Details for: SURF2

Gene ID: 6835

Symbol: SURF2

Ensembl ID: ENSG00000148291

Description: surfeit 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.67
    Marker Score: 481
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.55
    Marker Score: 2233.5
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.49
    Marker Score: 1333
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168083
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.44
    Marker Score: 12550
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.38
    Marker Score: 1731
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.38
    Marker Score: 341
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.28
    Marker Score: 376
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.16
    Marker Score: 706
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.15
    Marker Score: 921
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.15
    Marker Score: 767
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.1
    Marker Score: 745
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1
    Marker Score: 1616
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.09
    Marker Score: 2077
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.08
    Marker Score: 1765.5
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.07
    Marker Score: 242
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.05
    Marker Score: 36351
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.02
    Marker Score: 7577.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1
    Marker Score: 1076
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.99
    Marker Score: 1639.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30392
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.98
    Marker Score: 1016
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.98
    Marker Score: 347
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.97
    Marker Score: 2212.5
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.97
    Marker Score: 8336.5
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.96
    Marker Score: 678
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.95
    Marker Score: 3505
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.94
    Marker Score: 319
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2394
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.94
    Marker Score: 3689
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.93
    Marker Score: 985
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.93
    Marker Score: 424
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.93
    Marker Score: 492.5
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.92
    Marker Score: 783
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.91
    Marker Score: 1023
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2696
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.9
    Marker Score: 425
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.89
    Marker Score: 6971
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5078
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.88
    Marker Score: 1842
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.88
    Marker Score: 206
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.87
    Marker Score: 418
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5229
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.84
    Marker Score: 2261.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.84
    Marker Score: 851
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.84
    Marker Score: 9722
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.84
    Marker Score: 558
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.83
    Marker Score: 8220
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.82
    Marker Score: 1330
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.82
    Marker Score: 2060
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.81
    Marker Score: 3868
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.8
    Marker Score: 749
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.8
    Marker Score: 850
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 317
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.78
    Marker Score: 1327
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.78
    Marker Score: 261
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.77
    Marker Score: 647
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.77
    Marker Score: 1029
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.77
    Marker Score: 558
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.76
    Marker Score: 376
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.76
    Marker Score: 570
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.76
    Marker Score: 802
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.75
    Marker Score: 1517
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 569.5
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.74
    Marker Score: 777
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.74
    Marker Score: 1183.5
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.74
    Marker Score: 274
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.73
    Marker Score: 880
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.73
    Marker Score: 1031
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.72
    Marker Score: 1417
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.72
    Marker Score: 2943
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.71
    Marker Score: 674
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.71
    Marker Score: 1098
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.71
    Marker Score: 1678
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.71
    Marker Score: 784.5
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.71
    Marker Score: 443
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7
    Marker Score: 450
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.7
    Marker Score: 1108
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.7
    Marker Score: 1579
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.69
    Marker Score: 2467
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 631
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2887
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.69
    Marker Score: 206
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.68
    Marker Score: 432
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.68
    Marker Score: 359
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.68
    Marker Score: 235
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.68
    Marker Score: 721
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.68
    Marker Score: 683
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.68
    Marker Score: 959
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.67
    Marker Score: 371
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.67
    Marker Score: 649
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.67
    Marker Score: 808
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.67
    Marker Score: 1819.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.67
    Marker Score: 1811
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.66
    Marker Score: 6717

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Other Information

**Key Characteristics:** The SURF2 gene is a non-coding gene, meaning it does not encode a protein. Instead, it regulates gene expression through various mechanisms, including RNA interference, microRNA-mediated regulation, and chromatin remodeling. The SURF2 gene has been identified as a key regulator of cellular processes, including cell signaling, differentiation, and survival. It has been shown to interact with multiple signaling pathways, including the PI3K/AKT, MAPK/ERK, and NF-κB pathways. **Pathways and Functions:** The SURF2 gene has been implicated in multiple cellular processes, including: 1. **Cell Signaling:** SURF2 has been shown to regulate cell signaling pathways, including the PI3K/AKT, MAPK/ERK, and NF-κB pathways. These pathways play critical roles in cell survival, proliferation, and differentiation. 2. **Differentiation:** SURF2 has been implicated in the regulation of cellular differentiation, particularly in the development of male germ cells and oogonial cells. 3. **Apoptosis:** SURF2 has been shown to regulate apoptosis, or programmed cell death, in various cell types, including myeloid dendritic cells and pulmonary interstitial fibroblasts. 4. **Chromatin Remodeling:** SURF2 has been implicated in chromatin remodeling, which is essential for the regulation of gene expression. **Clinical Significance:** The SURF2 gene has been implicated in various diseases, including: 1. **Surfeit syndrome:** A rare genetic disorder characterized by an abnormal number of germ cells in the ovaries or testes. 2. **Cancer:** SURF2 has been implicated in the development and progression of various cancers, including leukemia, lymphoma, and solid tumors. 3. **Autoimmune diseases:** SURF2 has been implicated in the regulation of immune responses, and its dysregulation has been linked to autoimmune diseases, including multiple sclerosis and rheumatoid arthritis. 4. **Neurological disorders:** SURF2 has been implicated in the regulation of neuronal function and survival, and its dysregulation has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, the SURF2 gene is a critical regulator of various cellular processes, including cell signaling, differentiation, and survival. Its dysregulation has been implicated in various diseases, including cancer, autoimmune diseases, and neurological disorders. Further research is needed to fully understand the role of SURF2 in human health and disease.

Genular Protein ID: 4130779894

Symbol: SURF2_HUMAN

Name: Surfeit locus protein 2

UniProtKB Accession Codes:

Q15527 Q6IBP9 Q96CD1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 2 GO 4 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SAM 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7702754

Title: The Surf-1 and Surf-2 genes and their essential bidirectional promoter elements are conserved between mouse and human.

PubMed ID: 7702754

DOI: 10.1089/dna.1994.13.1117

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 256
  • Mass: 29618
  • Checksum: 5CA1BDFB228E5527
  • Sequence:
    • MSELPGDVRA FLREHPSLRL QTDARKVRCI LTGHELPCRL PELQVYTRGK KYQRLVRASP 
AFDYAEFEPH IVPSTKNPHQ LFCKLTLRHI NKCPEHVLRH TQGRRYQRAL CKYEECQKQG 
VEYVPACLVH RRRRREDQMD GDGPRPREAF WEPTSSDEGG AASDDSMTDL YPPELFTRKD 
LGSTEDGDGT DDFLTDKEDE KAKPPREKAT DEGRRETTVY RGLVQKRGKK QLGSLKKKFK 
SHHRKPKSFS SCKQPG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.