Details for: TP53

Gene ID: 7157

Symbol: TP53

Ensembl ID: ENSG00000141510

Description: tumor protein p53

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168244
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.33
    Marker Score: 5447
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.22
    Marker Score: 1230
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.21
    Marker Score: 1312.5
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.19
    Marker Score: 810
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.07
    Marker Score: 982.5
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.07
    Marker Score: 2537
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.07
    Marker Score: 1140
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.04
    Marker Score: 4345
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1
    Marker Score: 1205.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71694
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47919
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.99
    Marker Score: 21189
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.99
    Marker Score: 2697.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.99
    Marker Score: 10011
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.98
    Marker Score: 11046
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30394
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.95
    Marker Score: 358
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2393
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.93
    Marker Score: 3651
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.92
    Marker Score: 862
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.91
    Marker Score: 610
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5208
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.91
    Marker Score: 14277
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.91
    Marker Score: 1896
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2696
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.89
    Marker Score: 1317
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.89
    Marker Score: 942
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.89
    Marker Score: 1510
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.85
    Marker Score: 1483
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.84
    Marker Score: 198
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.83
    Marker Score: 529.5
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.82
    Marker Score: 613
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.82
    Marker Score: 3519
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.79
    Marker Score: 256
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.79
    Marker Score: 1856
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.79
    Marker Score: 279
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.78
    Marker Score: 735
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 311
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.77
    Marker Score: 766
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 580.5
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.73
    Marker Score: 1298
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.73
    Marker Score: 1658
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.73
    Marker Score: 193
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.73
    Marker Score: 228
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.72
    Marker Score: 754
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 370
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.71
    Marker Score: 350
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.71
    Marker Score: 799
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.7
    Marker Score: 1913
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.7
    Marker Score: 438
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.69
    Marker Score: 834
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.69
    Marker Score: 597
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2885
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.69
    Marker Score: 971
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.67
    Marker Score: 581
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.67
    Marker Score: 420
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.67
    Marker Score: 439
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 605
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.66
    Marker Score: 1323
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.66
    Marker Score: 270
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.66
    Marker Score: 635
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.66
    Marker Score: 227
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.65
    Marker Score: 210
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.65
    Marker Score: 320
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.65
    Marker Score: 188
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.65
    Marker Score: 22488
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.65
    Marker Score: 1318
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.65
    Marker Score: 388
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.65
    Marker Score: 340
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.64
    Marker Score: 392
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 425
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.64
    Marker Score: 826
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.64
    Marker Score: 5605
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.64
    Marker Score: 434
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.63
    Marker Score: 262
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.63
    Marker Score: 4001
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.63
    Marker Score: 558
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.63
    Marker Score: 658
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.62
    Marker Score: 141
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.62
    Marker Score: 1847
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.62
    Marker Score: 140
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.62
    Marker Score: 3048
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.62
    Marker Score: 149
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.62
    Marker Score: 155
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.62
    Marker Score: 1699
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.61
    Marker Score: 298
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.61
    Marker Score: 634
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.61
    Marker Score: 550
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.61
    Marker Score: 937
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.6
    Marker Score: 3627
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.6
    Marker Score: 439
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6
    Marker Score: 143
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.6
    Marker Score: 147

