Details for: GET1
Gene ID: 7485
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: GET1
Ensembl ID: ENSG00000182093
Description: guided entry of tail-anchored proteins factor 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 39.05rCSI 34.34%PRS 77.38
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CSI 24.69rCSI 33.65%PRS 79.55
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CSI 22.14rCSI 19.99%PRS 85.42
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CSI 12.81rCSI 29.2%PRS 79.94
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CSI 11.83rCSI 13.68%PRS 80.44
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CSI 11.59rCSI 20.43%PRS 82.26
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CSI 10.99rCSI 14.61%PRS 90.78
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CSI 10.35rCSI 11.09%PRS 88.69
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CSI 8.88rCSI 28.48%PRS 86.86
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CSI 8.42rCSI 21.29%PRS 90.01
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CSI 7.39rCSI 11.98%PRS 81.39
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CSI 6.54rCSI 4.35%PRS 88.63
-
CSI 6.12rCSI 10.8%PRS 90.16
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CSI 5.76rCSI 45.12%PRS 89.22
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CSI 5.7rCSI 8.68%PRS 83.82
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CSI 5.51rCSI 9.9%PRS 81.1
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CSI 5.43rCSI 16.03%PRS 87.3
-
CSI 5.38rCSI 5.37%PRS 81.05
-
CSI 5.36rCSI 8.46%PRS 87.7
-
CSI 5.34rCSI 4.01%PRS 90.99
-
CSI 5.05rCSI 8.13%PRS 78.11
-
CSI 4.8rCSI 10.21%PRS 80.53
-
CSI 4.64rCSI 6.9%PRS 86.16
-
CSI 4.63rCSI 7.77%PRS 71.44
-
CSI 4.51rCSI 5.21%PRS 79.27
-
CSI 4.42rCSI 6.14%PRS 85.11
-
CSI 4.38rCSI 4.22%PRS 81.84
-
CSI 4.24rCSI 18.86%PRS 87.31
-
CSI 4.09rCSI 5.66%PRS 83.31
-
CSI 3.77rCSI 10.07%PRS 80.02
-
CSI 3.62rCSI 2.94%PRS 86.26
-
CSI 3.59rCSI 4.6%PRS 83.17
-
CSI 3.47rCSI 3.8%PRS 88.32
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CSI 3.39rCSI 7.74%PRS 79.38
-
CSI 3.23rCSI 4.11%PRS 90.82
-
CSI 3.16rCSI 6.34%PRS 79.23
-
CSI 3.13rCSI 9.08%PRS 77.39
-
CSI 3.08rCSI 2.71%PRS 90.46
-
CSI 2.95rCSI 4.33%PRS 93.45
-
CSI 2.87rCSI 4.41%PRS 75.22
-
CSI 2.84rCSI 3.4%PRS 71.61
-
CSI 2.71rCSI 3.62%PRS 91.08
-
CSI 2.7rCSI 6.22%PRS 76.28
-
CSI 2.69rCSI 3.94%PRS 81.84
-
CSI 2.64rCSI 4.32%PRS 78.19
-
CSI 2.64rCSI 2.77%PRS 89.26
-
CSI 2.63rCSI 2.08%PRS 77.95
-
CSI 2.58rCSI 2.13%PRS 88.66
-
CSI 2.53rCSI 4.04%PRS 78.8
-
CSI 2.53rCSI 3.58%PRS 83.91
-
CSI 2.52rCSI 3.06%PRS 91.46
-
CSI 2.51rCSI 3.98%PRS 81.18
-
CSI 2.5rCSI 3.41%PRS 85.78
-
CSI 2.49rCSI 2.6%PRS 84.3
-
CSI 2.48rCSI 6.3%PRS 80.87
-
CSI 2.45rCSI 2.03%PRS 87.81
-
CSI 2.43rCSI 3.57%PRS 80.59
-
CSI 2.43rCSI 2.39%PRS 88.53
-
CSI 2.37rCSI 5.31%PRS 72.21
-
CSI 2.35rCSI 1.85%PRS 90.08
-
CSI 2.32rCSI 4.01%PRS 80.06
-
CSI 2.32rCSI 8.68%PRS 80.84
