Details for: DYNLT1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 452.0229
Cell Significance Index: -70.3100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 254.8854
Cell Significance Index: -64.6500 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 184.0768
Cell Significance Index: -75.8300 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 159.2171
Cell Significance Index: -75.1700 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 154.9019
Cell Significance Index: -62.9300 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 136.4541
Cell Significance Index: -70.1900 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 112.7236
Cell Significance Index: -75.6400 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 66.9866
Cell Significance Index: -63.9600 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 61.5188
Cell Significance Index: -75.8500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 20.8634
Cell Significance Index: -55.8900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 19.5436
Cell Significance Index: -77.1200 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 14.6185
Cell Significance Index: -44.9000 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.5946
Cell Significance Index: -18.8100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 4.0198
Cell Significance Index: 2195.3200 - Cell Name: kidney cell (CL1000497)
Fold Change: 3.5933
Cell Significance Index: 28.6900 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 3.0280
Cell Significance Index: 18.6400 - Cell Name: granulosa cell (CL0000501)
Fold Change: 2.9310
Cell Significance Index: 77.0700 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.9260
Cell Significance Index: 26.9500 - Cell Name: peg cell (CL4033014)
Fold Change: 2.7154
Cell Significance Index: 62.7400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.6202
Cell Significance Index: 195.2800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 2.4561
Cell Significance Index: 115.4400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.4557
Cell Significance Index: 442.6800 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 2.3845
Cell Significance Index: 82.8600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.3558
Cell Significance Index: 109.8400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.1647
Cell Significance Index: 266.1700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.9574
Cell Significance Index: 53.2800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.9119
Cell Significance Index: 262.5600 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.8836
Cell Significance Index: 243.3500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.7574
Cell Significance Index: 91.2900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.7294
Cell Significance Index: 36.2000 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.4111
Cell Significance Index: 26.0800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.1363
Cell Significance Index: 502.3900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.1230
Cell Significance Index: 79.4200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.1228
Cell Significance Index: 58.4900 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.1014
Cell Significance Index: 14.1100 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.9780
Cell Significance Index: 11.1100 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.9697
Cell Significance Index: 124.3100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7298
Cell Significance Index: 72.1900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.6925
Cell Significance Index: 44.6800 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.6738
Cell Significance Index: 7.3300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.5930
Cell Significance Index: 15.8400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4776
Cell Significance Index: 95.8000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4655
Cell Significance Index: 21.1000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3368
Cell Significance Index: 66.8400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3176
Cell Significance Index: 60.4500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.1948
Cell Significance Index: 147.4700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1875
Cell Significance Index: 67.2400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1748
Cell Significance Index: 4.8900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1014
Cell Significance Index: 17.3200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0997
Cell Significance Index: 6.1300 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.0814
Cell Significance Index: 2.3900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0685
Cell Significance Index: 50.2100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0642
Cell Significance Index: 1.0800 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0596
Cell Significance Index: 1.9100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0030
Cell Significance Index: -5.6100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0044
Cell Significance Index: -3.2300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0205
Cell Significance Index: -1.5800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0207
Cell Significance Index: -31.8700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0222
Cell Significance Index: -41.0100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0443
Cell Significance Index: -27.6800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0475
Cell Significance Index: -64.5300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0479
Cell Significance Index: -4.8900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0499
Cell Significance Index: -5.8900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0628
Cell Significance Index: -39.9100 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.0856
Cell Significance Index: -1.3000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0892
Cell Significance Index: -14.5100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0939
Cell Significance Index: -52.9300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1412
Cell Significance Index: -64.1000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1465
Cell Significance Index: -30.8600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1695
Cell Significance Index: -9.5100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.2077
Cell Significance Index: -22.5900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2151
Cell Significance Index: -61.8900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2681
Cell Significance Index: -30.7200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2840
Cell Significance Index: -8.1400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3281
Cell Significance Index: -38.2400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3374
Cell Significance Index: -49.0400 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3383
Cell Significance Index: -38.6200 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3387
Cell Significance Index: -9.0600 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.3437
Cell Significance Index: -5.1500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4354
Cell Significance Index: -27.4500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4420
Cell Significance Index: -35.0100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.5929
Cell Significance Index: -8.0900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.7249
Cell Significance Index: -75.4800 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.7878
Cell Significance Index: -11.6300 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.8077
Cell Significance Index: -48.4900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.8435
Cell Significance Index: -56.7200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.8794
Cell Significance Index: -15.0700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.9780
Cell Significance Index: -25.1400 - Cell Name: pro-T cell (CL0000827)
Fold Change: -1.0401
Cell Significance Index: -26.5700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -1.1417
Cell Significance Index: -32.9000 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.1862
Cell Significance Index: -34.9400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.2086
Cell Significance Index: -74.1000 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -1.2929
Cell Significance Index: -10.8600 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -1.3148
Cell Significance Index: -23.2400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.3169
Cell Significance Index: -69.1400 - Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: -1.4126
Cell Significance Index: -9.1900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.4304
Cell Significance Index: -63.2700 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -1.4319
Cell Significance Index: -20.0700 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -1.4830
Cell Significance Index: -8.9600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.4974
Cell Significance Index: -32.4400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3234002704
Symbol: DYLT1_HUMAN
Name: Dynein light chain Tctex-type 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8646886
Title: Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q.
PubMed ID: 8646886
DOI: 10.1159/000134329
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11751937
Title: Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis.
PubMed ID: 11751937
PubMed ID: 14583445
Title: Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension.
PubMed ID: 14583445
DOI: 10.1093/hmg/ddg365
PubMed ID: 15194795
Title: Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome.
PubMed ID: 15194795
PubMed ID: 16880273
Title: Supervillin modulation of focal adhesions involving TRIP6/ZRP-1.
PubMed ID: 16880273
PubMed ID: 17965411
Title: Interaction of the DYNLT (TCTEX1/RP3) light chains and the intermediate chains reveals novel intersubunit regulation during assembly of the dynein complex.
PubMed ID: 17965411
PubMed ID: 18647839
Title: D-retrovirus morphogenetic switch driven by the targeting signal accessibility to Tctex-1 of dynein.
PubMed ID: 18647839
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21166973
Title: Identification of the dynein light chains required for human papillomavirus infection.
PubMed ID: 21166973
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27502274
Title: Molecular basis for the protein recognition specificity of the dynein light chain DYNLT1/Tctex1: characterization of the interaction with activin receptor IIB.
PubMed ID: 27502274
Sequence Information:
- Length: 113
- Mass: 12452
- Checksum: A6BAD1D0744D1AA6
- Sequence:
MEDYQAAEET AFVVDEVSNI VKEAIESAIG GNAYQHSKVN QWTTNVVEQT LSQLTKLGKP FKYIVTCVIM QKNGAGLHTA SSCFWDSSTD GSCTVRWENK TMYCIVSAFG LSI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.