ELOC | ENSG00000154582 | NCBI 6921

Details for: ELOC

Gene ID: 6921

Symbol: ELOC

Ensembl ID: ENSG00000154582

Description: elongin C

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Axon guidance
(R-HSA-422475)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Evasion by rsv of host interferon responses
(R-HSA-9833109)
Formation of hiv-1 elongation complex containing hiv-1 tat
(R-HSA-167200)
Formation of hiv elongation complex in the absence of hiv tat
(R-HSA-167152)
Formation of rna pol ii elongation complex
(R-HSA-112382)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hiv elongation arrest and recovery
(R-HSA-167287)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Hiv transcription elongation
(R-HSA-167169)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Inactivation of csf3 (g-csf) signaling
(R-HSA-9705462)
Infectious disease
(R-HSA-5663205)
Late phase of hiv life cycle
(R-HSA-162599)
M-decay: degradation of maternal mrnas by maternally stored factors
(R-HSA-9820841)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Metabolism of proteins
(R-HSA-392499)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pausing and recovery of hiv elongation
(R-HSA-167290)
Pausing and recovery of tat-mediated hiv elongation
(R-HSA-167238)
Post-translational protein modification
(R-HSA-597592)
Regulation of expression of slits and robos
(R-HSA-9010553)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription elongation
(R-HSA-75955)
Rsv-host interactions
(R-HSA-9833110)
Signaling by csf3 (g-csf)
(R-HSA-9674555)
Signaling by robo receptors
(R-HSA-376176)
Tat-mediated elongation of the hiv-1 transcript
(R-HSA-167246)
Tat-mediated hiv elongation arrest and recovery
(R-HSA-167243)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcription of the hiv genome
(R-HSA-167172)
Vif-mediated degradation of apobec3g
(R-HSA-180585)
Viral infection pathways
(R-HSA-9824446)
Cul2-ring ubiquitin ligase complex
(GO:0031462)
Cul5-ring ubiquitin ligase complex
(GO:0031466)
Cytosol
(GO:0005829)
Elongin complex
(GO:0070449)
Nucleoplasm
(GO:0005654)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein ubiquitination
(GO:0016567)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Target-directed mirna degradation
(GO:0140958)
Transcription corepressor binding
(GO:0001222)
Transcription initiation at rna polymerase ii promoter
(GO:0006367)
Ubiquitin-dependent protein catabolic process
(GO:0006511)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: embryonic stem cell (CL0002322)
Fold Change: 190.1455
Cell Significance Index: -78.3300
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 160.9698
Cell Significance Index: -76.0000
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 160.8833
Cell Significance Index: -65.3600
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 143.2584
Cell Significance Index: -73.6900
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 113.7965
Cell Significance Index: -76.3600
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 69.2438
Cell Significance Index: -66.1100
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 22.1997
Cell Significance Index: -59.4700
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 15.9859
Cell Significance Index: -49.1000
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 6.5940
Cell Significance Index: 116.5300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.2214
Cell Significance Index: 92.3500
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 2.4617
Cell Significance Index: 17.6800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.8943
Cell Significance Index: 141.1800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.8940
Cell Significance Index: 51.5500
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.8483
Cell Significance Index: 48.6000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.6358
Cell Significance Index: 192.9100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.5565
Cell Significance Index: 191.3900
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.5522
Cell Significance Index: 32.4900
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.5251
Cell Significance Index: 44.7900
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.5018
Cell Significance Index: 820.1900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.4543
Cell Significance Index: 199.7200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.4062
Cell Significance Index: 73.8300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.3621
Cell Significance Index: 245.5400
Cell Name: lactocyte (CL0002325)
Fold Change: 1.3326
Cell Significance Index: 172.1600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.3193
Cell Significance Index: 583.3000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.2814
Cell Significance Index: 60.2300
Cell Name: odontoblast (CL0000060)
Fold Change: 1.2769
Cell Significance Index: 163.6900
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.2743
Cell Significance Index: 11.7400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.2446
Cell Significance Index: 58.0300
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.2271
Cell Significance Index: 13.9400
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.0449
Cell Significance Index: 73.9000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.9724
Cell Significance Index: 33.7900
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.8806
Cell Significance Index: 56.8200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.8382
Cell Significance Index: 43.5400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.8119
Cell Significance Index: 162.8600
Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: 0.7851
Cell Significance Index: 3.4800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6802
Cell Significance Index: 110.6400
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.6516
Cell Significance Index: 129.3100
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.6336
Cell Significance Index: 11.7100
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.6108
Cell Significance Index: 6.6400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4135
Cell Significance Index: 11.9200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.3459
Cell Significance Index: 21.8000
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.3281
Cell Significance Index: 17.0900
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3275
Cell Significance Index: 35.6200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2389
Cell Significance Index: 45.4700
Cell Name: theca cell (CL0000503)
Fold Change: 0.2366
Cell Significance Index: 1.3900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2157
Cell Significance Index: 77.3500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1320
Cell Significance Index: 22.5400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1176
Cell Significance Index: 5.3300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.1148
Cell Significance Index: 86.8700
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0618
Cell Significance Index: 3.1200
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0532
Cell Significance Index: 5.2600
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0476
Cell Significance Index: 1.2700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0027
Cell Significance Index: 2.0100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0013
