Details for: STK4

Gene ID: 6789

Symbol: STK4

Ensembl ID: ENSG00000101109

Description: serine/threonine kinase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 290.4621
    Cell Significance Index: -45.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 155.6516
    Cell Significance Index: -39.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 127.1116
    Cell Significance Index: -51.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 113.8264
    Cell Significance Index: -53.7400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 106.6321
    Cell Significance Index: -54.8500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 80.3252
    Cell Significance Index: -53.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.9308
    Cell Significance Index: -48.0000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.7385
    Cell Significance Index: -48.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.0297
    Cell Significance Index: -40.2600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.3008
    Cell Significance Index: -29.1100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.5036
    Cell Significance Index: -49.3400
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 3.7908
    Cell Significance Index: 10.1600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.6143
    Cell Significance Index: 76.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.6651
    Cell Significance Index: 196.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2475
    Cell Significance Index: 247.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1707
    Cell Significance Index: 75.5300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.1654
    Cell Significance Index: 21.5400
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 1.0117
    Cell Significance Index: 17.3800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8981
    Cell Significance Index: 97.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8595
    Cell Significance Index: 139.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8024
    Cell Significance Index: 48.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6661
    Cell Significance Index: 81.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5730
    Cell Significance Index: 103.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5304
    Cell Significance Index: 27.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4618
    Cell Significance Index: 165.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3843
    Cell Significance Index: 209.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3411
    Cell Significance Index: 19.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3260
    Cell Significance Index: 44.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3007
    Cell Significance Index: 271.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2458
    Cell Significance Index: 108.6800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2252
    Cell Significance Index: 155.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2186
    Cell Significance Index: 5.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1393
    Cell Significance Index: 6.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1202
    Cell Significance Index: 5.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1158
    Cell Significance Index: 23.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0643
    Cell Significance Index: 1.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0540
    Cell Significance Index: 101.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0433
    Cell Significance Index: 1.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0400
    Cell Significance Index: 25.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0254
    Cell Significance Index: 46.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0239
    Cell Significance Index: 36.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0170
    Cell Significance Index: 2.1800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0084
    Cell Significance Index: 0.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0022
    Cell Significance Index: 0.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0012
    Cell Significance Index: 0.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0038
    Cell Significance Index: -0.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0120
    Cell Significance Index: -0.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0147
    Cell Significance Index: -19.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0171
    Cell Significance Index: -0.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0219
    Cell Significance Index: -9.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0309
    Cell Significance Index: -22.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0353
    Cell Significance Index: -1.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0442
    Cell Significance Index: -27.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0482
    Cell Significance Index: -2.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0503
    Cell Significance Index: -38.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0507
    Cell Significance Index: -37.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0521
    Cell Significance Index: -29.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0661
    Cell Significance Index: -6.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0825
    Cell Significance Index: -15.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0863
    Cell Significance Index: -14.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1108
    Cell Significance Index: -5.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1115
    Cell Significance Index: -3.1200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1204
    Cell Significance Index: -3.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1489
    Cell Significance Index: -42.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1591
    Cell Significance Index: -33.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1841
    Cell Significance Index: -21.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1907
    Cell Significance Index: -27.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2071
    Cell Significance Index: -13.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2251
    Cell Significance Index: -29.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2351
    Cell Significance Index: -6.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2355
    Cell Significance Index: -17.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2571
    Cell Significance Index: -18.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3082
    Cell Significance Index: -13.9700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3292
    Cell Significance Index: -20.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3351
    Cell Significance Index: -38.3900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4149
    Cell Significance Index: -47.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4339
    Cell Significance Index: -20.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4362
    Cell Significance Index: -45.4200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4639
    Cell Significance Index: -5.5300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4751
    Cell Significance Index: -8.1900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5015
    Cell Significance Index: -3.0300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5610
    Cell Significance Index: -16.0100
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: -0.5736
    Cell Significance Index: -2.5700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6167
    Cell Significance Index: -32.3800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6604
    Cell Significance Index: -52.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6714
    Cell Significance Index: -41.1700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6720
    Cell Significance Index: -13.9400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6980
    Cell Significance Index: -20.0100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7148
    Cell Significance Index: -13.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7907
    Cell Significance Index: -13.5500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8173
    Cell Significance Index: -20.8800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8388
    Cell Significance Index: -42.3900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8895
    Cell Significance Index: -23.3900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.9694
    Cell Significance Index: -9.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.9793
    Cell Significance Index: -34.0300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.0470
    Cell Significance Index: -25.1100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.0696
    Cell Significance Index: -9.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0697
    Cell Significance Index: -34.2600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.0747
    Cell Significance Index: -24.8300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -1.1003
    Cell Significance Index: -6.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** STK4 is a serine/threonine kinase that is characterized by its ability to phosphorylate and regulate the activity of downstream targets. It is a member of the STE family of kinases, which are known for their role in signaling pathways that regulate cellular growth and development. STK4 is highly expressed in immune cells, particularly in T cells, and is involved in the regulation of immune responses, including the activation and proliferation of T cells. One of the key characteristics of STK4 is its ability to regulate the Hippo signaling pathway, which is a key regulator of organ growth and development. STK4 also plays a role in the regulation of the canonical Wnt signaling pathway, which is involved in cell differentiation and proliferation. Additionally, STK4 is involved in the regulation of the apoptotic process, which is the process by which cells die. **Pathways and Functions** STK4 is involved in several signaling pathways that regulate cellular processes, including: * **Hippo signaling pathway**: STK4 is a key regulator of the Hippo signaling pathway, which is involved in the regulation of organ growth and development. * **Canonical Wnt signaling pathway**: STK4 plays a role in the regulation of the canonical Wnt signaling pathway, which is involved in cell differentiation and proliferation. * **Apoptotic process**: STK4 is involved in the regulation of the apoptotic process, which is the process by which cells die. * **Cell differentiation**: STK4 is involved in the regulation of cell differentiation, which is the process by which cells become specialized. * **Cell proliferation**: STK4 is involved in the regulation of cell proliferation, which is the process by which cells divide and grow. **Clinical Significance** STK4 has been implicated in several diseases, including: * **Immunodeficiency disorders**: STK4 is highly expressed in immune cells, particularly in T cells, and is involved in the regulation of immune responses. Mutations in the STK4 gene have been associated with immunodeficiency disorders, including severe combined immunodeficiency (SCID) and autoimmune disorders. * **Cancer**: STK4 has been implicated in the regulation of cell proliferation and apoptosis in cancer cells. It is overexpressed in several types of cancer, including breast cancer and lung cancer. * **Cardiovascular disease**: STK4 has been implicated in the regulation of cardiovascular function and has been associated with cardiovascular disease. In conclusion, STK4 is a non-receptor tyrosine kinase that plays a crucial role in various cellular processes, including cell differentiation, proliferation, and apoptosis. Its involvement in the regulation of immune responses and its association with several diseases make it a potential target for the development of new therapeutic strategies for the treatment of immunodeficiency disorders, cancer, and cardiovascular disease.

