Details for: UTRN

Gene ID: 7402

Symbol: UTRN

Ensembl ID: ENSG00000152818

Description: utrophin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 549.9044
    Cell Significance Index: -85.5400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 316.0737
    Cell Significance Index: -80.1700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 176.9561
    Cell Significance Index: -83.5500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 173.0677
    Cell Significance Index: -70.3100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 152.3177
    Cell Significance Index: -78.3500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 73.8628
    Cell Significance Index: -70.5200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 69.3577
    Cell Significance Index: -85.5200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 32.5552
    Cell Significance Index: -71.2500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 28.8257
    Cell Significance Index: -77.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 21.7534
    Cell Significance Index: -85.8400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 21.2049
    Cell Significance Index: -65.1300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 8.7988
    Cell Significance Index: 126.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 6.8868
    Cell Significance Index: 134.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 4.3722
    Cell Significance Index: 867.6800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 3.6250
    Cell Significance Index: 77.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.3470
    Cell Significance Index: 256.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.9397
    Cell Significance Index: 130.0300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 2.8004
    Cell Significance Index: 42.2000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.0657
    Cell Significance Index: 107.6000
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.9850
    Cell Significance Index: 20.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.9032
    Cell Significance Index: 3583.5700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.8121
    Cell Significance Index: 46.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.7913
    Cell Significance Index: 100.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.4396
    Cell Significance Index: 653.3900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.4358
    Cell Significance Index: 18.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.4113
    Cell Significance Index: 146.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0272
    Cell Significance Index: 206.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.9284
    Cell Significance Index: 589.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8266
    Cell Significance Index: 23.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7154
    Cell Significance Index: 27.0900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6261
    Cell Significance Index: 37.5900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6110
    Cell Significance Index: 422.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.6100
    Cell Significance Index: 1124.9300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.5594
    Cell Significance Index: 3.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.5531
    Cell Significance Index: 851.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4811
    Cell Significance Index: 262.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4783
    Cell Significance Index: 65.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3295
    Cell Significance Index: 59.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3195
    Cell Significance Index: 39.2800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1790
    Cell Significance Index: 2.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1751
    Cell Significance Index: 77.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1555
    Cell Significance Index: 4.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1376
    Cell Significance Index: 13.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1006
    Cell Significance Index: 136.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0989
    Cell Significance Index: 16.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0917
    Cell Significance Index: 5.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0622
    Cell Significance Index: 2.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0051
    Cell Significance Index: 0.3100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0022
    Cell Significance Index: 0.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0122
    Cell Significance Index: -8.9800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0190
    Cell Significance Index: -0.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0194
    Cell Significance Index: -0.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0280
    Cell Significance Index: -10.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0485
    Cell Significance Index: -9.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0485
    Cell Significance Index: -36.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0515
    Cell Significance Index: -8.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1027
    Cell Significance Index: -76.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1112
    Cell Significance Index: -14.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1192
    Cell Significance Index: -8.2400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1290
    Cell Significance Index: -1.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1489
    Cell Significance Index: -92.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1498
    Cell Significance Index: -84.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1507
    Cell Significance Index: -7.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2179
    Cell Significance Index: -31.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2268
    Cell Significance Index: -10.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2508
    Cell Significance Index: -25.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2548
    Cell Significance Index: -73.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2771
    Cell Significance Index: -32.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3206
    Cell Significance Index: -41.4200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3399
    Cell Significance Index: -36.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3441
    Cell Significance Index: -40.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4374
    Cell Significance Index: -92.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4614
    Cell Significance Index: -34.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4717
    Cell Significance Index: -11.7900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5767
    Cell Significance Index: -9.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5881
    Cell Significance Index: -67.3800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6839
    Cell Significance Index: -12.6400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.7514
    Cell Significance Index: -6.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7812
    Cell Significance Index: -40.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.7835
    Cell Significance Index: -55.4200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7925
    Cell Significance Index: -16.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8015
    Cell Significance Index: -17.0700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.9190
    Cell Significance Index: -11.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9285
    Cell Significance Index: -73.5400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.9478
    Cell Significance Index: -13.9900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.1503
    Cell Significance Index: -58.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.1720
    Cell Significance Index: -15.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.2201
    Cell Significance Index: -33.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.2583
    Cell Significance Index: -84.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3231
    Cell Significance Index: -81.1200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.3922
    Cell Significance Index: -33.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.4315
    Cell Significance Index: -45.8500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.4412
    Cell Significance Index: -42.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.4489
    Cell Significance Index: -91.3200
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -1.4684
    Cell Significance Index: -22.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.4840
    Cell Significance Index: -77.9200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -1.5008
    Cell Significance Index: -15.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.5608
    Cell Significance Index: -51.1000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.6120
    Cell Significance Index: -38.6600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.6147
    Cell Significance Index: -20.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The UTRN gene is a single-copy gene located on chromosome 6q25. It is highly conserved across species, with a high degree of sequence similarity to the dystrophin gene. The UTRN protein shares a similar structure and function with dystrophin, with a rod domain, a globular domain, and a transmembrane domain. The UTRN protein is also a member of the dystrophin-associated glycoprotein complex (DGC), which plays a critical role in maintaining muscle cell integrity. **Pathways and Functions:** The UTRN gene is involved in various cellular pathways, including: 1. **Muscle contraction:** UTRN is required for the proper functioning of muscle contraction, as it interacts with dystrophin and other DGC components to maintain muscle cell integrity. 2. **Nervous system development:** UTRN is expressed in neurons and plays a role in the development and maintenance of the nervous system, particularly in the formation of synapses and synaptic signaling. 3. **Cytoskeleton organization:** UTRN is involved in the organization of the cytoskeleton, particularly in the formation of filopodia and the regulation of cell-matrix adhesion. 4. **Sarcolemma integrity:** UTRN helps to maintain the integrity of the sarcolemma, the muscle cell membrane, by interacting with dystrophin and other DGC components. **Clinical Significance:** Dysfunction of the UTRN gene has been linked to various neuromuscular disorders, including: 1. **Duchenne muscular dystrophy (DMD):** Mutations in the UTRN gene have been identified in patients with DMD, a severe form of muscular dystrophy characterized by progressive muscle weakness and degeneration. 2. **Becker muscular dystrophy (BMD):** UTRN mutations have also been associated with BMD, a milder form of muscular dystrophy characterized by progressive muscle weakness and degeneration. 3. **Neuromuscular junction disorders:** UTRN dysfunction has been implicated in various neuromuscular junction disorders, including myasthenia gravis and Lambert-Eaton myasthenic syndrome. In conclusion, the UTRN gene plays a critical role in muscle and nervous system development and function. Its dysfunction has been linked to various neuromuscular disorders, highlighting the importance of this gene in maintaining tissue integrity and function. Further studies are needed to fully understand the mechanisms by which UTRN regulates muscle and nervous system development and to develop effective therapeutic strategies for UTRN-related disorders.