Cell Significance Index: -2.4000
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0316
Cell Significance Index: -58.3200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0370
Cell Significance Index: -0.6200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0444
Cell Significance Index: -4.5400
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0455
Cell Significance Index: -70.1200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0501
Cell Significance Index: -37.0900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0564
Cell Significance Index: -76.6600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0791
Cell Significance Index: -50.2200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1095
Cell Significance Index: -49.6900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1154
Cell Significance Index: -65.0900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1325
Cell Significance Index: -15.1800
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1353
Cell Significance Index: -3.7800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1519
Cell Significance Index: -94.8600
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1725
Cell Significance Index: -49.6200
Cell Name: peg cell (CL4033014)
Fold Change: -0.2922
Cell Significance Index: -6.7500
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.3498
Cell Significance Index: -4.1700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3698
Cell Significance Index: -53.7600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3791
Cell Significance Index: -23.3000
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.3825
Cell Significance Index: -22.9700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3845
Cell Significance Index: -80.9900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3997
Cell Significance Index: -46.5800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.4470
Cell Significance Index: -34.3000
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5144
Cell Significance Index: -13.1400
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.5739
Cell Significance Index: -23.5200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.5802
Cell Significance Index: -32.5600
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.6368
Cell Significance Index: -42.8200
Cell Name: germ cell (CL0000586)
Fold Change: -0.6476
Cell Significance Index: -4.8900
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -0.6517
Cell Significance Index: -5.6000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6779
Cell Significance Index: -53.6900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.7048
Cell Significance Index: -73.3900
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.7978
Cell Significance Index: -4.8200
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.8773
Cell Significance Index: -11.9700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.8972
Cell Significance Index: -28.7400
Cell Name: kidney cell (CL1000497)
Fold Change: -0.9481
Cell Significance Index: -7.5700
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -0.9882
Cell Significance Index: -6.1400
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.0107
Cell Significance Index: -29.7700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.0164
Cell Significance Index: -22.0200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.0554
Cell Significance Index: -28.2300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.0636
Cell Significance Index: -27.3400
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -1.1110
Cell Significance Index: -19.0400
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.1953
Cell Significance Index: -29.8800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.2086
Cell Significance Index: -53.4600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.2207
Cell Significance Index: -74.8400
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.2440
Cell Significance Index: -18.6400
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -1.3727
Cell Significance Index: -14.2100
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.4215
Cell Significance Index: -53.8300
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -1.5508
Cell Significance Index: -19.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** ELOC is a 42-kDa protein that belongs to the elongin complex, which consists of two subunits: elongin B and elongin C. ELOC is a ring ubiquitin ligase that interacts with the E3 ubiquitin ligase complex, CUL2 and CUL5, to mediate the ubiquitination and degradation of target proteins. ELOC has a high affinity for the substrate protein, elongin B, and forms a heterodimeric complex that is essential for the ubiquitination process. ELOC is also involved in the regulation of transcriptional activity, particularly in the context of the HIV-1 life cycle, where it interacts with the viral protein Tat to facilitate transcriptional elongation. **Pathways and Functions** ELOC is involved in a wide range of cellular processes, including: 1. **Adaptive Immune System**: ELOC plays a crucial role in the regulation of immune responses, particularly in the context of antigen processing and presentation. It is involved in the ubiquitination and degradation of proteins that are essential for the proper functioning of the adaptive immune system. 2. **Antigen Processing: Ubiquitination & Proteasome Degradation**: ELOC is involved in the ubiquitination and degradation of proteins that are involved in antigen processing, including the MHC class I molecule and the antigen-presenting cell (APC) molecules. 3. **Cytokine Signaling in Immune System**: ELOC is involved in the regulation of cytokine signaling pathways, particularly in the context of the adaptive immune system. 4. **Transcriptional Regulation**: ELOC is involved in the regulation of transcriptional activity, particularly in the context of the HIV-1 life cycle, where it interacts with the viral protein Tat to facilitate transcriptional elongation. 5. **Cellular Responses to Stress**: ELOC is involved in the regulation of cellular responses to stress, particularly in the context of the adaptive immune system. **Clinical Significance** Dysregulation of ELOC has been implicated in various diseases, including: 1. **Cancer**: ELOC has been implicated in the regulation of cancer cell growth and survival, particularly in the context of the adaptive immune system. 2. **Infectious Diseases**: ELOC is involved in the regulation of the HIV-1 life cycle, and its dysregulation has been implicated in the progression of HIV-1 infection. 3. **Autoimmune Diseases**: ELOC is involved in the regulation of immune responses, particularly in the context of autoimmune diseases such as rheumatoid arthritis and lupus. 4. **Immunodeficiency Disorders**: ELOC is involved in the regulation of immune responses, particularly in the context of immunodeficiency disorders such as severe combined immunodeficiency (SCID). In conclusion, ELOC is a crucial component of the elongin complex, and its dysregulation has been implicated in various diseases, including cancer, infectious diseases, autoimmune diseases, and immunodeficiency disorders. Further research is needed to fully understand the role of ELOC in the regulation of gene expression and its implications in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Elongin-C

