Details for: TNFRSF1A

Gene ID: 7132

Symbol: TNFRSF1A

Ensembl ID: ENSG00000067182

Description: TNF receptor superfamily member 1A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.05
    Marker Score: 4419
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3
    Marker Score: 7633
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.24
    Marker Score: 9664
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.11
    Marker Score: 1814
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.03
    Marker Score: 2171
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.03
    Marker Score: 2954
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.03
    Marker Score: 1117
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2
    Marker Score: 3993
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.95
    Marker Score: 6128
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.92
    Marker Score: 65374
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.92
    Marker Score: 5022
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.9
    Marker Score: 2289
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.89
    Marker Score: 16566
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.87
    Marker Score: 666
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.86
    Marker Score: 527
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.85
    Marker Score: 4596
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.8
    Marker Score: 8632
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.79
    Marker Score: 3036.5
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.79
    Marker Score: 8797
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.79
    Marker Score: 100024
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.74
    Marker Score: 1995.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.72
    Marker Score: 4203
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.71
    Marker Score: 548
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.7
    Marker Score: 413
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.7
    Marker Score: 989
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.7
    Marker Score: 1336
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.69
    Marker Score: 1819
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.68
    Marker Score: 1685
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.68
    Marker Score: 1520
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.68
    Marker Score: 6459
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.65
    Marker Score: 1733
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.63
    Marker Score: 2013
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.63
    Marker Score: 2885
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.62
    Marker Score: 18270
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.61
    Marker Score: 342
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.59
    Marker Score: 908
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.55
    Marker Score: 2921
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.55
    Marker Score: 815
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.54
    Marker Score: 873
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.53
    Marker Score: 24529
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.52
    Marker Score: 350
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.52
    Marker Score: 590
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.51
    Marker Score: 2222
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.5
    Marker Score: 1415
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.49
    Marker Score: 1923
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.48
    Marker Score: 1432
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.47
    Marker Score: 2269.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.46
    Marker Score: 2848
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.46
    Marker Score: 2395
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.45
    Marker Score: 1303
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.42
    Marker Score: 2255
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.41
    Marker Score: 1932
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.41
    Marker Score: 316
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.4
    Marker Score: 9125
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.37
    Marker Score: 330
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.36
    Marker Score: 11737
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.36
    Marker Score: 34768
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.35
    Marker Score: 981
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.35
    Marker Score: 5529
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.34
    Marker Score: 10011
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.34
    Marker Score: 2149
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.33
    Marker Score: 17608
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.33
    Marker Score: 1554
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.32
    Marker Score: 2027
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.3
    Marker Score: 302
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.29
    Marker Score: 538
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.29
    Marker Score: 1296
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.28
    Marker Score: 5046
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.27
    Marker Score: 1534
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.26
    Marker Score: 2299
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.26
    Marker Score: 1451
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.26
    Marker Score: 9809
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.25
    Marker Score: 512
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.25
    Marker Score: 670
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.24
    Marker Score: 726
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.24
    Marker Score: 420
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.23
    Marker Score: 384
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.22
    Marker Score: 302
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.22
    Marker Score: 294
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.22
    Marker Score: 4325
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.22
    Marker Score: 1426
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.22
    Marker Score: 2867
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.21
    Marker Score: 14066
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.2
    Marker Score: 799
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.2
    Marker Score: 7827
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.18
    Marker Score: 474
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.18
    Marker Score: 573
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.18
    Marker Score: 704
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.17
    Marker Score: 7494
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.15
    Marker Score: 760
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.15
    Marker Score: 1100
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.15
    Marker Score: 325
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.15
    Marker Score: 783.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.15
    Marker Score: 2093
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.14
    Marker Score: 4748
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.14
    Marker Score: 1182
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.13
    Marker Score: 1040
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.13
    Marker Score: 39158.5
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.13
    Marker Score: 769
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.13
    Marker Score: 2559

