Details for: HSP90B1

Gene ID: 7184

Symbol: HSP90B1

Ensembl ID: ENSG00000166598

Description: heat shock protein 90 beta family member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 5.94
    Marker Score: 4652
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.82
    Marker Score: 3860
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 4.71
    Marker Score: 2664
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.43
    Marker Score: 3776
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 4.06
    Marker Score: 2861
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4
    Marker Score: 70973
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.97
    Marker Score: 135036
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 3.95
    Marker Score: 16474.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.93
    Marker Score: 6050
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.84
    Marker Score: 10299
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 3.69
    Marker Score: 1017
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.68
    Marker Score: 8998
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.66
    Marker Score: 3122
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.5
    Marker Score: 46198
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.39
    Marker Score: 22083
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 3.33
    Marker Score: 874
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.33
    Marker Score: 115187.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.31
    Marker Score: 3994
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.29
    Marker Score: 38230
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.26
    Marker Score: 4486
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.26
    Marker Score: 8221
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.24
    Marker Score: 15931
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.22
    Marker Score: 28275
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.21
    Marker Score: 10134
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.11
    Marker Score: 7084
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.1
    Marker Score: 3148
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.07
    Marker Score: 18225
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.07
    Marker Score: 1277
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.06
    Marker Score: 3272
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.05
    Marker Score: 728
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.03
    Marker Score: 973
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.98
    Marker Score: 3676
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.97
    Marker Score: 1336
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.94
    Marker Score: 2840
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.94
    Marker Score: 1964
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.93
    Marker Score: 1708
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.93
    Marker Score: 21829
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.92
    Marker Score: 7635
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.9
    Marker Score: 1501
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.87
    Marker Score: 3280
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.86
    Marker Score: 8026
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.86
    Marker Score: 15006
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.85
    Marker Score: 1625
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.84
    Marker Score: 2548
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.83
    Marker Score: 1507.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.81
    Marker Score: 31690
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.8
    Marker Score: 4599
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.8
    Marker Score: 1256
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 2.8
    Marker Score: 1945
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.78
    Marker Score: 696
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.77
    Marker Score: 2979
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.77
    Marker Score: 11868
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.76
    Marker Score: 24002
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.73
    Marker Score: 27468
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.72
    Marker Score: 5120
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.72
    Marker Score: 2133
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.71
    Marker Score: 11677
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.71
    Marker Score: 2408
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.71
    Marker Score: 7478
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 2.7
    Marker Score: 1178
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.7
    Marker Score: 2404
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.69
    Marker Score: 4316
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.69
    Marker Score: 4452
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.68
    Marker Score: 3797
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.67
    Marker Score: 3448
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.67
    Marker Score: 17387
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.66
    Marker Score: 9152
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.65
    Marker Score: 140307
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 2.65
    Marker Score: 925
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.65
    Marker Score: 1884
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.64
    Marker Score: 1254
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 2.61
    Marker Score: 1684
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.61
    Marker Score: 2612
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.61
    Marker Score: 3843
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.61
    Marker Score: 9266
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.61
    Marker Score: 3056
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.61
    Marker Score: 3670
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.6
    Marker Score: 5890
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.59
    Marker Score: 9983
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.58
    Marker Score: 1957
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.58
    Marker Score: 2035
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.58
    Marker Score: 684
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.58
    Marker Score: 5382
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.57
    Marker Score: 2730
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.57
    Marker Score: 6995
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.57
    Marker Score: 25443
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.57
    Marker Score: 3542
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 2.56
    Marker Score: 886
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.56
    Marker Score: 65492
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.55
    Marker Score: 8015.5
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 2.55
    Marker Score: 724
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.55
    Marker Score: 1825
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.54
    Marker Score: 628
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.54
    Marker Score: 1254
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.54
    Marker Score: 1096
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.53
    Marker Score: 2757
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 2.53
    Marker Score: 1580
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.53
    Marker Score: 933
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 2.53
    Marker Score: 510
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.52
    Marker Score: 1583.5