Genular Protein ID: 2007814074

Symbol: ELOC_HUMAN

Name: Elongin-C

UniProtKB Accession Codes:

Q15369 E5RGD9 Q567Q6

Database IDs:

Citations:

PubMed ID: 7821821

Title: A human cDNA encoding the small subunit of RNA polymerase II transcription factor SIII.

PubMed ID: 7821821

DOI: 10.1016/0378-1119(94)90467-7

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11006129

Title: Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity.

PubMed ID: 11006129

DOI: 10.1006/bbrc.2000.3451

PubMed ID: 12004003

Title: Amplification and overexpression of Elongin C gene discovered in prostate cancer by cDNA microarrays.

PubMed ID: 12004003

DOI: 10.1038/labinvest.3780457

PubMed ID: 15574592

Title: Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation.

PubMed ID: 15574592

DOI: 10.1101/gad.1249904

PubMed ID: 15467733

Title: TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3.

PubMed ID: 15467733

DOI: 10.1038/sj.onc.1208149

PubMed ID: 15590694

Title: Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling.

PubMed ID: 15590694

DOI: 10.1074/jbc.m408575200

PubMed ID: 17189197

Title: Structural basis for protein recognition by B30.2/SPRY domains.

PubMed ID: 17189197

DOI: 10.1016/j.molcel.2006.11.009

PubMed ID: 17304241

Title: The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components.

PubMed ID: 17304241

DOI: 10.1038/sj.embor.7400895

PubMed ID: 17251292

Title: Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase.

PubMed ID: 17251292

DOI: 10.1128/jvi.02303-06

PubMed ID: 19920177

Title: Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation.

PubMed ID: 19920177

DOI: 10.1073/pnas.0907052106

PubMed ID: 20532212

Title: The SOCS-box of HIV-1 Vif interacts with ElonginBC by induced-folding to recruit its Cul5-containing ubiquitin ligase complex.

PubMed ID: 20532212

DOI: 10.1371/journal.ppat.1000925

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21119685

Title: Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes.

PubMed ID: 21119685

DOI: 10.1038/cr.2010.165

PubMed ID: 21199876

Title: Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins.

PubMed ID: 21199876

DOI: 10.1074/jbc.m110.190678

PubMed ID: 21697472

Title: Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen reduces interleukin-8 expression in endothelial cells and impairs neutrophil chemotaxis by degrading nuclear p65.

PubMed ID: 21697472

DOI: 10.1128/jvi.00733-11

PubMed ID: 22190037

Title: Vif hijacks CBF-beta to degrade APOBEC3G and promote HIV-1 infection.

PubMed ID: 22190037

DOI: 10.1038/nature10693

PubMed ID: 22510880

Title: Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation.

PubMed ID: 22510880

DOI: 10.1038/emboj.2012.91

PubMed ID: 23102700

Title: The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5.

PubMed ID: 23102700

DOI: 10.1016/j.molcel.2012.09.018

PubMed ID: 24337577

Title: Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase.

