Details for: GET1

Gene ID: 7485

Symbol: GET1

Ensembl ID: ENSG00000182093

Description: guided entry of tail-anchored proteins factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 175.5117
    Cell Significance Index: -27.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 103.3341
    Cell Significance Index: -26.2100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 71.2226
    Cell Significance Index: -29.3400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 64.2841
    Cell Significance Index: -30.3500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 58.0304
    Cell Significance Index: -29.8500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 45.4829
    Cell Significance Index: -30.5200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.3967
    Cell Significance Index: -30.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.8103
    Cell Significance Index: -30.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 4.6731
    Cell Significance Index: 294.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.8764
    Cell Significance Index: 98.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.8545
    Cell Significance Index: 216.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.5686
    Cell Significance Index: 451.3300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.3837
    Cell Significance Index: 11.0500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.0171
    Cell Significance Index: 22.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9779
    Cell Significance Index: 534.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8665
    Cell Significance Index: 30.1100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7832
    Cell Significance Index: 47.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7788
    Cell Significance Index: 156.2200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6261
    Cell Significance Index: 16.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6115
    Cell Significance Index: 12.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6066
    Cell Significance Index: 217.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5069
    Cell Significance Index: 64.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4796
    Cell Significance Index: 22.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4647
    Cell Significance Index: 28.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4306
    Cell Significance Index: 59.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4018
    Cell Significance Index: 79.7400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.3981
    Cell Significance Index: 4.2300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3902
    Cell Significance Index: 42.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2995
    Cell Significance Index: 16.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2800
    Cell Significance Index: 252.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2738
    Cell Significance Index: 49.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2443
    Cell Significance Index: 46.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2343
    Cell Significance Index: 17.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2256
    Cell Significance Index: 99.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2066
    Cell Significance Index: 24.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1953
    Cell Significance Index: 19.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1879
    Cell Significance Index: 9.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1646
    Cell Significance Index: 7.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1624
    Cell Significance Index: 11.2300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1604
    Cell Significance Index: 8.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1583
    Cell Significance Index: 4.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1426
    Cell Significance Index: 4.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1390
    Cell Significance Index: 17.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1224
    Cell Significance Index: 4.6400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1214
    Cell Significance Index: 1.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1151
    Cell Significance Index: 14.8800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1117
    Cell Significance Index: 2.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1007
    Cell Significance Index: 17.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0876
    Cell Significance Index: 14.2600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0847
    Cell Significance Index: 1.0100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0804
    Cell Significance Index: 2.0600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0562
    Cell Significance Index: 0.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0299
    Cell Significance Index: 0.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0247
    Cell Significance Index: 0.7900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0167
    Cell Significance Index: 0.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0131
    Cell Significance Index: 0.4600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0126
    Cell Significance Index: 0.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0012
    Cell Significance Index: -0.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0017
    Cell Significance Index: -1.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0107
    Cell Significance Index: -0.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0124
    Cell Significance Index: -9.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0162
    Cell Significance Index: -30.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0166
    Cell Significance Index: -12.2800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0168
    Cell Significance Index: -1.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0196
    Cell Significance Index: -36.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0236
    Cell Significance Index: -36.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0274
    Cell Significance Index: -37.2900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0290
    Cell Significance Index: -0.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0298
    Cell Significance Index: -16.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0401
    Cell Significance Index: -4.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0449
    Cell Significance Index: -28.5100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0564
    Cell Significance Index: -0.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0576
    Cell Significance Index: -35.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0594
    Cell Significance Index: -6.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0623
    Cell Significance Index: -4.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0659
    Cell Significance Index: -29.9200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0894
    Cell Significance Index: -0.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1105
    Cell Significance Index: -2.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1324
    Cell Significance Index: -6.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1393
    Cell Significance Index: -29.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1453
    Cell Significance Index: -9.3800
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.1600
    Cell Significance Index: -0.9400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1628
    Cell Significance Index: -1.7700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1637
    Cell Significance Index: -1.8600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1697
    Cell Significance Index: -4.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1980
    Cell Significance Index: -28.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2032
    Cell Significance Index: -5.6800
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.2119
    Cell Significance Index: -1.6000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2666
    Cell Significance Index: -7.8300
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.2675
    Cell Significance Index: -1.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2778
    Cell Significance Index: -6.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3024
    Cell Significance Index: -31.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3417
    Cell Significance Index: -27.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3742
    Cell Significance Index: -22.9400
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.3859
    Cell Significance Index: -4.3600
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.3996
    Cell Significance Index: -3.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4069
    Cell Significance Index: -8.6700
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.4312
    Cell Significance Index: -4.2700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4552
    Cell Significance Index: -6.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4765
    Cell Significance Index: -12.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Role in protein insertion**: GET1 is specifically designed to facilitate the insertion of TAPs into the ER membrane, a process critical for protein folding, secretion, and membrane trafficking. 2. **Cellular localization**: GET1 is predominantly expressed in cells with high membrane protein expression, including retinal rod cells, ciliated columnar cells of the tracheobronchial tree, and peripheral nervous system neurons. 3. **Evolutionary conservation**: GET1 is conserved across species, suggesting its essential role in maintaining cellular homeostasis. 4. **Protein-protein interactions**: GET1 interacts with other proteins, including the ER membrane and TAPs, to facilitate protein insertion. **Pathways and Functions:** 1. **ER membrane insertion**: GET1 facilitates the insertion of TAPs into the ER membrane, ensuring proper protein folding, secretion, and membrane trafficking. 2. **Protein-membrane adaptor activity**: GET1 acts as a protein-membrane adaptor, bridging the ER membrane and TAPs to facilitate their interaction. 3. **Protein localization**: GET1 regulates the localization of TAPs to specific ER membrane domains, ensuring proper protein function. 4. **Protein stabilization**: GET1 contributes to the stabilization of TAPs, preventing their degradation and promoting their proper functioning. **Clinical Significance:** 1. **Congenital heart disease**: GET1 mutations have been linked to congenital heart disease, highlighting its critical role in cardiac development and function. 2. **Neurological disorders**: GET1 dysregulation has been implicated in various neurological disorders, including peripheral neuropathy and primary sensory neuron degeneration. 3. **Cancer**: GET1 expression is altered in certain types of cancer, suggesting its potential role in cancer progression and metastasis. 4. **Immunological disorders**: GET1 dysregulation may contribute to immunological disorders, such as autoimmune diseases and immunodeficiency disorders. In conclusion, GET1 plays a vital role in protein insertion, cellular homeostasis, and immunological processes. Its dysregulation has been linked to various diseases, highlighting the need for further research into its mechanisms and potential therapeutic applications. As an expert immunologist, it is essential to continue exploring the intricacies of GET1 to unravel its full immunological significance.

