Gene UBA52 - ENSG00000221983 | NCBI Gene ID: 7311

Details for: UBA52

Gene ID: 7311

Symbol: UBA52

Ensembl ID: ENSG00000221983

Description: ubiquitin A-52 residue ribosomal protein fusion product 1

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Adaptive immune system
(R-HSA-1280218)
Amyloid fiber formation
(R-HSA-977225)
Apoptosis
(R-HSA-109581)
Asparagine n-linked glycosylation
(R-HSA-446203)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Autophagy
(R-HSA-9612973)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to hypoxia
(R-HSA-1234174)
Cellular senescence
(R-HSA-2559583)
Chaperone mediated autophagy
(R-HSA-9613829)
Circadian clock
(R-HSA-400253)
Cytokine signaling in immune system
(R-HSA-1280215)
Cytosolic sensors of pathogen-associated dna
(R-HSA-1834949)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-HSA-168928)
Death receptor signaling
(R-HSA-73887)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of metabolism
(R-HSA-5668914)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna damage bypass
(R-HSA-73893)
Dna double-strand break repair
(R-HSA-5693532)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Eukaryotic translation elongation
(R-HSA-156842)
Fanconi anemia pathway
(R-HSA-6783310)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Intracellular signaling by second messengers
(R-HSA-9006925)
Ion channel transport
(R-HSA-983712)
Iron uptake and transport
(R-HSA-917937)
Late endosomal microautophagy
(R-HSA-9615710)
Macroautophagy
(R-HSA-1632852)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of carbohydrates
(R-HSA-71387)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Nucleotide excision repair
(R-HSA-5696398)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
Peroxisomal protein import
(R-HSA-9033241)
Pip3 activates akt signaling
(R-HSA-1257604)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Protein localization
(R-HSA-9609507)
Recognition of dna damage by pcna-containing replication complex
(R-HSA-110314)
Regulated necrosis
(R-HSA-5218859)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Rna polymerase ii transcription
(R-HSA-73857)
Rrna processing
(R-HSA-72312)
Selenoamino acid metabolism
(R-HSA-2408522)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb4
(R-HSA-1236394)
Signaling by fgfr
(R-HSA-190236)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch2
(R-HSA-1980145)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Stimuli-sensing channels
(R-HSA-2672351)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Toll-like receptor cascades
(R-HSA-168898)
Translation
(R-HSA-72766)
Translesion synthesis by y family dna polymerases bypasses lesions on dna template
(R-HSA-110313)
Transport of small molecules
(R-HSA-382551)
Vesicle-mediated transport
(R-HSA-5653656)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 5.43
Marker Score: 26656
Cell Name: malignant cell (CL0001064)
Fold Change: 5.29
Marker Score: 71101
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 5.28
Marker Score: 11065
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 5.21
Marker Score: 3934
Cell Name: mature T cell (CL0002419)
Fold Change: 5.2
Marker Score: 51457.5
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 5.07
Marker Score: 3679
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 4.99
Marker Score: 8568
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 4.99
Marker Score: 14564
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 4.98
Marker Score: 2560
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 4.87
Marker Score: 7496
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 4.84
Marker Score: 4743
Cell Name: naive B cell (CL0000788)
Fold Change: 4.82
Marker Score: 4307
Cell Name: radial glial cell (CL0000681)
Fold Change: 4.82
Marker Score: 1776.5
Cell Name: naive T cell (CL0000898)
Fold Change: 4.8
Marker Score: 3093.5
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.74
Marker Score: 14943
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.73
Marker Score: 160917
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 4.63
Marker Score: 2391.5
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.63
Marker Score: 244978
Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 4.5
Marker Score: 2536
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.46
Marker Score: 249199
Cell Name: elicited macrophage (CL0000861)
Fold Change: 4.33
Marker Score: 26298
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 4.3
Marker Score: 5607
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 4.3
Marker Score: 4779
Cell Name: blood cell (CL0000081)
Fold Change: 4.29
Marker Score: 49894.5
Cell Name: germinal center B cell (CL0000844)
Fold Change: 4.27
Marker Score: 2599
Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.26
Marker Score: 56210
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 4.24
Marker Score: 1377
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 4.23
Marker Score: 1011
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.22
Marker Score: 11670
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 4.21
Marker Score: 22118
Cell Name: memory T cell (CL0000813)
Fold Change: 4.19
Marker Score: 1801
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.17
Marker Score: 11701
