Details for: DYNLT1

Gene ID: 6993

Symbol: DYNLT1

Ensembl ID: ENSG00000146425

Description: dynein light chain Tctex-type 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.29
    Marker Score: 28596
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.2
    Marker Score: 110785
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.71
    Marker Score: 21132
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.63
    Marker Score: 3066
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.63
    Marker Score: 2947
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.61
    Marker Score: 2054
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.59
    Marker Score: 4725
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.58
    Marker Score: 22274
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.56
    Marker Score: 4076
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.54
    Marker Score: 9808
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.52
    Marker Score: 8942
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.52
    Marker Score: 4174
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.51
    Marker Score: 8636
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.49
    Marker Score: 4740
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.49
    Marker Score: 4002.5
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.47
    Marker Score: 14656
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.45
    Marker Score: 5977
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.44
    Marker Score: 11705
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.41
    Marker Score: 1243
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.4
    Marker Score: 2902
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.39
    Marker Score: 15545
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.37
    Marker Score: 4462
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.34
    Marker Score: 12290
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.34
    Marker Score: 1108
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.33
    Marker Score: 4870
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.31
    Marker Score: 1576
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.3
    Marker Score: 14979
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.29
    Marker Score: 25814
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.28
    Marker Score: 16984
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.26
    Marker Score: 9741
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.25
    Marker Score: 29648
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.24
    Marker Score: 774
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.24
    Marker Score: 825
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.24
    Marker Score: 2092
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.2
    Marker Score: 1962.5
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.2
    Marker Score: 738
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.19
    Marker Score: 1170
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.19
    Marker Score: 5512
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.18
    Marker Score: 3132
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.15
    Marker Score: 21685.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.15
    Marker Score: 1436
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.15
    Marker Score: 708
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.14
    Marker Score: 3154
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.14
    Marker Score: 2048
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.13
    Marker Score: 2162
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.11
    Marker Score: 3254
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.11
    Marker Score: 5661.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.11
    Marker Score: 3583
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.1
    Marker Score: 4937.5
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.1
    Marker Score: 2218
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.1
    Marker Score: 3714
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.1
    Marker Score: 605
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.08
    Marker Score: 2246
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.08
    Marker Score: 6517
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.07
    Marker Score: 8145.5
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.07
    Marker Score: 13221
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.07
    Marker Score: 736
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.06
    Marker Score: 975
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 2.06
    Marker Score: 1065.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.05
    Marker Score: 1455
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.04
    Marker Score: 1213
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.04
    Marker Score: 5557.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.04
    Marker Score: 655
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.01
    Marker Score: 112246
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2
    Marker Score: 2162
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2
    Marker Score: 1253
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.99
    Marker Score: 2567
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.98
    Marker Score: 1027
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.98
    Marker Score: 1250
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.98
    Marker Score: 2380.5
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.93
    Marker Score: 720
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.93
    Marker Score: 965
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.92
    Marker Score: 1203
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.9
    Marker Score: 3711
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.9
    Marker Score: 2478
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.9
    Marker Score: 2930
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.9
    Marker Score: 4332
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.9
    Marker Score: 4502
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.87
    Marker Score: 1984
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.87
    Marker Score: 4236
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.86
    Marker Score: 1989
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.86
    Marker Score: 1749.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.86
    Marker Score: 47561
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.85
    Marker Score: 1548
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.84
    Marker Score: 698
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.84
    Marker Score: 1737
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.84
    Marker Score: 1551
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.84
    Marker Score: 414
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.84
    Marker Score: 1209
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.84
    Marker Score: 581.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.83
    Marker Score: 2584
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.82
    Marker Score: 1000
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.81
    Marker Score: 1807
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.8
    Marker Score: 2955
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.8
    Marker Score: 20933
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.8
    Marker Score: 429
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.78
    Marker Score: 2451
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.78
    Marker Score: 505
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.77
    Marker Score: 1836
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.74
    Marker Score: 431

