Details for: TPM4

Gene ID: 7171

Symbol: TPM4

Ensembl ID: ENSG00000167460

Description: tropomyosin 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.78
    Marker Score: 9232
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.45
    Marker Score: 4749
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.34
    Marker Score: 3565
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.25
    Marker Score: 42932
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.13
    Marker Score: 2469
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.1
    Marker Score: 2643
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.1
    Marker Score: 6802
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.94
    Marker Score: 1661
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.94
    Marker Score: 5519
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.94
    Marker Score: 99865.5
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.9
    Marker Score: 14221
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.84
    Marker Score: 3704
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.79
    Marker Score: 12044
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.77
    Marker Score: 7641
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.74
    Marker Score: 30859
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.74
    Marker Score: 4212
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.72
    Marker Score: 3946.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.72
    Marker Score: 6848
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.69
    Marker Score: 3318
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.69
    Marker Score: 1123
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.68
    Marker Score: 1766
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.66
    Marker Score: 1516
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.61
    Marker Score: 16965.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.61
    Marker Score: 26418
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.6
    Marker Score: 16630
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.6
    Marker Score: 820
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.58
    Marker Score: 20159
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.58
    Marker Score: 6547
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.57
    Marker Score: 10524
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.57
    Marker Score: 825
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.56
    Marker Score: 2437
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.5
    Marker Score: 1701
  • Cell Name: platelet (CL0000233)
    Fold Change: 2.49
    Marker Score: 1125.5
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.47
    Marker Score: 2653
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.47
    Marker Score: 1440
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.46
    Marker Score: 932
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.46
    Marker Score: 2119
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.44
    Marker Score: 6388
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.44
    Marker Score: 548
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.43
    Marker Score: 6617
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.42
    Marker Score: 15439.5
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.42
    Marker Score: 2087
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.42
    Marker Score: 4088
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.42
    Marker Score: 5684
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.41
    Marker Score: 3548
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.4
    Marker Score: 4786.5
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.39
    Marker Score: 4242
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.38
    Marker Score: 82415
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.38
    Marker Score: 2718
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.36
    Marker Score: 2839
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.34
    Marker Score: 9006.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.33
    Marker Score: 2457
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.32
    Marker Score: 967
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.31
    Marker Score: 13725
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.31
    Marker Score: 964
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 2.31
    Marker Score: 1440.5
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.29
    Marker Score: 813
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.26
    Marker Score: 2125
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.25
    Marker Score: 1159
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.25
    Marker Score: 19389.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.25
    Marker Score: 7054
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.25
    Marker Score: 636
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.24
    Marker Score: 2009
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.22
    Marker Score: 1579
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.22
    Marker Score: 861
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.21
    Marker Score: 625
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.21
    Marker Score: 747
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.2
    Marker Score: 2220
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.2
    Marker Score: 4237
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.19
    Marker Score: 524
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.18
    Marker Score: 122006.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.18
    Marker Score: 2104
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 2.17
    Marker Score: 1963
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.16
    Marker Score: 2530
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.16
    Marker Score: 25077.5
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.14
    Marker Score: 874
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.14
    Marker Score: 963
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.14
    Marker Score: 1532
  • Cell Name: oocyte (CL0000023)
    Fold Change: 2.1
    Marker Score: 520
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.08
    Marker Score: 529
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.05
    Marker Score: 2210
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 2.05
    Marker Score: 710
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 2.05
    Marker Score: 1175.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.05
    Marker Score: 591
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.04
    Marker Score: 589
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.04
    Marker Score: 8021
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.04
    Marker Score: 503
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.04
    Marker Score: 6039
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.03
    Marker Score: 1911
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.02
    Marker Score: 8468
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.02
    Marker Score: 2862
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.02
    Marker Score: 1095
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.02
    Marker Score: 1274
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.01
    Marker Score: 5218
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.01
    Marker Score: 991
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2
    Marker Score: 51271.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2
    Marker Score: 2137
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.99
    Marker Score: 5399
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.97
    Marker Score: 7309
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.97
    Marker Score: 884