Genular Protein ID: 458974393

Symbol: GET1_HUMAN

Name: Congenital heart disease 5 protein

UniProtKB Accession Codes:

O00258 A8KAP8 A8MQ44 D3DSH9 O60740

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 3 Ensembl 4 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9544840

Title: Identification and characterization of a new human cDNA from chromosome 21q22.3 encoding a basic nuclear protein.

PubMed ID: 9544840

DOI: 10.1007/s004390050693

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21444755

Title: WRB is the receptor for TRC40/Asna1-mediated insertion of tail-anchored proteins into the ER membrane.

PubMed ID: 21444755

DOI: 10.1242/jcs.084277

PubMed ID: 23041287

Title: Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells.

PubMed ID: 23041287

DOI: 10.1016/j.molcel.2012.08.028

PubMed ID: 24392163

Title: WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane.

PubMed ID: 24392163

DOI: 10.1371/journal.pone.0085033

PubMed ID: 27226539

Title: Tail-anchored protein insertion in mammals: function and reciprocal interactions of the two subunits of the TRC40 receptor.

PubMed ID: 27226539

DOI: 10.1074/jbc.m115.707752

PubMed ID: 31417168

Title: The WRB Subunit of the Get3 Receptor is Required for the Correct Integration of its Partner CAML into the ER.

PubMed ID: 31417168

DOI: 10.1038/s41598-019-48363-2

PubMed ID: 32187542

Title: Differential Modes of Orphan Subunit Recognition for the WRB/CAML Complex.

PubMed ID: 32187542

DOI: 10.1016/j.celrep.2020.02.084

PubMed ID: 32910895

Title: Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex.

PubMed ID: 32910895

DOI: 10.1016/j.molcel.2020.08.012

Sequence Information:

  • Length: 174
  • Mass: 19780
  • Checksum: A01F11CC564EAB6E
  • Sequence:
    • MSSAAADHWA WLLVLSFVFG CNVLRILLPS FSSFMSRVLQ KDAEQESQMR AEIQDMKQEL 
STVNMMDEFA RYARLERKIN KMTDKLKTHV KARTAQLAKI KWVISVAFYV LQAALMISLI 
WKYYSVPVAV VPSKWITPLD RLVAFPTRVA GGVGITCWIL VCNKVVAIVL HPFS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.