Details for: TPP2
Gene ID: 7174
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: TPP2
Ensembl ID: ENSG00000134900
Description: tripeptidyl peptidase 2
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 13.97rCSI 10.76%PRS 34.25
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CSI 13.41rCSI 18.32%PRS 38.64
-
CSI 8.6rCSI 27.53%PRS 32.94
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CSI 7.87rCSI 18.79%PRS 47.39
-
CSI 7.64rCSI 5.72%PRS 50.1
-
CSI 6.7rCSI 20.94%PRS 23.97
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CSI 6.31rCSI 22.69%PRS 22.02
-
CSI 5.53rCSI 32.58%PRS 24.15
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CSI 5.45rCSI 8.62%PRS 36.52
-
CSI 5.34rCSI 26.78%PRS 45.58
-
CSI 5.26rCSI 10.86%PRS 44.5
-
CSI 5.13rCSI 3.69%PRS 47.47
-
CSI 5.04rCSI 12.24%PRS 22.33
-
CSI 4.93rCSI 3.32%PRS 44.46
-
CSI 4.76rCSI 7.07%PRS 39.17
-
CSI 4.75rCSI 3.52%PRS 30.85
-
CSI 4.71rCSI 11.33%PRS 52.39
-
CSI 4.6rCSI 10.49%PRS 35.12
-
CSI 4.6rCSI 3.63%PRS 25.53
-
CSI 4.47rCSI 3.11%PRS 47.66
-
CSI 4.38rCSI 10.01%PRS 35.39
-
CSI 4.21rCSI 3.7%PRS 40.5
-
CSI 4.16rCSI 19.95%PRS 34.09
-
CSI 4.16rCSI 18.05%PRS 52.35
-
CSI 4.12rCSI 5.94%PRS 45.72
-
CSI 4.05rCSI 10.83%PRS 30.51
-
CSI 4.01rCSI 11.05%PRS 33.69
-
CSI 4rCSI 3.21%PRS 56.73
-
CSI 3.76rCSI 6.05%PRS 24.84
-
CSI 3.73rCSI 2.94%PRS 41.57
-
CSI 3.63rCSI 2.93%PRS 47.61
-
CSI 3.37rCSI 1.99%PRS 48.99
-
CSI 3.34rCSI 27.14%PRS 32.2
-
CSI 3.31rCSI 3.87%PRS 49.5
-
CSI 3.3rCSI 4.74%PRS 28.77
-
CSI 3.29rCSI 9.34%PRS 36.84
-
CSI 3.2rCSI 3.3%PRS 52.55
-
CSI 3.17rCSI 5.76%PRS 51.48
-
CSI 3.13rCSI 2.38%PRS 45.65
-
CSI 3.11rCSI 5.82%PRS 27.41
-
CSI 3.08rCSI 2.7%PRS 45.17
-
CSI 3.07rCSI 10.4%PRS 47.01
-
CSI 2.98rCSI 4.56%PRS 40.15
-
CSI 2.97rCSI 2.5%PRS 52.25
-
CSI 2.95rCSI 11.04%PRS 30.61
-
CSI 2.89rCSI 2.03%PRS 61.18
-
CSI 2.86rCSI 3.57%PRS 46.77
-
CSI 2.81rCSI 2.86%PRS 47.75
-
CSI 2.79rCSI 3.33%PRS 55.12
-
CSI 2.78rCSI 66.51%PRS 22.47
-
CSI 2.77rCSI 3.96%PRS 38.45
-
CSI 2.73rCSI 65.85%PRS 23.25
-
CSI 2.55rCSI 2.46%PRS 59.95
-
CSI 2.52rCSI 2.48%PRS 50.37
-
CSI 2.49rCSI 1.73%PRS 43.04
-
CSI 2.49rCSI 1.86%PRS 70.05
-
CSI 2.47rCSI 3.38%PRS 39.95
-
CSI 2.37rCSI 2.36%PRS 30.91
