Details for: SYPL1

Gene ID: 6856

Symbol: SYPL1

Ensembl ID: ENSG00000008282

Description: synaptophysin like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 344.6586
    Cell Significance Index: -53.6100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 141.7739
    Cell Significance Index: -35.9600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 125.8783
    Cell Significance Index: -59.4300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 124.9455
    Cell Significance Index: -50.7600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 112.4741
    Cell Significance Index: -57.8600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 89.4382
    Cell Significance Index: -60.0200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 53.7946
    Cell Significance Index: -51.3600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 47.1388
    Cell Significance Index: -58.1200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.3959
    Cell Significance Index: -49.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.0328
    Cell Significance Index: -59.3200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.6227
    Cell Significance Index: -38.7700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.3576
    Cell Significance Index: -20.4800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 5.4716
    Cell Significance Index: 45.9600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 5.2114
    Cell Significance Index: 55.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.0824
    Cell Significance Index: 111.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.7502
    Cell Significance Index: 174.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 3.6679
    Cell Significance Index: 596.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.0627
    Cell Significance Index: 361.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.7706
    Cell Significance Index: 499.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.7653
    Cell Significance Index: 79.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.7238
    Cell Significance Index: 334.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.2531
    Cell Significance Index: 117.0400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.2175
    Cell Significance Index: 20.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.0740
    Cell Significance Index: 146.6800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.7466
    Cell Significance Index: 30.8700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.6781
    Cell Significance Index: 741.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.6532
    Cell Significance Index: 77.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5836
    Cell Significance Index: 864.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.5239
    Cell Significance Index: 98.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5122
    Cell Significance Index: 112.7000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.4486
    Cell Significance Index: 8.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.3415
    Cell Significance Index: 171.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.2653
    Cell Significance Index: 65.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2450
    Cell Significance Index: 170.9800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.2271
    Cell Significance Index: 13.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1020
    Cell Significance Index: 142.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.9567
    Cell Significance Index: 25.5900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.9423
    Cell Significance Index: 21.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7554
    Cell Significance Index: 20.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6605
    Cell Significance Index: 16.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6527
    Cell Significance Index: 14.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4149
    Cell Significance Index: 78.9600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.3935
    Cell Significance Index: 9.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3744
    Cell Significance Index: 13.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3529
    Cell Significance Index: 9.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2879
    Cell Significance Index: 7.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2454
    Cell Significance Index: 6.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2104
    Cell Significance Index: 42.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2002
    Cell Significance Index: 39.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0975
    Cell Significance Index: 4.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0870
    Cell Significance Index: 8.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0418
    Cell Significance Index: 15.0000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0348
    Cell Significance Index: 24.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0344
    Cell Significance Index: 26.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0335
    Cell Significance Index: 0.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0234
    Cell Significance Index: 17.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0114
    Cell Significance Index: 21.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0048
    Cell Significance Index: -0.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0177
    Cell Significance Index: -0.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0293
    Cell Significance Index: -53.9800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0302
    Cell Significance Index: -3.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0359
    Cell Significance Index: -55.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0389
    Cell Significance Index: -52.9000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0397
    Cell Significance Index: -0.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0542
    Cell Significance Index: -34.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0550
    Cell Significance Index: -24.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0678
    Cell Significance Index: -50.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0752
    Cell Significance Index: -12.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0953
    Cell Significance Index: -2.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1005
    Cell Significance Index: -56.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1078
    Cell Significance Index: -67.3300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.1321
    Cell Significance Index: -0.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1362
    Cell Significance Index: -2.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1374
    Cell Significance Index: -4.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1551
    Cell Significance Index: -18.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1701
    Cell Significance Index: -48.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2195
    Cell Significance Index: -16.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2239
    Cell Significance Index: -15.4900
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.2502
    Cell Significance Index: -1.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2697
    Cell Significance Index: -3.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2823
    Cell Significance Index: -7.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3017
    Cell Significance Index: -43.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3204
    Cell Significance Index: -67.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3343
    Cell Significance Index: -38.3000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4660
    Cell Significance Index: -23.5500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4828
    Cell Significance Index: -14.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5359
    Cell Significance Index: -55.8000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.6145
    Cell Significance Index: -6.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6206
    Cell Significance Index: -49.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6939
    Cell Significance Index: -38.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7180
    Cell Significance Index: -44.1300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.7469
    Cell Significance Index: -9.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7932
    Cell Significance Index: -49.9900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.8028
    Cell Significance Index: -6.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8211
    Cell Significance Index: -55.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.8256
    Cell Significance Index: -29.0100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.8438
    Cell Significance Index: -6.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.8528
    Cell Significance Index: -34.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8744
    Cell Significance Index: -45.9100
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.9427
    Cell Significance Index: -4.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SYPL1 is a small, membrane-bound protein that belongs to the synaptophysin-like protein family. It is characterized by its ability to interact with various cellular components, including synaptic vesicles, exosomes, and the plasma membrane. The SYPL1 protein is highly conserved across different species, suggesting its essential role in maintaining cellular homeostasis. Notably, SYPL1 is also expressed in malignant cells, suggesting its potential involvement in tumorigenesis. **Pathways and Functions:** SYPL1 is involved in several cellular pathways, including: 1. **Chemical synaptic transmission**: SYPL1 is localized to synaptic vesicles and plays a crucial role in regulating neurotransmitter release. 2. **Extracellular exosome secretion**: SYPL1 is involved in the formation and secretion of exosomes, which are small, membrane-bound vesicles that contain proteins, lipids, and RNA. 3. **Melanosome formation**: SYPL1 is expressed in melanocytes and is involved in the formation of melanosomes, which are organelles responsible for melanin production. 4. **Protein binding**: SYPL1 interacts with various proteins, including synaptic vesicle proteins and exosome-associated proteins, to regulate their activity and localization. **Clinical Significance:** The clinical significance of SYPL1 is multifaceted. Its expression in malignant cells suggests its potential involvement in tumorigenesis and cancer progression. Additionally, SYPL1's role in synaptic transmission and exosome secretion may have implications for understanding neurological disorders, such as Alzheimer's disease and Parkinson's disease. Furthermore, SYPL1's expression in various cell types, including pancreatic acinar cells and ovarian surface epithelial cells, highlights its potential as a biomarker for certain diseases. In conclusion, SYPL1 is a multifunctional protein that plays a critical role in various cellular processes, including synaptic transmission, exosome secretion, and protein binding. Its clinical significance is underscored by its expression in malignant cells and its potential involvement in neurological disorders and cancer progression. Further research is needed to fully elucidate the functions and clinical significance of SYPL1, but its discovery highlights the complexity and diversity of cellular biology.