Genular Protein ID: 4006281105

Symbol: UTRN_HUMAN

Name: Dystrophin-related protein 1

UniProtKB Accession Codes:

P46939 Q5SYY1 Q5SZ57 Q9UJ40

Database IDs:

ABCD 1 AGR 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 6 CORUM 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 8 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PIRSF 1 PRO 1 PROSITE 7 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1461283

Title: Primary structure of dystrophin-related protein.

PubMed ID: 1461283

DOI: 10.1038/360591a0

PubMed ID: 10369873

Title: Up71 and up140, two novel transcripts of utrophin that are homologues of short forms of dystrophin.

PubMed ID: 10369873

DOI: 10.1093/hmg/8.7.1271

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 10570192

Title: A second promoter provides an alternative target for therapeutic up-regulation of utrophin in Duchenne muscular dystrophy.

PubMed ID: 10570192

DOI: 10.1073/pnas.96.24.14025

PubMed ID: 7844150

Title: Syntrophin binds to an alternatively spliced exon of dystrophin.

PubMed ID: 7844150

DOI: 10.1083/jcb.128.3.363

PubMed ID: 8576247

Title: The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives.

PubMed ID: 8576247

DOI: 10.1074/jbc.271.5.2724

PubMed ID: 10767429

Title: Contribution of the different modules in the utrophin carboxy-terminal region to the formation and regulation of the DAP complex.

PubMed ID: 10767429

DOI: 10.1016/s0014-5793(00)01400-9

PubMed ID: 10769203

Title: Adhesion-dependent tyrosine phosphorylation of (beta)-dystroglycan regulates its interaction with utrophin.

PubMed ID: 10769203

DOI: 10.1242/jcs.113.10.1717

PubMed ID: 16777071

Title: Interactions of intermediate filament protein synemin with dystrophin and utrophin.

PubMed ID: 16777071

DOI: 10.1016/j.bbrc.2006.05.192

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24628267

Title: The actin binding affinity of the utrophin tandem calponin-homology domain is primarily determined by its N-terminal domain.

PubMed ID: 24628267

DOI: 10.1021/bi500149q

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9887274

Title: The 2.0-A structure of the second calponin homology domain from the actin-binding region of the dystrophin homologue utrophin.

PubMed ID: 9887274

DOI: 10.1006/jmbi.1998.2406

PubMed ID: 10647184

Title: Crystal structure of the actin-binding region of utrophin reveals a head-to-tail dimer.

PubMed ID: 10647184

DOI: 10.1016/s0969-2126(00)88344-6

PubMed ID: 10715214

Title: Structure of the utrophin actin-binding domain bound to F-actin reveals binding by an induced fit mechanism.

PubMed ID: 10715214

DOI: 10.1006/jmbi.2000.3583

Sequence Information:

