Gene TXN - ENSG00000136810 | NCBI Gene ID: 7295

Details for: TXN

Gene ID: 7295

Symbol: TXN

Ensembl ID: ENSG00000136810

Description: thioredoxin

Associated with

Cell recruitment (pro-inflammatory response)
(R-HSA-9664424)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular senescence
(R-HSA-2559583)
Detoxification of reactive oxygen species
(R-HSA-3299685)
Disease
(R-HSA-1643685)
Foxo-mediated transcription
(R-HSA-9614085)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Inflammasomes
(R-HSA-622312)
Innate immune system
(R-HSA-168249)
Interconversion of nucleotide di- and triphosphates
(R-HSA-499943)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Leishmania infection
(R-HSA-9658195)
Metabolism
(R-HSA-1430728)
Metabolism of nucleotides
(R-HSA-15869)
Metabolism of proteins
(R-HSA-392499)
Nfe2l2 regulating anti-oxidant/detoxification enzymes
(R-HSA-9818027)
Nuclear events mediated by nfe2l2
(R-HSA-9759194)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Oxidative stress induced senescence
(R-HSA-2559580)
Parasitic infection pathways
(R-HSA-9824443)
Protein repair
(R-HSA-5676934)
Purinergic signaling in leishmaniasis infection
(R-HSA-9660826)
Regulation of foxo transcriptional activity by acetylation
(R-HSA-9617629)
Rna polymerase ii transcription
(R-HSA-73857)
The nlrp3 inflammasome
(R-HSA-844456)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by tp53
(R-HSA-3700989)
Activation of protein kinase b activity
(GO:0032148)
Cell redox homeostasis
(GO:0045454)
Cellular detoxification of hydrogen peroxide
(GO:0061692)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Negative regulation of protein export from nucleus
(GO:0046826)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna binding
(GO:0043388)
Positive regulation of peptidyl-cysteine s-nitrosylation
(GO:2000170)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Protein-disulfide reductase (nad(p)) activity
(GO:0047134)
Protein-disulfide reductase activity
(GO:0015035)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Response to nitric oxide
(GO:0071731)
Response to radiation
(GO:0009314)
Rna binding
(GO:0003723)
Thioredoxin-disulfide reductase (nadp) activity
(GO:0004791)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 6.09
Marker Score: 4597
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 5.11
Marker Score: 4000.5
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.24
Marker Score: 144240.5
Cell Name: secretory cell (CL0000151)
Fold Change: 4.12
Marker Score: 7529
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 4.04
Marker Score: 6228
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.85
Marker Score: 9407
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 3.79
Marker Score: 19914
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.77
Marker Score: 24049
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.75
Marker Score: 13327
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 3.74
Marker Score: 1196
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.66
Marker Score: 27264.5
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 3.61
Marker Score: 3767
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 3.55
Marker Score: 27701
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 3.44
Marker Score: 29857
Cell Name: enterocyte (CL0000584)
Fold Change: 3.42
Marker Score: 16396.5
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.38
Marker Score: 2885.5
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 3.37
Marker Score: 10594
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 3.35
Marker Score: 16448
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.34
Marker Score: 21753
Cell Name: mucous neck cell (CL0000651)
Fold Change: 3.34
Marker Score: 7572
Cell Name: cell in vitro (CL0001034)
Fold Change: 3.3
Marker Score: 114185
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 3.27
Marker Score: 2577.5
Cell Name: epithelial cell (CL0000066)
Fold Change: 3.27
Marker Score: 5198
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 3.2
Marker Score: 12337.5
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 3.18
Marker Score: 1696
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.15
Marker Score: 176206.5
Cell Name: mesodermal cell (CL0000222)
Fold Change: 3.13
Marker Score: 41258.5
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 3.11
Marker Score: 26822
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 3.1
Marker Score: 1291
Cell Name: radial glial cell (CL0000681)
Fold Change: 3.1
Marker Score: 1142
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 3.05
Marker Score: 1032
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.04
Marker Score: 3245.5
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 3.02
Marker Score: 33977
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3.01
Marker Score: 2684.5
Cell Name: mature T cell (CL0002419)
Fold Change: 2.98
Marker Score: 29540
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 2.97
Marker Score: 3582
Cell Name: basal cell (CL0000646)
Fold Change: 2.97
Marker Score: 3834
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 2.95
Marker Score: 2831
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.93
Marker Score: 6676
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.91
Marker Score: 74618.5
Cell Name: reticular cell (CL0000432)
Fold Change: 2.91
Marker Score: 1063
Cell Name: pneumocyte (CL0000322)
Fold Change: 2.91
Marker Score: 4675
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.91
Marker Score: 4819
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 2.87
Marker Score: 3733
Cell Name: lung macrophage (CL1001603)
Fold Change: 2.86
Marker Score: 3277
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 2.86
Marker Score: 1912
Cell Name: club cell (CL0000158)
Fold Change: 2.86
Marker Score: 3334
Cell Name: dendritic cell (CL0000451)
Fold Change: 2.86
Marker Score: 1958
Cell Name: decidual cell (CL2000002)
Fold Change: 2.85
Marker Score: 12281.5
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 2.84
Marker Score: 1463
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.83
Marker Score: 4642
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.83
Marker Score: 5649.5
Cell Name: chondrocyte (CL0000138)
Fold Change: 2.83
Marker Score: 1273
Cell Name: supporting cell (CL0000630)
Fold Change: 2.82
Marker Score: 5306
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 2.82
Marker Score: 973
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 2.81
Marker Score: 1762
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 2.81
Marker Score: 7525
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 2.8
Marker Score: 1451
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.77
Marker Score: 4687
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 2.77
Marker Score: 1313
Cell Name: blood cell (CL0000081)
Fold Change: 2.76
Marker Score: 32122
Cell Name: neutrophil (CL0000775)
Fold Change: 2.76
Marker Score: 1680
Cell Name: inflammatory cell (CL0009002)
Fold Change: 2.75
Marker Score: 1182.5
Cell Name: serous secreting cell (CL0000313)
Fold Change: 2.74
Marker Score: 1092.5
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 2.74
Marker Score: 1604
Cell Name: myelocyte (CL0002193)
Fold Change: 2.73
Marker Score: 1179
Cell Name: granulocyte (CL0000094)
Fold Change: 2.72
Marker Score: 1218
Cell Name: basophil (CL0000767)
Fold Change: 2.71
Marker Score: 1288
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.71
Marker Score: 17330.5
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.71
Marker Score: 11085
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 2.7
Marker Score: 2735
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.69
Marker Score: 7432
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.68
Marker Score: 17425
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.67
Marker Score: 1522
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 2.62
Marker Score: 4985.5
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.62
Marker Score: 6865
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 2.61
Marker Score: 2227
Cell Name: keratinocyte (CL0000312)
Fold Change: 2.61
Marker Score: 2178
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 2.61
Marker Score: 629
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 2.6
Marker Score: 1011.5
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 2.59
Marker Score: 920.5
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 2.59
Marker Score: 6527
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 2.59
Marker Score: 1761
Cell Name: theca cell (CL0000503)
Fold Change: 2.58
Marker Score: 1849
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 2.58
Marker Score: 1271
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 2.57
Marker Score: 3175
Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 2.56
Marker Score: 1442
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.56
Marker Score: 2690
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 2.55
Marker Score: 2748
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 2.55
Marker Score: 1191
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 2.55
Marker Score: 3928
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 2.55
Marker Score: 2859
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 2.54
Marker Score: 633
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 2.52
Marker Score: 633
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.52
Marker Score: 5262
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 2.52
Marker Score: 1824
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.49
Marker Score: 596
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 2.48
Marker Score: 1560
Cell Name: stromal cell (CL0000499)
Fold Change: 2.48
Marker Score: 2902
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.48
Marker Score: 4389

