Details for: TSN

Gene ID: 7247

Symbol: TSN

Ensembl ID: ENSG00000211460

Description: translin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 181.4263
    Cell Significance Index: -28.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 104.7139
    Cell Significance Index: -26.5600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 82.7290
    Cell Significance Index: -34.0800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 72.4070
    Cell Significance Index: -34.1900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 70.8172
    Cell Significance Index: -28.7700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 64.6014
    Cell Significance Index: -33.2300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 51.2055
    Cell Significance Index: -34.3600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 30.2595
    Cell Significance Index: -28.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.7626
    Cell Significance Index: -34.2300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.2203
    Cell Significance Index: -24.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.0901
    Cell Significance Index: -35.8700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.1688
    Cell Significance Index: -25.0900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.8159
    Cell Significance Index: -10.5400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 3.5622
    Cell Significance Index: 57.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.0784
    Cell Significance Index: 242.2100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.3528
    Cell Significance Index: 47.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3357
    Cell Significance Index: 217.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.0176
    Cell Significance Index: 27.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8289
    Cell Significance Index: 166.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8246
    Cell Significance Index: 163.6500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8146
    Cell Significance Index: 56.3400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.7628
    Cell Significance Index: 6.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6652
    Cell Significance Index: 91.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6419
    Cell Significance Index: 75.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6352
    Cell Significance Index: 280.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6297
    Cell Significance Index: 17.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6038
    Cell Significance Index: 77.4000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.5556
    Cell Significance Index: 4.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5537
    Cell Significance Index: 68.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5422
    Cell Significance Index: 296.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5158
    Cell Significance Index: 33.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4955
    Cell Significance Index: 89.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4598
    Cell Significance Index: 21.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4295
    Cell Significance Index: 387.8300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4238
    Cell Significance Index: 29.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4218
    Cell Significance Index: 11.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3688
    Cell Significance Index: 27.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3538
    Cell Significance Index: 22.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3429
    Cell Significance Index: 122.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2995
    Cell Significance Index: 6.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2692
    Cell Significance Index: 12.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2680
    Cell Significance Index: 13.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2528
    Cell Significance Index: 6.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2131
    Cell Significance Index: 27.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1899
    Cell Significance Index: 5.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1764
    Cell Significance Index: 9.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1375
    Cell Significance Index: 26.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1088
    Cell Significance Index: 10.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0726
    Cell Significance Index: 12.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0622
    Cell Significance Index: 3.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0373
    Cell Significance Index: 2.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0349
    Cell Significance Index: 1.5800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0326
    Cell Significance Index: 0.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0251
    Cell Significance Index: 0.4200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0120
    Cell Significance Index: 0.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0010
    Cell Significance Index: -0.7300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0037
    Cell Significance Index: -0.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0058
    Cell Significance Index: -4.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0132
    Cell Significance Index: -9.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0177
    Cell Significance Index: -11.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0179
    Cell Significance Index: -32.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0227
    Cell Significance Index: -34.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0275
    Cell Significance Index: -37.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0300
    Cell Significance Index: -18.7100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0352
    Cell Significance Index: -19.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0411
    Cell Significance Index: -4.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0483
    Cell Significance Index: -1.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0514
    Cell Significance Index: -23.3200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0537
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0751
    Cell Significance Index: -15.8100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0770
    Cell Significance Index: -1.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0808
    Cell Significance Index: -9.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0984
    Cell Significance Index: -28.3100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1194
    Cell Significance Index: -6.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1251
    Cell Significance Index: -8.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1581
    Cell Significance Index: -22.9900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1673
    Cell Significance Index: -19.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1705
    Cell Significance Index: -5.9900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1758
    Cell Significance Index: -4.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1886
    Cell Significance Index: -5.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1974
    Cell Significance Index: -15.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2173
    Cell Significance Index: -6.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2280
    Cell Significance Index: -4.9400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2379
    Cell Significance Index: -6.8200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2417
    Cell Significance Index: -2.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2991
    Cell Significance Index: -8.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3006
    Cell Significance Index: -23.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3225
    Cell Significance Index: -4.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3363
    Cell Significance Index: -35.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3877
    Cell Significance Index: -17.1500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4002
    Cell Significance Index: -8.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4076
    Cell Significance Index: -8.6800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4359
    Cell Significance Index: -12.4400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4753
    Cell Significance Index: -9.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4753
    Cell Significance Index: -18.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4796
    Cell Significance Index: -29.4100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5562
    Cell Significance Index: -12.8500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.6186
    Cell Significance Index: -8.6700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6245
    Cell Significance Index: -11.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Translin is a 28-kDa protein that belongs to the arginine-rich protein family. It is characterized by its ability to interact with various proteins, RNAs, and DNA, facilitating its involvement in multiple cellular processes. Translin's unique structure, consisting of two arginine-rich domains, enables it to bind to single-stranded DNA, histones, and RNA, thereby regulating gene expression and DNA recombination. Its ability to interact with other proteins, such as histones, transcription factors, and RNA-binding proteins, further underscores its multifunctional nature. **Pathways and Functions:** Translin's involvement in various cellular processes can be attributed to its interactions with multiple molecules. Some of its key pathways and functions include: 1. **Gene Regulation:** Translin interacts with transcription factors and RNA-binding proteins to regulate gene expression. It can also participate in the regulation of gene silencing by RNA, thereby controlling the expression of specific genes. 2. **DNA Repair:** Translin's ability to bind to single-stranded DNA and histones enables it to participate in DNA repair processes, such as non-homologous end joining and homologous recombination. 3. **Cell Migration:** Translin's involvement in the cytoskeleton and its interaction with proteins such as actin and myosin facilitate cell migration, a process critical in development and tissue repair. 4. **Endoplasmic Reticulum Function:** Translin's interaction with proteins in the endoplasmic reticulum enables it to regulate the function of this organelle, which is crucial for protein folding, lipid synthesis, and calcium storage. 5. **Small Interfering RNA Biogenesis:** Translin's interaction with RNA-binding proteins enables it to participate in the biogenesis of small interfering RNAs (siRNAs), which play a critical role in RNA interference and gene silencing. **Clinical Significance:** Translin's involvement in various cellular processes has significant implications for human disease. Some of the clinical significance of translin includes: 1. **Cancer:** Translin's role in gene regulation and DNA repair makes it a potential target for cancer therapy. Alterations in translin expression have been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative Diseases:** Translin's involvement in gene regulation and DNA repair processes makes it a potential target for neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Infectious Diseases:** Translin's interaction with RNA-binding proteins enables it to participate in the biogenesis of small interfering RNAs, which play a critical role in RNA interference and gene silencing. Alterations in translin expression have been observed in infectious diseases, such as HIV and hepatitis C. In conclusion, translin is a multifunctional protein that plays a critical role in various cellular processes, including gene regulation, DNA repair, and cell migration. Its involvement in these processes has significant implications for human disease, making it a potential target for cancer therapy, neurodegenerative disease treatment, and infectious disease management. Further research on translin's role in human disease is necessary to fully understand its clinical significance and to explore its potential as a therapeutic target.