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Other Information

**Key Characteristics** 1. **Structure**: The TNFR1 is a type II transmembrane receptor, consisting of an extracellular ligand-binding domain, a transmembrane domain, and an intracellular death domain (DD). 2. **Expression**: The TNFR1 is widely expressed in various tissues, including endothelial cells, immune cells, and epithelial cells. 3. **Function**: The TNFR1 mediates the biological activities of TNF-α, including inflammation, apoptosis, and cell proliferation. 4. **Signaling pathways**: The TNFR1 activates several signaling pathways, including the NF-κB pathway, JNK pathway, and AP-1 pathway. **Pathways and Functions** 1. **Inflammatory response**: The TNFR1 plays a key role in mediating the inflammatory response by activating the NF-κB pathway, which regulates the expression of pro-inflammatory genes. 2. **Apoptosis**: The TNFR1 can induce apoptosis in certain cell types by activating the extrinsic apoptotic signaling pathway via the death domain. 3. **Cell proliferation**: The TNFR1 can regulate cell proliferation by modulating the expression of genes involved in cell cycle progression. 4. **Immune system**: The TNFR1 is essential for the proper functioning of the immune system, including the regulation of immune cell activation and differentiation. 5. **Cardiac function**: The TNFR1 has been implicated in the regulation of cardiac hypertrophy and fibrosis, highlighting its importance in cardiovascular health. **Clinical Significance** 1. **Inflammatory disorders**: The TNFR1 has been implicated in various inflammatory disorders, including rheumatoid arthritis, psoriasis, and multiple sclerosis. 2. **Cancer**: The TNFR1 is overexpressed in certain types of cancer, including lung, breast, and colon cancer, and is associated with tumor progression and metastasis. 3. **Cardiovascular disease**: The TNFR1 has been implicated in the regulation of cardiac hypertrophy and fibrosis, highlighting its importance in cardiovascular health. 4. **Neurological disorders**: The TNFR1 has been implicated in the regulation of neuroinflammation and neurodegenerative diseases, including Alzheimer's and Parkinson's disease. 5. **Therapeutic applications**: The TNFR1 has been targeted by various therapeutic agents, including monoclonal antibodies and small molecule inhibitors, which have shown promise in treating inflammatory and cancer disorders. In conclusion, the TNFRSF1A gene encodes for the TNFR1, a crucial component of the innate immune system that mediates the biological activities of TNF-α. The TNFR1 plays a pivotal role in regulating various cellular processes, including inflammation, apoptosis, and cell proliferation, and has significant clinical implications in various diseases, including inflammatory disorders, cancer, and cardiovascular disease.

Genular Protein ID: 837960306

Symbol: TNR1A_HUMAN

Name: Tumor necrosis factor receptor superfamily member 1A

UniProtKB Accession Codes:

P19438 A8K4X3 B2RDE4 B3KPQ1 B4DQB7 B4E309 B5M0B5 D3DUR1 Q9UCA4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 19 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 33 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 9 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 7 RefSeq 3 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2158862

Title: Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor.

PubMed ID: 2158862

DOI: 10.1016/0092-8674(90)90815-v

PubMed ID: 2158863

Title: Molecular cloning and expression of a receptor for human tumor necrosis factor.

PubMed ID: 2158863

DOI: 10.1016/0092-8674(90)90816-w

PubMed ID: 1702293

Title: Molecular cloning and expression of human and rat tumor necrosis factor receptor chain (p60) and its soluble derivative, tumor necrosis factor-binding protein.

PubMed ID: 1702293

DOI: 10.1089/dna.1990.9.705

PubMed ID: 1698610

Title: Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor.

PubMed ID: 1698610

DOI: 10.1002/j.1460-2075.1990.tb07526.x

PubMed ID: 2170974

Title: Cloning of human tumor necrosis factor (TNF) receptor cDNA and expression of recombinant soluble TNF-binding protein.

PubMed ID: 2170974

DOI: 10.1073/pnas.87.19.7380

PubMed ID: 1315717

Title: Structure of the human TNF receptor 1 (p60) gene (TNFR1) and localization to chromosome 12p13.

