Details for: TNFRSF1A

Gene ID: 7132

Symbol: TNFRSF1A

Ensembl ID: ENSG00000067182

Description: TNF receptor superfamily member 1A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 244.4305
    Cell Significance Index: -38.0200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 103.8072
    Cell Significance Index: -26.3300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 86.2385
    Cell Significance Index: -35.0400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 82.1609
    Cell Significance Index: -38.7900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 75.7215
    Cell Significance Index: -38.9500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 58.3885
    Cell Significance Index: -39.1800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 36.7429
    Cell Significance Index: -35.0800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.4123
    Cell Significance Index: -38.7300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.7905
    Cell Significance Index: -31.5900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.0925
    Cell Significance Index: -34.0700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.9608
    Cell Significance Index: -21.8000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.6869
    Cell Significance Index: -38.2300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 6.4335
    Cell Significance Index: 106.0200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.6763
    Cell Significance Index: 64.9700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 3.6620
    Cell Significance Index: 30.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.7947
    Cell Significance Index: 76.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.2450
    Cell Significance Index: 2027.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.2429
    Cell Significance Index: 116.8300
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.0415
    Cell Significance Index: 12.6300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.8837
    Cell Significance Index: 21.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6353
    Cell Significance Index: 224.5700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.5739
    Cell Significance Index: 29.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.5143
    Cell Significance Index: 43.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.5046
    Cell Significance Index: 43.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.2957
    Cell Significance Index: 96.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0639
    Cell Significance Index: 50.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0413
    Cell Significance Index: 22.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9745
    Cell Significance Index: 124.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9173
    Cell Significance Index: 112.8000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.8623
    Cell Significance Index: 14.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8497
    Cell Significance Index: 109.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7508
    Cell Significance Index: 53.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7325
    Cell Significance Index: 132.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7084
    Cell Significance Index: 313.2200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6781
    Cell Significance Index: 10.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6681
    Cell Significance Index: 364.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6355
    Cell Significance Index: 126.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5459
    Cell Significance Index: 28.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5396
    Cell Significance Index: 53.3800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.4646
    Cell Significance Index: 5.9500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.4208
    Cell Significance Index: 6.7900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4135
    Cell Significance Index: 11.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3412
    Cell Significance Index: 6.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3228
    Cell Significance Index: 9.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3040
    Cell Significance Index: 8.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2404
    Cell Significance Index: 11.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2219
    Cell Significance Index: 10.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2217
    Cell Significance Index: 42.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2025
    Cell Significance Index: 22.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1968
    Cell Significance Index: 9.9500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.1607
    Cell Significance Index: 3.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1476
    Cell Significance Index: 3.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1291
    Cell Significance Index: 4.5400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1078
    Cell Significance Index: 2.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0446
    Cell Significance Index: 83.9800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.0432
    Cell Significance Index: 0.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0359
    Cell Significance Index: 27.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0352
    Cell Significance Index: 22.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0269
    Cell Significance Index: 0.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0258
    Cell Significance Index: 5.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0232
    Cell Significance Index: 42.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0209
    Cell Significance Index: 3.5700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0087
    Cell Significance Index: 13.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0052
    Cell Significance Index: -0.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0092
