Details for: TPM4

Gene ID: 7171

Symbol: TPM4

Ensembl ID: ENSG00000167460

Description: tropomyosin 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 606.1260
    Cell Significance Index: -94.2800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 311.5398
    Cell Significance Index: -79.0200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 240.8559
    Cell Significance Index: -99.2200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 200.6242
    Cell Significance Index: -81.5100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 199.5032
    Cell Significance Index: -94.1900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 176.9880
    Cell Significance Index: -91.0400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 141.3590
    Cell Significance Index: -94.8600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 76.4991
    Cell Significance Index: -94.3200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 27.8514
    Cell Significance Index: -74.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.9759
    Cell Significance Index: -94.6100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 22.3477
    Cell Significance Index: -68.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 19.9855
    Cell Significance Index: -43.7400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 7.0431
    Cell Significance Index: 162.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.5150
    Cell Significance Index: 132.6000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 4.1027
    Cell Significance Index: 72.5000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.9645
    Cell Significance Index: 107.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.7272
    Cell Significance Index: 175.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.6837
    Cell Significance Index: 98.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.6802
    Cell Significance Index: 505.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.5604
    Cell Significance Index: 229.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.4197
    Cell Significance Index: 441.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.1813
    Cell Significance Index: 66.5900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.9244
    Cell Significance Index: 83.8300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.6346
    Cell Significance Index: 29.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.2233
    Cell Significance Index: 165.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.2023
    Cell Significance Index: 1202.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.9895
    Cell Significance Index: 103.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.9633
    Cell Significance Index: 241.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8512
    Cell Significance Index: 218.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.8367
    Cell Significance Index: 331.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6594
    Cell Significance Index: 269.8900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 1.4478
    Cell Significance Index: 6.6900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.1756
    Cell Significance Index: 15.0600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.1300
    Cell Significance Index: 9.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1229
    Cell Significance Index: 496.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1199
    Cell Significance Index: 52.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.1156
    Cell Significance Index: 143.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.0911
    Cell Significance Index: 28.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9024
    Cell Significance Index: 181.0300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.9003
    Cell Significance Index: 16.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8583
    Cell Significance Index: 60.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8251
    Cell Significance Index: 745.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.8226
    Cell Significance Index: 373.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6875
    Cell Significance Index: 136.4300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6310
    Cell Significance Index: 6.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5926
    Cell Significance Index: 64.4600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.4403
    Cell Significance Index: 2.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3955
    Cell Significance Index: 39.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3628
    Cell Significance Index: 683.0600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2437
    Cell Significance Index: 6.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2369
    Cell Significance Index: 84.9900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1371
    Cell Significance Index: 2.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1295
    Cell Significance Index: 24.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0794
    Cell Significance Index: 3.6000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0687
    Cell Significance Index: 1.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0131
    Cell Significance Index: 9.9100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0233
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0249
    Cell Significance Index: -15.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0267
    Cell Significance Index: -4.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0472
    Cell Significance Index: -34.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0621
    Cell Significance Index: -114.4500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0735
    Cell Significance Index: -113.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0758
    Cell Significance Index: -48.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0827
    Cell Significance Index: -112.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1060
    Cell Significance Index: -77.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1238
    Cell Significance Index: -69.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1241
    Cell Significance Index: -4.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1336
    Cell Significance Index: -13.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1668
    Cell Significance Index: -9.3600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2103
    Cell Significance Index: -24.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2367
    Cell Significance Index: -49.8600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.2398
    Cell Significance Index: -1.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2714
    Cell Significance Index: -27.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2732
    Cell Significance Index: -78.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2888
    Cell Significance Index: -17.7500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4462
    Cell Significance Index: -11.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4555
    Cell Significance Index: -15.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4660
    Cell Significance Index: -13.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4769
    Cell Significance Index: -54.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4808
    Cell Significance Index: -69.8900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.4915
    Cell Significance Index: -3.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5185
    Cell Significance Index: -60.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6157
    Cell Significance Index: -8.4000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.7750
    Cell Significance Index: -6.5100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.7926
    Cell Significance Index: -11.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8723
    Cell Significance Index: -44.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9141
    Cell Significance Index: -22.8500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.9632
    Cell Significance Index: -13.5100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.9684
    Cell Significance Index: -6.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9759
    Cell Significance Index: -65.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.0067
    Cell Significance Index: -21.8100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.0535
    Cell Significance Index: -15.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0787
    Cell Significance Index: -85.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.0991
    Cell Significance Index: -84.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.1376
    Cell Significance Index: -59.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3062
    Cell Significance Index: -80.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.4082
    Cell Significance Index: -29.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.4150
    Cell Significance Index: -73.7100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -1.4534
    Cell Significance Index: -9.0000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.4817
    Cell Significance Index: -60.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural role:** TPM4 is a coiled-coil protein that binds to actin filaments, regulating their dynamics and organization. 2. **Muscle contraction:** TPM4 is essential for striated muscle contraction, smooth muscle contraction, and skeletal muscle thin filament tropomyosin function. 3. **Signal transduction:** TPM4 interacts with various signaling molecules, including Rho GTPases, to regulate cellular responses to growth factors and second messengers. 4. **Cellular localization:** TPM4 is expressed in basal cells of prostate epithelium, bronchus fibroblasts, skeletal muscle satellite stem cells, and fibroblasts from connective tissue. **Pathways and Functions:** 1. **Actin filament regulation:** TPM4 regulates actin filament organization, dynamics, and interaction with other cytoskeletal proteins. 2. **Muscle contraction:** TPM4 is essential for striated muscle contraction, smooth muscle contraction, and skeletal muscle thin filament tropomyosin function. 3. **Signal transduction:** TPM4 interacts with Rho GTPases, influencing cellular responses to growth factors and second messengers. 4. **Osteoblast differentiation:** TPM4 regulates osteoblast differentiation and bone formation. 5. **Rho GTPase cycle:** TPM4 is involved in the regulation of the Rho GTPase cycle, influencing cytoskeleton organization and cellular signaling. **Clinical Significance:** 1. **Muscular dystrophy:** TPM4 mutations have been associated with muscular dystrophy, highlighting the gene's importance in maintaining muscle function. 2. **Cancer:** TPM4 expression is altered in various cancers, suggesting its role in tumor progression and metastasis. 3. **Prostate cancer:** TPM4 is significantly expressed in basal cells of prostate epithelium, making it a potential biomarker for prostate cancer diagnosis and prognosis. 4. **Osteoporosis:** TPM4 regulates osteoblast differentiation, and its dysregulation may contribute to osteoporosis. In conclusion, TPM4 plays a crucial role in regulating actin filament dynamics, muscle contraction, and signal transduction pathways in various cells. Its dysregulation has been implicated in muscular dystrophy, cancer, and osteoporosis, highlighting the importance of TPM4 in maintaining cellular homeostasis and overall health. Further studies are necessary to fully elucidate the mechanisms by which TPM4 regulates cellular processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 4012077868

