Details for: XPC

Gene ID: 7508

Symbol: XPC

Ensembl ID: ENSG00000154767

Description: XPC complex subunit, DNA damage recognition and repair factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 205.5672
    Cell Significance Index: -31.9800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 123.5199
    Cell Significance Index: -31.3300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 89.0162
    Cell Significance Index: -36.6700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 74.4510
    Cell Significance Index: -35.1500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 73.3526
    Cell Significance Index: -29.8000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 52.5616
    Cell Significance Index: -35.2700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.2859
    Cell Significance Index: -29.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.6652
    Cell Significance Index: -34.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.4265
    Cell Significance Index: -30.6100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.3485
    Cell Significance Index: -20.4600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.7708
    Cell Significance Index: -34.6100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.4520
    Cell Significance Index: -25.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.3554
    Cell Significance Index: 162.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1088
    Cell Significance Index: 220.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9759
    Cell Significance Index: 175.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8295
    Cell Significance Index: 134.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7788
    Cell Significance Index: 106.9500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7268
    Cell Significance Index: 656.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7184
    Cell Significance Index: 144.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6144
    Cell Significance Index: 43.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6121
    Cell Significance Index: 75.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5185
    Cell Significance Index: 14.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5095
    Cell Significance Index: 352.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4797
    Cell Significance Index: 172.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3994
    Cell Significance Index: 218.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3916
    Cell Significance Index: 50.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3507
    Cell Significance Index: 155.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3406
    Cell Significance Index: 9.2700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3254
    Cell Significance Index: 6.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3121
    Cell Significance Index: 17.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3088
    Cell Significance Index: 14.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2601
    Cell Significance Index: 13.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2070
    Cell Significance Index: 13.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1637
    Cell Significance Index: 19.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1588
    Cell Significance Index: 10.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1405
    Cell Significance Index: 6.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1246
    Cell Significance Index: 2.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1044
    Cell Significance Index: 10.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0973
    Cell Significance Index: 3.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0858
    Cell Significance Index: 14.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0787
    Cell Significance Index: 9.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0673
    Cell Significance Index: 12.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0645
    Cell Significance Index: 121.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0601
    Cell Significance Index: 110.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0530
    Cell Significance Index: 81.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0442
    Cell Significance Index: 28.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0406
    Cell Significance Index: 0.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0317
    Cell Significance Index: 2.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0269
    Cell Significance Index: 0.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0037
    Cell Significance Index: 0.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0017
    Cell Significance Index: 2.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0067
    Cell Significance Index: -0.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0077
    Cell Significance Index: -3.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0113
    Cell Significance Index: -7.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0127
    Cell Significance Index: -9.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0175
    Cell Significance Index: -13.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0279
    Cell Significance Index: -21.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0368
    Cell Significance Index: -2.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0376
    Cell Significance Index: -21.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0494
    Cell Significance Index: -2.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0729
    Cell Significance Index: -7.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0887
    Cell Significance Index: -18.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0893
    Cell Significance Index: -3.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1018
    Cell Significance Index: -29.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1115