PubMed ID: 1315717

DOI: 10.1016/0888-7543(92)90226-i

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19906316

Title: Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site.

PubMed ID: 19906316

DOI: 10.1186/1471-2164-10-518

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8015639

Title: Purification of two types of TNF inhibitors in the urine of the patient with chronic glomerulonephritis.

PubMed ID: 8015639

DOI: 10.1159/000187851

PubMed ID: 2153136

Title: Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors.

PubMed ID: 2153136

DOI: 10.1016/s0021-9258(19)40049-5

PubMed ID: 9115275

Title: MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase.

PubMed ID: 9115275

DOI: 10.1074/jbc.272.18.12069

PubMed ID: 9557650

Title: Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis.

PubMed ID: 9557650

DOI: 10.1128/jvi.72.5.3691-3697.1998

PubMed ID: 10356400

Title: The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.

PubMed ID: 10356400

DOI: 10.1093/emboj/18.11.3044

PubMed ID: 10542291

Title: F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis.

PubMed ID: 10542291

DOI: 10.1074/jbc.274.45.32461

PubMed ID: 10359574

Title: Identification of Grb2 as a novel binding partner of tumor necrosis factor (TNF) receptor I.

PubMed ID: 10359574

DOI: 10.1084/jem.189.11.1707

PubMed ID: 9915703

Title: Prevention of constitutive TNF receptor 1 signaling by silencer of death domains.

PubMed ID: 9915703

DOI: 10.1126/science.283.5401.543

PubMed ID: 15465831

Title: A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway.

PubMed ID: 15465831

DOI: 10.1074/jbc.m408678200

PubMed ID: 15247912

Title: Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1.

PubMed ID: 15247912

DOI: 10.1038/nm1079

PubMed ID: 16709567

Title: Staphylococcus aureus protein A activates TNFR1 signaling through conserved IgG binding domains.

PubMed ID: 16709567

DOI: 10.1074/jbc.m601956200

PubMed ID: 21976655

Title: The cytomegaloviral protein pUL138 acts as potentiator of tumor necrosis factor (TNF) receptor 1 surface density to enhance ULb'-encoded modulation of TNF-alpha signaling.

PubMed ID: 21976655

DOI: 10.1128/jvi.06005-11

PubMed ID: 22801493

Title: TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis.

PubMed ID: 22801493

DOI: 10.1038/nature11307

PubMed ID: 23955153

Title: Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains.

PubMed ID: 23955153

DOI: 10.1038/nature12436

PubMed ID: 24130170

Title: SH3RF2 functions as an oncogene by mediating PAK4 protein stability.

PubMed ID: 24130170

DOI: 10.1093/carcin/bgt338

PubMed ID: 26183779

Title: Tag7 (PGLYRP1) in Complex with Hsp70 Induces Alternative Cytotoxic Processes in Tumor Cells via TNFR1 Receptor.

PubMed ID: 26183779

DOI: 10.1074/jbc.m115.639732

PubMed ID: 28659487

Title: Mumps virus SH protein inhibits NF-kappaB activation by interacting with tumor necrosis factor receptor 1, interleukin-1 receptor 1, and Toll-like receptor 3 complexes.

PubMed ID: 28659487

DOI: 10.1128/jvi.01037-17

PubMed ID: 30979585

Title: Structural and functional insights into host death domains inactivation by the bacterial arginine GlcNAcyltransferase effector.

PubMed ID: 30979585

DOI: 10.1016/j.molcel.2019.03.028

PubMed ID: 32766249

Title: Arg-GlcNAcylation on TRADD by NleB and SseK1 is crucial for bacterial pathogenesis.

PubMed ID: 32766249

DOI: 10.3389/fcell.2020.00641

PubMed ID: 8387891

Title: Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.

PubMed ID: 8387891

DOI: 10.1016/0092-8674(93)90132-a

PubMed ID: 8939750

Title: Structures of the extracellular domain of the type I tumor necrosis factor receptor.