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Other Information

**Key Characteristics:** HSP90B1 is a 72-kDa protein that is predominantly expressed in various cell types, including thyroid follicular cells, early promyelocytes, endocardial cells, IgA plasma cells, and epithelial cells of the lower respiratory tract. It is a member of the HSP90 family, which is characterized by its ability to bind ATP and facilitate protein folding, stability, and degradation. HSP90B1 is also known to interact with various proteins, including the transcription factor ATF6-alpha, which regulates the expression of chaperone genes in response to endoplasmic reticulum stress. **Pathways and Functions:** HSP90B1 is involved in various cellular pathways, including: 1. **Protein Folding and Degradation:** HSP90B1 plays a crucial role in protein folding, stability, and degradation, which is essential for maintaining cellular homeostasis. 2. **Endoplasmic Reticulum Stress Response:** HSP90B1 interacts with ATF6-alpha, which regulates the expression of chaperone genes in response to endoplasmic reticulum stress. 3. **Immune Regulation:** HSP90B1 is involved in regulating immune responses, including cytokine signaling, Toll-like receptor cascades, and the trafficking and processing of endosomal TLRs. 4. **Cellular Stress Responses:** HSP90B1 is activated in response to various forms of cellular stress, including heat shock, hypoxia, and endoplasmic reticulum stress. 5. **Protein Trafficking:** HSP90B1 is involved in regulating protein trafficking, including retrograde and anterograde transport. **Clinical Significance:** Dysregulation of HSP90B1 has been implicated in various diseases, including: 1. **Cancer:** HSP90B1 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 2. **Autoimmune Diseases:** HSP90B1 is involved in regulating immune responses and has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Neurodegenerative Diseases:** HSP90B1 has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 4. **Infectious Diseases:** HSP90B1 is involved in regulating immune responses and has been implicated in infectious diseases, such as tuberculosis and malaria. In conclusion, HSP90B1 is a multifaceted protein that plays a crucial role in maintaining cellular homeostasis and immune function. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 1597284859

Symbol: ENPL_HUMAN

Name: Endoplasmin

UniProtKB Accession Codes:

P14625 Q96A97

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 9 EMBL 5 EMDB 8 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 40 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HAMAP 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 6 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2377606

Title: Human homologue of murine tumor rejection antigen gp96: 5'-regulatory and coding regions and relationship to stress-induced proteins.

PubMed ID: 2377606

DOI: 10.1073/pnas.87.15.5658

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2546060

Title: Glucose-regulated protein (GRP94 and GRP78) genes share common regulatory domains and are coordinately regulated by common trans-acting factors.

PubMed ID: 2546060

DOI: 10.1128/mcb.9.5.2153-2162.1989

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 12475965

Title: A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins.

PubMed ID: 12475965

DOI: 10.1091/mbc.e02-05-0311

PubMed ID: 12643545

Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

PubMed ID: 12643545

DOI: 10.1021/pr025562r

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20865800

Title: Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone.

PubMed ID: 20865800

DOI: 10.1038/ncomms1070

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 18264092

Title: OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD.

PubMed ID: 18264092

DOI: 10.1038/ncb1689

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23349634

Title: A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.

PubMed ID: 23349634

DOI: 10.1371/journal.pgen.1003210

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29192674

Title: Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway.

PubMed ID: 29192674

DOI: 10.1038/cr.2017.149

PubMed ID: 32272059

Title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.

PubMed ID: 32272059

DOI: 10.1016/j.cell.2020.03.031

Sequence Information:

  • Length: 803
  • Mass: 92469
  • Checksum: 9BF6705A7A2ED0D0
  • Sequence:
    • MRALWVLGLC CVLLTFGSVR ADDEVDVDGT VEEDLGKSRE GSRTDDEVVQ REEEAIQLDG 
LNASQIRELR EKSEKFAFQA EVNRMMKLII NSLYKNKEIF LRELISNASD ALDKIRLISL 
TDENALSGNE ELTVKIKCDK EKNLLHVTDT GVGMTREELV KNLGTIAKSG TSEFLNKMTE 
AQEDGQSTSE LIGQFGVGFY SAFLVADKVI VTSKHNNDTQ HIWESDSNEF SVIADPRGNT 
LGRGTTITLV LKEEASDYLE LDTIKNLVKK YSQFINFPIY VWSSKTETVE EPMEEEEAAK 
EEKEESDDEA AVEEEEEEKK PKTKKVEKTV WDWELMNDIK PIWQRPSKEV EEDEYKAFYK 
SFSKESDDPM AYIHFTAEGE VTFKSILFVP TSAPRGLFDE YGSKKSDYIK LYVRRVFITD 
DFHDMMPKYL NFVKGVVDSD DLPLNVSRET LQQHKLLKVI RKKLVRKTLD MIKKIADDKY 
NDTFWKEFGT NIKLGVIEDH SNRTRLAKLL RFQSSHHPTD ITSLDQYVER MKEKQDKIYF 
MAGSSRKEAE SSPFVERLLK KGYEVIYLTE PVDEYCIQAL PEFDGKRFQN VAKEGVKFDE 
SEKTKESREA VEKEFEPLLN WMKDKALKDK IEKAVVSQRL TESPCALVAS QYGWSGNMER 
IMKAQAYQTG KDISTNYYAS QKKTFEINPR HPLIRDMLRR IKEDEDDKTV LDLAVVLFET 
ATLRSGYLLP DTKAYGDRIE RMLRLSLNID PDAKVEEEPE EEPEETAEDT TEDTEQDEDE 
EMDVGTDEEE ETAKESTAEK DEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.