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Other Information

**Key Characteristics:** 1. **Structural role:** TPM4 is a coiled-coil protein that binds to actin filaments, regulating their dynamics and organization. 2. **Muscle contraction:** TPM4 is essential for striated muscle contraction, smooth muscle contraction, and skeletal muscle thin filament tropomyosin function. 3. **Signal transduction:** TPM4 interacts with various signaling molecules, including Rho GTPases, to regulate cellular responses to growth factors and second messengers. 4. **Cellular localization:** TPM4 is expressed in basal cells of prostate epithelium, bronchus fibroblasts, skeletal muscle satellite stem cells, and fibroblasts from connective tissue. **Pathways and Functions:** 1. **Actin filament regulation:** TPM4 regulates actin filament organization, dynamics, and interaction with other cytoskeletal proteins. 2. **Muscle contraction:** TPM4 is essential for striated muscle contraction, smooth muscle contraction, and skeletal muscle thin filament tropomyosin function. 3. **Signal transduction:** TPM4 interacts with Rho GTPases, influencing cellular responses to growth factors and second messengers. 4. **Osteoblast differentiation:** TPM4 regulates osteoblast differentiation and bone formation. 5. **Rho GTPase cycle:** TPM4 is involved in the regulation of the Rho GTPase cycle, influencing cytoskeleton organization and cellular signaling. **Clinical Significance:** 1. **Muscular dystrophy:** TPM4 mutations have been associated with muscular dystrophy, highlighting the gene's importance in maintaining muscle function. 2. **Cancer:** TPM4 expression is altered in various cancers, suggesting its role in tumor progression and metastasis. 3. **Prostate cancer:** TPM4 is significantly expressed in basal cells of prostate epithelium, making it a potential biomarker for prostate cancer diagnosis and prognosis. 4. **Osteoporosis:** TPM4 regulates osteoblast differentiation, and its dysregulation may contribute to osteoporosis. In conclusion, TPM4 plays a crucial role in regulating actin filament dynamics, muscle contraction, and signal transduction pathways in various cells. Its dysregulation has been implicated in muscular dystrophy, cancer, and osteoporosis, highlighting the importance of TPM4 in maintaining cellular homeostasis and overall health. Further studies are necessary to fully elucidate the mechanisms by which TPM4 regulates cellular processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 4012077868

Symbol: TPM4_HUMAN

Name: Tropomyosin alpha-4 chain

UniProtKB Accession Codes:

P67936 P07226 Q15659 Q5U0D9 Q9BU85 Q9H8Q3 Q9UCS1 Q9UCS2 Q9UCS3 Q9UCS4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CPTAC 3 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 1 EMBL 9 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3612796

Title: Characterization of a cDNA defining a gene family encoding TM30p1, a human fibroblast tropomyosin.

PubMed ID: 3612796

DOI: 10.1016/0022-2836(87)90710-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 1836432

Title: The calcium binding protein tropomyosin in human platelets and cardiac tissue: elevation in hypertensive cardiac hypertrophy.

PubMed ID: 1836432

DOI: 10.1111/j.1365-2362.1991.tb01397.x

PubMed ID: 3865200

Title: A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism.

PubMed ID: 3865200

DOI: 10.1073/pnas.82.23.7835

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 248
  • Mass: 28522
  • Checksum: 5D5CDF6BF76552A8
  • Sequence:
    • MAGLNSLEAV KRKIQALQQQ ADEAEDRAQG LQRELDGERE RREKAEGDVA ALNRRIQLVE 
EELDRAQERL ATALQKLEEA EKAADESERG MKVIENRAMK DEEKMEIQEM QLKEAKHIAE 
EADRKYEEVA RKLVILEGEL ERAEERAEVS ELKCGDLEEE LKNVTNNLKS LEAASEKYSE 
KEDKYEEEIK LLSDKLKEAE TRAEFAERTV AKLEKTIDDL EEKLAQAKEE NVGLHQTLDQ 
TLNELNCI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.