Details for: STK4
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 73.6rCSI 49.58%PRS 52.46
-
CSI 59.63rCSI 45.11%PRS 54.55
-
CSI 51.82rCSI 34.54%PRS 68.31
-
CSI 35.6rCSI 27.43%PRS 41.2
-
CSI 35.25rCSI 27.42%PRS 59.17
-
CSI 32.09rCSI 40.33%PRS 80.53
-
CSI 31.65rCSI 63.09%PRS 60.24
-
CSI 30.83rCSI 44.67%PRS 58.44
-
CSI 26.9rCSI 15.88%PRS 57.23
-
CSI 26.66rCSI 18.72%PRS 65.49
-
CSI 26.52rCSI 19.89%PRS 75.05
-
CSI 23.27rCSI 18.48%PRS 64.46
-
CSI 20.98rCSI 37.86%PRS 69.41
-
CSI 19.95rCSI 25.51%PRS 75.08
-
CSI 19.36rCSI 19.12%PRS 76.84
-
CSI 19.27rCSI 14.42%PRS 57.22
-
CSI 19rCSI 19.37%PRS 55.55
-
CSI 18.93rCSI 61.97%PRS 74.78
-
CSI 17.97rCSI 15.41%PRS 51.94
-
CSI 17.2rCSI 36.38%PRS 63.81
-
CSI 16.14rCSI 14.92%PRS 62.71
-
CSI 16.12rCSI 19.54%PRS 38.99
-
CSI 15.53rCSI 13.79%PRS 41.73
-
CSI 15.52rCSI 18.23%PRS 82.8
-
CSI 14.78rCSI 12.85%PRS 51.55
-
CSI 13.91rCSI 18.95%PRS 70.26
-
CSI 13.67rCSI 10.15%PRS 55.52
-
CSI 13.5rCSI 15.65%PRS 64.75
-
CSI 13.04rCSI 29.24%PRS 28.57
-
CSI 12.89rCSI 9.62%PRS 61.02
-
CSI 12.65rCSI 8.8%PRS 50.85
-
CSI 11.8rCSI 18.02%PRS 59.76
-
CSI 11.65rCSI 17.08%PRS 53.39
-
CSI 11.47rCSI 15.35%PRS 72.88
-
CSI 11.31rCSI 11.11%PRS 57.71
-
CSI 11.08rCSI 14.53%PRS 79.23
-
CSI 10.92rCSI 7.26%PRS 46.53
-
CSI 10.9rCSI 12.77%PRS 57.84
-
CSI 10.71rCSI 12.06%PRS 58.49
-
CSI 10.65rCSI 8.38%PRS 48.91
-
CSI 10.64rCSI 15.19%PRS 45.2
-
CSI 10.53rCSI 16.17%PRS 49.29
-
CSI 10.49rCSI 10.1%PRS 43.06
-
CSI 10.45rCSI 10.92%PRS 72.77
-
CSI 10.3rCSI 15.54%PRS 44.37
-
CSI 10.25rCSI 23.36%PRS 41.21
-
CSI 10.09rCSI 25.59%PRS 33.73
-
CSI 9.98rCSI 16.17%PRS 41.18
-
CSI 9.91rCSI 8.01%PRS 53.65
-
CSI 9.81rCSI 8.13%PRS 43.52
-
CSI 9.76rCSI 19.09%PRS 87.42
-
CSI 9.63rCSI 7.13%PRS 36.71
-
CSI 9.57rCSI 8.9%PRS 42.45
-
CSI 9.15rCSI 9.13%PRS 37.07
-
CSI 9.08rCSI 7.58%PRS 63.88
-
CSI 8.69rCSI 8.54%PRS 70.17
-
CSI 8.45rCSI 11.94%PRS 51.57
-
CSI 8.44rCSI 6.76%PRS 63.93
-
CSI 8.35rCSI 13.38%PRS 71.27
-
CSI 8.33rCSI 5.8%PRS 55.32
-
CSI 8.23rCSI 11.2%PRS 55.34
-
CSI 8.23rCSI 16.7%PRS 26.27
-
CSI 7.99rCSI 9.84%PRS 67.11
-
CSI 7.85rCSI 9.78%PRS 53.74
-
CSI 7.27rCSI 12.44%PRS 63.4
-
CSI 7.23rCSI 9.28%PRS 40.64
