Details for: DYNLT1

Gene ID: 6993

Symbol: DYNLT1

Ensembl ID: ENSG00000146425

Description: dynein light chain Tctex-type 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 452.0229
    Cell Significance Index: -70.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 254.8854
    Cell Significance Index: -64.6500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 184.0768
    Cell Significance Index: -75.8300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 159.2171
    Cell Significance Index: -75.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 154.9019
    Cell Significance Index: -62.9300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 136.4541
    Cell Significance Index: -70.1900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 112.7236
    Cell Significance Index: -75.6400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 66.9866
    Cell Significance Index: -63.9600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 61.5188
    Cell Significance Index: -75.8500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.8634
    Cell Significance Index: -55.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.5436
    Cell Significance Index: -77.1200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.6185
    Cell Significance Index: -44.9000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.5946
    Cell Significance Index: -18.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.0198
    Cell Significance Index: 2195.3200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.5933
    Cell Significance Index: 28.6900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.0280
    Cell Significance Index: 18.6400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.9310
    Cell Significance Index: 77.0700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.9260
    Cell Significance Index: 26.9500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.7154
    Cell Significance Index: 62.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.6202
    Cell Significance Index: 195.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.4561
    Cell Significance Index: 115.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.4557
    Cell Significance Index: 442.6800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.3845
    Cell Significance Index: 82.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.3558
    Cell Significance Index: 109.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.1647
    Cell Significance Index: 266.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9574
    Cell Significance Index: 53.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.9119
    Cell Significance Index: 262.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.8836
    Cell Significance Index: 243.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.7574
    Cell Significance Index: 91.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.7294
    Cell Significance Index: 36.2000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.4111
    Cell Significance Index: 26.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1363
    Cell Significance Index: 502.3900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1230
    Cell Significance Index: 79.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1228
    Cell Significance Index: 58.4900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.1014
    Cell Significance Index: 14.1100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9780
    Cell Significance Index: 11.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9697
    Cell Significance Index: 124.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7298
    Cell Significance Index: 72.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6925
    Cell Significance Index: 44.6800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6738
    Cell Significance Index: 7.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5930
    Cell Significance Index: 15.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4776
    Cell Significance Index: 95.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4655
    Cell Significance Index: 21.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3368
    Cell Significance Index: 66.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3176
    Cell Significance Index: 60.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1948
    Cell Significance Index: 147.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1875
    Cell Significance Index: 67.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1748
    Cell Significance Index: 4.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1014
    Cell Significance Index: 17.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0997
    Cell Significance Index: 6.1300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0814
    Cell Significance Index: 2.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0685
    Cell Significance Index: 50.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0642
    Cell Significance Index: 1.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0596
    Cell Significance Index: 1.9100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0030
    Cell Significance Index: -5.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0044
    Cell Significance Index: -3.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0205
    Cell Significance Index: -1.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0207
    Cell Significance Index: -31.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0222
    Cell Significance Index: -41.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0443
    Cell Significance Index: -27.6800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0475
    Cell Significance Index: -64.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0479
    Cell Significance Index: -4.8900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0499
    Cell Significance Index: -5.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0628
    Cell Significance Index: -39.9100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0856
    Cell Significance Index: -1.3000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0892
    Cell Significance Index: -14.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0939
    Cell Significance Index: -52.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1412
    Cell Significance Index: -64.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1465
    Cell Significance Index: -30.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1695
    Cell Significance Index: -9.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2077
    Cell Significance Index: -22.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2151
    Cell Significance Index: -61.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2681
    Cell Significance Index: -30.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2840
    Cell Significance Index: -8.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3281
    Cell Significance Index: -38.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3374
    Cell Significance Index: -49.0400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3383
    Cell Significance Index: -38.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3387
    Cell Significance Index: -9.0600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3437
    Cell Significance Index: -5.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4354
    Cell Significance Index: -27.4500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4420
    Cell Significance Index: -35.0100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5929
    Cell Significance Index: -8.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7249
    Cell Significance Index: -75.4800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7878
    Cell Significance Index: -11.6300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.8077
    Cell Significance Index: -48.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8435
    Cell Significance Index: -56.7200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8794
    Cell Significance Index: -15.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9780
    Cell Significance Index: -25.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.0401
    Cell Significance Index: -26.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.1417
    Cell Significance Index: -32.9000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.1862
    Cell Significance Index: -34.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2086
    Cell Significance Index: -74.1000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.2929
    Cell Significance Index: -10.8600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.3148
    Cell Significance Index: -23.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.3169
    Cell Significance Index: -69.1400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -1.4126
    Cell Significance Index: -9.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.4304
    Cell Significance Index: -63.2700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.4319
    Cell Significance Index: -20.0700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.4830
    Cell Significance Index: -8.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.4974
    Cell Significance Index: -32.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DYNLT1 is a member of the dynein light chain family, which plays a pivotal role in the formation and function of the cytoplasmic dynein complex. This complex is responsible for microtubule-based movement and intracellular transport of proteins and vesicles. DYNLT1 is specifically expressed in various cell types, including ciliated columnar cells of the tracheobronchial tree, peripheral nervous system neurons, and epithelial cells of the esophagus and urethra. The gene is also highly expressed in immune cells, such as neutrophils and macrophages, where it contributes to the regulation of immune responses. **Pathways and Functions:** DYNLT1 is involved in several key pathways, including: 1. **Cell Division:** DYNLT1 plays a critical role in the establishment of mitotic spindle orientation, ensuring proper chromosome segregation and cell division. 2. **Intracellular Transport:** The dynein complex, which contains DYNLT1, is responsible for the transport of proteins and vesicles along microtubules, facilitating the movement of cellular components within the cell. 3. **Immune Response:** DYNLT1 is essential for the regulation of immune responses, including neutrophil degranulation and the intracellular transport of viral proteins. 4. **Neuronal Development:** DYNLT1 is involved in the regulation of neuronal development, particularly in the establishment of mitotic spindle orientation and the transport of proteins within neurons. **Clinical Significance:** DYNLT1 has significant implications in various diseases, including: 1. **Neurological Disorders:** Dysregulation of DYNLT1 has been implicated in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Immune-Related Disorders:** Abnormal expression of DYNLT1 has been linked to immune-related disorders, including autoimmune diseases and cancer. 3. **Cancer:** DYNLT1 has been identified as a potential therapeutic target in cancer treatment, as its dysregulation can contribute to tumorigenesis and metastasis. In conclusion, DYNLT1 is a critical gene that plays a vital role in maintaining immune homeostasis, neuronal development, and intracellular transport. Its dysregulation has significant implications in various diseases, highlighting the need for further research into the molecular mechanisms underlying DYNLT1 function and its potential therapeutic applications.