-
CSI 2.33rCSI 2.88%PRS 32.2
-
CSI 2.31rCSI 6.84%PRS 46.82
-
CSI 2.3rCSI 4.17%PRS 31.2
-
CSI 2.23rCSI 1.48%PRS 40.07
-
CSI 2.22rCSI 1.68%PRS 46.94
-
CSI 2.2rCSI 4.41%PRS 27.4
-
CSI 2.19rCSI 3.84%PRS 29.23
-
CSI 2.18rCSI 7.16%PRS 26.65
-
CSI 2.15rCSI 1.67%PRS 35.63
-
CSI 2.11rCSI 3.72%PRS 22.16
-
CSI 2.08rCSI 1.72%PRS 36.58
-
CSI 2.05rCSI 1.43%PRS 37.57
-
CSI 2rCSI 2.39%PRS 22.93
-
CSI 1.99rCSI 4.46%PRS 23.51
-
CSI 1.99rCSI 8.24%PRS 47.86
-
CSI 1.98rCSI 2.81%PRS 33.59
-
CSI 1.97rCSI 2.52%PRS 40.41
-
CSI 1.96rCSI 39.84%PRS 30.3
-
CSI 1.96rCSI 9.64%PRS 46.3
-
CSI 1.95rCSI 1.8%PRS 36.95
-
CSI 1.94rCSI 5.02%PRS 32.92
-
CSI 1.94rCSI 2.28%PRS 39.52
-
CSI 1.93rCSI 1.45%PRS 38.53
-
CSI 1.92rCSI 3.06%PRS 30.4
-
CSI 1.92rCSI 3.67%PRS 52.26
-
CSI 1.9rCSI 1.47%PRS 50.82
-
CSI 1.88rCSI 4.3%PRS 30.94
-
CSI 1.87rCSI 1.77%PRS 36.97
-
CSI 1.81rCSI 2.93%PRS 34.97
-
CSI 1.81rCSI 1.74%PRS 36.6
-
CSI 1.8rCSI 8.26%PRS 58.45
-
CSI 1.8rCSI 3.07%PRS 62.17
-
CSI 1.78rCSI 3.92%PRS 39.73
-
CSI 1.77rCSI 7.15%PRS 34.81
-
CSI 1.77rCSI 2.71%PRS 41.91
-
CSI 1.76rCSI 1.92%PRS 39.59
-
CSI 1.75rCSI 2.17%PRS 21.7
-
CSI 1.74rCSI 2.09%PRS 34.31
-
CSI 1.73rCSI 1.61%PRS 35.66
-
CSI 1.72rCSI 2.06%PRS 54.51
-
CSI 1.7rCSI 2.72%PRS 30.79
-
CSI 1.7rCSI 2.22%PRS 48.32
-
CSI 0.1rCSI 0.9%PRS 68.0%
-
CSI 0.2rCSI 1.9%PRS 39.2%
-
CSI 0.2rCSI 1.1%PRS 48.2%
-
CSI 0.3rCSI 2.1%PRS 24.7%
-
CSI 0.3rCSI 1.0%PRS 51.9%
-
CSI 0.3rCSI 1.4%PRS 59.5%
-
CSI 0.4rCSI 2.6%PRS 29.7%
-
CSI 0.4rCSI 3.2%PRS 56.4%
-
CSI 0.4rCSI 1.7%PRS 31.8%
-
CSI 0.5rCSI 1.7%PRS 36.2%
-
CSI 0.5rCSI 2.1%PRS 55.1%
-
CSI 0.6rCSI 8.8%PRS 38.7%
-
CSI 0.6rCSI 2.5%PRS 81.0%
-
CSI 0.6rCSI 1.7%PRS 28.9%
-
CSI 0.6rCSI 1.5%PRS 28.2%
-
CSI 0.6rCSI 1.4%PRS 26.4%
-
CSI 0.6rCSI 1.0%PRS 34.0%
-
CSI 0.6rCSI 1.8%PRS 51.0%
-
CSI 0.7rCSI 2.0%PRS 25.9%
-
CSI 0.7rCSI 4.4%PRS 35.5%
-
CSI 0.7rCSI 2.3%PRS 30.1%
-
CSI 0.7rCSI 0.7%PRS 41.3%
-
CSI 0.7rCSI 1.4%PRS 44.8%
-
CSI 0.7rCSI 0.9%PRS 27.5%
-
CSI 0.8rCSI 1.3%PRS 45.0%
-
CSI 0.8rCSI 5.8%PRS 25.7%
-
CSI 0.8rCSI 1.6%PRS 53.3%
-
CSI 0.8rCSI 1.3%PRS 37.1%
-
CSI 0.8rCSI 4.0%PRS 56.8%
-
CSI 0.9rCSI 1.4%PRS 28.1%
-
CSI 0.9rCSI 2.3%PRS 44.6%
-
CSI 0.9rCSI 0.8%PRS 33.0%
