Details for: TAF10

Gene ID: 6881

Symbol: TAF10

Ensembl ID: ENSG00000166337

Description: TATA-box binding protein associated factor 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 183.6765
    Cell Significance Index: -28.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 112.8553
    Cell Significance Index: -28.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 68.6757
    Cell Significance Index: -27.9000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 60.5188
    Cell Significance Index: -31.1300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 30.1757
    Cell Significance Index: -28.8100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.6886
    Cell Significance Index: -30.4400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.1386
    Cell Significance Index: -27.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.8712
    Cell Significance Index: -31.0600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.4069
    Cell Significance Index: -22.7500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.8303
    Cell Significance Index: 65.3900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.1757
    Cell Significance Index: 20.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.8989
    Cell Significance Index: 122.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5467
    Cell Significance Index: 278.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5093
    Cell Significance Index: 824.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3519
    Cell Significance Index: 185.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3409
    Cell Significance Index: 164.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3342
    Cell Significance Index: 94.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1265
    Cell Significance Index: 52.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0806
    Cell Significance Index: 50.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.0657
    Cell Significance Index: 28.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.9752
    Cell Significance Index: 27.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9275
    Cell Significance Index: 150.8600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9261
    Cell Significance Index: 409.4700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.9002
    Cell Significance Index: 5.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6439
    Cell Significance Index: 33.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6176
    Cell Significance Index: 16.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5432
    Cell Significance Index: 59.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5244
    Cell Significance Index: 61.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5182
    Cell Significance Index: 26.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4805
    Cell Significance Index: 10.4100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4593
    Cell Significance Index: 12.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4225
    Cell Significance Index: 72.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3977
    Cell Significance Index: 29.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3518
    Cell Significance Index: 10.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3462
    Cell Significance Index: 44.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2696
    Cell Significance Index: 7.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2625
    Cell Significance Index: 11.9000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2391
    Cell Significance Index: 4.4200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2377
    Cell Significance Index: 2.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2185
    Cell Significance Index: 41.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1281
    Cell Significance Index: 25.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1272
    Cell Significance Index: 12.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1250
    Cell Significance Index: 25.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0990
    Cell Significance Index: 6.2400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.0966
    Cell Significance Index: 0.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0700
    Cell Significance Index: 8.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0498
    Cell Significance Index: 17.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0323
    Cell Significance Index: 23.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0028
    Cell Significance Index: -2.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0083
    Cell Significance Index: -15.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0089
    Cell Significance Index: -12.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0095
    Cell Significance Index: -5.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0113
    Cell Significance Index: -8.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0157
    Cell Significance Index: -29.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0157
    Cell Significance Index: -24.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0272
    Cell Significance Index: -0.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0300
    Cell Significance Index: -16.9000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0392
    Cell Significance Index: -0.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0413
    Cell Significance Index: -26.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0578
    Cell Significance Index: -5.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0590
    Cell Significance Index: -26.7600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0607
    Cell Significance Index: -0.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0640
    Cell Significance Index: -13.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0748
    Cell Significance Index: -8.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0799
    Cell Significance Index: -23.0000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1332
    Cell Significance Index: -15.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1519
    Cell Significance Index: -17.7000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1779
    Cell Significance Index: -25.8600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1782
    Cell Significance Index: -9.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2059
    Cell Significance Index: -16.3100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2588
    Cell Significance Index: -15.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2877
    Cell Significance Index: -8.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2946
    Cell Significance Index: -30.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2955
    Cell Significance Index: -22.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3087
    Cell Significance Index: -17.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3261
    Cell Significance Index: -8.5800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3288
    Cell Significance Index: -13.4700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3466
    Cell Significance Index: -8.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3540
    Cell Significance Index: -7.4100
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.3779
    Cell Significance Index: -3.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3797
    Cell Significance Index: -5.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3962
    Cell Significance Index: -26.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4306
    Cell Significance Index: -22.6100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4636
    Cell Significance Index: -16.1100
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.5000
    Cell Significance Index: -3.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5221
    Cell Significance Index: -32.0100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5296
    Cell Significance Index: -3.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5324
    Cell Significance Index: -8.9100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.5519
    Cell Significance Index: -11.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6170
    Cell Significance Index: -27.2900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.6310
    Cell Significance Index: -5.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6397
    Cell Significance Index: -20.4900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6914
    Cell Significance Index: -25.3800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7023
    Cell Significance Index: -7.2700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7167
    Cell Significance Index: -21.0500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7340
    Cell Significance Index: -12.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7407
    Cell Significance Index: -28.0500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.7509
    Cell Significance Index: -12.6300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.7635
    Cell Significance Index: -8.3000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7744
    Cell Significance Index: -22.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TAF10 is a highly conserved protein, with high sequence similarity across different species. Its molecular weight is approximately 30 kDa, and it belongs to the TATA-binding protein-associated factor family. TAF10 exhibits a unique structure, consisting of three distinct domains: a TFIID-binding domain, a histone acetyltransferase (HAT) domain, and a transcriptional activation domain. The HAT domain is responsible for the acetylation of histones, which is a key epigenetic modification that regulates chromatin structure and gene expression. **Pathways and Functions** TAF10 is involved in various biological pathways, including: 1. **Chromatin organization and remodeling**: TAF10 interacts with histones and other chromatin-modifying enzymes to regulate chromatin structure and gene expression. 2. **Gene expression (transcription)**: As a subunit of TFIID, TAF10 is essential for the recruitment of RNA polymerase II to specific promoters, allowing for the initiation of transcription. 3. **Apoptotic process**: TAF10 has been implicated in the regulation of apoptosis, particularly in the context of viral infections. 4. **Immune response**: TAF10 is expressed in various immune cells, including myeloid leukocytes and B cells, and plays a role in regulating immune responses. 5. **Cell differentiation**: TAF10 is involved in the regulation of cell differentiation, particularly in the context of hematopoiesis and embryonic development. **Clinical Significance** Dysregulation of TAF10 has been implicated in various diseases, including: 1. **Cancer**: TAF10 has been found to be overexpressed in certain types of cancer, including leukemia and lymphoma. 2. **Immune disorders**: Mutations in the TAF10 gene have been associated with immune disorders, such as autoimmune diseases and immunodeficiency syndromes. 3. **Neurological disorders**: TAF10 has been implicated in the regulation of gene expression in the brain, and dysregulation of TAF10 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, TAF10 is a critical transcriptional regulator that plays a significant role in various cellular processes, including gene expression, chromatin organization, and cell differentiation. Its involvement in numerous biological pathways and its dysregulation in various diseases highlight its importance in maintaining cellular homeostasis and overall health.