PubMed ID: 24337577

DOI: 10.1074/jbc.m113.534602

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26041281

Title: Poxvirus protein MC132 from molluscum contagiosum virus inhibits NF-B activation by targeting p65 for degradation.

PubMed ID: 26041281

DOI: 10.1128/jvi.00799-15

PubMed ID: 21980433

Title: The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levels.

PubMed ID: 21980433

DOI: 10.1371/journal.pone.0025358

PubMed ID: 25505247

Title: Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2).

PubMed ID: 25505247

DOI: 10.1074/jbc.m114.616664

PubMed ID: 26138980

Title: SELENOPROTEINS. CRL2 aids elimination of truncated selenoproteins produced by failed UGA/Sec decoding.

PubMed ID: 26138980

DOI: 10.1126/science.aab0515

PubMed ID: 29779948

Title: The eukaryotic proteome is shaped by E3 ubiquitin ligases targeting C-terminal degrons.

PubMed ID: 29779948

DOI: 10.1016/j.cell.2018.04.028

PubMed ID: 30166453

Title: CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.

PubMed ID: 30166453

DOI: 10.15252/embj.201797508

PubMed ID: 29775578

Title: C-terminal end-directed protein elimination by CRL2 ubiquitin ligases.

PubMed ID: 29775578

DOI: 10.1016/j.molcel.2018.04.006

PubMed ID: 31387940

Title: BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress.

PubMed ID: 31387940

DOI: 10.1083/jcb.201901156

PubMed ID: 33268465

Title: The mechanism of NEDD8 activation of CUL5 Ubiquitin E3 ligases.

PubMed ID: 33268465

DOI: 10.1074/mcp.ra120.002414

PubMed ID: 35486881

Title: Human Protein-l-isoaspartate O-Methyltransferase Domain-Containing Protein 1 (PCMTD1) Associates with Cullin-RING Ligase Proteins.

PubMed ID: 35486881

DOI: 10.1021/acs.biochem.2c00130

PubMed ID: 10205047

Title: Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function.

PubMed ID: 10205047

DOI: 10.1126/science.284.5413.455

PubMed ID: 12050673

Title: Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.

PubMed ID: 12050673

DOI: 10.1038/nature00767

PubMed ID: 12004076

Title: Structure of an HIF-1alpha-pVHL complex: hydroxyproline recognition in signaling.

PubMed ID: 12004076

DOI: 10.1126/science.1073440

PubMed ID: 17997974

Title: Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation.

PubMed ID: 17997974

DOI: 10.1016/j.str.2007.09.016

PubMed ID: 18562529

Title: Structural insight into the human immunodeficiency virus Vif SOCS box and its role in human E3 ubiquitin ligase assembly.

PubMed ID: 18562529

DOI: 10.1128/jvi.00767-08

PubMed ID: 23837592

Title: Multimeric complexes among ankyrin-repeat and SOCS-box protein 9 (ASB9), ElonginBC, and Cullin 5: insights into the structure and assembly of ECS-type Cullin-RING E3 ubiquitin ligases.

PubMed ID: 23837592

DOI: 10.1021/bi400758h

PubMed ID: 24225024

Title: Insight into the HIV-1 Vif SOCS-box-ElonginBC interaction.

PubMed ID: 24225024

DOI: 10.1098/rsob.130100

PubMed ID: 24402281

Title: Structural basis for hijacking CBF-beta and CUL5 E3 ligase complex by HIV-1 Vif.

PubMed ID: 24402281

DOI: 10.1038/nature12884

PubMed ID: 31182716

Title: Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase.

PubMed ID: 31182716

DOI: 10.1038/s41467-019-10190-4

PubMed ID: 32513959

Title: Structure and dynamics of the ASB9 CUL-RING E3 ligase.

PubMed ID: 32513959

DOI: 10.1038/s41467-020-16499-9

PubMed ID: 34857742

Title: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands.

PubMed ID: 34857742

DOI: 10.1038/s41467-021-26983-5

PubMed ID: 34700328

Title: A conserved mechanism for regulating replisome disassembly in eukaryotes.

PubMed ID: 34700328

DOI: 10.1038/s41586-021-04145-3

PubMed ID: 36754086

Title: The structural basis for HIV-1 Vif antagonism of human APOBEC3G.

PubMed ID: 36754086

DOI: 10.1038/s41586-023-05779-1

PubMed ID: 37640699

Title: Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H.

PubMed ID: 37640699

DOI: 10.1038/s41467-023-40955-x

PubMed ID: 37816714

Title: Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2.