Genular Protein ID: 2445420415

Symbol: STK4_HUMAN

Name: Serine/threonine-protein kinase 4

UniProtKB Accession Codes:

Q13043 B2RCR8 Q15802 Q4G156 Q5H982 Q6PD60 Q9BR32 Q9NTZ4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 2 ELM 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 51 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7665586

Title: Cloning and characterization of a human protein kinase with homology to Ste20.

PubMed ID: 7665586

DOI: 10.1074/jbc.270.37.21695

PubMed ID: 8816758

Title: Newly identified stress-responsive protein kinases, Krs-1 and Krs-2.

PubMed ID: 8816758

DOI: 10.1073/pnas.93.19.10099

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8702870

Title: The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain.

PubMed ID: 8702870

DOI: 10.1074/jbc.271.35.21049

PubMed ID: 11278283

Title: MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation.

PubMed ID: 11278283

DOI: 10.1074/jbc.m005109200

PubMed ID: 11517310

Title: Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation.

PubMed ID: 11517310

DOI: 10.1073/pnas.181161698

PubMed ID: 12757711

Title: Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase.

PubMed ID: 12757711

DOI: 10.1016/s0092-8674(03)00355-6

PubMed ID: 15109305

Title: Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras.

PubMed ID: 15109305

DOI: 10.1042/bj20040025

PubMed ID: 16510573

Title: Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis.

PubMed ID: 16510573

DOI: 10.1158/0008-5472.can-05-2951

PubMed ID: 16751106

Title: A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span.

PubMed ID: 16751106

DOI: 10.1016/j.cell.2006.03.046

PubMed ID: 16930133

Title: Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation.

PubMed ID: 16930133

DOI: 10.1111/j.1742-4658.2006.05427.x

PubMed ID: 17932490

Title: The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1.

PubMed ID: 17932490

DOI: 10.1038/sj.emboj.7601872

PubMed ID: 17726016

Title: Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation.