    Cell Significance Index: -6.8100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0189
    Cell Significance Index: -11.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0258
    Cell Significance Index: -11.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0297
    Cell Significance Index: -40.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0404
    Cell Significance Index: -27.9400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0424
    Cell Significance Index: -31.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0446
    Cell Significance Index: -25.1700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0463
    Cell Significance Index: -0.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0649
    Cell Significance Index: -23.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0694
    Cell Significance Index: -4.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0924
    Cell Significance Index: -2.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0982
    Cell Significance Index: -20.6800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1093
    Cell Significance Index: -12.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1189
    Cell Significance Index: -34.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1280
    Cell Significance Index: -18.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1500
    Cell Significance Index: -17.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1838
    Cell Significance Index: -14.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1953
    Cell Significance Index: -22.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2095
    Cell Significance Index: -5.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2341
    Cell Significance Index: -4.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2357
    Cell Significance Index: -8.1900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2734
    Cell Significance Index: -7.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2796
    Cell Significance Index: -3.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3306
    Cell Significance Index: -38.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3338
    Cell Significance Index: -34.7600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3977
    Cell Significance Index: -5.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4375
    Cell Significance Index: -29.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4536
    Cell Significance Index: -9.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4579
    Cell Significance Index: -36.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4696
    Cell Significance Index: -15.0400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.4755
    Cell Significance Index: -3.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5055
    Cell Significance Index: -4.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5348
    Cell Significance Index: -32.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5761
    Cell Significance Index: -16.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5904
    Cell Significance Index: -33.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6381
    Cell Significance Index: -39.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: The TNFR1 is a type II transmembrane receptor, consisting of an extracellular ligand-binding domain, a transmembrane domain, and an intracellular death domain (DD). 2. **Expression**: The TNFR1 is widely expressed in various tissues, including endothelial cells, immune cells, and epithelial cells. 3. **Function**: The TNFR1 mediates the biological activities of TNF-α, including inflammation, apoptosis, and cell proliferation. 4. **Signaling pathways**: The TNFR1 activates several signaling pathways, including the NF-κB pathway, JNK pathway, and AP-1 pathway. **Pathways and Functions** 1. **Inflammatory response**: The TNFR1 plays a key role in mediating the inflammatory response by activating the NF-κB pathway, which regulates the expression of pro-inflammatory genes. 2. **Apoptosis**: The TNFR1 can induce apoptosis in certain cell types by activating the extrinsic apoptotic signaling pathway via the death domain. 3. **Cell proliferation**: The TNFR1 can regulate cell proliferation by modulating the expression of genes involved in cell cycle progression. 4. **Immune system**: The TNFR1 is essential for the proper functioning of the immune system, including the regulation of immune cell activation and differentiation. 5. **Cardiac function**: The TNFR1 has been implicated in the regulation of cardiac hypertrophy and fibrosis, highlighting its importance in cardiovascular health. **Clinical Significance** 1. **Inflammatory disorders**: The TNFR1 has been implicated in various inflammatory disorders, including rheumatoid arthritis, psoriasis, and multiple sclerosis. 2. **Cancer**: The TNFR1 is overexpressed in certain types of cancer, including lung, breast, and colon cancer, and is associated with tumor progression and metastasis. 3. **Cardiovascular disease**: The TNFR1 has been implicated in the regulation of cardiac hypertrophy and fibrosis, highlighting its importance in cardiovascular health. 4. **Neurological disorders**: The TNFR1 has been implicated in the regulation of neuroinflammation and neurodegenerative diseases, including Alzheimer's and Parkinson's disease. 5. **Therapeutic applications**: The TNFR1 has been targeted by various therapeutic agents, including monoclonal antibodies and small molecule inhibitors, which have shown promise in treating inflammatory and cancer disorders. In conclusion, the TNFRSF1A gene encodes for the TNFR1, a crucial component of the innate immune system that mediates the biological activities of TNF-α. The TNFR1 plays a pivotal role in regulating various cellular processes, including inflammation, apoptosis, and cell proliferation, and has significant clinical implications in various diseases, including inflammatory disorders, cancer, and cardiovascular disease.

