Details for: TPP2

Gene ID: 7174

Symbol: TPP2

Ensembl ID: ENSG00000134900

Description: tripeptidyl peptidase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 261.0013
    Cell Significance Index: -40.6000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 151.6696
    Cell Significance Index: -38.4700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 101.3478
    Cell Significance Index: -41.7500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 94.2763
    Cell Significance Index: -44.5100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 93.2414
    Cell Significance Index: -37.8800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 83.2839
    Cell Significance Index: -42.8400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 66.4546
    Cell Significance Index: -44.5900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.9375
    Cell Significance Index: -38.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.7214
    Cell Significance Index: -42.8100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.6261
    Cell Significance Index: -41.8600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.9352
    Cell Significance Index: -39.7300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.9679
    Cell Significance Index: -43.2800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.0691
    Cell Significance Index: -17.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5913
    Cell Significance Index: 319.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3497
    Cell Significance Index: 75.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2494
    Cell Significance Index: 33.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2480
    Cell Significance Index: 447.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1897
    Cell Significance Index: 193.5000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.1211
    Cell Significance Index: 21.8800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0745
    Cell Significance Index: 64.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9976
    Cell Significance Index: 116.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9864
    Cell Significance Index: 195.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9223
    Cell Significance Index: 59.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8732
    Cell Significance Index: 39.5800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7795
    Cell Significance Index: 539.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7183
    Cell Significance Index: 55.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6522
    Cell Significance Index: 28.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6290
    Cell Significance Index: 23.8200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5714
    Cell Significance Index: 39.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4279
    Cell Significance Index: 9.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4241
    Cell Significance Index: 26.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3905
    Cell Significance Index: 48.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3888
    Cell Significance Index: 53.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3684
    Cell Significance Index: 19.1900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3579
    Cell Significance Index: 323.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3215
    Cell Significance Index: 57.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3203
    Cell Significance Index: 8.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2928
    Cell Significance Index: 34.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2708
    Cell Significance Index: 18.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2479
    Cell Significance Index: 135.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1950
    Cell Significance Index: 367.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1797
    Cell Significance Index: 9.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1780
    Cell Significance Index: 17.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1741
    Cell Significance Index: 5.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1719
    Cell Significance Index: 76.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1312
    Cell Significance Index: 24.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1257
    Cell Significance Index: 3.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1252
    Cell Significance Index: 4.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0833
    Cell Significance Index: 5.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0793
    Cell Significance Index: 50.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0705
    Cell Significance Index: 32.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0607
    Cell Significance Index: 93.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0555
    Cell Significance Index: 102.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0058
    Cell Significance Index: 7.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0069
    Cell Significance Index: -0.3600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0077
    Cell Significance Index: -0.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0173
    Cell Significance Index: -2.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0234
    Cell Significance Index: -3.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0257
    Cell Significance Index: -0.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0373
    Cell Significance Index: -27.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0404
    Cell Significance Index: -30.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0502
    Cell Significance Index: -37.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0619
    Cell Significance Index: -2.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0655
    Cell Significance Index: -11.1800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0680
    Cell Significance Index: -1.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0713
    Cell Significance Index: -40.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0722
    Cell Significance Index: -3.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0785
    Cell Significance Index: -49.0100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1049
    Cell Significance Index: -1.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1250
    Cell Significance Index: -12.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1303
    Cell Significance Index: -37.5000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1566
    Cell Significance Index: -3.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1805
    Cell Significance Index: -23.3300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2120
    Cell Significance Index: -5.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2261
    Cell Significance Index: -47.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2366
    Cell Significance Index: -16.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2561
    Cell Significance Index: -26.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2866
    Cell Significance Index: -9.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2921
    Cell Significance Index: -21.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3179
    Cell Significance Index: -36.4200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4015
    Cell Significance Index: -4.9800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4105
    Cell Significance Index: -12.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4192
    Cell Significance Index: -11.4100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4587
    Cell Significance Index: -13.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4713
    Cell Significance Index: -13.5100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4781
    Cell Significance Index: -10.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4962
    Cell Significance Index: -39.3000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5482
    Cell Significance Index: -7.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5500
    Cell Significance Index: -28.8800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5635
    Cell Significance Index: -11.9600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5803
    Cell Significance Index: -11.6500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.5921
    Cell Significance Index: -8.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5993
    Cell Significance Index: -20.8300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6040
    Cell Significance Index: -13.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6263
    Cell Significance Index: -38.4000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6472
    Cell Significance Index: -3.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6690
    Cell Significance Index: -17.9300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6893
    Cell Significance Index: -12.7400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7011
    Cell Significance Index: -10.3500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.7026
    Cell Significance Index: -10.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** TPP2 is a serine-type endopeptidase that hydrolyzes tripeptides, which are essential for the processing and presentation of antigens to the immune system. 2. **Expression Pattern:** TPP2 is widely expressed in various cell types, including GABAergic neurons, immune cells, and epithelial cells. 3. **Pathway Involvement:** TPP2 is involved in several key pathways, including adaptive immune system, antigen processing, and ubiquitination of proteins. 4. **Protein Binding:** TPP2 interacts with various proteins, including ubiquitin, which is essential for protein degradation and homeostasis. **Pathways and Functions:** 1. **Adaptive Immune System:** TPP2 plays a crucial role in the adaptive immune system by processing and presenting antigens to T-cells through MHC class I molecules. 2. **Antigen Processing:** TPP2 is involved in the ubiquitination and proteasomal degradation of antigens, which is essential for the presentation of antigens to T-cells. 3. **Intracellular Amino Acid Homeostasis:** TPP2 regulates intracellular amino acid levels by hydrolyzing tripeptides, which are essential for protein synthesis and degradation. 4. **Protein Polyubiquitination:** TPP2 interacts with ubiquitin, which is essential for protein degradation and homeostasis. **Clinical Significance:** 1. **Autoimmune Disorders:** Dysregulation of TPP2 has been implicated in several autoimmune disorders, including rheumatoid arthritis and multiple sclerosis. 2. **Neurological Conditions:** TPP2 has been linked to neurological conditions, including epilepsy and schizophrenia, due to its role in GABAergic neurotransmission. 3. **Cancer:** TPP2 has been found to be overexpressed in certain types of cancer, including lung and breast cancer, suggesting its potential role in tumorigenesis. 4. **Therapeutic Targeting:** TPP2 has been identified as a potential therapeutic target for the treatment of autoimmune disorders and neurological conditions. In conclusion, TPP2 is a crucial regulator of the immune response and cellular homeostasis. Its dysregulation has been implicated in several diseases, and its therapeutic targeting has shown promise in treating autoimmune disorders and neurological conditions. Further research is necessary to fully understand the mechanisms of TPP2 and its role in human disease.

