Details for: UBE2B

Gene ID: 7320

Symbol: UBE2B

Ensembl ID: ENSG00000119048

Description: ubiquitin conjugating enzyme E2 B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 629.2704
    Cell Significance Index: -97.8800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 394.8063
    Cell Significance Index: -100.1400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 231.3382
    Cell Significance Index: -109.2200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 217.5716
    Cell Significance Index: -88.3900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 196.9147
    Cell Significance Index: -101.2900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 162.8262
    Cell Significance Index: -109.2600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 93.1455
    Cell Significance Index: -88.9300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 78.1861
    Cell Significance Index: -96.4000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 35.0336
    Cell Significance Index: -93.8500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 27.8735
    Cell Significance Index: -109.9900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 25.1086
    Cell Significance Index: -77.1200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 21.7400
    Cell Significance Index: -47.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.0594
    Cell Significance Index: 145.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.6624
    Cell Significance Index: 71.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.4369
    Cell Significance Index: 66.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.3647
    Cell Significance Index: 111.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.3205
    Cell Significance Index: 465.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.5862
    Cell Significance Index: 195.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5150
    Cell Significance Index: 273.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.5039
    Cell Significance Index: 664.8900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.5008
    Cell Significance Index: 206.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.4252
    Cell Significance Index: 106.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4161
    Cell Significance Index: 773.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4090
    Cell Significance Index: 505.3900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.4058
    Cell Significance Index: 34.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3901
    Cell Significance Index: 275.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3666
    Cell Significance Index: 104.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2220
    Cell Significance Index: 157.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9180
    Cell Significance Index: 108.2600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8745
    Cell Significance Index: 112.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8638
    Cell Significance Index: 55.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8055
    Cell Significance Index: 49.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7834
    Cell Significance Index: 36.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7523
    Cell Significance Index: 74.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7396
    Cell Significance Index: 38.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6271
    Cell Significance Index: 16.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5591
    Cell Significance Index: 95.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5470
    Cell Significance Index: 28.7200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4765
    Cell Significance Index: 12.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4195
    Cell Significance Index: 290.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3861
    Cell Significance Index: 27.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3692
    Cell Significance Index: 695.0700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2897
    Cell Significance Index: 20.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2062
    Cell Significance Index: 11.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1328
    Cell Significance Index: 25.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1097
    Cell Significance Index: 17.8400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1060
    Cell Significance Index: 5.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0621
    Cell Significance Index: 84.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0584
    Cell Significance Index: 37.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0532
    Cell Significance Index: 98.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0368
    Cell Significance Index: 56.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0085
    Cell Significance Index: -6.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0186
    Cell Significance Index: -0.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0207
    Cell Significance Index: -0.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0223
    Cell Significance Index: -10.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0333
    Cell Significance Index: -25.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0378
    Cell Significance Index: -2.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0488
    Cell Significance Index: -36.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0639
    Cell Significance Index: -39.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0720
    Cell Significance Index: -7.3500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0873
    Cell Significance Index: -9.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1224
    Cell Significance Index: -69.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1498
    Cell Significance Index: -4.4000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1613
    Cell Significance Index: -1.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2431
    Cell Significance Index: -11.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2446
    Cell Significance Index: -51.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3144
    Cell Significance Index: -90.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3342
    Cell Significance Index: -38.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3468
    Cell Significance Index: -21.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3535
    Cell Significance Index: -51.3800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3609
    Cell Significance Index: -6.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3827
    Cell Significance Index: -6.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4997
    Cell Significance Index: -58.2300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5148
    Cell Significance Index: -7.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5853
    Cell Significance Index: -20.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6881
    Cell Significance Index: -23.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7097
    Cell Significance Index: -31.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7389
    Cell Significance Index: -20.6500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7733
    Cell Significance Index: -20.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8092
    Cell Significance Index: -11.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8971
    Cell Significance Index: -93.4100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9337
    Cell Significance Index: -11.1300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.9420
    Cell Significance Index: -15.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9586
    Cell Significance Index: -75.9200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9829
    Cell Significance Index: -37.2200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.0791
    Cell Significance Index: -25.8800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.0874
    Cell Significance Index: -19.2200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.1372
    Cell Significance Index: -17.0400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.1475
    Cell Significance Index: -24.8600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.2342
    Cell Significance Index: -35.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.3121
    Cell Significance Index: -27.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.5066
    Cell Significance Index: -40.3000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.5774
    Cell Significance Index: -17.9200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.5950
    Cell Significance Index: -31.1300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.7094
    Cell Significance Index: -10.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.7521
    Cell Significance Index: -107.4200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.8931
    Cell Significance Index: -23.4800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.9611
    Cell Significance Index: -33.0400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.9663
    Cell Significance Index: -11.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -2.0045
    Cell Significance Index: -46.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Ubiquitin-conjugating enzyme activity**: UBE2B has the ability to transfer ubiquitin to target proteins, which can mark them for degradation, modification, or localization to specific compartments. 2. **Adaptive immune system regulation**: UBE2B is involved in the regulation of the adaptive immune response, particularly in the processing and presentation of antigens to T-cells. 3. **Apoptosis regulation**: UBE2B can modulate apoptosis by regulating the ubiquitination of pro-apoptotic proteins, thereby influencing cell survival and death. 4. **Protein modification and degradation**: UBE2B is involved in the ubiquitination of proteins, which can lead to their degradation by the proteasome or modification by other enzymes. 5. **Cellular localization**: UBE2B is localized to various cellular compartments, including the nucleus, cytoplasm, and plasma membrane, highlighting its versatility in regulating different cellular processes. **Pathways and Functions** 1. **Adaptive immune system**: UBE2B plays a crucial role in the adaptive immune response by facilitating the processing and presentation of antigens to T-cells. 2. **Antigen processing and presentation**: UBE2B is involved in the ubiquitination of antigens, which are then processed and presented to T-cells by MHC class I molecules. 3. **Apoptosis regulation**: UBE2B can modulate apoptosis by regulating the ubiquitination of pro-apoptotic proteins, thereby influencing cell survival and death. 4. **Protein modification and degradation**: UBE2B is involved in the ubiquitination of proteins, which can lead to their degradation by the proteasome or modification by other enzymes. 5. **DNA damage response**: UBE2B can regulate the ubiquitination of proteins involved in DNA damage response, thereby influencing cell survival and proliferation. **Clinical Significance** 1. **Cancer**: UBE2B has been implicated in various cancers, including breast, prostate, and lung cancer, where its dysregulation can contribute to tumorigenesis and metastasis. 2. **Immunodeficiency**: UBE2B plays a crucial role in the adaptive immune response, and its dysregulation can lead to immunodeficiency disorders, such as HIV-associated immunodeficiency. 3. **Neurodegenerative diseases**: UBE2B has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where its dysregulation can contribute to protein aggregation and neurodegeneration. 4. **Infectious diseases**: UBE2B can regulate the ubiquitination of proteins involved in the response to infectious diseases, such as HIV and influenza. In conclusion, UBE2B is a critical gene involved in various cellular processes, including protein modification, regulation of apoptosis, and antigen processing. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its role in maintaining cellular homeostasis and responding to environmental stressors.