Genular Protein ID: 2696552193

Symbol: TAF10_HUMAN

Name: Transcription initiation factor TFIID subunit 10

UniProtKB Accession Codes:

Q12962 O00703 Q13175 Q6FH13

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 6 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 32 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 38 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 47 PDBsum 47 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 11 RefSeq 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7923369

Title: Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor.

PubMed ID: 7923369

DOI: 10.1016/0092-8674(94)90404-9

PubMed ID: 8530084

Title: Organization and chromosomal localization of the gene (TAF2H) encoding the human TBP-associated factor II 30 (TAFII30).

PubMed ID: 8530084

DOI: 10.1006/geno.1995.1243

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9674425

Title: Histone-like TAFs within the PCAF histone acetylase complex.

PubMed ID: 9674425

DOI: 10.1016/s0092-8674(00)81219-2

PubMed ID: 7729427

Title: Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID.

PubMed ID: 7729427

DOI: 10.1002/j.1460-2075.1995.tb07138.x

PubMed ID: 11564863

Title: Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.

PubMed ID: 11564863

DOI: 10.1128/mcb.21.20.6782-6795.2001

PubMed ID: 9885574

Title: The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily.

PubMed ID: 9885574

DOI: 10.1016/s1097-2765(00)80301-9

PubMed ID: 10373431

Title: Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction.

PubMed ID: 10373431

DOI: 10.1074/jbc.274.26.18285

PubMed ID: 11438666

Title: The TFIID components human TAFII140 and Drosophila BIP2 (TAFII155) are novel metazoan homologues of yeast TAFII47 containing a histone fold and a PHD finger.

PubMed ID: 11438666

DOI: 10.1128/mcb.21.15.5109-5121.2001

PubMed ID: 15099517

Title: Gene-specific modulation of TAF10 function by SET9-mediated methylation.

PubMed ID: 15099517

DOI: 10.1016/s1097-2765(04)00182-0

PubMed ID: 16415881

Title: Structural basis for the methylation site specificity of SET7/9.

PubMed ID: 16415881

DOI: 10.1038/nsmb1045

PubMed ID: 12601814

Title: Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis.

PubMed ID: 12601814

DOI: 10.1002/pmic.200390030

PubMed ID: 18206972

Title: A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.

PubMed ID: 18206972

DOI: 10.1016/j.molcel.2007.12.011

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25959397

Title: LOXL2 oxidizes methylated TAF10 and controls TFIID-dependent genes during neural progenitor differentiation.

PubMed ID: 25959397

DOI: 10.1016/j.molcel.2015.04.012

PubMed ID: 33795473

Title: Structural insights into preinitiation complex assembly on core promoters.

PubMed ID: 33795473

DOI: 10.1126/science.aba8490

Sequence Information:

  • Length: 218
  • Mass: 21711
  • Checksum: 032ED5CA97EBE411
  • Sequence:
    • MSCSGSGADP EAAPASAASA PGPAPPVSAP AALPSSTAAE NKASPAGTAG GPGAGAAAGG 
TGPLAARAGE PAERRGAAPV SAGGAAPPEG AISNGVYVLP SAANGDVKPV VSSTPLVDFL 
MQLEDYTPTI PDAVTGYYLN RAGFEASDPR IIRLISLAAQ KFISDIANDA LQHCKMKGTA 
SGSSRSKSKD RKYTLTMEDL TPALSEYGIN VKKPHYFT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.