Details for: STK4
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.25
Marker Score: 3205 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 3.19
Marker Score: 8947 - Cell Name: mature T cell (CL0002419)
Fold Change: 3.14
Marker Score: 31077 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 3.02
Marker Score: 1509 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 2.98
Marker Score: 157476 - Cell Name: naive T cell (CL0000898)
Fold Change: 2.89
Marker Score: 1859 - Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 2.86
Marker Score: 9039 - Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 2.82
Marker Score: 2640 - Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 2.75
Marker Score: 1993 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.72
Marker Score: 1174 - Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 2.72
Marker Score: 2288 - Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 2.72
Marker Score: 1396 - Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 2.69
Marker Score: 939 - Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.66
Marker Score: 825 - Cell Name: blood cell (CL0000081)
Fold Change: 2.66
Marker Score: 30882 - Cell Name: IgG memory B cell (CL0000979)
Fold Change: 2.62
Marker Score: 1579 - Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 2.61
Marker Score: 5477 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 2.59
Marker Score: 1964 - Cell Name: double negative thymocyte (CL0002489)
Fold Change: 2.59
Marker Score: 3567 - Cell Name: transitional stage B cell (CL0000818)
Fold Change: 2.56
Marker Score: 905 - Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 2.52
Marker Score: 7346 - Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 2.51
Marker Score: 6112 - Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.49
Marker Score: 4347 - Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.47
Marker Score: 10599 - Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 2.46
Marker Score: 4392.5 - Cell Name: memory T cell (CL0000813)
Fold Change: 2.44
Marker Score: 1051 - Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 2.43
Marker Score: 3578 - Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 2.37
Marker Score: 4062 - Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 2.36
Marker Score: 2626 - Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 2.35
Marker Score: 773 - Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 2.34
Marker Score: 2528 - Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 2.33
Marker Score: 2256 - Cell Name: type I NK T cell (CL0000921)
Fold Change: 2.33
Marker Score: 1828 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.32
Marker Score: 6398 - Cell Name: naive B cell (CL0000788)
Fold Change: 2.31
Marker Score: 2067 - Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 2.29
Marker Score: 1657 - Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 2.28
Marker Score: 5132 - Cell Name: memory B cell (CL0000787)
Fold Change: 2.23
Marker Score: 1687 - Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 2.19
Marker Score: 664 - Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 2.15
Marker Score: 4215 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.14
Marker Score: 13711 - Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 2.14
Marker Score: 1878 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 2.13
Marker Score: 5299 - Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 2.12
Marker Score: 1555 - Cell Name: class switched memory B cell (CL0000972)
Fold Change: 2.08
Marker Score: 1959 - Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 2.08
Marker Score: 1278 - Cell Name: microglial cell (CL0000129)
Fold Change: 2.06
Marker Score: 3754 - Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 2.06
Marker Score: 2918 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 2.06
Marker Score: 1023 - Cell Name: regulatory T cell (CL0000815)
Fold Change: 2.03
Marker Score: 2244 - Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 2.02
Marker Score: 2425 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.99
Marker Score: 111107 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.97
Marker Score: 712 - Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 1.97
Marker Score: 1748 - Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 1.94
Marker Score: 1648 - Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 1.93
Marker Score: 1705 - Cell Name: germinal center B cell (CL0000844)
Fold Change: 1.92
Marker Score: 1167 - Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 1.91
Marker Score: 621 - Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 1.89
Marker Score: 1551 - Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.88
Marker Score: 1083 - Cell Name: Unknown (CL0000548)
Fold Change: 1.87
Marker Score: 1365 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.86
Marker Score: 5516 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.85
Marker Score: 7734 - Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 1.83
Marker Score: 485 - Cell Name: IgA plasma cell (CL0000987)
Fold Change: 1.81
Marker Score: 1545 - Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 1.81
Marker Score: 1060 - Cell Name: natural killer cell (CL0000623)
Fold Change: 1.78
Marker Score: 2309 - Cell Name: immature B cell (CL0000816)
Fold Change: 1.78
Marker Score: 1179 - Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 1.77
Marker Score: 1928 - Cell Name: T follicular helper cell (CL0002038)
Fold Change: 1.77
Marker Score: 1467 - Cell Name: centroblast (CL0009112)
Fold Change: 1.74
Marker Score: 856 - Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 1.73
Marker Score: 622 - Cell Name: IgM plasma cell (CL0000986)
Fold Change: 1.71
Marker Score: 595 - Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 1.7
Marker Score: 1146 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.7
Marker Score: 407 - Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 1.69
Marker Score: 1151 - Cell Name: dendritic cell (CL0000451)
Fold Change: 1.69
Marker Score: 1156 - Cell Name: plasmablast (CL0000980)
Fold Change: 1.68
Marker Score: 2233 - Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 1.67
Marker Score: 328 - Cell Name: myelocyte (CL0002193)
Fold Change: 1.67
Marker Score: 723 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.66
Marker Score: 363 - Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 1.65
Marker Score: 359 - Cell Name: B-1b B cell (CL0000821)
Fold Change: 1.62
Marker Score: 373 - Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 1.62
Marker Score: 361 - Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.62
Marker Score: 3148 - Cell Name: cardiac mesenchymal cell (CL0000569)
Fold Change: 1.61
Marker Score: 397 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 1.61
Marker Score: 368 - Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 1.6
Marker Score: 654 - Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 1.58
Marker Score: 348 - Cell Name: granulocyte (CL0000094)
Fold Change: 1.57
Marker Score: 706 - Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 1.57
Marker Score: 356 - Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 1.56
Marker Score: 915 - Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 1.55
Marker Score: 2522 - Cell Name: ILC1, human (CL0001077)
Fold Change: 1.55
Marker Score: 393 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.55
Marker Score: 1420 - Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 1.54
Marker Score: 372 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.54
Marker Score: 94770 - Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 1.54
Marker Score: 408 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.54
Marker Score: 15612 - Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1.53
Marker Score: 3698
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Other Information
Genular Protein ID: 2445420415
Symbol: STK4_HUMAN
Name: Serine/threonine-protein kinase 4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7665586
Title: Cloning and characterization of a human protein kinase with homology to Ste20.