Genular Protein ID: 3095306497

Symbol: SYPL1_HUMAN

Name: Synaptophysin-like protein 1

UniProtKB Accession Codes:

Q16563 A4D0R2 Q96AR8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8034131

Title: Expression of the synaptophysin gene family is not restricted to neuronal and neuroendocrine differentiation in rat and human.

PubMed ID: 8034131

DOI: 10.1046/j.1432-0436.1994.5630163.x

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1730063

Title: Molecular cloning of a cDNA encoding a novel protein related to the neuronal vesicle protein synaptophysin.

PubMed ID: 1730063

DOI: 10.1016/0167-4781(92)90495-l

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 259
  • Mass: 28565
  • Checksum: 20D553779AA82085
  • Sequence:
    • MAPNIYLVRQ RISRLGQRMS GFQINLNPLK EPLGFIKVLE WIASIFAFAT CGGFKGQTEI 
QVNCPPAVTE NKTVTATFGY PFRLNEASFQ PPPGVNICDV NWKDYVLIGD YSSSAQFYVT 
FAVFVFLYCI AALLLYVGYT SLYLDSRKLP MIDFVVTLVA TFLWLVSTSA WAKALTDIKI 
ATGHNIIDEL PPCKKKAVLC YFGSVTSMGS LNVSVIFGFL NMILWGGNAW FVYKETSLHS 
PSNTSAPHSQ GGIPPPTGI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.