Genular Protein ID: 3234002704

Symbol: DYLT1_HUMAN

Name: Dynein light chain Tctex-type 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8646886

Title: Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q.

PubMed ID: 8646886

DOI: 10.1159/000134329

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11751937

Title: Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis.

PubMed ID: 11751937

DOI: 10.1074/jbc.m111937200

PubMed ID: 14583445

Title: Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension.

PubMed ID: 14583445

DOI: 10.1093/hmg/ddg365

PubMed ID: 15194795

Title: Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome.

PubMed ID: 15194795

DOI: 10.1128/jvi.78.13.7186-7198.2004

PubMed ID: 16880273

Title: Supervillin modulation of focal adhesions involving TRIP6/ZRP-1.

PubMed ID: 16880273

DOI: 10.1083/jcb.200512051

PubMed ID: 17965411

Title: Interaction of the DYNLT (TCTEX1/RP3) light chains and the intermediate chains reveals novel intersubunit regulation during assembly of the dynein complex.

PubMed ID: 17965411

DOI: 10.1074/jbc.m705991200

PubMed ID: 18647839

Title: D-retrovirus morphogenetic switch driven by the targeting signal accessibility to Tctex-1 of dynein.

PubMed ID: 18647839

DOI: 10.1073/pnas.0801765105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21166973

Title: Identification of the dynein light chains required for human papillomavirus infection.

PubMed ID: 21166973

DOI: 10.1111/j.1462-5822.2010.01515.x

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27502274

Title: Molecular basis for the protein recognition specificity of the dynein light chain DYNLT1/Tctex1: characterization of the interaction with activin receptor IIB.

PubMed ID: 27502274

DOI: 10.1074/jbc.m116.736884

Sequence Information:

  • Length: 113
  • Mass: 12452
  • Checksum: A6BAD1D0744D1AA6
  • Sequence:
  • MEDYQAAEET AFVVDEVSNI VKEAIESAIG GNAYQHSKVN QWTTNVVEQT LSQLTKLGKP 
    FKYIVTCVIM QKNGAGLHTA SSCFWDSSTD GSCTVRWENK TMYCIVSAFG LSI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.