-
CSI 7.11rCSI 16.24%PRS 36.55
-
CSI 6.99rCSI 5.88%PRS 59.78
-
CSI 6.99rCSI 8.34%PRS 62.88
-
CSI 6.92rCSI 18.84%PRS 80.55
-
CSI 6.76rCSI 6.21%PRS 49.65
-
CSI 6.72rCSI 24.33%PRS 61.67
-
CSI 6.62rCSI 12.54%PRS 76.41
-
CSI 6.5rCSI 8.16%PRS 52.08
-
CSI 6.46rCSI 6.74%PRS 43.19
-
CSI 6.43rCSI 5.64%PRS 47.42
-
CSI 6.42rCSI 15.31%PRS 44.93
-
CSI 6.28rCSI 7.53%PRS 61.72
-
CSI 6.27rCSI 5.66%PRS 39.3
-
CSI 6.24rCSI 16.68%PRS 36.07
-
CSI 6.21rCSI 5.98%PRS 33.71
-
CSI 6.17rCSI 29.56%PRS 41.18
-
CSI 6.17rCSI 13.59%PRS 46.38
-
CSI 6.12rCSI 15.95%PRS 41.72
-
CSI 6.11rCSI 4.39%PRS 55.14
-
CSI 6.04rCSI 10.45%PRS 33.83
-
CSI 5.99rCSI 14.57%PRS 27.11
-
CSI 5.82rCSI 4.43%PRS 53.65
-
CSI 5.75rCSI 21.54%PRS 36.21
-
CSI 5.65rCSI 10.21%PRS 65.05
-
CSI 5.58rCSI 5.14%PRS 43.47
-
CSI 5.57rCSI 4.88%PRS 52.17
-
CSI 5.53rCSI 5.22%PRS 43.56
-
CSI 5.47rCSI 4.11%PRS 45.79
-
CSI 5.39rCSI 12.34%PRS 41.95
-
CSI 5.38rCSI 29.09%PRS 78.14
-
CSI 5.31rCSI 12.45%PRS 51.83
-
CSI 5.21rCSI 12.37%PRS 48.33
-
CSI 5.2rCSI 11.49%PRS 31.69
-
CSI 5.15rCSI 14.63%PRS 42.76
-
CSI 0.1rCSI 0.7%PRS 30.9%
-
CSI 0.4rCSI 5.3%PRS 81.2%
-
CSI 0.4rCSI 2.5%PRS 54.8%
-
CSI 0.4rCSI 1.3%PRS 34.7%
-
CSI 0.5rCSI 2.8%PRS 53.3%
-
CSI 0.5rCSI 1.9%PRS 62.9%
-
CSI 0.7rCSI 6.5%PRS 83.2%
-
CSI 0.7rCSI 1.0%PRS 40.5%
-
CSI 0.7rCSI 1.1%PRS 22.7%
-
CSI 0.7rCSI 2.5%PRS 55.6%
-
CSI 0.7rCSI 2.3%PRS 32.1%
-
CSI 0.7rCSI 1.1%PRS 47.1%
-
CSI 0.7rCSI 1.7%PRS 85.0%
-
CSI 0.8rCSI 2.0%PRS 56.0%
-
CSI 0.8rCSI 1.1%PRS 39.0%
-
CSI 0.8rCSI 3.5%PRS 78.4%
-
CSI 0.8rCSI 0.8%PRS 48.3%
-
CSI 0.8rCSI 0.9%PRS 33.3%
-
CSI 0.8rCSI 2.1%PRS 73.4%
-
CSI 0.8rCSI 1.3%PRS 39.4%
-
CSI 0.8rCSI 1.7%PRS 42.1%
-
CSI 0.8rCSI 2.9%PRS 74.4%
-
CSI 0.9rCSI 1.5%PRS 29.9%
-
CSI 0.9rCSI 4.1%PRS 41.2%
-
CSI 0.9rCSI 1.5%PRS 46.2%
-
CSI 1.0rCSI 5.6%PRS 29.2%
-
CSI 1.0rCSI 1.9%PRS 33.0%
-
CSI 1.0rCSI 2.2%PRS 33.4%
-
CSI 1.1rCSI 1.9%PRS 27.9%
-
CSI 1.1rCSI 3.2%PRS 57.4%
-
CSI 1.1rCSI 1.5%PRS 36.4%
-
CSI 1.2rCSI 21.8%PRS 85.4%
-
CSI 1.3rCSI 6.4%PRS 54.1%
-
CSI 1.3rCSI 1.1%PRS 47.6%
-
CSI 1.3rCSI 2.4%PRS 62.5%
-
CSI 1.3rCSI 7.0%PRS 51.6%
-
CSI 1.3rCSI 2.1%PRS 43.2%
-
CSI 1.4rCSI 2.9%PRS 64.8%
-