  • Length: 3433
  • Mass: 394466
  • Checksum: C72CADE8CD666993
  • Sequence:
    • MAKYGEHEAS PDNGQNEFSD IIKSRSDEHN DVQKKTFTKW INARFSKSGK PPINDMFTDL 
KDGRKLLDLL EGLTGTSLPK ERGSTRVHAL NNVNRVLQVL HQNNVELVNI GGTDIVDGNH 
KLTLGLLWSI ILHWQVKDVM KDVMSDLQQT NSEKILLSWV RQTTRPYSQV NVLNFTTSWT 
DGLAFNAVLH RHKPDLFSWD KVVKMSPIER LEHAFSKAQT YLGIEKLLDP EDVAVQLPDK 
KSIIMYLTSL FEVLPQQVTI DAIREVETLP RKYKKECEEE AINIQSTAPE EEHESPRAET 
PSTVTEVDMD LDSYQIALEE VLTWLLSAED TFQEQDDISD DVEEVKDQFA THEAFMMELT 
AHQSSVGSVL QAGNQLITQG TLSDEEEFEI QEQMTLLNAR WEALRVESMD RQSRLHDVLM 
ELQKKQLQQL SAWLTLTEER IQKMETCPLD DDVKSLQKLL EEHKSLQSDL EAEQVKVNSL 
THMVVIVDEN SGESATAILE DQLQKLGERW TAVCRWTEER WNRLQEINIL WQELLEEQCL 
LKAWLTEKEE ALNKVQTSNF KDQKELSVSV RRLAILKEDM EMKRQTLDQL SEIGQDVGQL 
LDNSKASKKI NSDSEELTQR WDSLVQRLED SSNQVTQAVA KLGMSQIPQK DLLETVRVRE 
QAITKKSKQE LPPPPPPKKR QIHVDIEAKK KFDAISAELL NWILKWKTAI QTTEIKEYMK 
MQDTSEMKKK LKALEKEQRE RIPRADELNQ TGQILVEQMG KEGLPTEEIK NVLEKVSSEW 
KNVSQHLEDL ERKIQLQEDI NAYFKQLDEL EKVIKTKEEW VKHTSISESS RQSLPSLKDS 
CQRELTNLLG LHPKIEMARA SCSALMSQPS APDFVQRGFD SFLGRYQAVQ EAVEDRQQHL 
ENELKGQPGH AYLETLKTLK DVLNDSENKA QVSLNVLNDL AKVEKALQEK KTLDEILENQ 
KPALHKLAEE TKALEKNVHP DVEKLYKQEF DDVQGKWNKL KVLVSKDLHL LEEIALTLRA 
FEADSTVIEK WMDGVKDFLM KQQAAQGDDA GLQRQLDQCS AFVNEIETIE SSLKNMKEIE 
TNLRSGPVAG IKTWVQTRLG DYQTQLEKLS KEIATQKSRL SESQEKAANL KKDLAEMQEW 
MTQAEEEYLE RDFEYKSPEE LESAVEEMKR AKEDVLQKEV RVKILKDNIK LLAAKVPSGG 
QELTSELNVV LENYQLLCNR IRGKCHTLEE VWSCWIELLH YLDLETTWLN TLEERMKSTE 
VLPEKTDAVN EALESLESVL RHPADNRTQI RELGQTLIDG GILDDIISEK LEAFNSRYED 
LSHLAESKQI SLEKQLQVLR ETDQMLQVLQ ESLGELDKQL TTYLTDRIDA FQVPQEAQKI 
QAEISAHELT LEELRRNMRS QPLTSPESRT ARGGSQMDVL QRKLREVSTK FQLFQKPANF 
EQRMLDCKRV LDGVKAELHV LDVKDVDPDV IQTHLDKCMK LYKTLSEVKL EVETVIKTGR 
HIVQKQQTDN PKGMDEQLTS LKVLYNDLGA QVTEGKQDLE RASQLARKMK KEAASLSEWL 
SATETELVQK STSEGLLGDL DTEISWAKNV LKDLEKRKAD LNTITESSAA LQNLIEGSEP 
ILEERLCVLN AGWSRVRTWT EDWCNTLMNH QNQLEIFDGN VAHISTWLYQ AEALLDEIEK 