Genular Protein ID: 2594628091

Symbol: TPP2_HUMAN

Name: Tripeptidyl-peptidase 2

UniProtKB Accession Codes:

P29144 Q5VZU8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1840501

Title: Nucleotide sequence of cDNA covering the N-terminus of human tripeptidyl peptidase II.

PubMed ID: 1840501

PubMed ID: 1670990

Title: Characterization of cDNA for human tripeptidyl peptidase II: the N-terminal part of the enzyme is similar to subtilisin.

PubMed ID: 1670990

DOI: 10.1021/bi00215a025

PubMed ID: 1691635

Title: Immunological cross-reactivity between human tripeptidyl peptidase II and fibronectin.

PubMed ID: 1691635

DOI: 10.1042/bj2670149

PubMed ID: 3313395

Title: Active site of tripeptidyl peptidase II from human erythrocytes is of the subtilisin type.

PubMed ID: 3313395

DOI: 10.1073/pnas.84.21.7508

PubMed ID: 19747897

Title: A role for nuclear translocation of tripeptidyl-peptidase II in reactive oxygen species-dependent DNA damage responses.

PubMed ID: 19747897

DOI: 10.1016/j.bbrc.2009.09.021

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25525876

Title: Dual proteolytic pathways govern glycolysis and immune competence.

PubMed ID: 25525876

DOI: 10.1016/j.cell.2014.12.001

PubMed ID: 30533531

Title: TPP2 mutation associated with sterile brain inflammation mimicking MS.

PubMed ID: 30533531

DOI: 10.1212/nxg.0000000000000285

Sequence Information:

  • Length: 1249
  • Mass: 138350
  • Checksum: A26A6249DBF7F3DD
  • Sequence:
    • MATAATEEPF PFHGLLPKKE TGAASFLCRY PEYDGRGVLI AVLDTGVDPG APGMQVTTDG 
KPKIVDIIDT TGSGDVNTAT EVEPKDGEIV GLSGRVLKIP ASWTNPSGKY HIGIKNGYDF 
YPKALKERIQ KERKEKIWDP VHRVALAEAC RKQEEFDVAN NGSSQANKLI KEELQSQVEL 
LNSFEKKYSD PGPVYDCLVW HDGEVWRACI DSNEDGDLSK STVLRNYKEA QEYGSFGTAE 
MLNYSVNIYD DGNLLSIVTS GGAHGTHVAS IAAGHFPEEP ERNGVAPGAQ ILSIKIGDTR 
LSTMETGTGL IRAMIEVINH KCDLVNYSYG EATHWPNSGR ICEVINEAVW KHNIIYVSSA 
GNNGPCLSTV GCPGGTTSSV IGVGAYVSPD MMVAEYSLRE KLPANQYTWS SRGPSADGAL 
GVSISAPGGA IASVPNWTLR GTQLMNGTSM SSPNACGGIA LILSGLKANN IDYTVHSVRR 
ALENTAVKAD NIEVFAQGHG IIQVDKAYDY LVQNTSFANK LGFTVTVGNN RGIYLRDPVQ 
VAAPSDHGVG IEPVFPENTE NSEKISLQLH LALTSNSSWV QCPSHLELMN QCRHINIRVD 
PRGLREGLHY TEVCGYDIAS PNAGPLFRVP ITAVIAAKVN ESSHYDLAFT DVHFKPGQIR 
RHFIEVPEGA TWAEVTVCSC SSEVSAKFVL HAVQLVKQRA YRSHEFYKFC SLPEKGTLTE 
AFPVLGGKAI EFCIARWWAS LSDVNIDYTI SFHGIVCTAP QLNIHASEGI NRFDVQSSLK 
YEDLAPCITL KNWVQTLRPV SAKTKPLGSR DVLPNNRQLY EMVLTYNFHQ PKSGEVTPSC 
PLLCELLYES EFDSQLWIIF DQNKRQMGSG DAYPHQYSLK LEKGDYTIRL QIRHEQISDL 
ERLKDLPFIV SHRLSNTLSL DIHENHSFAL LGKKKSSNLT LPPKYNQPFF VTSLPDDKIP 
KGAGPGCYLA GSLTLSKTEL GKKADVIPVH YYLIPPPTKT KNGSKDKEKD SEKEKDLKEE 
FTEALRDLKI QWMTKLDSSD IYNELKETYP NYLPLYVARL HQLDAEKERM KRLNEIVDAA 
NAVISHIDQT ALAVYIAMKT DPRPDAATIK NDMDKQKSTL VDALCRKGCA LADHLLHTQA 
QDGAISTDAE GKEEEGESPL DSLAETFWET TKWTDLFDNK VLTFAYKHAL VNKMYGRGLK 
FATKLVEEKP TKENWKNCIQ LMKLLGWTHC ASFTENWLPI MYPPDYCVF

