UBA52 | ENSG00000221983 | NCBI 7311

Details for: UBA52

Gene ID: 7311

Symbol: UBA52

Ensembl ID: ENSG00000221983

Description: ubiquitin A-52 residue ribosomal protein fusion product 1

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Adaptive immune system
(R-HSA-1280218)
Aerobic respiration and respiratory electron transport
(R-HSA-1428517)
Amyloid fiber formation
(R-HSA-977225)
Apoptosis
(R-HSA-109581)
Asparagine n-linked glycosylation
(R-HSA-446203)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Autophagy
(R-HSA-9612973)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to hypoxia
(R-HSA-1234174)
Cellular senescence
(R-HSA-2559583)
Chaperone mediated autophagy
(R-HSA-9613829)
Circadian clock
(R-HSA-400253)
Cytokine signaling in immune system
(R-HSA-1280215)
Cytosolic sensors of pathogen-associated dna
(R-HSA-1834949)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-HSA-168928)
Death receptor signaling
(R-HSA-73887)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of metabolism
(R-HSA-5668914)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna damage bypass
(R-HSA-73893)
Dna double-strand break repair
(R-HSA-5693532)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Eukaryotic translation elongation
(R-HSA-156842)
Fanconi anemia pathway
(R-HSA-6783310)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Intracellular signaling by second messengers
(R-HSA-9006925)
Ion channel transport
(R-HSA-983712)
Iron uptake and transport
(R-HSA-917937)
Late endosomal microautophagy
(R-HSA-9615710)
Macroautophagy
(R-HSA-1632852)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of carbohydrates
(R-HSA-71387)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g2-g2/m phases
(R-HSA-453274)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Nucleotide excision repair
(R-HSA-5696398)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
Peroxisomal protein import
(R-HSA-9033241)
Pip3 activates akt signaling
(R-HSA-1257604)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Protein localization
(R-HSA-9609507)
Recognition of dna damage by pcna-containing replication complex
(R-HSA-110314)
Regulated necrosis
(R-HSA-5218859)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Rna polymerase ii transcription
(R-HSA-73857)
Rrna processing
(R-HSA-72312)
Selenoamino acid metabolism
(R-HSA-2408522)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb4
(R-HSA-1236394)
Signaling by fgfr
(R-HSA-190236)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch2
(R-HSA-1980145)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Stimuli-sensing channels
(R-HSA-2672351)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Toll-like receptor cascades
(R-HSA-168898)
Translation
(R-HSA-72766)
Translesion synthesis by y family dna polymerases bypasses lesions on dna template
(R-HSA-110313)
Transport of small molecules
(R-HSA-382551)
Vesicle-mediated transport
(R-HSA-5653656)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 1015.7174
Cell Significance Index: -157.9900
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 622.8036
Cell Significance Index: -157.9700
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 588.6428
Cell Significance Index: -242.4900
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 478.2867
Cell Significance Index: -225.8100
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 461.0747
Cell Significance Index: -237.1700
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 337.9620
Cell Significance Index: -226.7800
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 153.9552
Cell Significance Index: -189.8200
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 68.8924
Cell Significance Index: -211.6000
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 57.0495
Cell Significance Index: -225.1200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 30.9124
Cell Significance Index: -82.8100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 12.6982
Cell Significance Index: 339.6700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 10.2313
Cell Significance Index: 477.0300
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 9.6647
Cell Significance Index: 178.6300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 8.8014
Cell Significance Index: 413.6600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 7.6298
Cell Significance Index: 1047.7800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 6.9490
Cell Significance Index: 1252.6800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 6.9380
Cell Significance Index: 853.1000
Cell Name: cell in vitro (CL0001034)
Fold Change: 6.9075
Cell Significance Index: 3772.3300
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 6.7004
Cell Significance Index: 76.1200
Cell Name: lactocyte (CL0002325)
Fold Change: 6.3122
Cell Significance Index: 815.5000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 6.2343
Cell Significance Index: 402.2100
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 6.2309
Cell Significance Index: 169.6000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 6.2168
Cell Significance Index: 178.2100
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 6.0292
Cell Significance Index: 426.4100
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 6.0057
Cell Significance Index: 176.3800
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 6.0008
Cell Significance Index: 707.6800
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 5.9045
Cell Significance Index: 104.3400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 5.7381
Cell Significance Index: 2536.9400
Cell Name: granulosa cell (CL0000501)
Fold Change: 5.4273
Cell Significance Index: 142.7100
Cell Name: peg cell (CL4033014)
Fold Change: 5.3858
Cell Significance Index: 124.4300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 5.2865
Cell Significance Index: 394.0000
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 4.9242
Cell Significance Index: 45.3500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 4.5871
Cell Significance Index: 783.2700
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 4.4187
Cell Significance Index: 37.9700
Cell Name: odontoblast (CL0000060)
Fold Change: 3.8972
Cell Significance Index: 499.6000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 3.2109
Cell Significance Index: 67.2100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 3.1118
Cell Significance Index: 108.1400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.0598
Cell Significance Index: 55.0000
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.0220
Cell Significance Index: 25.9000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.8494
Cell Significance Index: 96.0700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 1.5271
Cell Significance Index: 1155.9000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.4920
Cell Significance Index: 1347.2100
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.9871
Cell Significance Index: 6.0700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.7957
Cell Significance Index: 151.4300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.6705
Cell Significance Index: 133.0700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.3847
Cell Significance Index: 282.0500
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2640
Cell Significance Index: 26.1200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1765
Cell Significance Index: 8.0000
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.0294
Cell Significance Index: 0.3200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0288