    Cell Significance Index: -8.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1179
    Cell Significance Index: -17.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1218
    Cell Significance Index: -14.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1381
    Cell Significance Index: -4.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1505
    Cell Significance Index: -5.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1640
    Cell Significance Index: -8.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1942
    Cell Significance Index: -13.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2226
    Cell Significance Index: -11.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2455
    Cell Significance Index: -3.3500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2570
    Cell Significance Index: -29.3400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2763
    Cell Significance Index: -4.6600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2833
    Cell Significance Index: -2.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2845
    Cell Significance Index: -29.6200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3022
    Cell Significance Index: -6.4600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3212
    Cell Significance Index: -8.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3383
    Cell Significance Index: -17.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3409
    Cell Significance Index: -27.0000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3932
    Cell Significance Index: -8.2300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3934
    Cell Significance Index: -11.5600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4167
    Cell Significance Index: -9.6300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4353
    Cell Significance Index: -2.6300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4640
    Cell Significance Index: -12.2000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4976
    Cell Significance Index: -13.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5323
    Cell Significance Index: -17.0500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5430
    Cell Significance Index: -5.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5590
    Cell Significance Index: -9.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5614
    Cell Significance Index: -34.4200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5746
    Cell Significance Index: -16.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6099
    Cell Significance Index: -12.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6141
    Cell Significance Index: -16.4600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.6779
    Cell Significance Index: -9.6500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6855
    Cell Significance Index: -16.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6956
    Cell Significance Index: -17.8800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6978
    Cell Significance Index: -10.3000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7181
    Cell Significance Index: -21.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7247
    Cell Significance Index: -23.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **XPC complex subunit:** The XPC gene encodes for a 55-kDa protein that is a part of the XPC complex, which is a heterodimeric protein that recognizes and binds to damaged DNA. 2. **DNA damage recognition:** The XPC protein is a DNA damage sensor that recognizes and binds to various types of DNA damage, including UV-induced pyrimidine dimers, oxidative lesions, and other types of DNA damage. 3. **Repair function:** The XPC protein is involved in the repair of DNA damage by facilitating the recruitment of other repair proteins to the site of damage. 4. **Signaling pathways:** The XPC protein is also involved in signaling pathways that regulate cell cycle progression, apoptosis, and DNA damage response. **Pathways and Functions:** 1. **Nucleotide-excision repair (NER):** The XPC protein is a key component of the NER pathway, which is responsible for repairing DNA damage caused by oxidative lesions, UV radiation, and other mutagens. 2. **Global genome nucleotide excision repair (GG-NER):** The XPC protein is involved in the GG-NER pathway, which is responsible for repairing DNA damage throughout the genome. 3. **Base excision repair (BER):** The XPC protein is also involved in the BER pathway, which is responsible for repairing DNA damage caused by oxidative lesions and other types of DNA damage. 4. **Mitotic intra-S DNA damage checkpoint signaling:** The XPC protein is involved in signaling pathways that regulate cell cycle progression and DNA damage response during mitosis. **Clinical Significance:** 1. **Cancer susceptibility:** Mutations in the XPC gene have been associated with an increased risk of cancer, including skin cancer, breast cancer, and colon cancer. 2. **Xeroderma pigmentosum:** The XPC gene is also associated with xeroderma pigmentosum, a rare genetic disorder characterized by an increased sensitivity to UV radiation and a high risk of skin cancer. 3. **Neurological disorders:** The XPC protein has been implicated in the pathogenesis of various neurological disorders, including Parkinson's disease and Alzheimer's disease. 4. **Environmental toxins:** The XPC protein is also involved in the repair of DNA damage caused by environmental toxins, such as pesticides and heavy metals. In conclusion, the XPC gene plays a crucial role in maintaining genome stability through its involvement in DNA damage recognition and repair. Mutations in the XPC gene can lead to increased cancer susceptibility and other diseases, highlighting the importance of this gene in human health and disease. Further research is needed to fully understand the molecular mechanisms of XPC and its role in human disease.