-
CSI 0.9rCSI 3.0%PRS 26.8%
-
CSI 0.9rCSI 3.4%PRS 23.8%
-
CSI 0.9rCSI 1.4%PRS 52.3%
-
CSI 0.9rCSI 2.2%PRS 27.2%
-
CSI 0.9rCSI 2.5%PRS 42.3%
-
CSI 0.9rCSI 1.3%PRS 39.6%
-
CSI 1.0rCSI 1.6%PRS 28.2%
-
CSI 1.0rCSI 1.8%PRS 44.2%
-
CSI 1.1rCSI 2.3%PRS 50.2%
-
CSI 1.1rCSI 5.6%PRS 46.3%
-
CSI 1.1rCSI 1.7%PRS 46.4%
-
CSI 1.1rCSI 0.9%PRS 44.1%
-
CSI 1.1rCSI 2.9%PRS 49.3%
-
CSI 1.1rCSI 3.4%PRS 48.2%
-
CSI 1.1rCSI 2.9%PRS 42.0%
-
CSI 1.1rCSI 2.5%PRS 45.6%
-
CSI 1.1rCSI 3.0%PRS 35.1%
-
CSI 1.1rCSI 1.4%PRS 38.2%
-
CSI 1.1rCSI 1.7%PRS 36.1%
-
CSI 1.2rCSI 1.7%PRS 33.1%
-
CSI 1.2rCSI 1.4%PRS 42.4%
-
CSI 1.2rCSI 2.9%PRS 34.1%
-
CSI 1.2rCSI 2.4%PRS 32.7%
-
CSI 1.2rCSI 1.5%PRS 23.8%
-
CSI 1.2rCSI 1.6%PRS 30.8%
-
CSI 1.2rCSI 1.5%PRS 44.6%
-
CSI 1.2rCSI 1.7%PRS 51.1%
-
CSI 1.2rCSI 1.6%PRS 58.2%
-
CSI 1.2rCSI 1.1%PRS 42.2%
-
CSI 1.2rCSI 4.8%PRS 45.5%
-
CSI 1.3rCSI 2.1%PRS 56.9%
-
CSI 1.3rCSI 1.0%PRS 34.3%
-
CSI 1.3rCSI 2.1%PRS 23.0%
-
CSI 1.3rCSI 2.3%PRS 34.2%
-
CSI 1.3rCSI 2.8%PRS 41.5%
-
CSI 1.3rCSI 1.1%PRS 39.4%
-
CSI 1.3rCSI 3.0%PRS 29.7%
-
CSI 1.3rCSI 1.7%PRS 33.4%
-
CSI 1.3rCSI 27.0%PRS 31.5%
-
CSI 1.3rCSI 2.1%PRS 38.9%
-
CSI 1.4rCSI 3.9%PRS 51.7%
-
CSI 1.4rCSI 2.8%PRS 34.8%
-
CSI 1.4rCSI 1.6%PRS 31.3%
-
CSI 1.4rCSI 2.5%PRS 34.8%
-
CSI 1.4rCSI 1.1%PRS 36.2%
-
CSI 1.4rCSI 1.9%PRS 37.7%
-
CSI 1.4rCSI 1.5%PRS 33.6%
-
CSI 1.5rCSI 2.4%PRS 40.7%
-
CSI 1.5rCSI 20.7%PRS 30.0%
-
CSI 1.5rCSI 1.5%PRS 27.8%
-
CSI 1.5rCSI 1.6%PRS 54.7%
-
CSI 1.5rCSI 3.6%PRS 38.8%
-
CSI 1.6rCSI 2.4%PRS 53.3%
-
CSI 1.6rCSI 2.7%PRS 28.1%
-
CSI 1.6rCSI 3.2%PRS 21.6%
-
CSI 1.6rCSI 1.5%PRS 50.4%
-
CSI 1.6rCSI 1.4%PRS 26.8%
-
CSI 1.7rCSI 1.8%PRS 33.5%
-
CSI 1.7rCSI 1.5%PRS 35.3%
-
CSI 1.7rCSI 2.2%PRS 48.3%
-
CSI 1.7rCSI 2.7%PRS 30.8%
-
CSI 1.7rCSI 2.1%PRS 54.5%
-
CSI 1.7rCSI 1.6%PRS 35.7%
-
CSI 1.7rCSI 2.1%PRS 34.3%
-
CSI 1.8rCSI 2.2%PRS 21.7%
-
CSI 1.8rCSI 1.9%PRS 39.6%
-
CSI 1.8rCSI 2.7%PRS 41.9%
-
CSI 1.8rCSI 7.2%PRS 34.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2594628091
Symbol: TPP2_HUMAN
Name: Tripeptidyl-peptidase 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15057823
Title: The DNA sequence and analysis of human chromosome 13.