-
CSI 2.27rCSI 3.11%PRS 78.57
-
CSI 2.19rCSI 4.51%PRS 74.14
-
CSI 2.17rCSI 4.3%PRS 82.79
-
CSI 2.16rCSI 2.95%PRS 86.76
-
CSI 2.12rCSI 4.82%PRS 86.01
-
CSI 2.03rCSI 3.11%PRS 93.08
-
CSI 2.01rCSI 3.9%PRS 89.09
-
CSI 2rCSI 2.92%PRS 90.66
-
CSI 1.99rCSI 2.57%PRS 72.63
-
CSI 1.97rCSI 2.92%PRS 89.12
-
CSI 1.97rCSI 1.6%PRS 88.48
-
CSI 1.97rCSI 2.45%PRS 69.32
-
CSI 1.88rCSI 3.51%PRS 76.96
-
CSI 1.85rCSI 3.31%PRS 85.92
-
CSI 1.8rCSI 5.11%PRS 82.69
-
CSI 1.77rCSI 4.6%PRS 86.29
-
CSI 1.76rCSI 2.51%PRS 87.18
-
CSI 1.71rCSI 3.79%PRS 74.49
-
CSI 1.66rCSI 2.68%PRS 72.71
-
CSI 1.62rCSI 7.04%PRS 89.51
-
CSI 1.57rCSI 5.1%PRS 84.73
-
CSI 1.55rCSI 3.67%PRS 85.18
-
CSI 1.54rCSI 1.84%PRS 85.13
-
CSI 1.51rCSI 8.67%PRS 89.88
-
CSI 1.46rCSI 2.79%PRS 95.2
-
CSI 1.44rCSI 5.99%PRS 83.65
-
CSI 1.42rCSI 4.8%PRS 82.38
-
CSI 1.37rCSI 2.12%PRS 85.46
-
CSI 1.3rCSI 3.3%PRS 78.96
-
CSI 0.95rCSI 2.1%PRS 86.62
-
CSI 0.94rCSI 2.93%PRS 74.95
-
CSI 0.9rCSI 2.2%PRS 69.25
-
CSI 0.71rCSI 2.21%PRS 72.82
-
CSI 0.67rCSI 2.55%PRS 71.76
-
CSI 0.63rCSI 15.32%PRS 69.48
-
CSI 0.57rCSI 2.05%PRS 69.43
-
CSI 0.5rCSI 2.7%PRS 90.67
-
CSI 0.42rCSI 2.48%PRS 71.86
-
CSI 0.3rCSI 5.7%PRS 77.9%
-
CSI 0.4rCSI 2.5%PRS 71.9%
-
CSI 0.5rCSI 2.7%PRS 90.7%
-
CSI 0.6rCSI 2.1%PRS 69.4%
-
CSI 0.6rCSI 15.3%PRS 69.5%
-
CSI 0.7rCSI 2.6%PRS 71.8%
-
CSI 0.7rCSI 2.2%PRS 72.8%
-
CSI 0.9rCSI 2.2%PRS 69.3%
-
CSI 0.9rCSI 2.9%PRS 75.0%
-
CSI 1.0rCSI 2.1%PRS 86.6%
-
CSI 1.3rCSI 3.3%PRS 79.0%
-
CSI 1.4rCSI 2.1%PRS 85.5%
-
CSI 1.4rCSI 4.8%PRS 82.4%
-
CSI 1.4rCSI 6.0%PRS 83.7%
-
CSI 1.5rCSI 2.8%PRS 95.2%
-
CSI 1.5rCSI 8.7%PRS 89.9%
-
CSI 1.5rCSI 1.8%PRS 85.1%
-
CSI 1.6rCSI 3.7%PRS 85.2%
-
CSI 1.6rCSI 5.1%PRS 84.7%
-
CSI 1.6rCSI 7.0%PRS 89.5%
-
CSI 1.7rCSI 2.7%PRS 72.7%
-
CSI 1.7rCSI 3.8%PRS 74.5%
-
CSI 1.8rCSI 2.5%PRS 87.2%
-
CSI 1.8rCSI 4.6%PRS 86.3%
-
CSI 1.8rCSI 5.1%PRS 82.7%
-
CSI 1.9rCSI 3.3%PRS 85.9%
-
CSI 1.9rCSI 3.5%PRS 77.0%
-
CSI 2.0rCSI 2.5%PRS 69.3%
-
CSI 2.0rCSI 1.6%PRS 88.5%
-
CSI 2.0rCSI 2.9%PRS 89.1%
-
CSI 2.0rCSI 2.6%PRS 72.6%
-
CSI 2.0rCSI 2.9%PRS 90.7%
-
CSI 2.0rCSI 3.9%PRS 89.1%
-
CSI 2.0rCSI 3.1%PRS 93.1%
-
CSI 2.1rCSI 4.8%PRS 86.0%
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CSI 2.2rCSI 3.0%PRS 86.8%
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CSI 2.2rCSI 4.3%PRS 82.8%
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CSI 2.2rCSI 4.5%PRS 74.1%
-
CSI 2.3rCSI 3.1%PRS 78.6%
-
CSI 2.3rCSI 8.7%PRS 80.8%
-
CSI 2.3rCSI 4.0%PRS 80.1%
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CSI 2.4rCSI 1.9%PRS 90.1%
-
CSI 2.4rCSI 5.3%PRS 72.2%
-
CSI 2.4rCSI 2.4%PRS 88.5%
-
CSI 2.4rCSI 3.6%PRS 80.6%
-
CSI 2.5rCSI 2.0%PRS 87.8%
-
CSI 2.5rCSI 6.3%PRS 80.9%
-
CSI 2.5rCSI 2.6%PRS 84.3%
-
CSI 2.5rCSI 3.4%PRS 85.8%
-
CSI 2.5rCSI 4.0%PRS 81.2%
-
CSI 2.5rCSI 3.1%PRS 91.5%
-
CSI 2.5rCSI 3.6%PRS 83.9%
-
CSI 2.5rCSI 4.0%PRS 78.8%
-
CSI 2.6rCSI 2.1%PRS 88.7%
-
CSI 2.6rCSI 2.1%PRS 78.0%
-
CSI 2.6rCSI 2.8%PRS 89.3%
