Details for: TALDO1

Gene ID: 6888

Symbol: TALDO1

Ensembl ID: ENSG00000177156

Description: transaldolase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 296.5697
    Cell Significance Index: -46.1300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 195.7530
    Cell Significance Index: -80.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 170.3371
    Cell Significance Index: -80.4200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 168.3047
    Cell Significance Index: -68.3800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 150.9569
    Cell Significance Index: -77.6500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 148.1213
    Cell Significance Index: -37.5700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 120.1898
    Cell Significance Index: -80.6500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 72.9987
    Cell Significance Index: -69.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 47.2929
    Cell Significance Index: -58.3100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 21.6361
    Cell Significance Index: -57.9600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.9225
    Cell Significance Index: -78.6200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.7733
    Cell Significance Index: -54.5900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.4085
    Cell Significance Index: -22.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 8.2049
    Cell Significance Index: 956.1900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 7.8257
    Cell Significance Index: 144.6400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 6.6686
    Cell Significance Index: 178.3800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.8204
    Cell Significance Index: 44.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.9380
    Cell Significance Index: 136.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.5403
    Cell Significance Index: 1387.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.4917
    Cell Significance Index: 160.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.4198
    Cell Significance Index: 436.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.3513
    Cell Significance Index: 289.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.3460
    Cell Significance Index: 68.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.3108
    Cell Significance Index: 108.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6981
    Cell Significance Index: 233.2000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.5938
    Cell Significance Index: 13.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.5066
    Cell Significance Index: 177.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3516
    Cell Significance Index: 36.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1815
    Cell Significance Index: 83.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1438
    Cell Significance Index: 505.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.1309
    Cell Significance Index: 39.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1196
    Cell Significance Index: 144.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.0768
    Cell Significance Index: 22.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9895
    Cell Significance Index: 73.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9123
    Cell Significance Index: 24.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8826
    Cell Significance Index: 45.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7536
    Cell Significance Index: 96.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7113
    Cell Significance Index: 15.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5109
    Cell Significance Index: 102.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5052
    Cell Significance Index: 14.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4977
    Cell Significance Index: 84.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4489
    Cell Significance Index: 5.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4340
    Cell Significance Index: 19.6700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4207
    Cell Significance Index: 9.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3655
    Cell Significance Index: 19.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2953
    Cell Significance Index: 58.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2499
    Cell Significance Index: 6.5700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2392
    Cell Significance Index: 1.9100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2267
    Cell Significance Index: 156.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2205
    Cell Significance Index: 21.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1132
    Cell Significance Index: 21.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1027
    Cell Significance Index: 36.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0899
    Cell Significance Index: 68.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0447
    Cell Significance Index: 32.8000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0437
    Cell Significance Index: 0.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0065
    Cell Significance Index: -0.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0162
    Cell Significance Index: -1.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0227
    Cell Significance Index: -0.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0237
    Cell Significance Index: -36.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0257
    Cell Significance Index: -47.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0344
    Cell Significance Index: -25.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0435
    Cell Significance Index: -59.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0467
    Cell Significance Index: -29.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0746
    Cell Significance Index: -47.3600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0809
    Cell Significance Index: -8.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0809
    Cell Significance Index: -45.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1455
    Cell Significance Index: -66.0200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1821
    Cell Significance Index: -3.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1935
    Cell Significance Index: -10.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1963
    Cell Significance Index: -41.3400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2139
    Cell Significance Index: -5.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2195
    Cell Significance Index: -25.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2209
    Cell Significance Index: -63.5600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2682
    Cell Significance Index: -30.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3653
    Cell Significance Index: -11.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4022
    Cell Significance Index: -11.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4298
    Cell Significance Index: -27.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4577
    Cell Significance Index: -66.5300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4927
    Cell Significance Index: -6.7200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5663
    Cell Significance Index: -44.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6032
    Cell Significance Index: -37.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7256
    Cell Significance Index: -75.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7853
    Cell Significance Index: -60.2700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.7975
    Cell Significance Index: -11.9500
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.8039
    Cell Significance Index: -13.8100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9236
    Cell Significance Index: -5.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9871
    Cell Significance Index: -55.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.0085
    Cell Significance Index: -67.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2890
    Cell Significance Index: -79.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3485
    Cell Significance Index: -39.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.4865
    Cell Significance Index: -38.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.5769
    Cell Significance Index: -69.7500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.6736
    Cell Significance Index: -19.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.7262
    Cell Significance Index: -17.8700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.7356
    Cell Significance Index: -87.7100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.7479
    Cell Significance Index: -22.3900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.7904
    Cell Significance Index: -14.6000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.8001
    Cell Significance Index: -63.0600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.8532
    Cell Significance Index: -68.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Enzyme Function**: TALDO1 is a dual-specificity enzyme that catalyzes the transfer of 3-carbon units between intermediates in the non-oxidative branch of the PPP. 2. **Substrate Specificity**: The enzyme exhibits specificity for fructose-6-phosphate (Fru-6-P) and xylulose-5-phosphate (Xyl-5-P), with a preference for Fru-6-P. 3. **Regulation**: TALDO1 activity is regulated by various factors, including NFE2L2, a transcription factor that promotes the expression of PPP genes. 4. **Cellular Expression**: TALDO1 is highly expressed in early promyelocytes, CD14-positive, CD16-negative classical monocytes, blood cells, and hematopoietic stem cells. **Pathways and Functions** 1. **Pentose Phosphate Pathway (PPP)**: TALDO1 is a key enzyme in the non-oxidative branch of the PPP, facilitating the transfer of 3-carbon units between intermediates. 2. **Fructose 6-phosphate Metabolic Process**: TALDO1 is involved in the interconversion of Fru-6-P and Xyl-5-P, which are critical intermediates in glucose metabolism. 3. **Cytokine Signaling in Immune System**: TALDO1 has been implicated in the regulation of cytokine signaling pathways, including the IL-12/STAT signaling cascade. 4. **Keap1-NFE2L2 Pathway**: TALDO1 is regulated by the Keap1-NFE2L2 pathway, which promotes the expression of PPP genes in response to oxidative stress. **Clinical Significance** 1. **Diseases of Carbohydrate Metabolism**: TALDO1 deficiency has been associated with impaired glucose metabolism and an increased risk of developing diseases related to carbohydrate metabolism, such as diabetes and metabolic syndrome. 2. **Pentose Phosphate Pathway Disease**: Mutations in the TALDO1 gene have been linked to pentose phosphate pathway disease, a rare genetic disorder characterized by impaired glucose metabolism and an increased risk of developing metabolic disorders. 3. **Immune System Dysregulation**: TALDO1 has been implicated in the regulation of cytokine signaling pathways, which are critical for immune system function. Dysregulation of TALDO1 has been associated with immune system dysfunction and an increased risk of developing autoimmune diseases. 4. **Cancer Metabolism**: TALDO1 has been shown to play a role in cancer metabolism, with implications for the development of cancer therapies targeting the PPP. In conclusion, TALDO1 is a critical enzyme involved in the regulation of glucose metabolism and immune system function. Its dysregulation has been associated with various diseases, including carbohydrate metabolism disorders, pentose phosphate pathway disease, and immune system dysregulation. Further research is needed to fully elucidate the role of TALDO1 in human health and disease.