Genular Protein ID: 2323860654

Symbol: XPC_HUMAN

Name: DNA repair protein complementing XP-C cells

UniProtKB Accession Codes:

Q01831 B4DIP3 E9PB96 E9PH69 Q53GT7 Q96AX0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 20 EMDB 7 Ensembl 2 ExpressionAtlas 1 GO 32 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8168482

Title: Purification and cloning of a nucleotide excision repair complex involving the Xeroderma pigmentosum group C protein and a human homologue of yeast RAD23.

PubMed ID: 8168482

DOI: 10.1002/j.1460-2075.1994.tb06452.x

PubMed ID: 12177305

Title: The human XPC DNA repair gene: arrangement, splice site information content and influence of a single nucleotide polymorphism in a splice acceptor site on alternative splicing and function.

PubMed ID: 12177305

DOI: 10.1093/nar/gkf469

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

DOI: 10.1038/ncomms4650

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1522891

Title: Expression cloning of a human DNA repair gene involved in Xeroderma pigmentosum group C.

PubMed ID: 1522891

DOI: 10.1038/359070a0

PubMed ID: 1461286

Title:

PubMed ID: 1461286

DOI: 10.1038/360610b0

PubMed ID: 8692695

Title: XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexes.

PubMed ID: 8692695

DOI: 10.1093/nar/24.13.2551

PubMed ID: 9372924

Title: Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity.

PubMed ID: 9372924

DOI: 10.1128/mcb.17.12.6924

PubMed ID: 9734359

Title: Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair.

PubMed ID: 9734359

DOI: 10.1016/s1097-2765(00)80132-x

PubMed ID: 10734143

Title: The xeroderma pigmentosum group C protein complex XPC-HR23B plays an important role in the recruitment of transcription factor IIH to damaged DNA.

PubMed ID: 10734143

DOI: 10.1074/jbc.275.13.9870

PubMed ID: 10873465

Title: Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites.

PubMed ID: 10873465

DOI: 10.1006/jmbi.2000.3857

PubMed ID: 11279143

Title: Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair.

PubMed ID: 11279143

DOI: 10.1074/jbc.m100855200

PubMed ID: 12509299

Title: A molecular mechanism for DNA damage recognition by the xeroderma pigmentosum group C protein complex.

PubMed ID: 12509299

DOI: 10.1016/s1568-7864(01)00008-8

PubMed ID: 12509233

Title: The carboxy-terminal domain of the XPC protein plays a crucial role in nucleotide excision repair through interactions with transcription factor IIH.

PubMed ID: 12509233

DOI: 10.1016/s1568-7864(02)00031-9

PubMed ID: 12547395

Title: DNA bending by the human damage recognition complex XPC-HR23B.

PubMed ID: 12547395

DOI: 10.1016/s1568-7864(02)00222-7

PubMed ID: 12505994

Title: Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase.

PubMed ID: 12505994

DOI: 10.1093/emboj/cdg016

PubMed ID: 15882621

Title: UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.

PubMed ID: 15882621

DOI: 10.1016/j.cell.2005.02.035

PubMed ID: 15964821

Title: Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein.

PubMed ID: 15964821

DOI: 10.1128/mcb.25.13.5664-5674.2005

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 17682058

Title: In vivo destabilization and functional defects of the xeroderma pigmentosum C protein caused by a pathogenic missense mutation.

PubMed ID: 17682058

DOI: 10.1128/mcb.02166-06

PubMed ID: 17355181

Title: An aromatic sensor with aversion to damaged strands confers versatility to DNA repair.

PubMed ID: 17355181

DOI: 10.1371/journal.pbio.0050079

PubMed ID: 18682493

Title: Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC.

PubMed ID: 18682493

DOI: 10.1242/jcs.031708

PubMed ID: 19609301

Title: Two-stage dynamic DNA quality check by xeroderma pigmentosum group C protein.

PubMed ID: 19609301

DOI: 10.1038/emboj.2009.187

PubMed ID: 19941824

Title: Two-step recognition of DNA damage for mammalian nucleotide excision repair: Directional binding of the XPC complex and DNA strand scanning.

PubMed ID: 19941824

DOI: 10.1016/j.molcel.2009.09.035

PubMed ID: 20649465

Title: Dissection of the xeroderma pigmentosum group C protein function by site-directed mutagenesis.

PubMed ID: 20649465

DOI: 10.1089/ars.2010.3399

PubMed ID: 20028083

Title: Photo-cross-linking of XPC-Rad23B to cisplatin-damaged DNA reveals contacts with both strands of the DNA duplex and spans the DNA adduct.

PubMed ID: 20028083

DOI: 10.1021/bi901575h

PubMed ID: 20798892

Title: Stimulation of DNA glycosylase activities by XPC Protein Complex: Roles of protein-protein interactions.

PubMed ID: 20798892

DOI: 10.4061/2010/805698

PubMed ID: 23751493

Title: RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response.

PubMed ID: 23751493

DOI: 10.1083/jcb.201212075

PubMed ID: 29973595

Title: XPC is an RNA polymerase II cofactor recruiting ATAC to promoters by interacting with E2F1.