KPTSKQEEIV KRLVSELDDA NLQVENVRDQ ALILMNARGS SSRELVEPKL AELNRNFEKV 
SQHIKSAKLL IAQEPLYQCL VTTETFETGV PFSDLEKLEN DIENMLKFVE KHLESSDEDE 
KMDEESAQIE EVLQRGEEML HQPMEDNKKE KIRLQLLLLH TRYNKIKAIP IQQRKMGQLA 
SGIRSSLLPT DYLVEINKIL LCMDDVELSL NVPELNTAIY EDFSFQEDSL KNIKDQLDKL 
GEQIAVIHEK QPDVILEASG PEAIQIRDTL TQLNAKWDRI NRMYSDRKGC FDRAMEEWRQ 
FHCDLNDLTQ WITEAEELLV DTCAPGGSLD LEKARIHQQE LEVGISSHQP SFAALNRTGD 
GIVQKLSQAD GSFLKEKLAG LNQRWDAIVA EVKDRQPRLK GESKQVMKYR HQLDEIICWL 
TKAEHAMQKR STTELGENLQ ELRDLTQEME VHAEKLKWLN RTELEMLSDK SLSLPERDKI 
SESLRTVNMT WNKICREVPT TLKECIQEPS SVSQTRIAAH PNVQKVVLVS SASDIPVQSH 
RTSEISIPAD LDKTITELAD WLVLIDQMLK SNIVTVGDVE EINKTVSRMK ITKADLEQRH 
PQLDYVFTLA QNLKNKASSS DMRTAITEKL ERVKNQWDGT QHGVELRQQQ LEDMIIDSLQ 
WDDHREETEE LMRKYEARLY ILQQARRDPL TKQISDNQIL LQELGPGDGI VMAFDNVLQK 
LLEEYGSDDT RNVKETTEYL KTSWINLKQS IADRQNALEA EWRTVQASRR DLENFLKWIQ 
EAETTVNVLV DASHRENALQ DSILARELKQ QMQDIQAEID AHNDIFKSID GNRQKMVKAL 
GNSEEATMLQ HRLDDMNQRW NDLKAKSASI RAHLEASAEK WNRLLMSLEE LIKWLNMKDE 
ELKKQMPIGG DVPALQLQYD HCKALRRELK EKEYSVLNAV DQARVFLADQ PIEAPEEPRR 
NLQSKTELTP EERAQKIAKA MRKQSSEVKE KWESLNAVTS NWQKQVDKAL EKLRDLQGAM 
DDLDADMKEA ESVRNGWKPV GDLLIDSLQD HIEKIMAFRE EIAPINFKVK TVNDLSSQLS 
PLDLHPSLKM SRQLDDLNMR WKLLQVSVDD RLKQLQEAHR DFGPSSQHFL STSVQLPWQR 
SISHNKVPYY INHQTQTTCW DHPKMTELFQ SLADLNNVRF SAYRTAIKIR RLQKALCLDL 
LELSTTNEIF KQHKLNQNDQ LLSVPDVINC LTTTYDGLEQ MHKDLVNVPL CVDMCLNWLL 
NVYDTGRTGK IRVQSLKIGL MSLSKGLLEE KYRYLFKEVA GPTEMCDQRQ LGLLLHDAIQ 
IPRQLGEVAA FGGSNIEPSV RSCFQQNNNK PEISVKEFID WMHLEPQSMV WLPVLHRVAA 
AETAKHQAKC NICKECPIVG FRYRSLKHFN YDVCQSCFFS GRTAKGHKLH YPMVEYCIPT 
TSGEDVRDFT KVLKNKFRSK KYFAKHPRLG YLPVQTVLEG DNLETPITLI SMWPEHYDPS 
QSPQLFHDDT HSRIEQYATR LAQMERTNGS FLTDSSSTTG SVEDEHALIQ QYCQTLGGES 
PVSQPQSPAQ ILKSVEREER GELERIIADL EEEQRNLQVE YEQLKDQHLR RGLPVGSPPE 
SIISPHHTSE DSELIAEAKL LRQHKGRLEA RMQILEDHNK QLESQLHRLR QLLEQPESDS 
RINGVSPWAS PQHSALSYSL DPDASGPQFH QAAGEDLLAP PHDTSTDLTE VMEQIHSTFP 
SCCPNVPSRP QAM

