Details for: ZNF32

Gene ID: 7580

Symbol: ZNF32

Ensembl ID: ENSG00000169740

Description: zinc finger protein 32

Associated with

  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 162.6537
    Cell Significance Index: -25.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 73.9227
    Cell Significance Index: -18.7500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 50.6648
    Cell Significance Index: -23.9200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 44.2081
    Cell Significance Index: -22.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.8118
    Cell Significance Index: -25.6600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.6334
    Cell Significance Index: -17.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.6167
    Cell Significance Index: -26.1100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.1322
    Cell Significance Index: 17.9100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4230
    Cell Significance Index: 85.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3106
    Cell Significance Index: 129.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2368
    Cell Significance Index: 134.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0631
    Cell Significance Index: 123.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9425
    Cell Significance Index: 153.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7840
    Cell Significance Index: 16.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7445
    Cell Significance Index: 102.2400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.7309
    Cell Significance Index: 9.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6836
    Cell Significance Index: 35.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6650
    Cell Significance Index: 18.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6300
    Cell Significance Index: 43.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5952
    Cell Significance Index: 27.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5930
    Cell Significance Index: 37.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5733
    Cell Significance Index: 29.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5695
    Cell Significance Index: 7.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5668
    Cell Significance Index: 72.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5203
    Cell Significance Index: 18.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4965
    Cell Significance Index: 61.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4811
    Cell Significance Index: 212.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4500
    Cell Significance Index: 81.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4463
    Cell Significance Index: 28.8000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3839
    Cell Significance Index: 3.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3392
    Cell Significance Index: 23.9900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3330
    Cell Significance Index: 3.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3213
    Cell Significance Index: 41.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3063
    Cell Significance Index: 61.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3036
    Cell Significance Index: 14.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2947
    Cell Significance Index: 160.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2875
    Cell Significance Index: 7.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2647
    Cell Significance Index: 19.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2315
    Cell Significance Index: 14.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1954
    Cell Significance Index: 37.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1556
    Cell Significance Index: 3.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1509
    Cell Significance Index: 54.1300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1385
    Cell Significance Index: 3.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0855
    Cell Significance Index: 4.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0724
    Cell Significance Index: 14.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0599
    Cell Significance Index: 0.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0251
    Cell Significance Index: 0.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0234
    Cell Significance Index: 1.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0206
    Cell Significance Index: 15.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0092
    Cell Significance Index: 1.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0042
    Cell Significance Index: 7.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0047
    Cell Significance Index: -3.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0089
    Cell Significance Index: -16.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0105
    Cell Significance Index: -16.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0111
    Cell Significance Index: -7.0800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0141
    Cell Significance Index: -0.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0177
    Cell Significance Index: -24.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0223
    Cell Significance Index: -16.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0250
    Cell Significance Index: -0.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0259
    Cell Significance Index: -2.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0322
    Cell Significance Index: -1.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0330
    Cell Significance Index: -14.9900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0359
    Cell Significance Index: -4.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0368
    Cell Significance Index: -20.7600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0438
    Cell Significance Index: -1.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0453
    Cell Significance Index: -28.2900
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0506
    Cell Significance Index: -0.3100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0587
    Cell Significance Index: -1.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0675
    Cell Significance Index: -19.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0734
