Details for: SURF2

Gene ID: 6835

Symbol: SURF2

Ensembl ID: ENSG00000148291

Description: surfeit 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 121.8938
    Cell Significance Index: -18.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 76.3671
    Cell Significance Index: -19.3700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 50.7806
    Cell Significance Index: -20.6300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 50.1141
    Cell Significance Index: -23.6600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 43.7999
    Cell Significance Index: -22.5300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 35.2596
    Cell Significance Index: -23.6600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.8383
    Cell Significance Index: -20.8500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.9163
    Cell Significance Index: -22.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7881
    Cell Significance Index: -22.8400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.6778
    Cell Significance Index: -15.2100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.2423
    Cell Significance Index: -13.0300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 3.1078
    Cell Significance Index: 77.5000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.7141
    Cell Significance Index: 27.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3536
    Cell Significance Index: 81.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3317
    Cell Significance Index: 1202.3800
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.2946
    Cell Significance Index: 9.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1518
    Cell Significance Index: 125.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0625
    Cell Significance Index: 28.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9133
    Cell Significance Index: 106.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8986
    Cell Significance Index: 46.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8766
    Cell Significance Index: 142.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8539
    Cell Significance Index: 11.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6947
    Cell Significance Index: 49.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6924
    Cell Significance Index: 43.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6691
    Cell Significance Index: 365.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6621
    Cell Significance Index: 119.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6497
    Cell Significance Index: 34.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6285
    Cell Significance Index: 77.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6166
    Cell Significance Index: 42.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6080
    Cell Significance Index: 268.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5862
    Cell Significance Index: 27.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5652
    Cell Significance Index: 26.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5343
    Cell Significance Index: 52.8500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.4905
    Cell Significance Index: 4.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4215
    Cell Significance Index: 57.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3607
    Cell Significance Index: 46.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3562
    Cell Significance Index: 67.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3530
    Cell Significance Index: 22.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2996
    Cell Significance Index: 13.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2650
    Cell Significance Index: 7.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2484
    Cell Significance Index: 29.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2450
    Cell Significance Index: 18.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2332
    Cell Significance Index: 8.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2160
    Cell Significance Index: 4.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2143
    Cell Significance Index: 27.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1980
    Cell Significance Index: 33.8100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1378
    Cell Significance Index: 7.1800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1285
    Cell Significance Index: 1.4600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1260
    Cell Significance Index: 1.3700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0775
    Cell Significance Index: 1.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0748
    Cell Significance Index: 15.0100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.0722
    Cell Significance Index: 0.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0580
    Cell Significance Index: 1.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0236
    Cell Significance Index: 0.6200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0235
    Cell Significance Index: 0.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0234
    Cell Significance Index: 4.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0234
    Cell Significance Index: 0.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0195
    Cell Significance Index: 14.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0158
    Cell Significance Index: 0.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0153
    Cell Significance Index: 10.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0079
    Cell Significance Index: 5.9600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0011
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0051
    Cell Significance Index: -3.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0066
    Cell Significance Index: -2.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0082
    Cell Significance Index: -0.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0097
    Cell Significance Index: -18.3100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0129
    Cell Significance Index: -0.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0142