Genular Protein ID: 1883449860

Symbol: Q5VZU9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5VZU9

Database IDs:

ARBA 9 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 4 GeneTree 1 HGNC 1 IntAct 1 InterPro 13 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 10 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1262
  • Mass: 139766
  • Checksum: FD7528A15433F987
  • Sequence:
    • MATAATEEPF PFHGLLPKKE TGAASFLCRY PEYDGRGVLI AVLDTGVDPG APGMQVTTDG 
KPKIVDIIDT TGSGDVNTAT EVEPKDGEIV GLSGRVLKIP ASWTNPSGKY HIGIKNGYDF 
YPKALKERIQ KERKEKIWDP VHRVALAEAC RKQEEFDVAN NGSSQANKLI KEELQSQVEL 
LNSFEKKYSD PGPVYDCLVW HDGEVWRACI DSNEDGDLSK STVLRNYKEA QEYGSFGTAE 
MLNYSVNIYD DGNLLSIVTS GGAHGTHVAS IAAGHFPEEP ERNGVAPGAQ ILSIKIGDTR 
LSTMETGTGL IRAMIEVINH KCDLVNYSYG EATHWPNSGR ICEVINEAVW KHNIIYVSSA 
GNNGPCLSTV GCPGGTTSSV IGVGAYVSPD MMVAEYSLRE KLPANQYTWS SRGPSADGAL 
GVSISAPGGA IASVPNWTLR GTQLMNGTSM SSPNACGGIA LILSGLKANN IDYTVHSVRR 
ALENTAVKAD NIEVFAQGHG IIQVDKAYDY LVQNTSFANK LGFTVTVGNN RGIYLRDPVQ 
VAAPSDHGVG IEPVFPENTE NSEKISLQLH LALTSNSSWV QCPSHLELMN QCRHINIRVD 
PRGLREGLHY TEVCGYDIAS PNAGPLFRVP ITAVIAAKVN ESSHYDLAFT DVHFKPGQIR 
RHFIEVPEGA TWAEVTVCSC SSEVSAKFVL HAVQLVKQRA YRSHEFYKFC SLPEKGTLTE 
AFPVLGGKAI EFCIARWWAS LSDVNIDYTI SFHGIVCTAP QLNIHASEGI NRFDVQSSLK 
YEDLAPCITL KNWVQTLRPV SAKTKPLGSR DVLPNNRQLY EMVLTYNFHQ PKSGEVTPSC 
PLLCELLYES EFDSQLWIIF DQNKRQMGSG DAYPHQYSLK LEKGDYTIRL QIRHEQISDL 
ERLKDLPFIV SHRLSNTLSL DIHENHSFAL LGKKKSSNLT LPPKYNQPFF VTSLPDDKIP 
KGAGPGCYLA GSLTLSKTEL GKKAGQSAAK RQGKFKKDVI PVHYYLIPPP TKTKNGSKDK 
EKDSEKEKDL KEEFTEALRD LKIQWMTKLD SSDIYNELKE TYPNYLPLYV ARLHQLDAEK 
ERMKRLNEIV DAANAVISHI DQTALAVYIA MKTDPRPDAA TIKNDMDKQK STLVDALCRK 
GCALADHLLH TQAQDGAIST DAEGKEEEGE SPLDSLAETF WETTKWTDLF DNKVLTFAYK 
HALVNKMYGR GLKFATKLVE EKPTKENWKN CIQLMKLLGW THCASFTENW LPIMYPPDYC 
VF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.