Hover over a box to see details here...

**Key Characteristics** TXN is a small, 12-kDa protein that belongs to the thioredoxin superfamily. Its structure consists of a single domain with a cysteine residue at its active site, which is essential for its redox activity. The protein exhibits high affinity for reduced glutathione (GSH), allowing it to efficiently reduce oxidized cysteine residues in target proteins. TXN is also capable of disulfide bond formation and reduction, enabling it to participate in protein disulfide reductase activity. **Pathways and Functions** TXN's functions are mediated through its interactions with various cellular pathways, including: 1. **Cellular Redox Homeostasis**: TXN's primary role is to maintain the balance of reduced and oxidized glutathione levels, ensuring that the cellular redox environment remains optimal for protein function. 2. **Protein Function Regulation**: TXN reduces oxidized cysteine residues in target proteins, thereby restoring their proper function and activity. 3. **Immune Response**: TXN modulates immune responses by regulating the activity of key immune molecules, such as inflammatory cytokines and transcription factors. 4. **Cellular Stress Response**: TXN participates in the cellular response to stress, including oxidative stress, heat shock, and radiation-induced damage. 5. **Detoxification of Reactive Oxygen Species**: TXN helps to neutralize reactive oxygen species (ROS) by reducing hydrogen peroxide and other oxidants. **Clinical Significance** TXN's dysregulation has been implicated in various diseases, including: 1. **Oxidative Stress-Related Disorders**: TXN's dysfunction has been linked to conditions such as atherosclerosis, cancer, and neurodegenerative diseases. 2. **Infectious Diseases**: TXN plays a crucial role in the immune response to infections, and its dysregulation has been implicated in diseases such as Leishmania infection. 3. **Metabolic Disorders**: TXN's role in regulating metabolic pathways, including glucose and lipid metabolism, makes it an important target for the treatment of metabolic disorders. 4. **Cancer**: TXN's expression and activity have been found to be altered in various types of cancer, suggesting its potential as a biomarker or therapeutic target. In conclusion, TXN is a multifunctional protein that plays a critical role in maintaining cellular redox homeostasis, regulating protein function, and modulating immune responses. Its dysregulation has been implicated in various diseases, highlighting its importance as a therapeutic target and potential biomarker.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Thioredoxin