Cell Significance Index: -2.9400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0804
Cell Significance Index: -151.4700
Cell Name: kidney cell (CL1000497)
Fold Change: -0.0877
Cell Significance Index: -0.7000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0888
Cell Significance Index: -65.7700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.1353
Cell Significance Index: -48.5300
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.1390
Cell Significance Index: -256.4000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1423
Cell Significance Index: -28.5500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1491
Cell Significance Index: -93.0800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.1690
Cell Significance Index: -260.1400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.2031
Cell Significance Index: -276.1100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2813
Cell Significance Index: -14.7700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.3014
Cell Significance Index: -170.0000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.3111
Cell Significance Index: -197.5600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.4795
Cell Significance Index: -217.6400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.5229
Cell Significance Index: -110.1400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5954
Cell Significance Index: -19.0700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.6649
Cell Significance Index: -191.3100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.6988
Cell Significance Index: -80.0600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.8167
Cell Significance Index: -23.5300
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.9934
Cell Significance Index: -78.6800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.0299
Cell Significance Index: -64.9100
Cell Name: pro-T cell (CL0000827)
Fold Change: -1.0952
Cell Significance Index: -27.9800
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -1.3050
Cell Significance Index: -148.9600
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -1.3901
Cell Significance Index: -162.0000
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -1.4015
Cell Significance Index: -24.1600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.4570
Cell Significance Index: -89.5600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -1.4574
Cell Significance Index: -51.2100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -1.4692
Cell Significance Index: -213.5600
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -1.5939
Cell Significance Index: -9.6300
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.6043
Cell Significance Index: -26.8500
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.9527
Cell Significance Index: -29.2600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -2.1479
Cell Significance Index: -223.6500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -2.3926
Cell Significance Index: -134.2600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -2.5682
Cell Significance Index: -35.0400
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -3.0659
Cell Significance Index: -76.6400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -3.0702
Cell Significance Index: -206.4400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -3.0922
Cell Significance Index: -237.2900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -3.2440
Cell Significance Index: -198.8900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -3.5385
Cell Significance Index: -76.6600
Cell Name: retinal rod cell (CL0000604)
Fold Change: -4.5962
Cell Significance Index: -54.7900
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -4.6187
Cell Significance Index: -136.0400
Cell Name: perivascular cell (CL4033054)
Fold Change: -4.8211
Cell Significance Index: -22.2600
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -4.9130
Cell Significance Index: -26.7900
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -5.2805
Cell Significance Index: -32.8100
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -5.4359
Cell Significance Index: -145.6600
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -5.5615
Cell Significance Index: -204.1600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -5.7973
Cell Significance Index: -256.4300
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -6.1829
Cell Significance Index: -312.4700
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -6.2506
Cell Significance Index: -133.1200
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -6.4604
Cell Significance Index: -211.5200
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -6.4877
Cell Significance Index: -227.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** UBA52 is a gene that encodes a fusion protein, which is a result of the fusion of the ribosomal protein L40 (RL40) with the ubiquitin A-52 residue. This unique protein is primarily expressed in cells of the immune system, including myoepithelial cells of the mammary gland, malignant cells, and various types of hematopoietic stem cells. UBA52 exhibits a high degree of expression in cells that are involved in immune responses, highlighting its potential role in modulating immune system function. **Pathways and Functions:** UBA52 is implicated in a wide range of cellular processes, including: 1. **Immune system regulation**: UBA52 is expressed in various immune cells, suggesting its involvement in regulating immune responses. 2. **Autophagy**: UBA52 has been shown to be involved in autophagy, a process by which cells recycle damaged or dysfunctional components. 3. **Apoptosis**: UBA52 may play a role in regulating apoptosis, or programmed cell death. 4. **Cell cycle regulation**: UBA52 is involved in regulating the cell cycle, particularly in the G1/S transition. 5. **Translation and protein synthesis**: UBA52 is required for efficient translation and protein synthesis. **Clinical Significance:** UBA52 has been implicated in various diseases, including: 1. **Cancer**: UBA52 is overexpressed in certain types of cancer, suggesting its potential role in tumorigenesis. 2. **Immune disorders**: UBA52 may contribute to the development of immune disorders, such as autoimmune diseases. 3. **Neurological disorders**: UBA52 has been linked to neurological disorders, including neurodegenerative diseases. **Conclusion:** UBA52 is a complex gene that plays a multifaceted role in various cellular processes. Its involvement in immune system regulation, autophagy, apoptosis, and cell cycle regulation highlights its potential as a therapeutic target for various diseases. Further research is necessary to fully elucidate the functions of UBA52 and its clinical significance. As an expert immunologist, it is essential to continue investigating the intricacies of UBA52, with the aim of unraveling its secrets and harnessing its potential for the benefit of human health. **Recommendations:** 1. **Further research**: Conduct studies to elucidate the mechanisms by which UBA52 regulates immune system function. 2. **Therapeutic targeting**: Explore the potential of UBA52 as a therapeutic target for various diseases, including cancer and immune disorders. 3. **Cellular modeling**: Utilize cellular models to study the functions of UBA52 and its role in disease pathology. By continuing to investigate the complexities of UBA52, we can gain a deeper understanding of its role in human health and disease, ultimately leading to the development of novel therapeutic strategies.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

