Details for: XPC
Gene ID: 7508
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: XPC
Ensembl ID: ENSG00000154767
Description: XPC complex subunit, DNA damage recognition and repair factor
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 17.24rCSI 25.29%PRS 56.2
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CSI 9.76rCSI 13.8%PRS 53.63
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CSI 9.14rCSI 8.81%PRS 35.87
-
CSI 6.53rCSI 9.65%PRS 50.05
-
CSI 5.47rCSI 8.4%PRS 51.98
-
CSI 3.74rCSI 4.48%PRS 43.17
-
CSI 3.56rCSI 7.87%PRS 42.34
-
CSI 3.51rCSI 2.9%PRS 45.9
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CSI 3.38rCSI 2.57%PRS 56.22
-
CSI 3.29rCSI 5.13%PRS 71.73
-
CSI 3.24rCSI 2.33%PRS 57.87
-
CSI 3.22rCSI 2.58%PRS 66.29
-
CSI 3.14rCSI 7.57%PRS 63.03
-
CSI 3.13rCSI 2.63%PRS 62.35
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CSI 2.98rCSI 2.93%PRS 47.33
-
CSI 2.97rCSI 2.22%PRS 63.46
-
CSI 2.9rCSI 9.29%PRS 42
-
CSI 2.84rCSI 2.47%PRS 54.44
-
CSI 2.8rCSI 14.06%PRS 55.89
-
CSI 2.76rCSI 2.08%PRS 57.22
-
CSI 2.74rCSI 4.18%PRS 54.18
-
CSI 2.71rCSI 2.2%PRS 45.59
-
CSI 2.65rCSI 3.63%PRS 41.3
-
CSI 2.56rCSI 1.99%PRS 61.84
-
CSI 2.55rCSI 2.67%PRS 47.73
-
CSI 2.49rCSI 3.65%PRS 48.06
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CSI 2.44rCSI 1.92%PRS 51.37
-
CSI 2.37rCSI 3.17%PRS 53.39
-
CSI 2.35rCSI 2.65%PRS 61.37
-
CSI 2.35rCSI 1.74%PRS 38.65
-
CSI 2.34rCSI 1.63%PRS 53.54
-
CSI 2.29rCSI 3.71%PRS 43.47
-
CSI 2.26rCSI 2.25%PRS 39.31
-
CSI 2.24rCSI 5.03%PRS 30.36
-
CSI 2.19rCSI 1.48%PRS 55.3
-
CSI 2.17rCSI 1.28%PRS 60.1
-
CSI 2.15rCSI 3.19%PRS 47.53
-
CSI 2.09rCSI 3.79%PRS 61.19
-
CSI 2.07rCSI 6%PRS 36.59
-
CSI 2.03rCSI 2.59%PRS 50.33
-
CSI 2.03rCSI 2.12%PRS 44.49
-
CSI 2.03rCSI 3.2%PRS 46.04
-
CSI 2.01rCSI 2.1%PRS 45.61
-
CSI 2.01rCSI 1.59%PRS 33.03
-
CSI 1.98rCSI 2.32%PRS 60.51
-
CSI 1.97rCSI 3.76%PRS 61.61
-
CSI 1.94rCSI 2.7%PRS 44.43
-
CSI 1.94rCSI 1.44%PRS 58.17
-
CSI 1.94rCSI 4.93%PRS 40.99
-
CSI 1.92rCSI 9.22%PRS 43.63
-
CSI 1.92rCSI 2.72%PRS 42.04
-
CSI 1.87rCSI 2.28%PRS 52.52
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CSI 1.86rCSI 3.62%PRS 47.07
-
CSI 1.85rCSI 1.62%PRS 54.65
-
CSI 1.84rCSI 1.59%PRS 53.41
-
CSI 1.84rCSI 1.28%PRS 57.81
-