Symbol: TPM4_HUMAN

Name: Tropomyosin alpha-4 chain

UniProtKB Accession Codes:

P67936 P07226 Q15659 Q5U0D9 Q9BU85 Q9H8Q3 Q9UCS1 Q9UCS2 Q9UCS3 Q9UCS4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CPTAC 3 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 20 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3612796

Title: Characterization of a cDNA defining a gene family encoding TM30p1, a human fibroblast tropomyosin.

PubMed ID: 3612796

DOI: 10.1016/0022-2836(87)90710-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 1836432

Title: The calcium binding protein tropomyosin in human platelets and cardiac tissue: elevation in hypertensive cardiac hypertrophy.

PubMed ID: 1836432

DOI: 10.1111/j.1365-2362.1991.tb01397.x

PubMed ID: 3865200

Title: A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism.

PubMed ID: 3865200

DOI: 10.1073/pnas.82.23.7835

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28134622

Title: Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia.

PubMed ID: 28134622

DOI: 10.1172/jci86154

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 27479822

Title: Whole exome sequencing identifies genetic variants in inherited thrombocytopenia with secondary qualitative function defects.

PubMed ID: 27479822

DOI: 10.3324/haematol.2016.146316

PubMed ID: 34758189

Title: Rare missense variants in Tropomyosin-4 (TPM4) are associated with platelet dysfunction, cytoskeletal defects, and excessive bleeding.

PubMed ID: 34758189

DOI: 10.1111/jth.15584

PubMed ID: 35596517

Title: Corrigendum.

PubMed ID: 35596517

DOI: 10.1111/jth.15719

PubMed ID: 35170221

Title: A novel nonsense variant in TPM4 caused dominant macrothrombocytopenia, mild bleeding tendency and disrupted cytoskeleton remodeling.

PubMed ID: 35170221

DOI: 10.1111/jth.15672

Sequence Information:

  • Length: 248
  • Mass: 28522
  • Checksum: 5D5CDF6BF76552A8
  • Sequence:
    • MAGLNSLEAV KRKIQALQQQ ADEAEDRAQG LQRELDGERE RREKAEGDVA ALNRRIQLVE 
EELDRAQERL ATALQKLEEA EKAADESERG MKVIENRAMK DEEKMEIQEM QLKEAKHIAE 
EADRKYEEVA RKLVILEGEL ERAEERAEVS ELKCGDLEEE LKNVTNNLKS LEAASEKYSE 
KEDKYEEEIK LLSDKLKEAE TRAEFAERTV AKLEKTIDDL EEKLAQAKEE NVGLHQTLDQ 
TLNELNCI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.