PubMed ID: 29973595

DOI: 10.1038/s41467-018-05010-0

PubMed ID: 31527837

Title: DNA repair complex licenses acetylation of H2A.Z.1 by KAT2A during transcription.

PubMed ID: 31527837

DOI: 10.1038/s41589-019-0354-y

PubMed ID: 16533048

Title: Flexibility and plasticity of human centrin 2 binding to the xeroderma pigmentosum group C protein (XPC) from nuclear excision repair.

PubMed ID: 16533048

DOI: 10.1021/bi0524868

PubMed ID: 16627479

Title: The structure of the human centrin 2-xeroderma pigmentosum group C protein complex.

PubMed ID: 16627479

DOI: 10.1074/jbc.m513667200

PubMed ID: 17897675

Title: Structural, thermodynamic, and cellular characterization of human centrin 2 interaction with xeroderma pigmentosum group C protein.

PubMed ID: 17897675

DOI: 10.1016/j.jmb.2007.08.046

PubMed ID: 10447254

Title: A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy.

PubMed ID: 10447254

DOI: 10.1002/(sici)1098-1004(1999)14:1<9::aid-humu2>3.0.co;2-6

PubMed ID: 8298653

Title: Characterization of molecular defects in Xeroderma pigmentosum group C.

PubMed ID: 8298653

DOI: 10.1038/ng1293-413

PubMed ID: 10766188

Title: Mutations in the XPC gene in families with xeroderma pigmentosum and consequences at the cell, protein, and transcript levels.

PubMed ID: 10766188

Sequence Information:

  • Length: 940
  • Mass: 105953
  • Checksum: 2F8C80D43FAA1256
  • Sequence:
    • MARKRAAGGE PRGRELRSQK SKAKSKARRE EEEEDAFEDE KPPKKSLLSK VSQGKRKRGC 
SHPGGSADGP AKKKVAKVTV KSENLKVIKD EALSDGDDLR DFPSDLKKAH HLKRGATMNE 
DSNEEEEESE NDWEEVEELS EPVLGDVRES TAFSRSLLPV KPVEIEIETP EQAKTRERSE 
KIKLEFETYL RRAMKRFNKG VHEDTHKVHL LCLLANGFYR NNICSQPDLH AIGLSIIPAR 
FTRVLPRDVD TYYLSNLVKW FIGTFTVNAE LSASEQDNLQ TTLERRFAIY SARDDEELVH 
IFLLILRALQ LLTRLVLSLQ PIPLKSATAK GKKPSKERLT ADPGGSSETS SQVLENHTKP 
KTSKGTKQEE TFAKGTCRPS AKGKRNKGGR KKRSKPSSSE EDEGPGDKQE KATQRRPHGR 
ERRVASRVSY KEESGSDEAG SGSDFELSSG EASDPSDEDS EPGPPKQRKA PAPQRTKAGS 
KSASRTHRGS HRKDPSLPAA SSSSSSSKRG KKMCSDGEKA EKRSIAGIDQ WLEVFCEQEE 
KWVCVDCVHG VVGQPLTCYK YATKPMTYVV GIDSDGWVRD VTQRYDPVWM TVTRKCRVDA 
EWWAETLRPY QSPFMDREKK EDLEFQAKHM DQPLPTAIGL YKNHPLYALK RHLLKYEAIY 
PETAAILGYC RGEAVYSRDC VHTLHSRDTW LKKARVVRLG EVPYKMVKGF SNRARKARLA 
EPQLREENDL GLFGYWQTEE YQPPVAVDGK VPRNEFGNVY LFLPSMMPIG CVQLNLPNLH 
RVARKLDIDC VQAITGFDFH GGYSHPVTDG YIVCEEFKDV LLTAWENEQA VIERKEKEKK 
EKRALGNWKL LAKGLLIRER LKRRYGPKSE AAAPHTDAGG GLSSDEEEGT SSQAEAARIL 
AASWPQNRED EEKQKLKGGP KKTKREKKAA ASHLFPFEQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.