID: 31899195

DOI: 10.1016/j.imlet.2019.12.008

PubMed ID: 32797246

Title: The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis.

PubMed ID: 32797246

DOI: 10.1007/s00018-020-03616-6

PubMed ID: 17881745

Title: STAT3 mutations in the hyper-IgE syndrome.

PubMed ID: 17881745

DOI: 10.1056/nejmoa073687

PubMed ID: 17676033

Title: Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome.

PubMed ID: 17676033

DOI: 10.1038/nature06096

PubMed ID: 23342295

Title: Signal transducer and activator of transcription 3 mutation with invasive eosinophilic disease.

PubMed ID: 23342295

DOI: 10.2500/ar.2012.3.0035

PubMed ID: 25038750

Title: Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease.

PubMed ID: 25038750

DOI: 10.1038/ng.3040

PubMed ID: 26293184

Title: Functional characterization of two new STAT3 mutations associated with hyper-IgE syndrome in a Mexican cohort.

PubMed ID: 26293184

DOI: 10.1111/cge.12658

PubMed ID: 28073828

Title: An activating mutation in STAT3 results in neonatal diabetes through reduced insulin synthesis.

PubMed ID: 28073828

DOI: 10.2337/db16-0867

Sequence Information:

Length: 770
Mass: 88068
Checksum: 6C00632211C8012D
Sequence:

MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE SHATLVFHNL 
LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME IARIVARCLW EESRLLQTAA 
TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK 
SQGDMQDLNG NNQSVTRQKM QQLEQMLTAL DQMRRSIVSE LAGLLSAMEY VQKTLTDEEL 
ADWKRRQQIA CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ 
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR LLVKFPELNY 
QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN NGSLSAEFKH LTLREQRCGN 
GGRANCDASL IVTEELHLIT FETEVYHQGL KIDLETHSLP VVVISNICQM PNAWASILWY 
NMLTNNPKNV NFFTKPPIGT WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS 
GCQITWAKFC KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST 
KPPGTFLLRF SESSKEGGVT FTWVEKDISG KTQIQSVEPY TKQQLNNMSF AEIIMGYKIM 
DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG SAAPYLKTKF ICVTPTTCSN 
TIDLPMSPRT LDSLMQFGNN GEGAEPSAGG QFESLTFDME LTSECATSPM

Genular Protein ID: 3288287561

Symbol: A0A7I2V395_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7I2V395

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

Length: 721
Mass: 83039
Checksum: AFEF635C8F409247
Sequence:

MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE SHATLVFHNL 
LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME IARIVARCLW EESRLLQTAA 
TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK 
SQGDMQDLNG NNQSVTRQKM QQLEQMLTAL DQMRRSIVSE LAGLLSAMEY VQKTLTDEEL 
ADWKRRQQIA CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ 
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR LLVKFPELNY 
QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN NGSLSAEFKH LTLREQRCGN 
GGRANCDASL IVTEELHLIT FETEVYHQGL KIDLETHSLP VVVISNICQM PNAWASILWY 
NMLTNNPKNV NFFTKPPIGT WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS 
GCQITWAKFC KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST 
KPPGTFLLRF SESSKEGGVT FTWVEKDISG KTQIQSVEPY TKQQLNNMSF AEIIMGYKIM 
DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG AAPYLKTKFI CVTPFIDAVW 
K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: STAT3

Associated with

Cells (max top 100)

Other Information

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. PubMed ID: 7512451

Highly conserved amino-acid sequence between murine STAT3 and a revised human STAT3 sequence. PubMed ID: 9630560

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Requirement of serine phosphorylation for formation of STAT-promoter complexes. PubMed ID: 7701321

Specific inhibition of Stat3 signal transduction by PIAS3. PubMed ID: 9388184

Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation. PubMed ID: 10688651

The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation. PubMed ID: 12359225

Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a. PubMed ID: 11773079

Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation. PubMed ID: 12208879

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. PubMed ID: 12023369

Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor. PubMed ID: 12873986

Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway. PubMed ID: 12763138

Characterization of the signaling capacities of the novel gp130-like cytokine receptor. PubMed ID: 15194700

IRAK1 serves as a novel regulator essential for lipopolysaccharide-induced interleukin-10 gene expression. PubMed ID: 15465816

TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3. PubMed ID: 15467733

Proline-, glutamic acid-, and leucine-rich protein-1 is essential in growth factor regulation of signal transducers and activators of transcription 3 activation. PubMed ID: 15994929

STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen. PubMed ID: 16285960

Physical and functional interactions between STAT3 and ZIP kinase. PubMed ID: 16219639

Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation. PubMed ID: 15677474

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3. PubMed ID: 15919823

Stat3 dimerization regulated by reversible acetylation of a single lysine residue. PubMed ID: 15653507

Identification of STAT3 as a specific substrate of breast tumor kinase. PubMed ID: 16568091

Protein kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer. PubMed ID: 17875724

leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. PubMed ID: 17344214

The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression. PubMed ID: 17956865

up-regulation of survivin by leptin/STAT3 signaling in MCF-7 cells. PubMed ID: 18242580

Role for DYRK family kinases on regulation of apoptosis. PubMed ID: 18599021

Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts. PubMed ID: 18070987

BART is essential for nuclear retention of STAT3. PubMed ID: 18234692

The STAT3 NH2-terminal domain stabilizes enhanceosome assembly by interacting with the p300 bromodomain. PubMed ID: 18782771

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

The Fer tyrosine kinase cooperates with interleukin-6 to activate signal transducer and activator of transcription 3 and promote human prostate cancer cell growth. PubMed ID: 19147545

Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity. PubMed ID: 20826784

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells. PubMed ID: 21135090

Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase. PubMed ID: 22306293

Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity. PubMed ID: 23084476

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity. PubMed ID: 25476455

Germline variant FGFR4 p.G388R exposes a membrane-proximal STAT3 binding site. PubMed ID: 26675719

Human Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFNgamma-Like Response. PubMed ID: 27387064

Lysyl oxidase 3 is a dual-specificity enzyme involved in STAT3 deacetylation and deacetylimination modulation. PubMed ID: 28065600

Distinct roles of Brd2 and Brd4 in potentiating the transcriptional program for th17 cell differentiation. PubMed ID: 28262505

Salmonella Activation of STAT3 Signaling by SarA Effector Promotes Intracellular Replication and Production of IL-10. PubMed ID: 29924996

Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation. PubMed ID: 31462771

PubMed ID: 32555452

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis. PubMed ID: 32929201

Prohibitin 1 interacts with signal transducer and activator of transcription 3 in T-helper 17 cells. PubMed ID: 31899195

The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis. PubMed ID: 32797246

STAT3 mutations in the hyper-IgE syndrome. PubMed ID: 17881745

Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. PubMed ID: 17676033

Signal transducer and activator of transcription 3 mutation with invasive eosinophilic disease. PubMed ID: 23342295

Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease. PubMed ID: 25038750

Functional characterization of two new STAT3 mutations associated with hyper-IgE syndrome in a Mexican cohort. PubMed ID: 26293184

An activating mutation in STAT3 results in neonatal diabetes through reduced insulin synthesis. PubMed ID: 28073828

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

Database document:

PubMed ID: 7512451

PubMed ID: 9630560

PubMed ID: 14702039

PubMed ID: 16625196

PubMed ID: 15489334

PubMed ID: 7701321

PubMed ID: 9388184

PubMed ID: 10688651

PubMed ID: 12359225

PubMed ID: 11773079

PubMed ID: 12208879

PubMed ID: 12023369

PubMed ID: 12873986

PubMed ID: 12763138

PubMed ID: 15194700

PubMed ID: 15465816

PubMed ID: 15467733

PubMed ID: 15994929

PubMed ID: 16285960

PubMed ID: 16219639

PubMed ID: 15677474

PubMed ID: 15592455

PubMed ID: 15919823

PubMed ID: 15653507

PubMed ID: 16568091

PubMed ID: 17875724

PubMed ID: 17344214

PubMed ID: 17956865

PubMed ID: 18242580

PubMed ID: 18599021

PubMed ID: 18070987

PubMed ID: 18234692

PubMed ID: 18782771

PubMed ID: 18691976

PubMed ID: 18669648

PubMed ID: 19413330

PubMed ID: 19147545

PubMed ID: 20826784

PubMed ID: 20068231

PubMed ID: 21269460

PubMed ID: 21135090

PubMed ID: 22306293

PubMed ID: 23084476

PubMed ID: 22223895

PubMed ID: 22814378

PubMed ID: 23186163

PubMed ID: 24275569

PubMed ID: 25476455

PubMed ID: 26675719

PubMed ID: 27387064

PubMed ID: 28065600

PubMed ID: 28262505

PubMed ID: 29924996

PubMed ID: 31462771

PubMed ID: 32929201

PubMed ID: 31899195

PubMed ID: 32797246

PubMed ID: 17881745

PubMed ID: 17676033

PubMed ID: 23342295

PubMed ID: 25038750

PubMed ID: 26293184

PubMed ID: 28073828

PubMed ID: 11237011

PubMed ID: 15496913

PubMed ID: 16625196