PubMed ID: 37816714

DOI: 10.1038/s41467-023-41894-3

PubMed ID: 38418882

Title: The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation.

PubMed ID: 38418882

DOI: 10.1038/s41586-024-07112-w

Sequence Information:

Length: 112
Mass: 12473
Checksum: 98D88696E883538B
Sequence:

MDGEEKTYGG CEGPDAMYVK LISSDGHEFI VKREHALTSG TIKAMLSGPG QFAENETNEV 
NFREIPSHVL SKVCMYFTYK VRYTNSSTEI PEFPIAPEIA LELLMAANFL DC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ELOC

Associated with

Cells (max top 100)

Other Information

A human cDNA encoding the small subunit of RNA polymerase II transcription factor SIII. PubMed ID: 7821821

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

DNA sequence and analysis of human chromosome 8. PubMed ID: 16421571

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity. PubMed ID: 11006129

Amplification and overexpression of Elongin C gene discovered in prostate cancer by cDNA microarrays. PubMed ID: 12004003

Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation. PubMed ID: 15574592

TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3. PubMed ID: 15467733

Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling. PubMed ID: 15590694

Structural basis for protein recognition by B30.2/SPRY domains. PubMed ID: 17189197

The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components. PubMed ID: 17304241

Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase. PubMed ID: 17251292

Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation. PubMed ID: 19920177

The SOCS-box of HIV-1 Vif interacts with ElonginBC by induced-folding to recruit its Cul5-containing ubiquitin ligase complex. PubMed ID: 20532212

Initial characterization of the human central proteome. PubMed ID: 21269460

Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes. PubMed ID: 21119685

Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins. PubMed ID: 21199876

Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen reduces interleukin-8 expression in endothelial cells and impairs neutrophil chemotaxis by degrading nuclear p65. PubMed ID: 21697472

Vif hijacks CBF-beta to degrade APOBEC3G and promote HIV-1 infection. PubMed ID: 22190037

Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation. PubMed ID: 22510880

The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5. PubMed ID: 23102700

Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. PubMed ID: 24337577

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Poxvirus protein MC132 from molluscum contagiosum virus inhibits NF-B activation by targeting p65 for degradation. PubMed ID: 26041281

The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levels. PubMed ID: 21980433

Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2). PubMed ID: 25505247

SELENOPROTEINS. CRL2 aids elimination of truncated selenoproteins produced by failed UGA/Sec decoding. PubMed ID: 26138980

The eukaryotic proteome is shaped by E3 ubiquitin ligases targeting C-terminal degrons. PubMed ID: 29779948

CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling. PubMed ID: 30166453

C-terminal end-directed protein elimination by CRL2 ubiquitin ligases. PubMed ID: 29775578

BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress. PubMed ID: 31387940

The mechanism of NEDD8 activation of CUL5 Ubiquitin E3 ligases. PubMed ID: 33268465

Human Protein-l-isoaspartate O-Methyltransferase Domain-Containing Protein 1 (PCMTD1) Associates with Cullin-RING Ligase Proteins. PubMed ID: 35486881

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function. PubMed ID: 10205047

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. PubMed ID: 12050673

Structure of an HIF-1alpha-pVHL complex: hydroxyproline recognition in signaling. PubMed ID: 12004076

Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation. PubMed ID: 17997974

Structural insight into the human immunodeficiency virus Vif SOCS box and its role in human E3 ubiquitin ligase assembly. PubMed ID: 18562529

Multimeric complexes among ankyrin-repeat and SOCS-box protein 9 (ASB9), ElonginBC, and Cullin 5: insights into the structure and assembly of ECS-type Cullin-RING E3 ubiquitin ligases. PubMed ID: 23837592

Insight into the HIV-1 Vif SOCS-box-ElonginBC interaction. PubMed ID: 24225024

Structural basis for hijacking CBF-beta and CUL5 E3 ligase complex by HIV-1 Vif. PubMed ID: 24402281

Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase. PubMed ID: 31182716

Structure and dynamics of the ASB9 CUL-RING E3 ligase. PubMed ID: 32513959

Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands. PubMed ID: 34857742

A conserved mechanism for regulating replisome disassembly in eukaryotes. PubMed ID: 34700328

The structural basis for HIV-1 Vif antagonism of human APOBEC3G. PubMed ID: 36754086

Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H. PubMed ID: 37640699

Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. PubMed ID: 37816714

The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation. PubMed ID: 38418882