PubMed ID: 15057823
DOI: 10.1038/nature02379
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1840501
Title: Nucleotide sequence of cDNA covering the N-terminus of human tripeptidyl peptidase II.
PubMed ID: 1840501
PubMed ID: 1670990
Title: Characterization of cDNA for human tripeptidyl peptidase II: the N-terminal part of the enzyme is similar to subtilisin.
PubMed ID: 1670990
DOI: 10.1021/bi00215a025
PubMed ID: 1691635
Title: Immunological cross-reactivity between human tripeptidyl peptidase II and fibronectin.
PubMed ID: 1691635
DOI: 10.1042/bj2670149
PubMed ID: 3313395
Title: Active site of tripeptidyl peptidase II from human erythrocytes is of the subtilisin type.
PubMed ID: 3313395
PubMed ID: 19747897
Title: A role for nuclear translocation of tripeptidyl-peptidase II in reactive oxygen species-dependent DNA damage responses.
PubMed ID: 19747897
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25525876
Title: Dual proteolytic pathways govern glycolysis and immune competence.
PubMed ID: 25525876
PubMed ID: 30533531
Title: TPP2 mutation associated with sterile brain inflammation mimicking MS.
PubMed ID: 30533531
Sequence Information:
- Length: 1249
- Mass: 138350
- Checksum: A26A6249DBF7F3DD
- Sequence:
MATAATEEPF PFHGLLPKKE TGAASFLCRY PEYDGRGVLI AVLDTGVDPG APGMQVTTDG KPKIVDIIDT TGSGDVNTAT EVEPKDGEIV GLSGRVLKIP ASWTNPSGKY HIGIKNGYDF YPKALKERIQ KERKEKIWDP VHRVALAEAC RKQEEFDVAN NGSSQANKLI KEELQSQVEL LNSFEKKYSD PGPVYDCLVW HDGEVWRACI DSNEDGDLSK STVLRNYKEA QEYGSFGTAE MLNYSVNIYD DGNLLSIVTS GGAHGTHVAS IAAGHFPEEP ERNGVAPGAQ ILSIKIGDTR LSTMETGTGL IRAMIEVINH KCDLVNYSYG EATHWPNSGR ICEVINEAVW KHNIIYVSSA GNNGPCLSTV GCPGGTTSSV IGVGAYVSPD MMVAEYSLRE KLPANQYTWS SRGPSADGAL GVSISAPGGA IASVPNWTLR GTQLMNGTSM SSPNACGGIA LILSGLKANN IDYTVHSVRR ALENTAVKAD NIEVFAQGHG IIQVDKAYDY LVQNTSFANK LGFTVTVGNN RGIYLRDPVQ VAAPSDHGVG IEPVFPENTE NSEKISLQLH LALTSNSSWV QCPSHLELMN QCRHINIRVD PRGLREGLHY TEVCGYDIAS PNAGPLFRVP ITAVIAAKVN ESSHYDLAFT DVHFKPGQIR RHFIEVPEGA TWAEVTVCSC SSEVSAKFVL HAVQLVKQRA YRSHEFYKFC SLPEKGTLTE AFPVLGGKAI EFCIARWWAS LSDVNIDYTI SFHGIVCTAP QLNIHASEGI NRFDVQSSLK YEDLAPCITL KNWVQTLRPV SAKTKPLGSR DVLPNNRQLY EMVLTYNFHQ PKSGEVTPSC PLLCELLYES EFDSQLWIIF DQNKRQMGSG DAYPHQYSLK LEKGDYTIRL QIRHEQISDL ERLKDLPFIV SHRLSNTLSL DIHENHSFAL LGKKKSSNLT LPPKYNQPFF VTSLPDDKIP KGAGPGCYLA GSLTLSKTEL GKKADVIPVH YYLIPPPTKT KNGSKDKEKD SEKEKDLKEE FTEALRDLKI QWMTKLDSSD IYNELKETYP NYLPLYVARL HQLDAEKERM KRLNEIVDAA NAVISHIDQT ALAVYIAMKT DPRPDAATIK NDMDKQKSTL VDALCRKGCA LADHLLHTQA QDGAISTDAE GKEEEGESPL DSLAETFWET TKWTDLFDNK VLTFAYKHAL VNKMYGRGLK FATKLVEEKP TKENWKNCIQ LMKLLGWTHC ASFTENWLPI MYPPDYCVF
Genular Protein ID: 1883449860
Symbol: Q5VZU9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15057823
Title: The DNA sequence and analysis of human chromosome 13.