CSI 1.4rCSI 1.8%PRS 38.6%
-
CSI 1.5rCSI 12.0%PRS 37.7%
-
CSI 1.5rCSI 3.6%PRS 60.3%
-
CSI 1.5rCSI 3.7%PRS 40.8%
-
CSI 1.5rCSI 2.7%PRS 36.4%
-
CSI 1.5rCSI 31.9%PRS 82.9%
-
CSI 1.5rCSI 7.9%PRS 66.5%
-
CSI 1.5rCSI 2.2%PRS 45.4%
-
CSI 1.6rCSI 8.6%PRS 61.5%
-
CSI 1.6rCSI 1.6%PRS 40.0%
-
CSI 1.6rCSI 2.8%PRS 26.5%
-
CSI 1.6rCSI 2.7%PRS 33.9%
-
CSI 1.7rCSI 4.6%PRS 39.7%
-
CSI 1.7rCSI 2.5%PRS 52.5%
-
CSI 1.7rCSI 44.1%PRS 83.5%
-
CSI 1.8rCSI 3.9%PRS 62.6%
-
CSI 1.8rCSI 4.2%PRS 32.8%
-
CSI 1.8rCSI 3.2%PRS 41.1%
-
CSI 1.8rCSI 8.4%PRS 61.8%
-
CSI 1.8rCSI 6.4%PRS 26.8%
-
CSI 1.8rCSI 2.2%PRS 45.2%
-
CSI 1.8rCSI 30.7%PRS 75.1%
-
CSI 1.8rCSI 2.3%PRS 47.2%
-
CSI 1.9rCSI 3.4%PRS 58.7%
-
CSI 1.9rCSI 7.9%PRS 43.8%
-
CSI 1.9rCSI 5.5%PRS 59.8%
-
CSI 1.9rCSI 2.0%PRS 45.1%
-
CSI 1.9rCSI 1.6%PRS 41.0%
-
CSI 2.0rCSI 3.8%PRS 72.3%
-
CSI 2.0rCSI 14.5%PRS 31.4%
-
CSI 2.0rCSI 2.7%PRS 64.9%
-
CSI 2.0rCSI 2.2%PRS 46.4%
-
CSI 2.1rCSI 6.2%PRS 65.6%
-
CSI 2.1rCSI 1.7%PRS 43.1%
-
CSI 2.1rCSI 1.9%PRS 46.2%
-
CSI 2.1rCSI 24.8%PRS 78.3%
-
CSI 2.2rCSI 2.8%PRS 47.7%
-
CSI 2.2rCSI 5.0%PRS 48.3%
-
CSI 2.2rCSI 4.9%PRS 52.5%
-
CSI 2.2rCSI 2.1%PRS 66.7%
-
CSI 2.2rCSI 3.7%PRS 48.0%
-
CSI 2.2rCSI 2.6%PRS 65.4%
-
CSI 2.2rCSI 7.0%PRS 29.0%
-
CSI 2.3rCSI 3.9%PRS 68.3%
-
CSI 2.3rCSI 55.7%PRS 28.3%
-
CSI 2.4rCSI 6.1%PRS 47.9%
-
CSI 2.4rCSI 56.6%PRS 27.4%
-
CSI 2.5rCSI 9.9%PRS 41.3%
-
CSI 2.5rCSI 10.9%PRS 58.4%
-
CSI 2.5rCSI 3.2%PRS 55.7%
-
CSI 2.5rCSI 10.3%PRS 40.4%
-
CSI 2.7rCSI 3.7%PRS 63.2%
-
CSI 2.7rCSI 6.0%PRS 39.9%
-
CSI 2.8rCSI 2.2%PRS 31.1%
-
CSI 2.8rCSI 8.2%PRS 60.5%
-
CSI 2.8rCSI 2.6%PRS 57.5%
-
CSI 3.0rCSI 2.6%PRS 32.4%
-
CSI 3.0rCSI 19.5%PRS 73.7%
-
CSI 3.0rCSI 13.4%PRS 83.4%
-
CSI 3.1rCSI 5.3%PRS 35.4%
-
CSI 3.1rCSI 11.2%PRS 76.4%
-
CSI 3.1rCSI 3.1%PRS 44.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2445420415
Symbol: STK4_HUMAN
Name: Serine/threonine-protein kinase 4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7665586
Title: Cloning and characterization of a human protein kinase with homology to Ste20.
PubMed ID: 7665586
PubMed ID: 8816758
Title: Newly identified stress-responsive protein kinases, Krs-1 and Krs-2.