Genular Protein ID: 837960306

Symbol: TNR1A_HUMAN

Name: Tumor necrosis factor receptor superfamily member 1A

UniProtKB Accession Codes:

P19438 A8K4X3 B2RDE4 B3KPQ1 B4DQB7 B4E309 B5M0B5 D3DUR1 Q9UCA4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 19 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 37 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 7 RefSeq 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2158862

Title: Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor.

PubMed ID: 2158862

DOI: 10.1016/0092-8674(90)90815-v

PubMed ID: 2158863

Title: Molecular cloning and expression of a receptor for human tumor necrosis factor.

PubMed ID: 2158863

DOI: 10.1016/0092-8674(90)90816-w

PubMed ID: 1702293

Title: Molecular cloning and expression of human and rat tumor necrosis factor receptor chain (p60) and its soluble derivative, tumor necrosis factor-binding protein.

PubMed ID: 1702293

DOI: 10.1089/dna.1990.9.705

PubMed ID: 1698610

Title: Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor.

PubMed ID: 1698610

DOI: 10.1002/j.1460-2075.1990.tb07526.x

PubMed ID: 2170974

Title: Cloning of human tumor necrosis factor (TNF) receptor cDNA and expression of recombinant soluble TNF-binding protein.

PubMed ID: 2170974

DOI: 10.1073/pnas.87.19.7380

PubMed ID: 1315717

Title: Structure of the human TNF receptor 1 (p60) gene (TNFR1) and localization to chromosome 12p13.

PubMed ID: 1315717

DOI: 10.1016/0888-7543(92)90226-i

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19906316

Title: Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site.

PubMed ID: 19906316

DOI: 10.1186/1471-2164-10-518

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8015639

Title: Purification of two types of TNF inhibitors in the urine of the patient with chronic glomerulonephritis.

PubMed ID: 8015639

DOI: 10.1159/000187851

PubMed ID: 2153136

Title: Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors.

PubMed ID: 2153136

DOI: 10.1016/s0021-9258(19)40049-5

PubMed ID: 9115275

Title: MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase.

PubMed ID: 9115275

DOI: 10.1074/jbc.272.18.12069

PubMed ID: 9557650

Title: Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis.

PubMed ID: 9557650

DOI: 10.1128/jvi.72.5.3691-3697.1998

PubMed ID: 10356400

Title: The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.

PubMed ID: 10356400

DOI: 10.1093/emboj/18.11.3044

PubMed ID: 10542291

Title: F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis.

PubMed ID: 10542291

DOI: 10.1074/jbc.274.45.32461

PubMed ID: 10359574

Title: Identification of Grb2 as a novel binding partner of tumor necrosis factor (TNF) receptor I.

PubMed ID: 10359574

DOI: 10.1084/jem.189.11.1707

PubMed ID: 9915703

Title: Prevention of constitutive TNF receptor 1 signaling by silencer of death domains.

PubMed ID: 9915703

DOI: 10.1126/science.283.5401.543

PubMed ID: 15465831

Title: A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway.

PubMed ID: 15465831

DOI: 10.1074/jbc.m408678200

PubMed ID: 15247912

Title: Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1.

PubMed ID: 15247912

DOI: 10.1038/nm1079

PubMed ID: 16709567

Title: Staphylococcus aureus protein A activates TNFR1 signaling through conserved IgG binding domains.

PubMed ID: 16709567

DOI: 10.1074/jbc.m601956200

PubMed ID: 21976655

Title: The cytomegaloviral protein pUL138 acts as potentiator of tumor necrosis factor (TNF) receptor 1 surface density to enhance ULb'-encoded modulation of TNF-alpha signaling.

PubMed ID: 21976655

DOI: 10.1128/jvi.06005-11

PubMed ID: 22801493

Title: TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis.

PubMed ID: 22801493

DOI: 10.1038/nature11307

PubMed ID: 23955153

Title: Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains.

PubMed ID: 23955153

DOI: 10.1038/nature12436

PubMed ID: 24130170

Title: SH3RF2 functions as an oncogene by mediating PAK4 protein stability.

PubMed ID: 24130170

DOI: 10.1093/carcin/bgt338

PubMed ID: 26183779

Title: Tag7 (PGLYRP1) in Complex with Hsp70 Induces Alternative Cytotoxic Processes in Tumor Cells via TNFR1 Receptor.

PubMed ID: 26183779

DOI: 10.1074/jbc.m115.639732

PubMed ID: 28659487

Title: Mumps virus SH protein inhibits NF-kappaB activation by interacting with tumor necrosis factor receptor 1, interleukin-1 receptor 1, and Toll-like receptor 3 complexes.

PubMed ID: 28659487

DOI: 10.1128/jvi.01037-17

PubMed ID: 30979585

Title: Structural and functional insights into host death domains inactivation by the bacterial arginine GlcNAcyltransferase effector.

PubMed ID: 30979585

DOI: 10.1016/j.molcel.2019.03.028

PubMed ID: 32766249

Title: Arg-GlcNAcylation on TRADD by NleB and SseK1 is crucial for bacterial pathogenesis.