PubMed ID: 15057823
DOI: 10.1038/nature02379
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 1262
- Mass: 139766
- Checksum: FD7528A15433F987
- Sequence:
MATAATEEPF PFHGLLPKKE TGAASFLCRY PEYDGRGVLI AVLDTGVDPG APGMQVTTDG KPKIVDIIDT TGSGDVNTAT EVEPKDGEIV GLSGRVLKIP ASWTNPSGKY HIGIKNGYDF YPKALKERIQ KERKEKIWDP VHRVALAEAC RKQEEFDVAN NGSSQANKLI KEELQSQVEL LNSFEKKYSD PGPVYDCLVW HDGEVWRACI DSNEDGDLSK STVLRNYKEA QEYGSFGTAE MLNYSVNIYD DGNLLSIVTS GGAHGTHVAS IAAGHFPEEP ERNGVAPGAQ ILSIKIGDTR LSTMETGTGL IRAMIEVINH KCDLVNYSYG EATHWPNSGR ICEVINEAVW KHNIIYVSSA GNNGPCLSTV GCPGGTTSSV IGVGAYVSPD MMVAEYSLRE KLPANQYTWS SRGPSADGAL GVSISAPGGA IASVPNWTLR GTQLMNGTSM SSPNACGGIA LILSGLKANN IDYTVHSVRR ALENTAVKAD NIEVFAQGHG IIQVDKAYDY LVQNTSFANK LGFTVTVGNN RGIYLRDPVQ VAAPSDHGVG IEPVFPENTE NSEKISLQLH LALTSNSSWV QCPSHLELMN QCRHINIRVD PRGLREGLHY TEVCGYDIAS PNAGPLFRVP ITAVIAAKVN ESSHYDLAFT DVHFKPGQIR RHFIEVPEGA TWAEVTVCSC SSEVSAKFVL HAVQLVKQRA YRSHEFYKFC SLPEKGTLTE AFPVLGGKAI EFCIARWWAS LSDVNIDYTI SFHGIVCTAP QLNIHASEGI NRFDVQSSLK YEDLAPCITL KNWVQTLRPV SAKTKPLGSR DVLPNNRQLY EMVLTYNFHQ PKSGEVTPSC PLLCELLYES EFDSQLWIIF DQNKRQMGSG DAYPHQYSLK LEKGDYTIRL QIRHEQISDL ERLKDLPFIV SHRLSNTLSL DIHENHSFAL LGKKKSSNLT LPPKYNQPFF VTSLPDDKIP KGAGPGCYLA GSLTLSKTEL GKKAGQSAAK RQGKFKKDVI PVHYYLIPPP TKTKNGSKDK EKDSEKEKDL KEEFTEALRD LKIQWMTKLD SSDIYNELKE TYPNYLPLYV ARLHQLDAEK ERMKRLNEIV DAANAVISHI DQTALAVYIA MKTDPRPDAA TIKNDMDKQK STLVDALCRK GCALADHLLH TQAQDGAIST DAEGKEEEGE SPLDSLAETF WETTKWTDLF DNKVLTFAYK HALVNKMYGR GLKFATKLVE EKPTKENWKN CIQLMKLLGW THCASFTENW LPIMYPPDYC VF