PubMed ID: 8939750

DOI: 10.1016/s0969-2126(96)00134-7

PubMed ID: 10199409

Title: Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes.

PubMed ID: 10199409

DOI: 10.1016/s0092-8674(00)80721-7

PubMed ID: 10902757

Title: A novel missense mutation (C30S) in the gene encoding tumor necrosis factor receptor 1 linked to autosomal-dominant recurrent fever with localized myositis in a French family.

PubMed ID: 10902757

DOI: 10.1002/1529-0131(200007)43:7<1535::aid-anr18>3.0.co;2-c

PubMed ID: 11443543

Title: The tumor-necrosis-factor receptor-associated periodic syndrome: new mutations in TNFRSF1A, ancestral origins, genotype-phenotype studies, and evidence for further genetic heterogeneity of periodic fevers.

PubMed ID: 11443543

DOI: 10.1086/321976

PubMed ID: 13130484

Title: Heterogeneity among patients with tumor necrosis factor receptor-associated periodic syndrome phenotypes.

PubMed ID: 13130484

DOI: 10.1002/art.11215

PubMed ID: 14610673

Title: Tumour necrosis factor receptor-associated periodic syndrome with a novel mutation in the TNFRSF1A gene in a Japanese family.

PubMed ID: 14610673

DOI: 10.1007/s00431-003-1338-0

Sequence Information:

  • Length: 455
  • Mass: 50495
  • Checksum: 4CEFBA96D03B8225
  • Sequence:
    • MGLSTVPDLL LPLVLLELLV GIYPSGVIGL VPHLGDREKR DSVCPQGKYI HPQNNSICCT 
KCHKGTYLYN DCPGPGQDTD CRECESGSFT ASENHLRHCL SCSKCRKEMG QVEISSCTVD 
RDTVCGCRKN QYRHYWSENL FQCFNCSLCL NGTVHLSCQE KQNTVCTCHA GFFLRENECV 
SCSNCKKSLE CTKLCLPQIE NVKGTEDSGT TVLLPLVIFF GLCLLSLLFI GLMYRYQRWK 
SKLYSIVCGK STPEKEGELE GTTTKPLAPN PSFSPTPGFT PTLGFSPVPS STFTSSSTYT 
PGDCPNFAAP RREVAPPYQG ADPILATALA SDPIPNPLQK WEDSAHKPQS LDTDDPATLY 
AVVENVPPLR WKEFVRRLGL SDHEIDRLEL QNGRCLREAQ YSMLATWRRR TPRREATLEL 
LGRVLRDMDL LGCLEDIEEA LCGPAALPPA PSLLR

Genular Protein ID: 4082423854

Symbol: J9PH39_HUMAN

Name: N/A

UniProtKB Accession Codes:

J9PH39

Database IDs:

ARBA 15 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 5 Gene3D 2 GenomeRNAi 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 Pfam 2 RefSeq 1 SAM 2 SMART 2 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 347
  • Mass: 38651
  • Checksum: 8C629DAF8D7BA515
  • Sequence:
    • MGQVEISSCT VDRDTVCGCR KNQYRHYWSE NLFQCFNCSL CLNGTVHLSC QEKQNTVCTC 
HAGFFLRENE CVSCSNCKKS LECTKLCLPQ IENVKGTEDS GTTVLLPLVI FFGLCLLSLL 
FIGLMYRYQR WKSKLYSIVC GKSTPEKEGE LEGTTTKPLA PNPSFSPTPG FTPTLGFSPV 
PSSTFTSSST YTPGDCPNFA APRREVAPPY QGADPILATA LASDPIPNPL QKWEDSAHKP 
QSLDTDDPAT LYAVVENVPP LRWKEFVRRL GLSDHEIDRL ELQNGRCLRE AQYSMLATWR 
RRTPRREATL ELLGRVLRDM DLLGCLEDIE EALCGPAALP PAPSLLR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.