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.15
Marker Score: 10139
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.11
Marker Score: 9369
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 4.08
Marker Score: 2394
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 4.06
Marker Score: 945
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 4.05
Marker Score: 3449
Cell Name: theca cell (CL0000503)
Fold Change: 4.04
Marker Score: 2893
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 4.04
Marker Score: 17309
Cell Name: chondrocyte (CL0000138)
Fold Change: 4.02
Marker Score: 1809
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.99
Marker Score: 3930
Cell Name: type I NK T cell (CL0000921)
Fold Change: 3.99
Marker Score: 3129
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 3.99
Marker Score: 3852
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.97
Marker Score: 4238
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 3.93
Marker Score: 3349
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 3.93
Marker Score: 2096
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.87
Marker Score: 13742
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 3.86
Marker Score: 4767
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.84
Marker Score: 3417
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.84
Marker Score: 24496
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.79
Marker Score: 24732
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 3.79
Marker Score: 5585
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 3.79
Marker Score: 6768.5
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 3.78
Marker Score: 9230
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 3.78
Marker Score: 9618
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 3.78
Marker Score: 2540
Cell Name: supporting cell (CL0000630)
Fold Change: 3.77
Marker Score: 7085
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 3.77
Marker Score: 3543
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 3.76
Marker Score: 1718
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 3.75
Marker Score: 986
Cell Name: club cell (CL0000158)
Fold Change: 3.72
Marker Score: 4340
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 3.71
Marker Score: 851
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 3.7
Marker Score: 1185
Cell Name: granulocyte (CL0000094)
Fold Change: 3.69
Marker Score: 1655
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 3.69
Marker Score: 9892
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 3.69
Marker Score: 3969
Cell Name: memory B cell (CL0000787)
Fold Change: 3.67
Marker Score: 2777
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.66
Marker Score: 4192
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.66
Marker Score: 3217.5
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.65
Marker Score: 1202
Cell Name: immature B cell (CL0000816)
Fold Change: 3.64
Marker Score: 2413
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 3.63
Marker Score: 880
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 3.63
Marker Score: 1021
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 3.62
Marker Score: 3189
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 3.61
Marker Score: 2999
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3.6
Marker Score: 3215
Cell Name: exhausted T cell (CL0011025)
Fold Change: 3.59
Marker Score: 2066
Cell Name: reticular cell (CL0000432)
Fold Change: 3.59
Marker Score: 1309
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.59
Marker Score: 23320
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 3.58
Marker Score: 2934
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 3.58
Marker Score: 1016
Cell Name: regulatory T cell (CL0000815)
Fold Change: 3.58
Marker Score: 3955
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 3.57
Marker Score: 2091
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.57
Marker Score: 3001
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 3.56
Marker Score: 8587
Cell Name: late pro-B cell (CL0002048)
Fold Change: 3.55
Marker Score: 4185
Cell Name: epithelial cell (CL0000066)
Fold Change: 3.55
Marker Score: 5639
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 3.54
Marker Score: 2371
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 3.53
Marker Score: 3687
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 3.53
Marker Score: 2512
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 3.53
Marker Score: 1948
Cell Name: endothelial cell (CL0000115)
Fold Change: 3.53
Marker Score: 3164
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 3.52
Marker Score: 2754
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 3.48
Marker Score: 1803
Cell Name: basophil (CL0000767)
Fold Change: 3.48
Marker Score: 1654
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 3.48
Marker Score: 2993
Cell Name: mucous neck cell (CL0000651)
Fold Change: 3.48
Marker Score: 7888
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 3.48
Marker Score: 2287
Cell Name: neutrophil (CL0000775)
Fold Change: 3.47
Marker Score: 2117
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 3.47
Marker Score: 5696.5

Hover over a box to see details here...