CSI 1.82rCSI 1.68%PRS 64.95
-
CSI 1.82rCSI 1.27%PRS 46.74
-
CSI 1.82rCSI 7.07%PRS 65.39
-
CSI 1.81rCSI 2.47%PRS 72.59
-
CSI 1.81rCSI 1.69%PRS 44.73
-
CSI 1.81rCSI 2.88%PRS 38.24
-
CSI 1.77rCSI 3.15%PRS 60.37
-
CSI 1.76rCSI 4.6%PRS 44.07
-
CSI 1.76rCSI 4.66%PRS 52.65
-
CSI 1.74rCSI 1.44%PRS 43.53
-
CSI 1.73rCSI 1.79%PRS 50.81
-
CSI 1.7rCSI 1.31%PRS 43.84
-
CSI 1.7rCSI 2.03%PRS 65.3
-
CSI 1.68rCSI 2.95%PRS 37.57
-
CSI 1.67rCSI 2.99%PRS 43.4
-
CSI 1.65rCSI 1.7%PRS 62.71
-
CSI 1.64rCSI 1.27%PRS 45.44
-
CSI 1.61rCSI 3.68%PRS 38.57
-
CSI 1.61rCSI 1.48%PRS 52.33
-
CSI 1.59rCSI 3.79%PRS 55.51
-
CSI 1.58rCSI 2.53%PRS 48.8
-
CSI 1.58rCSI 5.9%PRS 38.24
-
CSI 1.54rCSI 1.69%PRS 48.89
-
CSI 1.53rCSI 1.15%PRS 48.41
-
CSI 1.53rCSI 2.77%PRS 38.81
-
CSI 1.52rCSI 1.89%PRS 40.94
-
CSI 1.52rCSI 2.64%PRS 35.95
-
CSI 1.52rCSI 3.48%PRS 44.38
-
CSI 1.52rCSI 3.08%PRS 27.98
-
CSI 1.5rCSI 1.32%PRS 34.41
-
CSI 1.46rCSI 5.9%PRS 43.52
-
CSI 1.44rCSI 1.72%PRS 29.59
-
CSI 1.42rCSI 3.59%PRS 53.29
-
CSI 1.4rCSI 1.29%PRS 45.85
-
CSI 1.39rCSI 2.79%PRS 35.09
-
CSI 1.37rCSI 3.89%PRS 45
-
CSI 1.34rCSI 2.51%PRS 35.04
-
CSI 1.34rCSI 2.4%PRS 38.57
-
CSI 1.33rCSI 1.54%PRS 39.43
-
CSI 1.32rCSI 1.55%PRS 48.59
-
CSI 1.32rCSI 1.69%PRS 49.67
-
CSI 1.31rCSI 1.69%PRS 42.98
-
CSI 1.3rCSI 1.78%PRS 38.45
-
CSI 1.3rCSI 1.5%PRS 35.4
-
CSI 0.1rCSI 0.9%PRS 32.9%
-
CSI 0.2rCSI 1.2%PRS 33.3%
-
CSI 0.2rCSI 1.2%PRS 57.0%
-
CSI 0.2rCSI 5.6%PRS 30.0%
-
CSI 0.3rCSI 7.5%PRS 29.1%
-
CSI 0.4rCSI 1.1%PRS 47.4%
-
CSI 0.4rCSI 0.9%PRS 43.5%
-
CSI 0.4rCSI 1.4%PRS 30.8%
-
CSI 0.5rCSI 1.3%PRS 41.8%
-
CSI 0.5rCSI 2.3%PRS 56.9%
-
CSI 0.5rCSI 1.5%PRS 33.1%
-
CSI 0.5rCSI 1.7%PRS 28.5%
-
CSI 0.6rCSI 0.7%PRS 64.2%
-
CSI 0.6rCSI 1.9%PRS 52.5%
-
CSI 0.6rCSI 1.6%PRS 38.1%
-
CSI 0.6rCSI 2.2%PRS 64.1%
-
CSI 0.6rCSI 1.0%PRS 35.9%
-
CSI 0.6rCSI 2.7%PRS 38.6%
-
CSI 0.7rCSI 1.6%PRS 75.1%
-
CSI 0.7rCSI 1.1%PRS 29.6%
-
CSI 0.7rCSI 1.1%PRS 42.8%
-
CSI 0.7rCSI 1.0%PRS 36.6%
-
CSI 0.7rCSI 2.8%PRS 30.6%
-
CSI 0.7rCSI 1.2%PRS 31.7%
-
CSI 0.8rCSI 2.0%PRS 35.8%
-
CSI 0.8rCSI 1.4%PRS 53.6%
-
CSI 0.8rCSI 2.0%PRS 50.7%
-
CSI 0.8rCSI 1.8%PRS 33.6%
-
CSI 0.9rCSI 1.3%PRS 45.6%
-
CSI 0.9rCSI 5.4%PRS 31.1%
-
CSI 0.9rCSI 1.6%PRS 65.5%
-
CSI 1.0rCSI 2.3%PRS 28.8%
-
CSI 1.0rCSI 0.7%PRS 48.7%
-