Genular Protein ID: 806067228

Symbol: Q6LBS5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6LBS5

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 2 SMART 1 SUPFAM 2

Citations:

PubMed ID: 2541343

Title: An autosomal transcript in skeletal muscle with homology to dystrophin.

PubMed ID: 2541343

DOI: 10.1038/339055a0

Sequence Information:

  • Length: 490
  • Mass: 55577
  • Checksum: 9D4E4347292DD669
  • Sequence:
    • DTGRTGKIRV QSLKIGLMSL SKGLLEEKYR YLFKEVAGPT EMCDQRQLGL LLHDAIQIPR 
QLGEVAAFGG SNIEPSVRSC FQQNNNKPEI SVKEFIDWMH LEPQSMVWLP VLHRVAAAET 
AKHQAKCNIC KECPIVGFRY RSLKHFNYDV CQSCFFSGRT AKGHKLHYPM VEYCIPTTSG 
EDVRDFTKVL KNKFRSKKYF AKHPRLGYLP VQTVLEGDNL ETPITLISMW PEHYDPSQSP 
QLFHDDTHSR IEQYATRLAQ MERTNGSFLT DSSSTTGSVE DEHALIQQYC QTLGGESPVS 
QPQSPAQILK SVEREERGEL ERIIADLEEE QRNLQVEYEQ LKDQHLRRGL PVGSPPESII 
SPHHTSEDSE LIAEAKLLRQ HKGRLEARMQ ILEDHNKQLE SQLHRLRQLL EQPESDSRIN 
GVSPWASPQH SALSYSLDPD ASGPQFHQAA GEDLLAPPHD TSTDLTEVME QIHSTFPSCC 
PNVPSRPQAM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.