PubMed ID: 8816758
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8702870
Title: The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain.
PubMed ID: 8702870
PubMed ID: 11278283
Title: MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation.
PubMed ID: 11278283
PubMed ID: 11517310
Title: Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation.
PubMed ID: 11517310
PubMed ID: 12757711
Title: Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase.
PubMed ID: 12757711
PubMed ID: 15109305
Title: Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras.
PubMed ID: 15109305
DOI: 10.1042/bj20040025
PubMed ID: 16510573
Title: Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis.
PubMed ID: 16510573
PubMed ID: 16751106
Title: A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span.
PubMed ID: 16751106
PubMed ID: 16930133
Title: Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation.
PubMed ID: 16930133
PubMed ID: 17932490
Title: The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1.
PubMed ID: 17932490
PubMed ID: 17726016
Title: Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation.
PubMed ID: 17726016
PubMed ID: 18328708
Title: MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.
PubMed ID: 18328708
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19484742
Title: Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling.
PubMed ID: 19484742
DOI: 10.1002/biof.47
PubMed ID: 18986304
Title: Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1.
PubMed ID: 18986304
DOI: 10.1042/bj20081340
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19525978
Title: RASSF2 associates with and stabilizes the proapoptotic kinase MST2.
PubMed ID: 19525978
DOI: 10.1038/onc.2009.152
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19940129
Title: Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120.
PubMed ID: 19940129
PubMed ID: 27825096
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21245099
Title: Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner.
PubMed ID: 21245099
PubMed ID: 21512132
Title: MST1 is a multifunctional caspase-independent inhibitor of androgenic signaling.
PubMed ID: 21512132
PubMed ID: 21199877
Title: The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2.
PubMed ID: 21199877
PubMed ID: 21212262
Title: MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation.
PubMed ID: 21212262
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22294732
Title: The phenotype of human STK4 deficiency.
PubMed ID: 22294732
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 28087714
Title: DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.
PubMed ID: 28087714
PubMed ID: 28169360
Title: Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway.
PubMed ID: 28169360
DOI: 10.1038/srep42125
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 487
- Mass: 55630
- Checksum: 150758EBC5F77D5C
- Sequence:
METVQLRNPP RRQLKKLDED SLTKQPEEVF DVLEKLGEGS YGSVYKAIHK ETGQIVAIKQ VPVESDLQEI IKEISIMQQC DSPHVVKYYG SYFKNTDLWI VMEYCGAGSV SDIIRLRNKT LTEDEIATIL QSTLKGLEYL HFMRKIHRDI KAGNILLNTE GHAKLADFGV AGQLTDTMAK RNTVIGTPFW MAPEVIQEIG YNCVADIWSL GITAIEMAEG KPPYADIHPM RAIFMIPTNP PPTFRKPELW SDNFTDFVKQ CLVKSPEQRA TATQLLQHPF VRSAKGVSIL RDLINEAMDV KLKRQESQQR EVDQDDEENS EEDEMDSGTM VRAVGDEMGT VRVASTMTDG ANTMIEHDDT LPSQLGTMVI NAEDEEEEGT MKRRDETMQP AKPSFLEYFE QKEKENQINS FGKSVPGPLK NSSDWKIPQD GDYEFLKSWT VEDLQKRLLA LDPMMEQEIE EIRQKYQSKR QPILDAIEAK KRRQQNF
Genular Protein ID: 2009015293
Symbol: A0A087WVN8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
Sequence Information:
- Length: 411
- Mass: 46984
- Checksum: 84D03FE1E81334D9
- Sequence:
MQQCDSPHVV KYYGSYFKNT DLWIVMEYCG AGSVSDIIRL RNKTLTEDEI ATILQSTLKG LEYLHFMRKI HRDIKAGNIL LNTEGHAKLA DFGVAGQLTD TMAKRNTVIG TPFWMAPEVI QEIGYNCVAD IWSLGITAIE MAEGKPPYAD IHPMRAIFMI PTNPPPTFRK PELWSDNFTD FVKQCLVKSP EQRATATQLL QHPFVRSAKG VSILRDLINE AMDVKLKRQE SQQREVDQDD EENSEEDEMD SGTMVRAVGD EMGTVRVAST MTDGANTMIE HDDTLPSQLG TMVINAEDEE EEGTMKRRDE TMQPAKPSFL EYFEQKEKEN QINSFGKSVP GPLKNSSDWK IPQDGDYEFL KSWTVEDLQK RLLALDPMME QEIEEIRQKY QSKRQPILDA IEAKKRRQQN F