CEP52
Q7Z4P3_HUMAN

Genular Protein ID: 4027796776

Symbol: RL40_HUMAN

Name: CEP52

UniProtKB Accession Codes:

P62987 P02248 P02249 P02250 P14793 P62988 Q29120 Q6LBL4 Q6LDU5 Q8WYN8 Q91887 Q91888 Q9BWD6 Q9BX98 Q9UEF2 Q9UEG1 Q9UEK8 Q9UPK7

Database IDs:

Citations:

PubMed ID: 1850507

Title: The human ubiquitin-52 amino acid fusion protein gene shares several structural features with mammalian ribosomal protein genes.

PubMed ID: 1850507

DOI: 10.1093/nar/19.5.1035

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 1128706

Title: Molecular conservation of 74 amino acid sequence of ubiquitin between cattle and man.

PubMed ID: 1128706

DOI: 10.1038/255423a0

PubMed ID: 16443603

Title: Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.

PubMed ID: 16443603

DOI: 10.1074/jbc.m512786200

PubMed ID: 3037496

Title: cDNA encoding a human homolog of yeast ubiquitin 1.

PubMed ID: 3037496

DOI: 10.1093/nar/15.13.5485

PubMed ID: 15147878

Title: Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domains.

PubMed ID: 15147878

DOI: 10.1016/j.febslet.2004.04.031

PubMed ID: 16543144

Title: Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain.

PubMed ID: 16543144

DOI: 10.1016/j.molcel.2006.02.018

PubMed ID: 15466860

Title: Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis.

PubMed ID: 15466860

DOI: 10.1074/jbc.m402916200

PubMed ID: 18719106

Title: Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks.

PubMed ID: 18719106

DOI: 10.1073/pnas.0805685105

PubMed ID: 19754430

Title: The emerging complexity of protein ubiquitination.

PubMed ID: 19754430

DOI: 10.1042/bst0370937

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23169626

Title: A ribosome-specialized translation initiation pathway is required for cap-dependent translation of vesicular stomatitis virus mRNAs.