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Other Information

**Key Characteristics** 1. **Tumor suppressor function**: TP53 is a tumor suppressor gene that prevents cancer formation by regulating cell cycle arrest, apoptosis, and DNA repair. 2. **Transcriptional regulation**: TP53 regulates the expression of genes involved in cell cycle arrest, apoptosis, and DNA repair, including p21, BAX, and BCL2. 3. **Cell cycle regulation**: TP53 regulates the cell cycle, particularly at the G1/S and G2/M checkpoints, to prevent damaged cells from entering S phase. 4. **Apoptosis regulation**: TP53 regulates apoptosis by inducing the expression of pro-apoptotic genes, such as BAX and PUMA, and inhibiting anti-apoptotic genes, such as BCL2. 5. **DNA repair regulation**: TP53 regulates DNA repair by inducing the expression of genes involved in nucleotide excision repair, mismatch repair, and base excision repair. **Pathways and Functions** 1. **Activation of BH3-only proteins**: TP53 induces the expression of BH3-only proteins, such as PUMA and NOXA, which activate pro-apoptotic signaling pathways. 2. **Activation of NOXA and PUMA**: TP53 activates the expression of NOXA and PUMA, which translocate to mitochondria and induce apoptosis. 3. **Antiviral mechanism**: TP53 regulates the expression of interferon-stimulated genes, which provide antiviral defense against viral infections. 4. **Apoptosis signaling pathway**: TP53 regulates apoptosis by inducing the expression of pro-apoptotic genes and inhibiting anti-apoptotic genes. 5. **DNA damage response**: TP53 regulates the DNA damage response by inducing the expression of genes involved in DNA repair and cell cycle arrest. **Clinical Significance** 1. **Cancer**: Mutations in TP53 are among the most common alterations found in human cancers, including breast, lung, and colon cancers. 2. **Tumor suppressor deficiency**: TP53 mutations can lead to tumor suppressor deficiency, resulting in uncontrolled cell growth and cancer formation. 3. **Genetic instability**: TP53 mutations can also lead to genetic instability, resulting in chromosomal instability and cancer formation. 4. **Immunotherapy**: TP53 can serve as a therapeutic target for immunotherapy, as it regulates immune responses and can be targeted by immunotherapeutic agents. 5. **Cancer diagnosis and prognosis**: TP53 mutations can be used as diagnostic markers for cancer and as prognostic markers for predicting cancer outcomes. In conclusion, TP53 is a critical regulator of cellular homeostasis, and its activity is tightly regulated by post-translational modifications. Mutations in TP53 are among the most common alterations found in human cancers, and understanding the functions and pathways of TP53 is essential for developing effective cancer therapies.

Genular Protein ID: 2166009464

Symbol: P53_HUMAN

Name: Cellular tumor antigen p53

UniProtKB Accession Codes:

P04637 Q15086 Q15087 Q15088 Q16535 Q16807 Q16808 Q16809 Q16810 Q16811 Q16848 Q2XN98 Q3LRW1 Q3LRW2 Q3LRW3 Q3LRW4 Q3LRW5 Q86UG1 Q8J016 Q99659 Q9BTM4 Q9HAQ8 Q9NP68 Q9NPJ2 Q9NZD0 Q9UBI2 Q9UQ61

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 9 CDD 1 CORUM 1 CPTAC 3 CPTC 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 8 ELM 1 EMBL 85 EMDB 10 EPD 1 Ensembl 15 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 17 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 18 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 9 Pumba 1 RNAct 1 Reactome 44 RefSeq 15 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 4006916

Title: Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells.

PubMed ID: 4006916

DOI: 10.1002/j.1460-2075.1985.tb03768.x

PubMed ID: 2946935

Title: Characterization of the human p53 gene.

PubMed ID: 2946935

DOI: 10.1128/mcb.6.5.1379-1385.1986

PubMed ID: 3894933

Title: Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53.

PubMed ID: 3894933

DOI: 10.1128/mcb.5.7.1601-1610.1985

PubMed ID: 3025664

Title: Molecular basis for heterogeneity of the human p53 protein.

PubMed ID: 3025664

DOI: 10.1128/mcb.6.12.4650-4656.1986

PubMed ID: 2905688

Title: A variation in the structure of the protein-coding region of the human p53 gene.

PubMed ID: 2905688

DOI: 10.1016/0378-1119(88)90196-5

PubMed ID: 1915267

Title: p53 is frequently mutated in Burkitt's lymphoma cell lines.

PubMed ID: 1915267

DOI: 10.1002/j.1460-2075.1991.tb07837.x

PubMed ID: 8316628

Title: Isolation of two cell lines from a human malignant glioma specimen differing in sensitivity to radiation and chemotherapeutic drugs.

PubMed ID: 8316628

DOI: 10.2307/3578196

PubMed ID: 11058590

Title: Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity.

PubMed ID: 11058590

DOI: 10.1074/jbc.m007140200

PubMed ID: 16131611

Title: p53 isoforms can regulate p53 transcriptional activity.

PubMed ID: 16131611

DOI: 10.1101/gad.1339905

PubMed ID: 11023613

Title: Human TP53 from the malignant glioma-derived cell lines M059J and M059K has a cancer-associated mutation in exon 8.

PubMed ID: 11023613

DOI: 10.1667/0033-7587(2000)154[0473:htftmg]2.0.co;2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14660794

Title: Inhibition of mutant p53 expression and growth of DMS-153 small cell lung carcinoma by antagonists of growth hormone-releasing hormone and bombesin.

PubMed ID: 14660794

DOI: 10.1073/pnas.2536558100

PubMed ID: 6396087

Title: Isolation and characterization of a human p53 cDNA clone: expression of the human p53 gene.