Genular Protein ID: 3996409614

Symbol: TSN_HUMAN

Name: Translin

UniProtKB Accession Codes:

Q15631 B7Z3X8 Q5U0K7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EC 1 EMBL 11 EMDB 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7663511

Title: A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations.

PubMed ID: 7663511

DOI: 10.1038/ng0695-167

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9244443

Title: Genomic structure and chromosomal localization of the gene encoding translin, a recombination hotspot binding protein.

PubMed ID: 9244443

DOI: 10.1006/geno.1997.4796

PubMed ID: 9111049

Title: The translin ring specifically recognizes DNA ends at recombination hot spots in the human genome.

PubMed ID: 9111049

DOI: 10.1074/jbc.272.17.11402

PubMed ID: 10025964

Title: The DNA binding activity of Translin is mediated by a basic region in the ring-shaped structure conserved in evolution.

PubMed ID: 10025964

DOI: 10.1016/s0014-5793(99)00010-1

PubMed ID: 11801738

Title: DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX).

PubMed ID: 11801738

DOI: 10.1242/jcs.115.1.207

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 21552258

Title: Structure of C3PO and mechanism of human RISC activation.

PubMed ID: 21552258

DOI: 10.1038/nsmb.2032

Sequence Information:

  • Length: 228
  • Mass: 26183
  • Checksum: 3CAAF20BED7C4939
  • Sequence:
    • MSVSEIFVEL QGFLAAEQDI REEIRKVVQS LEQTAREILT LLQGVHQGAG FQDIPKRCLK 
AREHFGTVKT HLTSLKTKFP AEQYYRFHEH WRFVLQRLVF LAAFVVYLET ETLVTREAVT 
EILGIEPDRE KGFHLDVEDY LSGVLILASE LSRLSVNSVT AGDYSRPLHI STFINELDSG 
FRLLNLKNDS LRKRYDGLKY DVKKVEEVVY DLSIRGFNKE TAAACVEK

Genular Protein ID: 2529862965

Symbol: B3KRM8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KRM8

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 7 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 181
  • Mass: 20951
  • Checksum: E973DE5D6381BC37
  • Sequence:
    • MAIMLYVPKR CLKAREHFGT VKTHLTSLKT KFPAEQYYRF HEHWRFVLQR LVFLAAFVVY 
LETETLVTRE AVTEILGIEP DREKGFHLDV EDYLSGVLIL ASELSRLSVN SVTAGDYSRP 
LHISTFINEL DSGFRLLNLK NDSLRKRYDG LKYDVKKVEE VVYDLSIRGF NKETAAACVE 
K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.