CSI 1.0rCSI 1.9%PRS 78.4%
-
CSI 1.0rCSI 2.8%PRS 62.7%
-
CSI 1.0rCSI 1.3%PRS 49.8%
-
CSI 1.1rCSI 0.8%PRS 66.9%
-
CSI 1.1rCSI 1.9%PRS 71.1%
-
CSI 1.1rCSI 1.5%PRS 46.5%
-
CSI 1.1rCSI 1.5%PRS 30.5%
-
CSI 1.1rCSI 2.7%PRS 55.2%
-
CSI 1.2rCSI 1.4%PRS 28.2%
-
CSI 1.2rCSI 1.0%PRS 41.7%
-
CSI 1.2rCSI 2.9%PRS 43.0%
-
CSI 1.2rCSI 1.0%PRS 49.9%
-
CSI 1.2rCSI 1.2%PRS 58.1%
-
CSI 1.2rCSI 2.1%PRS 28.7%
-
CSI 1.2rCSI 3.2%PRS 41.3%
-
CSI 1.2rCSI 1.8%PRS 47.0%
-
CSI 1.2rCSI 3.0%PRS 41.1%
-
CSI 1.2rCSI 2.0%PRS 36.0%
-
CSI 1.2rCSI 1.5%PRS 52.8%
-
CSI 1.3rCSI 1.6%PRS 58.0%
-
CSI 1.3rCSI 1.4%PRS 43.0%
-
CSI 1.3rCSI 1.9%PRS 49.6%
-
CSI 1.3rCSI 1.2%PRS 45.5%
-
CSI 1.3rCSI 2.0%PRS 62.2%
-
CSI 1.3rCSI 2.1%PRS 39.0%
-
CSI 1.3rCSI 1.5%PRS 35.4%
-
CSI 1.3rCSI 1.8%PRS 38.5%
-
CSI 1.3rCSI 1.7%PRS 43.0%
-
CSI 1.3rCSI 1.7%PRS 49.7%
-
CSI 1.3rCSI 1.6%PRS 48.6%
-
CSI 1.3rCSI 1.5%PRS 39.4%
-
CSI 1.3rCSI 2.4%PRS 38.6%
-
CSI 1.3rCSI 2.5%PRS 35.0%
-
CSI 1.4rCSI 3.9%PRS 45.0%
-
CSI 1.4rCSI 2.8%PRS 35.1%
-
CSI 1.4rCSI 1.3%PRS 45.9%
-
CSI 1.4rCSI 3.6%PRS 53.3%
-
CSI 1.4rCSI 1.7%PRS 29.6%
-
CSI 1.5rCSI 5.9%PRS 43.5%
-
CSI 1.5rCSI 1.3%PRS 34.4%
-
CSI 1.5rCSI 3.1%PRS 28.0%
-
CSI 1.5rCSI 3.5%PRS 44.4%
-
CSI 1.5rCSI 2.6%PRS 36.0%
-
CSI 1.5rCSI 1.9%PRS 40.9%
-
CSI 1.5rCSI 2.8%PRS 38.8%
-
CSI 1.5rCSI 1.2%PRS 48.4%
-
CSI 1.5rCSI 1.7%PRS 48.9%
-
CSI 1.6rCSI 5.9%PRS 38.2%
-
CSI 1.6rCSI 2.5%PRS 48.8%
-
CSI 1.6rCSI 3.8%PRS 55.5%
-
CSI 1.6rCSI 1.5%PRS 52.3%
-
CSI 1.6rCSI 3.7%PRS 38.6%
-
CSI 1.6rCSI 1.3%PRS 45.4%
-
CSI 1.7rCSI 1.7%PRS 62.7%
-
CSI 1.7rCSI 3.0%PRS 43.4%
-
CSI 1.7rCSI 3.0%PRS 37.6%
-
CSI 1.7rCSI 2.0%PRS 65.3%
-
CSI 1.7rCSI 1.3%PRS 43.8%
-
CSI 1.7rCSI 1.8%PRS 50.8%
-
CSI 1.7rCSI 1.4%PRS 43.5%
-
CSI 1.8rCSI 4.7%PRS 52.7%
-
CSI 1.8rCSI 4.6%PRS 44.1%
-
CSI 1.8rCSI 3.2%PRS 60.4%
-
CSI 1.8rCSI 2.9%PRS 38.2%
-
CSI 1.8rCSI 1.7%PRS 44.7%
-
CSI 1.8rCSI 2.5%PRS 72.6%
-
CSI 1.8rCSI 7.1%PRS 65.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2323860654
Symbol: XPC_HUMAN
Name: DNA repair protein complementing XP-C cells
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8168482
Title: Purification and cloning of a nucleotide excision repair complex involving the Xeroderma pigmentosum group C protein and a human homologue of yeast RAD23.