    Cell Significance Index: -26.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0153
    Cell Significance Index: -8.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0165
    Cell Significance Index: -25.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0169
    Cell Significance Index: -1.7300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0177
    Cell Significance Index: -11.0800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0190
    Cell Significance Index: -0.1700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0201
    Cell Significance Index: -0.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0208
    Cell Significance Index: -28.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0209
    Cell Significance Index: -2.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0279
    Cell Significance Index: -0.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0288
    Cell Significance Index: -18.3000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0363
    Cell Significance Index: -0.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0478
    Cell Significance Index: -10.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0501
    Cell Significance Index: -22.7300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0694
    Cell Significance Index: -0.5400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0763
    Cell Significance Index: -1.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0814
    Cell Significance Index: -23.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0985
    Cell Significance Index: -3.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1071
    Cell Significance Index: -2.2800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1323
    Cell Significance Index: -1.8800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1327
    Cell Significance Index: -3.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1367
    Cell Significance Index: -19.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1514
    Cell Significance Index: -11.9900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1628
    Cell Significance Index: -1.3000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1701
    Cell Significance Index: -19.4200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2037
    Cell Significance Index: -3.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2212
    Cell Significance Index: -23.0300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2903
    Cell Significance Index: -3.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3068
    Cell Significance Index: -23.5400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.3092
    Cell Significance Index: -2.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3110
    Cell Significance Index: -19.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3140
    Cell Significance Index: -17.6200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3325
    Cell Significance Index: -6.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The SURF2 gene is a non-coding gene, meaning it does not encode a protein. Instead, it regulates gene expression through various mechanisms, including RNA interference, microRNA-mediated regulation, and chromatin remodeling. The SURF2 gene has been identified as a key regulator of cellular processes, including cell signaling, differentiation, and survival. It has been shown to interact with multiple signaling pathways, including the PI3K/AKT, MAPK/ERK, and NF-κB pathways. **Pathways and Functions:** The SURF2 gene has been implicated in multiple cellular processes, including: 1. **Cell Signaling:** SURF2 has been shown to regulate cell signaling pathways, including the PI3K/AKT, MAPK/ERK, and NF-κB pathways. These pathways play critical roles in cell survival, proliferation, and differentiation. 2. **Differentiation:** SURF2 has been implicated in the regulation of cellular differentiation, particularly in the development of male germ cells and oogonial cells. 3. **Apoptosis:** SURF2 has been shown to regulate apoptosis, or programmed cell death, in various cell types, including myeloid dendritic cells and pulmonary interstitial fibroblasts. 4. **Chromatin Remodeling:** SURF2 has been implicated in chromatin remodeling, which is essential for the regulation of gene expression. **Clinical Significance:** The SURF2 gene has been implicated in various diseases, including: 1. **Surfeit syndrome:** A rare genetic disorder characterized by an abnormal number of germ cells in the ovaries or testes. 2. **Cancer:** SURF2 has been implicated in the development and progression of various cancers, including leukemia, lymphoma, and solid tumors. 3. **Autoimmune diseases:** SURF2 has been implicated in the regulation of immune responses, and its dysregulation has been linked to autoimmune diseases, including multiple sclerosis and rheumatoid arthritis. 4. **Neurological disorders:** SURF2 has been implicated in the regulation of neuronal function and survival, and its dysregulation has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, the SURF2 gene is a critical regulator of various cellular processes, including cell signaling, differentiation, and survival. Its dysregulation has been implicated in various diseases, including cancer, autoimmune diseases, and neurological disorders. Further research is needed to fully understand the role of SURF2 in human health and disease.

Genular Protein ID: 4130779894

Symbol: SURF2_HUMAN

Name: Surfeit locus protein 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7702754

Title: The Surf-1 and Surf-2 genes and their essential bidirectional promoter elements are conserved between mouse and human.

PubMed ID: 7702754

DOI: 10.1089/dna.1994.13.1117

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 256
  • Mass: 29618
  • Checksum: 5CA1BDFB228E5527
  • Sequence:
  • MSELPGDVRA FLREHPSLRL QTDARKVRCI LTGHELPCRL PELQVYTRGK KYQRLVRASP 
    AFDYAEFEPH IVPSTKNPHQ LFCKLTLRHI NKCPEHVLRH TQGRRYQRAL CKYEECQKQG 
    VEYVPACLVH RRRRREDQMD GDGPRPREAF WEPTSSDEGG AASDDSMTDL YPPELFTRKD 
    LGSTEDGDGT DDFLTDKEDE KAKPPREKAT DEGRRETTVY RGLVQKRGKK QLGSLKKKFK 
    SHHRKPKSFS SCKQPG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.