**Key characteristics:** * UBA52 is a transmembrane protein with a molecular weight of approximately 100 kDa. * It is expressed in a variety of cell types, including myoepithelial cells of the mammary gland, malignant cells, CD38-negative naive B cells, cord blood hematopoietic stem cells, mature T cells, activated CD8-positive and alpha-beta T cells, naive thymus-derived CD4-positive, alpha-beta T cells, NKp46-positive innate lymphoid cells, and human natural T-regulatory cells. * It is a key regulator of cellular responses to various stimuli, including growth factors, cytokines, and stress factors. **Pathways and functions:** * UBA52 is involved in the regulation of apoptosis, autophagy, and cell cycle progression. * It is a key regulator of tumor growth and metastasis. * It is also involved in the regulation of immune responses, including the activation of cytotoxic T cells and the regulation of inflammatory responses. **Clinical significance:** * UBA52 mutations have been linked to a number of human diseases, including breast cancer, lung cancer, and multiple sclerosis. * Targeting UBA52 has been shown to be a promising strategy for the treatment of these diseases. **Conclusion:** UBA52 is a critical regulator of cellular processes in health and disease. Its mutations have significant implications for human health, and its inhibition could provide new therapeutic avenues for a variety of diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

CEP52
Q7Z4P3_HUMAN

Genular Protein ID: 4027796776

Symbol: RL40_HUMAN

Name: CEP52

UniProtKB Accession Codes:

P62987 P02248 P02249 P02250 P14793 P62988 Q29120 Q6LBL4 Q6LDU5 Q8WYN8 Q91887 Q91888 Q9BWD6 Q9BX98 Q9UEF2 Q9UEG1 Q9UEK8 Q9UPK7

Database IDs:

Citations:

PubMed ID: 1850507

Title: The human ubiquitin-52 amino acid fusion protein gene shares several structural features with mammalian ribosomal protein genes.

PubMed ID: 1850507

DOI: 10.1093/nar/19.5.1035

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 1128706

Title: Molecular conservation of 74 amino acid sequence of ubiquitin between cattle and man.

PubMed ID: 1128706

DOI: 10.1038/255423a0

PubMed ID: 16443603

Title: Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.

PubMed ID: 16443603

DOI: 10.1074/jbc.m512786200

PubMed ID: 3037496

Title: cDNA encoding a human homolog of yeast ubiquitin 1.

PubMed ID: 3037496

DOI: 10.1093/nar/15.13.5485

PubMed ID: 15147878

Title: Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domains.

PubMed ID: 15147878

DOI: 10.1016/j.febslet.2004.04.031

PubMed ID: 16543144

Title: Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain.

PubMed ID: 16543144

DOI: 10.1016/j.molcel.2006.02.018

PubMed ID: 15466860

Title: Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis.

PubMed ID: 15466860

DOI: 10.1074/jbc.m402916200

PubMed ID: 18719106

Title: Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks.

PubMed ID: 18719106

DOI: 10.1073/pnas.0805685105

PubMed ID: 19754430

Title: The emerging complexity of protein ubiquitination.

PubMed ID: 19754430

DOI: 10.1042/bst0370937

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23169626

Title: A ribosome-specialized translation initiation pathway is required for cap-dependent translation of vesicular stomatitis virus mRNAs.

PubMed ID: 23169626

DOI: 10.1073/pnas.1216454109

PubMed ID: 24660806

Title: Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.

PubMed ID: 24660806

DOI: 10.1042/bj20140334

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24751536

Title: PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.