Genular Protein ID: 1291118948

Symbol: THIO_HUMAN

Name: Thioredoxin

UniProtKB Accession Codes:

P10599 B1ALW1 O60744 Q53X69 Q96KI3 Q9UDG5

Database IDs:

Citations:

PubMed ID: 3170595

Title: Cloning and expression of a cDNA for human thioredoxin.

PubMed ID: 3170595

DOI: 10.1016/s0021-9258(19)37617-3

PubMed ID: 2785919

Title: ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous to thioredoxin; possible involvement of dithiol-reduction in the IL-2 receptor induction.

PubMed ID: 2785919

DOI: 10.1002/j.1460-2075.1989.tb03436.x

PubMed ID: 1874447

Title: Isolation and characterization of human thioredoxin-encoding genes.

PubMed ID: 1874447

DOI: 10.1016/0378-1119(91)90081-l

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7818492

Title: Characterization of a thioredoxin-related surface protein.

PubMed ID: 7818492

DOI: 10.1042/bj3040861

PubMed ID: 1998498

Title: Identification of a thioredoxin-related protein associated with plasma membranes.

PubMed ID: 1998498

DOI: 10.1016/s0006-291x(05)81209-4

PubMed ID: 2176490

Title: Human thioredoxin reactivity-structure/function relationship.

PubMed ID: 2176490

DOI: 10.1016/s0006-291x(05)80940-4

PubMed ID: 1332947

Title: Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway.

PubMed ID: 1332947

DOI: 10.1016/s0021-9258(18)35742-9

PubMed ID: 9108029

Title: AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1.

PubMed ID: 9108029

DOI: 10.1073/pnas.94.8.3633

PubMed ID: 11118054

Title: Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation.

PubMed ID: 11118054

PubMed ID: 15246877

Title: S-nitrosation of thioredoxin in the nitrogen monoxide/superoxide system activates apoptosis signal-regulating kinase 1.

PubMed ID: 15246877

DOI: 10.1016/j.abb.2004.06.004

PubMed ID: 16408020

Title: Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine.

PubMed ID: 16408020

DOI: 10.1038/nchembio720

PubMed ID: 17182577

Title: Cross-reactivity and 1.4-A crystal structure of Malassezia sympodialis thioredoxin (Mala s 13), a member of a new pan-allergen family.

PubMed ID: 17182577

DOI: 10.4049/jimmunol.178.1.389

PubMed ID: 17606900

Title: Thioredoxin is required for S-nitrosation of procaspase-3 and the inhibition of apoptosis in Jurkat cells.

PubMed ID: 17606900

DOI: 10.1073/pnas.0704898104

PubMed ID: 19032234

Title: Auto- and cross-reactivity to thioredoxin allergens in allergic bronchopulmonary aspergillosis.

PubMed ID: 19032234

DOI: 10.1111/j.1398-9995.2008.01777.x

PubMed ID: 19690162

Title: Salmonella type III secretion effector SlrP is an E3 ubiquitin ligase for mammalian thioredoxin.

PubMed ID: 19690162

DOI: 10.1074/jbc.m109.010363

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21489611

Title: Malassezia sympodialis thioredoxin-specific T cells are highly cross-reactive to human thioredoxin in atopic dermatitis.

PubMed ID: 21489611

DOI: 10.1016/j.jaci.2011.02.043

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 2684271

Title: A proton nuclear magnetic resonance assignment and secondary structure determination of recombinant human thioredoxin.