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics:** DYNLT1 is a member of the dynein light chain family, which plays a pivotal role in the formation and function of the cytoplasmic dynein complex. This complex is responsible for microtubule-based movement and intracellular transport of proteins and vesicles. DYNLT1 is specifically expressed in various cell types, including ciliated columnar cells of the tracheobronchial tree, peripheral nervous system neurons, and epithelial cells of the esophagus and urethra. The gene is also highly expressed in immune cells, such as neutrophils and macrophages, where it contributes to the regulation of immune responses. **Pathways and Functions:** DYNLT1 is involved in several key pathways, including: 1. **Cell Division:** DYNLT1 plays a critical role in the establishment of mitotic spindle orientation, ensuring proper chromosome segregation and cell division. 2. **Intracellular Transport:** The dynein complex, which contains DYNLT1, is responsible for the transport of proteins and vesicles along microtubules, facilitating the movement of cellular components within the cell. 3. **Immune Response:** DYNLT1 is essential for the regulation of immune responses, including neutrophil degranulation and the intracellular transport of viral proteins. 4. **Neuronal Development:** DYNLT1 is involved in the regulation of neuronal development, particularly in the establishment of mitotic spindle orientation and the transport of proteins within neurons. **Clinical Significance:** DYNLT1 has significant implications in various diseases, including: 1. **Neurological Disorders:** Dysregulation of DYNLT1 has been implicated in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Immune-Related Disorders:** Abnormal expression of DYNLT1 has been linked to immune-related disorders, including autoimmune diseases and cancer. 3. **Cancer:** DYNLT1 has been identified as a potential therapeutic target in cancer treatment, as its dysregulation can contribute to tumorigenesis and metastasis. In conclusion, DYNLT1 is a critical gene that plays a vital role in maintaining immune homeostasis, neuronal development, and intracellular transport. Its dysregulation has significant implications in various diseases, highlighting the need for further research into the molecular mechanisms underlying DYNLT1 function and its potential therapeutic applications.

Genular Protein ID: 3234002704

Symbol: DYLT1_HUMAN

Name: Dynein light chain Tctex-type 1

UniProtKB Accession Codes:

P63172 Q15763 Q5VTU4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 1 EPD 1 Ensembl 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8646886

Title: Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q.

PubMed ID: 8646886

DOI: 10.1159/000134329

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11751937

Title: Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis.

PubMed ID: 11751937

DOI: 10.1074/jbc.m111937200

PubMed ID: 14583445

Title: Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension.

PubMed ID: 14583445

DOI: 10.1093/hmg/ddg365

PubMed ID: 15194795

Title: Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome.

PubMed ID: 15194795

DOI: 10.1128/jvi.78.13.7186-7198.2004

PubMed ID: 16880273

Title: Supervillin modulation of focal adhesions involving TRIP6/ZRP-1.

PubMed ID: 16880273

DOI: 10.1083/jcb.200512051

PubMed ID: 17965411

Title: Interaction of the DYNLT (TCTEX1/RP3) light chains and the intermediate chains reveals novel intersubunit regulation during assembly of the dynein complex.

PubMed ID: 17965411

DOI: 10.1074/jbc.m705991200

PubMed ID: 18647839

Title: D-retrovirus morphogenetic switch driven by the targeting signal accessibility to Tctex-1 of dynein.

PubMed ID: 18647839

DOI: 10.1073/pnas.0801765105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21166973

Title: Identification of the dynein light chains required for human papillomavirus infection.

PubMed ID: 21166973

DOI: 10.1111/j.1462-5822.2010.01515.x

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27502274

Title: Molecular basis for the protein recognition specificity of the dynein light chain DYNLT1/Tctex1: characterization of the interaction with activin receptor IIB.

PubMed ID: 27502274

DOI: 10.1074/jbc.m116.736884

Sequence Information:

  • Length: 113
  • Mass: 12452
  • Checksum: A6BAD1D0744D1AA6
  • Sequence:
    • MEDYQAAEET AFVVDEVSNI VKEAIESAIG GNAYQHSKVN QWTTNVVEQT LSQLTKLGKP 
FKYIVTCVIM QKNGAGLHTA SSCFWDSSTD GSCTVRWENK TMYCIVSAFG LSI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.