PubMed ID: 23169626

DOI: 10.1073/pnas.1216454109

PubMed ID: 24660806

Title: Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.

PubMed ID: 24660806

DOI: 10.1042/bj20140334

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24751536

Title: PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.

PubMed ID: 24751536

DOI: 10.1083/jcb.201402104

PubMed ID: 24784582

Title: Ubiquitin is phosphorylated by PINK1 to activate parkin.

PubMed ID: 24784582

DOI: 10.1038/nature13392

PubMed ID: 25474007

Title: Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering.

PubMed ID: 25474007

DOI: 10.1371/journal.pgen.1004861

PubMed ID: 25527291

Title: Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis.

PubMed ID: 25527291

DOI: 10.15252/embj.201489847

PubMed ID: 28525742

Title: Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9.

PubMed ID: 28525742

DOI: 10.1016/j.molcel.2017.04.028

PubMed ID: 32330457

Title: Threonine ADP-ribosylation of ubiquitin by a bacterial effector family blocks host ubiquitination.

PubMed ID: 32330457

DOI: 10.1016/j.molcel.2020.03.016

PubMed ID: 34239127

Title: K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle.

PubMed ID: 34239127

DOI: 10.1038/s41589-021-00823-5

PubMed ID: 22729708

Title: Determination of structural fluctuations of proteins from structure-based calculations of residual dipolar couplings.

PubMed ID: 22729708

DOI: 10.1007/s10858-012-9644-3

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 25752573

Title: K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of K29 polyubiquitin.

PubMed ID: 25752573

DOI: 10.1016/j.molcel.2015.01.041

PubMed ID: 25752577

Title: Assembly and specific recognition of K29- and K33-linked polyubiquitin.

PubMed ID: 25752577

DOI: 10.1016/j.molcel.2015.01.042

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

Length: 128
Mass: 14728
Checksum: 7BCB602ABEFAD02A
Sequence:

MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN 
IQKESTLHLV LRLRGGIIEP SLRQLAQKYN CDKMICRKCY ARLHPRAVNC RKKKCGHTNN 
LRPKKKVK

Genular Protein ID: 1044920739

Symbol: Q7Z4P3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z4P3

Database IDs:

Sequence Information:

Length: 101
Mass: 11270
Checksum: 996764093CD7AA17
Sequence:

MLSRLVLNSW AQAIRPSQPL KVLGLQARTA MPDPVLSFLF VCLFVCFETE SCSVAQAGVQ 
WRSLGLLQPL PPGFTSFSCL SLPSSWDYRC PPQLLANFLY F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: UBA52

Associated with

Cells (max top 100)

Other Information

The human ubiquitin-52 amino acid fusion protein gene shares several structural features with mammalian ribosomal protein genes. PubMed ID: 1850507

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

Molecular conservation of 74 amino acid sequence of ubiquitin between cattle and man. PubMed ID: 1128706

Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation. PubMed ID: 16443603

cDNA encoding a human homolog of yeast ubiquitin 1. PubMed ID: 3037496

Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domains. PubMed ID: 15147878

Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. PubMed ID: 16543144

Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis. PubMed ID: 15466860

Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. PubMed ID: 18719106

The emerging complexity of protein ubiquitination. PubMed ID: 19754430

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

A ribosome-specialized translation initiation pathway is required for cap-dependent translation of vesicular stomatitis virus mRNAs. PubMed ID: 23169626

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65. PubMed ID: 24660806

A new system for naming ribosomal proteins. PubMed ID: 24524803

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. PubMed ID: 24751536

Ubiquitin is phosphorylated by PINK1 to activate parkin. PubMed ID: 24784582

Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering. PubMed ID: 25474007

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis. PubMed ID: 25527291

Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9. PubMed ID: 28525742

Threonine ADP-ribosylation of ubiquitin by a bacterial effector family blocks host ubiquitination. PubMed ID: 32330457

K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle. PubMed ID: 34239127

Determination of structural fluctuations of proteins from structure-based calculations of residual dipolar couplings. PubMed ID: 22729708

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of K29 polyubiquitin. PubMed ID: 25752573

Assembly and specific recognition of K29- and K33-linked polyubiquitin. PubMed ID: 25752577

Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. PubMed ID: 32669547