PubMed ID: 6396087

DOI: 10.1002/j.1460-2075.1984.tb02287.x

PubMed ID: 19011621

Title: Arginine methylation regulates the p53 response.

PubMed ID: 19011621

DOI: 10.1038/ncb1802

PubMed ID: 2175676

Title: The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53.

PubMed ID: 2175676

DOI: 10.1016/0092-8674(90)90409-8

PubMed ID: 2156209

Title: The p53 nuclear localisation signal is structurally linked to a p34cdc2 kinase motif.

PubMed ID: 2156209

PubMed ID: 2141171

Title: Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.

PubMed ID: 2141171

DOI: 10.1073/pnas.87.12.4766

PubMed ID: 1705009

Title: The tumor suppressor p53 is bound to RNA by a stable covalent linkage.

PubMed ID: 1705009

DOI: 10.1128/mcb.11.3.1598-1606.1991

PubMed ID: 1848668

Title: Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen.

PubMed ID: 1848668

DOI: 10.1128/mcb.11.4.1996-2003.1991

PubMed ID: 8632903

Title: The human tumour suppressor gene p53 is alternatively spliced in normal cells.

PubMed ID: 8632903

PubMed ID: 8632915

Title: Regulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus.

PubMed ID: 8632915

PubMed ID: 9372954

Title: p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner.

PubMed ID: 9372954

DOI: 10.1128/mcb.17.12.7220

PubMed ID: 9840937

Title: Regulation of CAK kinase activity by p53.

PubMed ID: 9840937

DOI: 10.1038/sj.onc.1202504

PubMed ID: 10606744

Title: Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15.

PubMed ID: 10606744

DOI: 10.1016/s0014-5793(99)01647-6

PubMed ID: 10551826

Title: A bipartite nuclear localization signal is required for p53 nuclear import regulated by a carboxyl-terminal domain.

PubMed ID: 10551826

DOI: 10.1074/jbc.274.46.32699

PubMed ID: 10570149

Title: Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage.

PubMed ID: 10570149

DOI: 10.1073/pnas.96.24.13777

PubMed ID: 10722742

Title: Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.

PubMed ID: 10722742

DOI: 10.1074/jbc.275.12.8945

PubMed ID: 10656795

Title: Post-translational modification of p53 protein in response to ionizing radiation analyzed by mass spectrometry.

PubMed ID: 10656795

DOI: 10.1006/jmbi.1999.3415

PubMed ID: 10884347

Title: The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A.

PubMed ID: 10884347

DOI: 10.1006/jmbi.2000.3830

PubMed ID: 11025664

Title: The function of PML in p53-dependent apoptosis.

PubMed ID: 11025664

DOI: 10.1038/35036365

PubMed ID: 10644996

Title: p53 is involved in the p120E4F-mediated growth arrest.

PubMed ID: 10644996

DOI: 10.1038/sj.onc.1203250

PubMed ID: 10951572

Title: The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.

PubMed ID: 10951572

DOI: 10.1038/sj.onc.1203709

PubMed ID: 11554448

Title: Zinc binding and redox control of p53 structure and function.

PubMed ID: 11554448

DOI: 10.1089/15230860152542961

PubMed ID: 11554766

Title: Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line.

PubMed ID: 11554766

DOI: 10.1006/bbrc.2001.5627

PubMed ID: 11672523

Title: hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.

PubMed ID: 11672523

DOI: 10.1016/s0092-8674(01)00527-x

PubMed ID: 11007800

Title: p53 amino acids 339-346 represent the minimal p53 repression domain.

PubMed ID: 11007800

DOI: 10.1074/jbc.m008231200

PubMed ID: 11447225

Title: Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3.

PubMed ID: 11447225

DOI: 10.1074/jbc.m104157200

PubMed ID: 11551930

Title: Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.

PubMed ID: 11551930

DOI: 10.1074/jbc.m106050200

PubMed ID: 11124955

Title: SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting.

PubMed ID: 11124955

DOI: 10.1074/jbc.m009476200

PubMed ID: 11546806

Title: Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes.

PubMed ID: 11546806

DOI: 10.1074/jbc.m105669200

PubMed ID: 11239457

Title: A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.

PubMed ID: 11239457

DOI: 10.1016/s1097-2765(01)00176-9

PubMed ID: 12507430

Title: Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde.

PubMed ID: 12507430

DOI: 10.1016/s0092-8674(02)01199-6

PubMed ID: 11706030

Title: Differential effect of ik3-1/cables on p53- and p73-induced cell death.