Genular Protein ID: 946932762

Symbol: TALDO_HUMAN

Name: Transaldolase

UniProtKB Accession Codes:

P37837 B2R8M2 O00751 Q8WV32 Q8WZ45

Database IDs:

AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRIDE 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 6 RefSeq 1 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8300619

Title: Cloning and expression of the human gene for transaldolase. A novel highly repetitive element constitutes an integral part of the coding sequence.

PubMed ID: 8300619

DOI: 10.1016/s0021-9258(17)42020-5

PubMed ID: 9339383

Title: The human transaldolase gene (TALDO1) is located on chromosome 11 at p15.4-p15.5.

PubMed ID: 9339383

DOI: 10.1006/geno.1997.4932

PubMed ID: 9524206

Title: Cloning and chromosomal localization of a paralog and a mouse homolog of the human transaldolase gene.

PubMed ID: 9524206

DOI: 10.1016/s0378-1119(97)00639-2

PubMed ID: 10702296

Title: Human transaldolase-associated repetitive elements are transcribed by RNA polymerase III.

PubMed ID: 10702296

DOI: 10.1074/jbc.275.10.7261

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8955144

Title: Glutathione levels and sensitivity to apoptosis are regulated by changes in transaldolase expression.

PubMed ID: 8955144

DOI: 10.1074/jbc.271.51.32994

PubMed ID: 18687684

Title: Replacement of a phenylalanine by a tyrosine in the active site confers fructose-6-phosphate aldolase activity to the transaldolase of Escherichia coli and human origin.

PubMed ID: 18687684

DOI: 10.1074/jbc.m803184200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 10869557

Title: The three-dimensional structure of human transaldolase.

PubMed ID: 10869557

DOI: 10.1016/s0014-5793(00)01658-6

PubMed ID: 27703206

Title: Two isoforms of TALDO1 generated by alternative translational initiation show differential nucleocytoplasmic distribution to regulate the global metabolic network.

PubMed ID: 27703206

DOI: 10.1038/srep34648

PubMed ID: 11283793

Title: Transaldolase deficiency: liver cirrhosis associated with a new inborn error in the pentose phosphate pathway.

PubMed ID: 11283793

DOI: 10.1086/320108

PubMed ID: 25388407

Title: Transaldolase deficiency caused by the homozygous p.R192C mutation of the TALDO1 gene in four Emirati patients with considerable phenotypic variability.

PubMed ID: 25388407

DOI: 10.1007/s00431-014-2449-5

Sequence Information:

  • Length: 337
  • Mass: 37540
  • Checksum: 8CB4992AEF364E64
  • Sequence:
    • MSSSPVKRQR MESALDQLKQ FTTVVADTGD FHAIDEYKPQ DATTNPSLIL AAAQMPAYQE 
LVEEAIAYGR KLGGSQEDQI KNAIDKLFVL FGAEILKKIP GRVSTEVDAR LSFDKDAMVA 
RARRLIELYK EAGISKDRIL IKLSSTWEGI QAGKELEEQH GIHCNMTLLF SFAQAVACAE 
AGVTLISPFV GRILDWHVAN TDKKSYEPLE DPGVKSVTKI YNYYKKFSYK TIVMGASFRN 
TGEIKALAGC DFLTISPKLL GELLQDNAKL VPVLSAKAAQ ASDLEKIHLD EKSFRWLHNE 
DQMAVEKLSD GIRKFAADAV KLERMLTERM FNAENGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.