PubMed ID: 7665586
PubMed ID: 8816758
Title: Newly identified stress-responsive protein kinases, Krs-1 and Krs-2.
PubMed ID: 8816758
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8702870
Title: The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain.
PubMed ID: 8702870
PubMed ID: 11278283
Title: MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation.
PubMed ID: 11278283
PubMed ID: 11517310
Title: Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation.
PubMed ID: 11517310
PubMed ID: 12757711
Title: Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase.
PubMed ID: 12757711
PubMed ID: 15109305
Title: Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras.
PubMed ID: 15109305
DOI: 10.1042/bj20040025
PubMed ID: 16510573
Title: Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis.
PubMed ID: 16510573
PubMed ID: 16751106
Title: A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span.
PubMed ID: 16751106
PubMed ID: 16930133
Title: Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation.
PubMed ID: 16930133
PubMed ID: 17932490
Title: The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1.
PubMed ID: 17932490
PubMed ID: 17726016
Title: Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation.
PubMed ID: 17726016
PubMed ID: 18328708
Title: MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.
PubMed ID: 18328708
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19484742
Title: Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling.
PubMed ID: 19484742
DOI: 10.1002/biof.47
PubMed ID: 18986304
Title: Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1.
PubMed ID: 18986304
DOI: 10.1042/bj20081340
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19525978
Title: RASSF2 associates with and stabilizes the proapoptotic kinase MST2.
PubMed ID: 19525978
DOI: 10.1038/onc.2009.152
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19940129
Title: Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120.
PubMed ID: 19940129
PubMed ID: 27825096
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21245099
Title: Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner.
PubMed ID: 21245099
PubMed ID: 21512132
Title: MST1 is a multifunctional caspase-independent inhibitor of androgenic signaling.
PubMed ID: 21512132
PubMed ID: 21199877
Title: The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2.
PubMed ID: 21199877
PubMed ID: 21212262
Title: MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation.
PubMed ID: 21212262
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22294732
Title: The phenotype of human STK4 deficiency.
PubMed ID: 22294732
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 28087714
Title: DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.
PubMed ID: 28087714
PubMed ID: 28169360
Title: Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway.
PubMed ID: 28169360
DOI: 10.1038/srep42125
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 487
- Mass: 55630
- Checksum: 150758EBC5F77D5C
- Sequence:
METVQLRNPP RRQLKKLDED SLTKQPEEVF DVLEKLGEGS YGSVYKAIHK ETGQIVAIKQ VPVESDLQEI IKEISIMQQC DSPHVVKYYG SYFKNTDLWI VMEYCGAGSV SDIIRLRNKT LTEDEIATIL QSTLKGLEYL HFMRKIHRDI KAGNILLNTE GHAKLADFGV AGQLTDTMAK RNTVIGTPFW MAPEVIQEIG YNCVADIWSL GITAIEMAEG KPPYADIHPM RAIFMIPTNP PPTFRKPELW SDNFTDFVKQ CLVKSPEQRA TATQLLQHPF VRSAKGVSIL RDLINEAMDV KLKRQESQQR EVDQDDEENS EEDEMDSGTM VRAVGDEMGT VRVASTMTDG ANTMIEHDDT LPSQLGTMVI NAEDEEEEGT MKRRDETMQP AKPSFLEYFE QKEKENQINS FGKSVPGPLK NSSDWKIPQD GDYEFLKSWT VEDLQKRLLA LDPMMEQEIE EIRQKYQSKR QPILDAIEAK KRRQQNF
Genular Protein ID: 2009015293
Symbol: A0A087WVN8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
Sequence Information:
- Length: 411
- Mass: 46984
- Checksum: 84D03FE1E81334D9
- Sequence:
MQQCDSPHVV KYYGSYFKNT DLWIVMEYCG AGSVSDIIRL RNKTLTEDEI ATILQSTLKG LEYLHFMRKI HRDIKAGNIL LNTEGHAKLA DFGVAGQLTD TMAKRNTVIG TPFWMAPEVI QEIGYNCVAD IWSLGITAIE MAEGKPPYAD IHPMRAIFMI PTNPPPTFRK PELWSDNFTD FVKQCLVKSP EQRATATQLL QHPFVRSAKG VSILRDLINE AMDVKLKRQE SQQREVDQDD EENSEEDEMD SGTMVRAVGD EMGTVRVAST MTDGANTMIE HDDTLPSQLG TMVINAEDEE EEGTMKRRDE TMQPAKPSFL EYFEQKEKEN QINSFGKSVP GPLKNSSDWK IPQDGDYEFL KSWTVEDLQK RLLALDPMME QEIEEIRQKY QSKRQPILDA IEAKKRRQQN F
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.