    Cell Significance Index: -5.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0866
    Cell Significance Index: -2.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0998
    Cell Significance Index: -14.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1025
    Cell Significance Index: -11.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1313
    Cell Significance Index: -27.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1616
    Cell Significance Index: -12.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1654
    Cell Significance Index: -4.7400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1686
    Cell Significance Index: -2.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1811
    Cell Significance Index: -12.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1832
    Cell Significance Index: -5.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2237
    Cell Significance Index: -6.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2405
    Cell Significance Index: -25.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2702
    Cell Significance Index: -4.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3252
    Cell Significance Index: -6.9300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3286
    Cell Significance Index: -7.8800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3388
    Cell Significance Index: -9.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3752
    Cell Significance Index: -16.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3942
    Cell Significance Index: -24.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4539
    Cell Significance Index: -12.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4592
    Cell Significance Index: -17.3900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.4632
    Cell Significance Index: -3.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4893
    Cell Significance Index: -13.1100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.5068
    Cell Significance Index: -8.0400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5712
    Cell Significance Index: -20.9700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5804
    Cell Significance Index: -12.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5901
    Cell Significance Index: -19.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5947
    Cell Significance Index: -16.9700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6006
    Cell Significance Index: -13.1500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.6014
    Cell Significance Index: -6.3900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.6117
    Cell Significance Index: -10.0800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6135
    Cell Significance Index: -11.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF32 is a member of the zinc finger protein family, characterized by its ability to bind to specific DNA sequences through its C-terminal zinc finger domain. This domain is crucial for its function, as it allows ZNF32 to recognize and interact with specific regulatory elements in the genome. The protein's small size and compact structure enable it to bind to DNA with high specificity and affinity. Furthermore, ZNF32's ability to bind to RNA polymerase II and other transcription factors underscores its role in regulating gene expression. **Pathways and Functions:** ZNF32's primary function is to regulate gene expression by binding to specific DNA sequences and influencing the transcriptional machinery. Its involvement in DNA-binding transcription factor activity, RNA polymerase II-specific regulation, and sequence-specific double-stranded DNA binding highlights its critical role in transcriptional control. Additionally, ZNF32's interaction with metal ions and its presence in the nucleus underscore its involvement in various cellular processes, including DNA repair and replication. ZNF32's functions can be broadly categorized into two main areas: 1. **Transcriptional Regulation:** ZNF32's ability to bind to specific DNA sequences allows it to regulate gene expression by influencing the recruitment of transcription factors and RNA polymerase II to target gene promoters. 2. **Cellular Processes:** ZNF32's interaction with metal ions and its presence in the nucleus suggest its involvement in DNA repair, replication, and other cellular processes. **Clinical Significance:** While ZNF32's role in various cell types is well established, its clinical significance is less understood. However, its involvement in regulating gene expression and cellular processes suggests its potential involvement in diseases related to transcriptional dysregulation, such as cancer, neurodegenerative disorders, and autoimmune diseases. Moreover, ZNF32's expression in specific cell types, such as pancreatic acinar cells and GABAergic amacrine cells, suggests its potential role in regulating gene expression in these tissues. Further research is needed to elucidate the clinical significance of ZNF32 and its potential as a therapeutic target for various diseases. In conclusion, ZNF32 is a multifaceted protein that plays a crucial role in regulating gene expression and cellular processes. Its clinical significance is an area of active research, and further investigation is needed to fully understand its role in human disease. As an expert immunologist, I highlight the importance of ZNF32 in understanding the complexities of gene regulation and its potential implications for human health.

Genular Protein ID: 1406792126

Symbol: ZNF32_HUMAN

Name: Zinc finger protein 32

UniProtKB Accession Codes:

P17041 Q92951

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 20 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 5 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9475118

Title: C2H2-546: a zinc finger protein differentially expressed in HTLV-1 infected T cells.

PubMed ID: 9475118

DOI: 10.3109/13550289709031192

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

Sequence Information:

  • Length: 273
  • Mass: 31029
  • Checksum: 91E7148C665C4734
  • Sequence:
    • MFGFPTATLL DCHGRYAQNV AFFNVMTEAH HKYDHSEATG SSSWDIQNSF RREKLEQKSP 
DSKTLQEDSP GVRQRVYECQ ECGKSFRQKG SLTLHERIHT GQKPFECTHC GKSFRAKGNL 
VTHQRIHTGE KPYQCKECGK SFSQRGSLAV HERLHTGQKP YECAICQRSF RNQSNLAVHR 
RVHSGEKPYR CDQCGKAFSQ KGSLIVHIRV HTGLKPYACT QCRKSFHTRG NCILHGKIHT 
GETPYLCGQC GKSFTQRGSL AVHQRSCSQR LTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.