PubMed ID: 24751536

DOI: 10.1083/jcb.201402104

PubMed ID: 24784582

Title: Ubiquitin is phosphorylated by PINK1 to activate parkin.

PubMed ID: 24784582

DOI: 10.1038/nature13392

PubMed ID: 25474007

Title: Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering.

PubMed ID: 25474007

DOI: 10.1371/journal.pgen.1004861

PubMed ID: 25527291

Title: Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis.

PubMed ID: 25527291

DOI: 10.15252/embj.201489847

PubMed ID: 28525742

Title: Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9.

PubMed ID: 28525742

DOI: 10.1016/j.molcel.2017.04.028

PubMed ID: 32330457

Title: Threonine ADP-ribosylation of ubiquitin by a bacterial effector family blocks host ubiquitination.

PubMed ID: 32330457

DOI: 10.1016/j.molcel.2020.03.016

PubMed ID: 34239127

Title: K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle.

PubMed ID: 34239127

DOI: 10.1038/s41589-021-00823-5

PubMed ID: 22729708

Title: Determination of structural fluctuations of proteins from structure-based calculations of residual dipolar couplings.

PubMed ID: 22729708

DOI: 10.1007/s10858-012-9644-3

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 25752573

Title: K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of K29 polyubiquitin.

PubMed ID: 25752573

DOI: 10.1016/j.molcel.2015.01.041

PubMed ID: 25752577

Title: Assembly and specific recognition of K29- and K33-linked polyubiquitin.

PubMed ID: 25752577

DOI: 10.1016/j.molcel.2015.01.042

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

Length: 128
Mass: 14728
Checksum: 7BCB602ABEFAD02A
Sequence:

MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN 
IQKESTLHLV LRLRGGIIEP SLRQLAQKYN CDKMICRKCY ARLHPRAVNC RKKKCGHTNN 
LRPKKKVK

Genular Protein ID: 1044920739

Symbol: Q7Z4P3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z4P3

Database IDs:

Sequence Information:

Length: 101
Mass: 11270
Checksum: 996764093CD7AA17
Sequence:

MLSRLVLNSW AQAIRPSQPL KVLGLQARTA MPDPVLSFLF VCLFVCFETE SCSVAQAGVQ 
WRSLGLLQPL PPGFTSFSCL SLPSSWDYRC PPQLLANFLY F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: UBA52

Associated with

Cells (max top 100)

Other Information

The human ubiquitin-52 amino acid fusion protein gene shares several structural features with mammalian ribosomal protein genes. PubMed ID: 1850507

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

Molecular conservation of 74 amino acid sequence of ubiquitin between cattle and man. PubMed ID: 1128706

Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation. PubMed ID: 16443603

cDNA encoding a human homolog of yeast ubiquitin 1. PubMed ID: 3037496

Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domains. PubMed ID: 15147878

Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. PubMed ID: 16543144

Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis. PubMed ID: 15466860

Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. PubMed ID: 18719106

The emerging complexity of protein ubiquitination. PubMed ID: 19754430

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

A ribosome-specialized translation initiation pathway is required for cap-dependent translation of vesicular stomatitis virus mRNAs. PubMed ID: 23169626

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65. PubMed ID: 24660806

A new system for naming ribosomal proteins. PubMed ID: 24524803

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. PubMed ID: 24751536

Ubiquitin is phosphorylated by PINK1 to activate parkin. PubMed ID: 24784582

Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering. PubMed ID: 25474007

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis. PubMed ID: 25527291

Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9. PubMed ID: 28525742

Threonine ADP-ribosylation of ubiquitin by a bacterial effector family blocks host ubiquitination. PubMed ID: 32330457

K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle. PubMed ID: 34239127

Determination of structural fluctuations of proteins from structure-based calculations of residual dipolar couplings. PubMed ID: 22729708

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of K29 polyubiquitin. PubMed ID: 25752573

Assembly and specific recognition of K29- and K33-linked polyubiquitin. PubMed ID: 25752577

Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. PubMed ID: 32669547