PubMed ID: 17726016

DOI: 10.1074/jbc.m704542200

PubMed ID: 18328708

Title: MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.

PubMed ID: 18328708

DOI: 10.1016/j.cub.2008.02.006

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19484742

Title: Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling.

PubMed ID: 19484742

DOI: 10.1002/biof.47

PubMed ID: 18986304

Title: Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1.

PubMed ID: 18986304

DOI: 10.1042/bj20081340

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19525978

Title: RASSF2 associates with and stabilizes the proapoptotic kinase MST2.

PubMed ID: 19525978

DOI: 10.1038/onc.2009.152

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19940129

Title: Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120.

PubMed ID: 19940129

DOI: 10.1074/jbc.m109.059675

PubMed ID: 27825096

Title:

PubMed ID: 27825096

DOI: 10.1074/jbc.a109.059675

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21245099

Title: Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner.

PubMed ID: 21245099

DOI: 10.1158/0008-5472.can-10-2203

PubMed ID: 21512132

Title: MST1 is a multifunctional caspase-independent inhibitor of androgenic signaling.

PubMed ID: 21512132

DOI: 10.1158/0008-5472.can-10-4532

PubMed ID: 21199877

Title: The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2.

PubMed ID: 21199877

DOI: 10.1074/jbc.m110.178210

PubMed ID: 21212262

Title: MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation.

PubMed ID: 21212262

DOI: 10.1074/jbc.m110.182543

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22294732

Title: The phenotype of human STK4 deficiency.

PubMed ID: 22294732

DOI: 10.1182/blood-2011-09-378158

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28087714

Title: DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.

PubMed ID: 28087714

DOI: 10.1101/gad.284539.116

PubMed ID: 28169360

Title: Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway.

PubMed ID: 28169360

DOI: 10.1038/srep42125

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 487
  • Mass: 55630
  • Checksum: 150758EBC5F77D5C
  • Sequence:
    • METVQLRNPP RRQLKKLDED SLTKQPEEVF DVLEKLGEGS YGSVYKAIHK ETGQIVAIKQ 
VPVESDLQEI IKEISIMQQC DSPHVVKYYG SYFKNTDLWI VMEYCGAGSV SDIIRLRNKT 
LTEDEIATIL QSTLKGLEYL HFMRKIHRDI KAGNILLNTE GHAKLADFGV AGQLTDTMAK 
RNTVIGTPFW MAPEVIQEIG YNCVADIWSL GITAIEMAEG KPPYADIHPM RAIFMIPTNP 
PPTFRKPELW SDNFTDFVKQ CLVKSPEQRA TATQLLQHPF VRSAKGVSIL RDLINEAMDV 
KLKRQESQQR EVDQDDEENS EEDEMDSGTM VRAVGDEMGT VRVASTMTDG ANTMIEHDDT 
LPSQLGTMVI NAEDEEEEGT MKRRDETMQP AKPSFLEYFE QKEKENQINS FGKSVPGPLK 
NSSDWKIPQD GDYEFLKSWT VEDLQKRLLA LDPMMEQEIE EIRQKYQSKR QPILDAIEAK 
KRRQQNF

Genular Protein ID: 2009015293

Symbol: A0A087WVN8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WVN8

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 2 CTD 1 ChEBI 11 ChiTaRS 1 EC 2 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 4 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 8 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 411
  • Mass: 46984
  • Checksum: 84D03FE1E81334D9
  • Sequence:
    • MQQCDSPHVV KYYGSYFKNT DLWIVMEYCG AGSVSDIIRL RNKTLTEDEI ATILQSTLKG 
LEYLHFMRKI HRDIKAGNIL LNTEGHAKLA DFGVAGQLTD TMAKRNTVIG TPFWMAPEVI 
QEIGYNCVAD IWSLGITAIE MAEGKPPYAD IHPMRAIFMI PTNPPPTFRK PELWSDNFTD 
FVKQCLVKSP EQRATATQLL QHPFVRSAKG VSILRDLINE AMDVKLKRQE SQQREVDQDD 
EENSEEDEMD SGTMVRAVGD EMGTVRVAST MTDGANTMIE HDDTLPSQLG TMVINAEDEE 
EEGTMKRRDE TMQPAKPSFL EYFEQKEKEN QINSFGKSVP GPLKNSSDWK IPQDGDYEFL 
KSWTVEDLQK RLLALDPMME QEIEEIRQKY QSKRQPILDA IEAKKRRQQN F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.