PubMed ID: 8168482
PubMed ID: 12177305
Title: The human XPC DNA repair gene: arrangement, splice site information content and influence of a single nucleotide polymorphism in a splice acceptor site on alternative splicing and function.
PubMed ID: 12177305
DOI: 10.1093/nar/gkf469
PubMed ID: 24722188
Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
PubMed ID: 24722188
DOI: 10.1038/ncomms4650
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1522891
Title: Expression cloning of a human DNA repair gene involved in Xeroderma pigmentosum group C.
PubMed ID: 1522891
DOI: 10.1038/359070a0
PubMed ID: 1461286
PubMed ID: 8692695
Title: XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexes.
PubMed ID: 8692695
PubMed ID: 9372924
Title: Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity.
PubMed ID: 9372924
PubMed ID: 9734359
Title: Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair.
PubMed ID: 9734359
PubMed ID: 10734143
Title: The xeroderma pigmentosum group C protein complex XPC-HR23B plays an important role in the recruitment of transcription factor IIH to damaged DNA.
PubMed ID: 10734143
PubMed ID: 10873465
Title: Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites.
PubMed ID: 10873465
PubMed ID: 11279143
Title: Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair.
PubMed ID: 11279143
PubMed ID: 12509299
Title: A molecular mechanism for DNA damage recognition by the xeroderma pigmentosum group C protein complex.
PubMed ID: 12509299
PubMed ID: 12509233
Title: The carboxy-terminal domain of the XPC protein plays a crucial role in nucleotide excision repair through interactions with transcription factor IIH.
PubMed ID: 12509233
PubMed ID: 12547395
Title: DNA bending by the human damage recognition complex XPC-HR23B.
PubMed ID: 12547395
PubMed ID: 12505994
Title: Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase.
PubMed ID: 12505994
DOI: 10.1093/emboj/cdg016
PubMed ID: 15882621
Title: UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.
PubMed ID: 15882621
PubMed ID: 15964821
Title: Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein.
PubMed ID: 15964821
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 17487921
Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.
PubMed ID: 17487921
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18318008
Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
PubMed ID: 18318008
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25772364
Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
PubMed ID: 25772364
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 17682058
Title: In vivo destabilization and functional defects of the xeroderma pigmentosum C protein caused by a pathogenic missense mutation.
PubMed ID: 17682058
DOI: 10.1128/mcb.02166-06
PubMed ID: 17355181
Title: An aromatic sensor with aversion to damaged strands confers versatility to DNA repair.
PubMed ID: 17355181
PubMed ID: 18682493
Title: Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC.
PubMed ID: 18682493
DOI: 10.1242/jcs.031708
PubMed ID: 19609301
Title: Two-stage dynamic DNA quality check by xeroderma pigmentosum group C protein.
PubMed ID: 19609301
PubMed ID: 19941824
Title: Two-step recognition of DNA damage for mammalian nucleotide excision repair: Directional binding of the XPC complex and DNA strand scanning.
PubMed ID: 19941824
PubMed ID: 20649465
Title: Dissection of the xeroderma pigmentosum group C protein function by site-directed mutagenesis.
PubMed ID: 20649465
PubMed ID: 20028083
Title: Photo-cross-linking of XPC-Rad23B to cisplatin-damaged DNA reveals contacts with both strands of the DNA duplex and spans the DNA adduct.