PubMed ID: 32766249

DOI: 10.3389/fcell.2020.00641

PubMed ID: 8387891

Title: Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.

PubMed ID: 8387891

DOI: 10.1016/0092-8674(93)90132-a

PubMed ID: 8939750

Title: Structures of the extracellular domain of the type I tumor necrosis factor receptor.

PubMed ID: 8939750

DOI: 10.1016/s0969-2126(96)00134-7

PubMed ID: 10199409

Title: Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes.

PubMed ID: 10199409

DOI: 10.1016/s0092-8674(00)80721-7

PubMed ID: 10902757

Title: A novel missense mutation (C30S) in the gene encoding tumor necrosis factor receptor 1 linked to autosomal-dominant recurrent fever with localized myositis in a French family.

PubMed ID: 10902757

DOI: 10.1002/1529-0131(200007)43:7<1535::aid-anr18>3.0.co;2-c

PubMed ID: 11443543

Title: The tumor-necrosis-factor receptor-associated periodic syndrome: new mutations in TNFRSF1A, ancestral origins, genotype-phenotype studies, and evidence for further genetic heterogeneity of periodic fevers.

PubMed ID: 11443543

DOI: 10.1086/321976

PubMed ID: 13130484

Title: Heterogeneity among patients with tumor necrosis factor receptor-associated periodic syndrome phenotypes.

PubMed ID: 13130484

DOI: 10.1002/art.11215

PubMed ID: 14610673

Title: Tumour necrosis factor receptor-associated periodic syndrome with a novel mutation in the TNFRSF1A gene in a Japanese family.

PubMed ID: 14610673

DOI: 10.1007/s00431-003-1338-0

Sequence Information:

  • Length: 455
  • Mass: 50495
  • Checksum: 4CEFBA96D03B8225
  • Sequence:
    • MGLSTVPDLL LPLVLLELLV GIYPSGVIGL VPHLGDREKR DSVCPQGKYI HPQNNSICCT 
KCHKGTYLYN DCPGPGQDTD CRECESGSFT ASENHLRHCL SCSKCRKEMG QVEISSCTVD 
RDTVCGCRKN QYRHYWSENL FQCFNCSLCL NGTVHLSCQE KQNTVCTCHA GFFLRENECV 
SCSNCKKSLE CTKLCLPQIE NVKGTEDSGT TVLLPLVIFF GLCLLSLLFI GLMYRYQRWK 
SKLYSIVCGK STPEKEGELE GTTTKPLAPN PSFSPTPGFT PTLGFSPVPS STFTSSSTYT 
PGDCPNFAAP RREVAPPYQG ADPILATALA SDPIPNPLQK WEDSAHKPQS LDTDDPATLY 
AVVENVPPLR WKEFVRRLGL SDHEIDRLEL QNGRCLREAQ YSMLATWRRR TPRREATLEL 
LGRVLRDMDL LGCLEDIEEA LCGPAALPPA PSLLR

Genular Protein ID: 4082423854

Symbol: J9PH39_HUMAN

Name: N/A

UniProtKB Accession Codes:

J9PH39

Database IDs:

ARBA 15 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 2 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 Pfam 2 RefSeq 1 SAM 2 SMART 2 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 347
  • Mass: 38651
  • Checksum: 8C629DAF8D7BA515
  • Sequence:
    • MGQVEISSCT VDRDTVCGCR KNQYRHYWSE NLFQCFNCSL CLNGTVHLSC QEKQNTVCTC 
HAGFFLRENE CVSCSNCKKS LECTKLCLPQ IENVKGTEDS GTTVLLPLVI FFGLCLLSLL 
FIGLMYRYQR WKSKLYSIVC GKSTPEKEGE LEGTTTKPLA PNPSFSPTPG FTPTLGFSPV 
PSSTFTSSST YTPGDCPNFA APRREVAPPY QGADPILATA LASDPIPNPL QKWEDSAHKP 
QSLDTDDPAT LYAVVENVPP LRWKEFVRRL GLSDHEIDRL ELQNGRCLRE AQYSMLATWR 
RRTPRREATL ELLGRVLRDM DLLGCLEDIE EALCGPAALP PAPSLLR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.