PubMed ID: 11706030

DOI: 10.1074/jbc.m108535200

PubMed ID: 11925430

Title: Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo.

PubMed ID: 11925430

DOI: 10.1074/jbc.m200153200

PubMed ID: 11740489

Title: Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2.

PubMed ID: 11740489

DOI: 10.1038/ncb715

PubMed ID: 11780126

Title: Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

PubMed ID: 11780126

DOI: 10.1038/ncb714

PubMed ID: 12750254

Title: p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity.

PubMed ID: 12750254

PubMed ID: 12724314

Title: Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305.

PubMed ID: 12724314

DOI: 10.1074/jbc.m212574200

PubMed ID: 12810724

Title: The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation.

PubMed ID: 12810724

DOI: 10.1074/jbc.m301264200

PubMed ID: 12851404

Title: TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity.

PubMed ID: 12851404

DOI: 10.1074/jbc.m301979200

PubMed ID: 12944468

Title: Nucleocytoplasmic shuttling of p53 is essential for MDM2-mediated cytoplasmic degradation but not ubiquitination.

PubMed ID: 12944468

DOI: 10.1128/mcb.23.18.6396-6405.2003

PubMed ID: 12524540

Title: iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

PubMed ID: 12524540

DOI: 10.1038/ng1070

PubMed ID: 12702766

Title: Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1).

PubMed ID: 12702766

DOI: 10.1073/pnas.0530308100

PubMed ID: 15109303

Title: Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control.

PubMed ID: 15109303

DOI: 10.1042/bj20040337

PubMed ID: 15186775

Title: Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53.

PubMed ID: 15186775

DOI: 10.1016/j.cell.2004.05.009

PubMed ID: 15136035

Title: The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle.

PubMed ID: 15136035

DOI: 10.1016/j.jmb.2004.03.071

PubMed ID: 15053879

Title: Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression.

PubMed ID: 15053879

DOI: 10.1016/s1097-2765(04)00123-6

PubMed ID: 15053880

Title: A dynamic role of HAUSP in the p53-Mdm2 pathway.

PubMed ID: 15053880

DOI: 10.1016/s1097-2765(04)00157-1

PubMed ID: 15340061

Title: Regulation of human p53 activity and cell localization by alternative splicing.

PubMed ID: 15340061

DOI: 10.1128/mcb.24.18.7987-7997.2004

PubMed ID: 15525938

Title: Regulation of p53 activity through lysine methylation.

PubMed ID: 15525938

DOI: 10.1038/nature03117

PubMed ID: 15448695

Title: A new effector pathway links ATM kinase with the DNA damage response.

PubMed ID: 15448695

DOI: 10.1038/ncb1170

PubMed ID: 14702041

Title: Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53.

PubMed ID: 14702041

DOI: 10.1038/ng1279

PubMed ID: 15687255

Title: A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73.

PubMed ID: 15687255

DOI: 10.1101/gad.319905

PubMed ID: 16322561

Title: NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.

PubMed ID: 16322561

DOI: 10.1101/gad.351205

PubMed ID: 15701641

Title: Tumor suppressor SMAR1 activates and stabilizes p53 through its arginine-serine-rich motif.

PubMed ID: 15701641

DOI: 10.1074/jbc.m413200200

PubMed ID: 32144153

Title:

PubMed ID: 32144153

DOI: 10.1074/jbc.w120.012894

PubMed ID: 15855171

Title: Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53.

PubMed ID: 15855171

DOI: 10.1074/jbc.m414172200

PubMed ID: 16219768

Title: WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53.

PubMed ID: 16219768

DOI: 10.1074/jbc.m505590200

PubMed ID: 15866171

Title: AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.

PubMed ID: 15866171

DOI: 10.1016/j.molcel.2005.03.027

PubMed ID: 17108107

Title: LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation.

PubMed ID: 17108107

DOI: 10.1158/0008-5472.can-06-0999

PubMed ID: 16704422

Title: The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines.

PubMed ID: 16704422

DOI: 10.1111/j.1742-4658.2006.05256.x

PubMed ID: 16376338

Title: Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon.

PubMed ID: 16376338

DOI: 10.1016/j.febslet.2005.12.024

PubMed ID: 16377624

Title: Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage.

PubMed ID: 16377624

DOI: 10.1074/jbc.m512074200

PubMed ID: 17108971

Title: Repression of p53 activity by Smyd2-mediated methylation.

PubMed ID: 17108971

DOI: 10.1038/nature05287

PubMed ID: 16845383

Title: Critical role for Daxx in regulating Mdm2.