PubMed ID: 20028083
DOI: 10.1021/bi901575h
PubMed ID: 20798892
Title: Stimulation of DNA glycosylase activities by XPC Protein Complex: Roles of protein-protein interactions.
PubMed ID: 20798892
DOI: 10.4061/2010/805698
PubMed ID: 23751493
Title: RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response.
PubMed ID: 23751493
PubMed ID: 29973595
Title: XPC is an RNA polymerase II cofactor recruiting ATAC to promoters by interacting with E2F1.
PubMed ID: 29973595
PubMed ID: 31527837
Title: DNA repair complex licenses acetylation of H2A.Z.1 by KAT2A during transcription.
PubMed ID: 31527837
PubMed ID: 16533048
Title: Flexibility and plasticity of human centrin 2 binding to the xeroderma pigmentosum group C protein (XPC) from nuclear excision repair.
PubMed ID: 16533048
DOI: 10.1021/bi0524868
PubMed ID: 16627479
Title: The structure of the human centrin 2-xeroderma pigmentosum group C protein complex.
PubMed ID: 16627479
PubMed ID: 17897675
Title: Structural, thermodynamic, and cellular characterization of human centrin 2 interaction with xeroderma pigmentosum group C protein.
PubMed ID: 17897675
PubMed ID: 10447254
Title: A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy.
PubMed ID: 10447254
DOI: 10.1002/(sici)1098-1004(1999)14:1<9::aid-humu2>3.0.co;2-6
PubMed ID: 8298653
Title: Characterization of molecular defects in Xeroderma pigmentosum group C.
PubMed ID: 8298653
DOI: 10.1038/ng1293-413
PubMed ID: 10766188
Title: Mutations in the XPC gene in families with xeroderma pigmentosum and consequences at the cell, protein, and transcript levels.
PubMed ID: 10766188
Sequence Information:
- Length: 940
- Mass: 105953
- Checksum: 2F8C80D43FAA1256
- Sequence:
MARKRAAGGE PRGRELRSQK SKAKSKARRE EEEEDAFEDE KPPKKSLLSK VSQGKRKRGC SHPGGSADGP AKKKVAKVTV KSENLKVIKD EALSDGDDLR DFPSDLKKAH HLKRGATMNE DSNEEEEESE NDWEEVEELS EPVLGDVRES TAFSRSLLPV KPVEIEIETP EQAKTRERSE KIKLEFETYL RRAMKRFNKG VHEDTHKVHL LCLLANGFYR NNICSQPDLH AIGLSIIPAR FTRVLPRDVD TYYLSNLVKW FIGTFTVNAE LSASEQDNLQ TTLERRFAIY SARDDEELVH IFLLILRALQ LLTRLVLSLQ PIPLKSATAK GKKPSKERLT ADPGGSSETS SQVLENHTKP KTSKGTKQEE TFAKGTCRPS AKGKRNKGGR KKRSKPSSSE EDEGPGDKQE KATQRRPHGR ERRVASRVSY KEESGSDEAG SGSDFELSSG EASDPSDEDS EPGPPKQRKA PAPQRTKAGS KSASRTHRGS HRKDPSLPAA SSSSSSSKRG KKMCSDGEKA EKRSIAGIDQ WLEVFCEQEE KWVCVDCVHG VVGQPLTCYK YATKPMTYVV GIDSDGWVRD VTQRYDPVWM TVTRKCRVDA EWWAETLRPY QSPFMDREKK EDLEFQAKHM DQPLPTAIGL YKNHPLYALK RHLLKYEAIY PETAAILGYC RGEAVYSRDC VHTLHSRDTW LKKARVVRLG EVPYKMVKGF SNRARKARLA EPQLREENDL GLFGYWQTEE YQPPVAVDGK VPRNEFGNVY LFLPSMMPIG CVQLNLPNLH RVARKLDIDC VQAITGFDFH GGYSHPVTDG YIVCEEFKDV LLTAWENEQA VIERKEKEKK EKRALGNWKL LAKGLLIRER LKRRYGPKSE AAAPHTDAGG GLSSDEEEGT SSQAEAARIL AASWPQNRED EEKQKLKGGP KKTKREKKAA ASHLFPFEQL