Genular Protein ID: 4014735426

Symbol: UBE2B_HUMAN

Name: E2 ubiquitin-conjugating enzyme B

UniProtKB Accession Codes:

P63146 B2R503 D3DQA2 P23567 Q4PJ15 Q9D0J6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 11 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 42 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2158443

Title: The human ubiquitin carrier protein E2(Mr = 17,000) is homologous to the yeast DNA repair gene RAD6.

PubMed ID: 2158443

DOI: 10.1002/j.1460-2075.1990.tb08259.x

PubMed ID: 1883845

Title: Mammalian mRNAs encoding protein closely related to ubiquitin-conjugating enzyme encoded by yeast DNA repair gene RAD6.

PubMed ID: 1883845

DOI: 10.1016/0167-4781(91)90039-o

PubMed ID: 1717990

Title: Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6.

PubMed ID: 1717990

DOI: 10.1073/pnas.88.20.8865

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8062904

Title: The human ubiquitin-conjugating enzyme UbcH1 is involved in the repair of UV-damaged, alkylated and cross-linked DNA.

PubMed ID: 8062904

DOI: 10.1016/0014-5793(94)00656-3

PubMed ID: 10908344

Title: The human RAD18 gene product interacts with HHR6A and HHR6B.

PubMed ID: 10908344

DOI: 10.1093/nar/28.14.2847

PubMed ID: 16337599

Title: The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions.

PubMed ID: 16337599

DOI: 10.1016/j.molcel.2005.11.012

PubMed ID: 17130289

Title: Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination.

PubMed ID: 17130289

DOI: 10.1083/jcb.200606145

PubMed ID: 17108083

Title: Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen.

PubMed ID: 17108083

DOI: 10.1073/pnas.0608595103

PubMed ID: 20061386

Title: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

PubMed ID: 20061386

DOI: 10.1074/jbc.m109.089003

PubMed ID: 21329877

Title: WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription.

PubMed ID: 21329877

DOI: 10.1016/j.molcel.2011.01.024

PubMed ID: 38182926

Title: UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4.

PubMed ID: 38182926

DOI: 10.1038/s41594-023-01192-4

PubMed ID: 11885984

Title: The NMR structure of the class I human ubiquitin-conjugating enzyme 2b.

PubMed ID: 11885984

DOI: 10.1023/a:1013807519703

Sequence Information:

  • Length: 152
  • Mass: 17312
  • Checksum: CFDEEEE7E06840BE
  • Sequence:
    • MSTPARRRLM RDFKRLQEDP PVGVSGAPSE NNIMQWNAVI FGPEGTPFED GTFKLVIEFS 
EEYPNKPPTV RFLSKMFHPN VYADGSICLD ILQNRWSPTY DVSSILTSIQ SLLDEPNPNS 
PANSQAAQLY QENKREYEKR VSAIVEQSWN DS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.