PubMed ID: 2684271

DOI: 10.1021/bi00443a045

PubMed ID: 2001356

Title: High-resolution three-dimensional structure of reduced recombinant human thioredoxin in solution.

PubMed ID: 2001356

DOI: 10.1021/bi00224a017

PubMed ID: 7922028

Title: The high-resolution three-dimensional solution structures of the oxidized and reduced states of human thioredoxin.

PubMed ID: 7922028

DOI: 10.1016/s0969-2126(00)00051-4

PubMed ID: 7788295

Title: Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NF kappa B.

PubMed ID: 7788295

DOI: 10.1016/s0969-2126(01)00159-9

PubMed ID: 8736558

Title: The solution structure of human thioredoxin complexed with its target from Ref-1 reveals peptide chain reversal.

PubMed ID: 8736558

DOI: 10.1016/s0969-2126(96)00065-2

PubMed ID: 8805557

Title: Crystal structures of reduced, oxidized, and mutated human thioredoxins: evidence for a regulatory homodimer.

PubMed ID: 8805557

DOI: 10.1016/s0969-2126(96)00079-2

PubMed ID: 9369469

Title: Human thioredoxin homodimers: regulation by pH, role of aspartate 60, and crystal structure of the aspartate 60 --> asparagine mutant.

PubMed ID: 9369469

DOI: 10.1021/bi971004s

PubMed ID: 17260951

Title: Buried S-nitrosocysteine revealed in crystal structures of human thioredoxin.

PubMed ID: 17260951

DOI: 10.1021/bi061878r

Sequence Information:

Length: 105
Mass: 11737
Checksum: 256F4E3C8A187693
Sequence:

MVKQIESKTA FQEALDAAGD KLVVVDFSAT WCGPCKMIKP FFHSLSEKYS NVIFLEVDVD 
DCQDVASECE VKCMPTFQFF KKGQKVGEFS GANKEKLEAT INELV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: TXN

Associated with

Cells (max top 100)

Other Information

Cloning and expression of a cDNA for human thioredoxin. PubMed ID: 3170595

ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous to thioredoxin; possible involvement of dithiol-reduction in the IL-2 receptor induction. PubMed ID: 2785919

Isolation and characterization of human thioredoxin-encoding genes. PubMed ID: 1874447

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of a thioredoxin-related surface protein. PubMed ID: 7818492

Identification of a thioredoxin-related protein associated with plasma membranes. PubMed ID: 1998498

Human thioredoxin reactivity-structure/function relationship. PubMed ID: 2176490

Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway. PubMed ID: 1332947

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. PubMed ID: 9108029

Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation. PubMed ID: 11118054

S-nitrosation of thioredoxin in the nitrogen monoxide/superoxide system activates apoptosis signal-regulating kinase 1. PubMed ID: 15246877

Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine. PubMed ID: 16408020

Cross-reactivity and 1.4-A crystal structure of Malassezia sympodialis thioredoxin (Mala s 13), a member of a new pan-allergen family. PubMed ID: 17182577

Thioredoxin is required for S-nitrosation of procaspase-3 and the inhibition of apoptosis in Jurkat cells. PubMed ID: 17606900

Auto- and cross-reactivity to thioredoxin allergens in allergic bronchopulmonary aspergillosis. PubMed ID: 19032234

Salmonella type III secretion effector SlrP is an E3 ubiquitin ligase for mammalian thioredoxin. PubMed ID: 19690162

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Malassezia sympodialis thioredoxin-specific T cells are highly cross-reactive to human thioredoxin in atopic dermatitis. PubMed ID: 21489611

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

A proton nuclear magnetic resonance assignment and secondary structure determination of recombinant human thioredoxin. PubMed ID: 2684271

High-resolution three-dimensional structure of reduced recombinant human thioredoxin in solution. PubMed ID: 2001356

The high-resolution three-dimensional solution structures of the oxidized and reduced states of human thioredoxin. PubMed ID: 7922028

Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NF kappa B. PubMed ID: 7788295

The solution structure of human thioredoxin complexed with its target from Ref-1 reveals peptide chain reversal. PubMed ID: 8736558

Crystal structures of reduced, oxidized, and mutated human thioredoxins: evidence for a regulatory homodimer. PubMed ID: 8805557

Human thioredoxin homodimers: regulation by pH, role of aspartate 60, and crystal structure of the aspartate 60 --&gt; asparagine mutant. PubMed ID: 9369469

Buried S-nitrosocysteine revealed in crystal structures of human thioredoxin. PubMed ID: 17260951