PubMed ID: 16845383

DOI: 10.1038/ncb1442

PubMed ID: 16415881

Title: Structural basis for the methylation site specificity of SET7/9.

PubMed ID: 16415881

DOI: 10.1038/nsmb1045

PubMed ID: 17145718

Title: Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.

PubMed ID: 17145718

DOI: 10.1093/nar/gkl878

PubMed ID: 17254968

Title: PRAK is essential for ras-induced senescence and tumor suppression.

PubMed ID: 17254968

DOI: 10.1016/j.cell.2006.11.050

PubMed ID: 17719541

Title: Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation.

PubMed ID: 17719541

DOI: 10.1016/j.cell.2007.06.013

PubMed ID: 17170702

Title: Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'.

PubMed ID: 17170702

DOI: 10.1038/sj.emboj.7601490

PubMed ID: 17245430

Title: A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.

PubMed ID: 17245430

DOI: 10.1038/sj.emboj.7601519

PubMed ID: 17904127

Title: SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53.

PubMed ID: 17904127

DOI: 10.1016/j.febslet.2007.09.025

PubMed ID: 18022393

Title: Novel homeodomain-interacting protein kinase family member, HIPK4, phosphorylates human p53 at serine 9.

PubMed ID: 18022393

DOI: 10.1016/j.febslet.2007.11.022

PubMed ID: 17467953

Title: Nine-amino-acid transactivation domain: establishment and prediction utilities.

PubMed ID: 17467953

DOI: 10.1016/j.ygeno.2007.02.003

PubMed ID: 17121812

Title: CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation.

PubMed ID: 17121812

DOI: 10.1074/jbc.m610793200

PubMed ID: 17317671

Title: The notch regulator MAML1 interacts with p53 and functions as a coactivator.

PubMed ID: 17317671

DOI: 10.1074/jbc.m608974200

PubMed ID: 17591690

Title: Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death.

PubMed ID: 17591690

DOI: 10.1242/jcs.03468

PubMed ID: 17332504

Title: Dynamic regulation of p53 subnuclear localization and senescence by MORC3.

PubMed ID: 17332504

DOI: 10.1091/mbc.e06-08-0747

PubMed ID: 17349958

Title: DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage.

PubMed ID: 17349958

DOI: 10.1016/j.molcel.2007.02.007

PubMed ID: 17805299

Title: p53 is regulated by the lysine demethylase LSD1.

PubMed ID: 17805299

DOI: 10.1038/nature06092

PubMed ID: 17707234

Title: Modulation of p53 function by SET8-mediated methylation at lysine 382.

PubMed ID: 17707234

DOI: 10.1016/j.molcel.2007.07.012

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18249187

Title: Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53.

PubMed ID: 18249187

DOI: 10.1016/j.bbrc.2008.01.114

PubMed ID: 18585004

Title: Histone methyltransferase protein SETD2 interacts with p53 and selectively regulates its downstream genes.

PubMed ID: 18585004

DOI: 10.1016/j.cellsig.2008.05.012

PubMed ID: 18690848

Title: NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress.

PubMed ID: 18690848

DOI: 10.2174/156800908785133196

PubMed ID: 18206965

Title: Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation.

PubMed ID: 18206965

DOI: 10.1016/j.molcel.2007.11.031

PubMed ID: 17954561

Title: Hbo1 Links p53-dependent stress signaling to DNA replication licensing.

PubMed ID: 17954561

DOI: 10.1128/mcb.00662-07

PubMed ID: 17967874

Title: Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A.

PubMed ID: 17967874

DOI: 10.1128/mcb.00983-07

Sequence Information:

  • Length: 393
  • Mass: 43653
  • Checksum: AD5C149FD8106131
  • Sequence:
    • MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI EQWFTEDPGP 
DEAPRMPEAA PPVAPAPAAP TPAAPAPAPS WPLSSSVPSQ KTYQGSYGFR LGFLHSGTAK 
SVTCTYSPAL NKMFCQLAKT CPVQLWVDST PPPGTRVRAM AIYKQSQHMT EVVRRCPHHE 
RCSDSDGLAP PQHLIRVEGN LRVEYLDDRN TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS 
SCMGGMNRRP ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENLR KKGEPHHELP 
PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QIRGRERFEM FRELNEALEL KDAQAGKEPG 
GSRAHSSHLK SKKGQSTSRH KKLMFKTEGP DSD

Genular Protein ID: 205148929

Symbol: H2EHT1_HUMAN

Name: N/A

UniProtKB Accession Codes:

H2EHT1

Database IDs:

ARBA 18 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 9 Gene3D 3 GenomeRNAi 1 InterPro 7 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 1 Pfam 6 RefSeq 3 RuleBase 1 SAM 1 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 21112961

Title: G-quadruplex structures in TP53 intron 3: role in alternative splicing and in production of p53 mRNA isoforms.