-
CSI 2.6rCSI 4.3%PRS 78.2%
-
CSI 2.7rCSI 3.9%PRS 81.8%
-
CSI 2.7rCSI 6.2%PRS 76.3%
-
CSI 2.7rCSI 3.6%PRS 91.1%
-
CSI 2.8rCSI 3.4%PRS 71.6%
-
CSI 2.9rCSI 4.4%PRS 75.2%
-
CSI 3.0rCSI 4.3%PRS 93.5%
-
CSI 3.1rCSI 2.7%PRS 90.5%
-
CSI 3.1rCSI 9.1%PRS 77.4%
-
CSI 3.2rCSI 6.3%PRS 79.2%
-
CSI 3.2rCSI 4.1%PRS 90.8%
-
CSI 3.4rCSI 7.7%PRS 79.4%
-
CSI 3.5rCSI 3.8%PRS 88.3%
-
CSI 3.6rCSI 4.6%PRS 83.2%
-
CSI 3.6rCSI 2.9%PRS 86.3%
-
CSI 3.8rCSI 10.1%PRS 80.0%
-
CSI 4.1rCSI 5.7%PRS 83.3%
-
CSI 4.2rCSI 18.9%PRS 87.3%
-
CSI 4.4rCSI 4.2%PRS 81.8%
-
CSI 4.4rCSI 6.1%PRS 85.1%
-
CSI 4.5rCSI 5.2%PRS 79.3%
-
CSI 4.6rCSI 7.8%PRS 71.4%
-
CSI 4.6rCSI 6.9%PRS 86.2%
-
CSI 4.8rCSI 10.2%PRS 80.5%
-
CSI 5.1rCSI 8.1%PRS 78.1%
-
CSI 5.3rCSI 4.0%PRS 91.0%
-
CSI 5.4rCSI 8.5%PRS 87.7%
-
CSI 5.4rCSI 5.4%PRS 81.1%
-
CSI 5.4rCSI 16.0%PRS 87.3%
-
CSI 5.5rCSI 9.9%PRS 81.1%
-
CSI 5.7rCSI 8.7%PRS 83.8%
-
CSI 5.8rCSI 45.1%PRS 89.2%
-
CSI 6.1rCSI 10.8%PRS 90.2%
-
CSI 6.5rCSI 4.4%PRS 88.6%
-
CSI 7.4rCSI 12.0%PRS 81.4%
-
CSI 8.4rCSI 21.3%PRS 90.0%
-
CSI 8.9rCSI 28.5%PRS 86.9%
-
CSI 10.4rCSI 11.1%PRS 88.7%
-
CSI 11.0rCSI 14.6%PRS 90.8%
-
CSI 11.6rCSI 20.4%PRS 82.3%
-
CSI 11.8rCSI 13.7%PRS 80.4%
-
CSI 12.8rCSI 29.2%PRS 79.9%
-
CSI 22.1rCSI 20.0%PRS 85.4%
-
CSI 24.7rCSI 33.7%PRS 79.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 458974393
Symbol: GET1_HUMAN
Name: Congenital heart disease 5 protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9544840
Title: Identification and characterization of a new human cDNA from chromosome 21q22.3 encoding a basic nuclear protein.
PubMed ID: 9544840
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 10830953
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 21444755
Title: WRB is the receptor for TRC40/Asna1-mediated insertion of tail-anchored proteins into the ER membrane.
PubMed ID: 21444755
DOI: 10.1242/jcs.084277
PubMed ID: 23041287
Title: Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells.
PubMed ID: 23041287
PubMed ID: 24392163
Title: WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane.
PubMed ID: 24392163
PubMed ID: 27226539
Title: Tail-anchored protein insertion in mammals: function and reciprocal interactions of the two subunits of the TRC40 receptor.
PubMed ID: 27226539
PubMed ID: 31417168
Title: The WRB Subunit of the Get3 Receptor is Required for the Correct Integration of its Partner CAML into the ER.
PubMed ID: 31417168
PubMed ID: 32187542
Title: Differential Modes of Orphan Subunit Recognition for the WRB/CAML Complex.
PubMed ID: 32187542
PubMed ID: 32910895
Title: Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex.
PubMed ID: 32910895
Sequence Information:
- Length: 174
- Mass: 19780
- Checksum: A01F11CC564EAB6E
- Sequence:
MSSAAADHWA WLLVLSFVFG CNVLRILLPS FSSFMSRVLQ KDAEQESQMR AEIQDMKQEL STVNMMDEFA RYARLERKIN KMTDKLKTHV KARTAQLAKI KWVISVAFYV LQAALMISLI WKYYSVPVAV VPSKWITPLD RLVAFPTRVA GGVGITCWIL VCNKVVAIVL HPFS