PubMed ID: 21112961

DOI: 10.1093/carcin/bgq253

Sequence Information:

  • Length: 354
  • Mass: 39320
  • Checksum: 6F12310423325770
  • Sequence:
    • MDDLMLSPDD IEQWFTEDPG PDEAPRMPEA APPVAPAPAA PTPAAPAPAP SWPLSSSVPS 
QKTYQGSYGF RLGFLHSGTA KSVTCTYSPA LNKMFCQLAK TCPVQLWVDS TPPPGTRVRA 
MAIYKQSQHM TEVVRRCPHH ERCSDSDGLA PPQHLIRVEG NLRVEYLDDR NTFRHSVVVP 
YEPPEVGSDC TTIHYNYMCN SSCMGGMNRR PILTIITLED SSGNLLGRNS FEVRVCACPG 
RDRRTEEENL RKKGEPHHEL PPGSTKRALP NNTSSSPQPK KKPLDGEYFT LQIRGRERFE 
MFRELNEALE LKDAQAGKEP GGSRAHSSHL KSKKGQSTSR HKKLMFKTEG PDSD

Genular Protein ID: 1268272858

Symbol: A0A087WT22_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WT22

Database IDs:

ARBA 17 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 187
  • Mass: 21416
  • Checksum: C60E05EDDBC150C2
  • Sequence:
    • MAIYKQSQHM TEVVRRCPHH ERCSDSDGLA PPQHLIRVEG NLRVEYLDDR NTFRHSVVVP 
YEPPEVGSDC TTIHYNYMCN SSCMGGMNRR PILTIITLED SSGNLLGRNS FEVRVCACPG 
RDRRTEEENL RKKGEPHHEL PPGSTKRALP NNTSSSPQPK KKPLDGEYFT LQMLLDLRWC 
YFLINSS

Genular Protein ID: 3828279244

Symbol: A0A087WXZ1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WXZ1

Database IDs:

ARBA 17 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 182
  • Mass: 20741
  • Checksum: 141DBA75C051D39D
  • Sequence:
    • MAIYKQSQHM TEVVRRCPHH ERCSDSDGLA PPQHLIRVEG NLRVEYLDDR NTFRHSVVVP 
YEPPEVGSDC TTIHYNYMCN SSCMGGMNRR PILTIITLED SSGNLLGRNS FEVRVCACPG 
RDRRTEEENL RKKGEPHHEL PPGSTKRALP NNTSSSPQPK KKPLDGEYFT LQDQTSFQKE 
NC

Genular Protein ID: 2872483117

Symbol: Q53GA5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53GA5

Database IDs:

ARBA 19 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 3 DNASU 1 EMBL 2 GO 7 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 15 SAM 1 SMR 1 SUPFAM 2

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 158
  • Mass: 17656
  • Checksum: 5C1AD3B95EB611D7
  • Sequence:
    • YMCNSSCMGG MNGRPILTII TLEDSSGNLL GRNSFEVRVC ACPGRDRRTE EENLRKKGEP 
HHELPPGSTK RALPNNTSSS PQPKKKPLDG EYFTLQIRGR ERFEMFRELN EALELKDAQA 
GKEPGGSRAH SSHLKSKKGQ STSRHKKLMF KTEGPDSD

Genular Protein ID: 1794551100

Symbol: A0A087X1Q1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087X1Q1

Database IDs:

ARBA 18 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EMBL 2 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 IntAct 1 InterPro 6 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 4 Proteomes 2 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 234
  • Mass: 26569
  • Checksum: AABDD005298DDF31
  • Sequence:
    • MAIYKQSQHM TEVVRRCPHH ERCSDSDGLA PPQHLIRVEG NLRVEYLDDR NTFRHSVVVP 
YEPPEVGSDC TTIHYNYMCN SSCMGGMNRR PILTIITLED SSGNLLGRNS FEVRVCACPG 
RDRRTEEENL RKKGEPHHEL PPGSTKRALP NNTSSSPQPK KKPLDGEYFT LQIRGRERFE 
MFRELNEALE LKDAQAGKEP GGSRAHSSHL KSKKGQSTSR HKKLMFKTEG PDSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.