Details for: ZNF205

Gene ID: 7755

Symbol: ZNF205

Ensembl ID: ENSG00000122386

Description: zinc finger protein 205

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Mitochondrion
    (GO:0005739)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Positive regulation of hydrogen peroxide biosynthetic process
    (GO:0010729)
  • Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
    (GO:1901030)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Zinc ion binding
    (GO:0008270)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 87.6272
    Cell Significance Index: -13.6300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 53.3820
    Cell Significance Index: -13.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 29.1661
    Cell Significance Index: -13.7700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.8307
    Cell Significance Index: -12.2500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.3143
    Cell Significance Index: -13.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5567
    Cell Significance Index: -14.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.3397
    Cell Significance Index: 92.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8166
    Cell Significance Index: 95.1700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.8003
    Cell Significance Index: 12.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7726
    Cell Significance Index: 35.0200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7301
    Cell Significance Index: 79.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7177
    Cell Significance Index: 43.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6511
    Cell Significance Index: 18.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5912
    Cell Significance Index: 96.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5211
    Cell Significance Index: 11.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5006
    Cell Significance Index: 451.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3698
    Cell Significance Index: 19.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3211
    Cell Significance Index: 20.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2351
    Cell Significance Index: 32.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2240
    Cell Significance Index: 122.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2092
    Cell Significance Index: 92.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1991
    Cell Significance Index: 19.7000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1789
    Cell Significance Index: 2.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1787
    Cell Significance Index: 3.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1718
    Cell Significance Index: 12.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1664
    Cell Significance Index: 33.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1435
    Cell Significance Index: 6.6900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1309
    Cell Significance Index: 2.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1269
    Cell Significance Index: 24.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1261
    Cell Significance Index: 6.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1259
    Cell Significance Index: 22.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1202
    Cell Significance Index: 24.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0963
    Cell Significance Index: 2.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0869
    Cell Significance Index: 11.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0832
    Cell Significance Index: 2.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0737
    Cell Significance Index: 26.4500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0524
    Cell Significance Index: 0.4400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0453
    Cell Significance Index: 0.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0430
    Cell Significance Index: 1.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0408
    Cell Significance Index: 1.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0335
    Cell Significance Index: 4.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0304
    Cell Significance Index: 0.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0149
    Cell Significance Index: 10.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0143
    Cell Significance Index: 2.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0022
    Cell Significance Index: 0.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0026
    Cell Significance Index: -4.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0055
    Cell Significance Index: -0.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0062
    Cell Significance Index: -11.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0065
    Cell Significance Index: -0.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0070
    Cell Significance Index: -10.8300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0084
    Cell Significance Index: -6.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0090
    Cell Significance Index: -6.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0098
    Cell Significance Index: -13.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0118
    Cell Significance Index: -0.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0124
    Cell Significance Index: -0.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0142
    Cell Significance Index: -9.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0170
    Cell Significance Index: -12.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0174
    Cell Significance Index: -0.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0216
    Cell Significance Index: -12.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0218
    Cell Significance Index: -2.2300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0230
    Cell Significance Index: -0.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0233
    Cell Significance Index: -0.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0248
    Cell Significance Index: -11.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0250
    Cell Significance Index: -15.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0354
    Cell Significance Index: -10.1800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0359
    Cell Significance Index: -0.5700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0391
    Cell Significance Index: -1.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0670
    Cell Significance Index: -7.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0687
    Cell Significance Index: -5.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0734
    Cell Significance Index: -15.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0773
    Cell Significance Index: -11.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1159
    Cell Significance Index: -7.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1319
    Cell Significance Index: -13.7300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1412
    Cell Significance Index: -1.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1482
    Cell Significance Index: -4.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1535
    Cell Significance Index: -12.1600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1651
    Cell Significance Index: -2.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1880
    Cell Significance Index: -10.5500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1897
    Cell Significance Index: -2.1600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1916
    Cell Significance Index: -1.5300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2065
    Cell Significance Index: -2.6500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2118
    Cell Significance Index: -3.0400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2210
    Cell Significance Index: -3.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2220
    Cell Significance Index: -14.3200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2223
    Cell Significance Index: -3.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2262
    Cell Significance Index: -13.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2419
    Cell Significance Index: -10.7000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2437
    Cell Significance Index: -5.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2587
    Cell Significance Index: -3.5300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2642
    Cell Significance Index: -2.7400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2740
    Cell Significance Index: -8.0700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2806
    Cell Significance Index: -7.5100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2840
    Cell Significance Index: -3.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2923
    Cell Significance Index: -11.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2957
    Cell Significance Index: -7.6000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3066
    Cell Significance Index: -10.7400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3122
    Cell Significance Index: -8.9500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3277
    Cell Significance Index: -7.8600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.3375
    Cell Significance Index: -2.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3459
    Cell Significance Index: -11.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcription Factor**: ZNF205 is a transcription factor protein that regulates gene expression by binding to specific DNA sequences and modulating the activity of RNA polymerase II. 2. **DNA Binding**: The ZNF205 protein exhibits specific DNA-binding activity, particularly to RNA polymerase II cis-regulatory regions, which allows it to regulate transcriptional processes. 3. **Zinc Ion Binding**: ZNF205 contains a zinc finger domain, which is essential for its DNA-binding activity and overall protein stability. 4. **Cell Type Specificity**: The expression of ZNF205 is restricted to specific cell types, including pulmonary interstitial fibroblasts, extravillous trophoblasts, and intestinal epithelial cells. **Pathways and Functions** 1. **Transcription Regulation**: ZNF205 regulates gene expression by modulating the activity of RNA polymerase II, which is essential for transcriptional processes. 2. **DNA-templated Transcription**: The ZNF205 protein participates in DNA-templated transcription, which is a critical process for the regulation of gene expression. 3. **Apoptosis and Oxidative Stress**: ZNF205 is involved in the regulation of mitochondrial outer membrane permeabilization, which is a key process in apoptotic signaling pathways and oxidative stress responses. 4. **Cellular Differentiation**: The ZNF205 protein may play a role in cellular differentiation, particularly in the development of intestinal epithelial cells and extravillous trophoblasts. **Clinical Significance** 1. **Cancer Research**: ZNF205 has been identified as a potential biomarker for various types of cancer, including lung cancer and colon cancer, due to its overexpression in these tissues. 2. **Immunological Disorders**: The ZNF205 protein may play a role in immunological disorders, such as autoimmune diseases, due to its involvement in the regulation of immune cell function and cytokine production. 3. **Neurological Disorders**: ZNF205 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease, due to its role in the regulation of gene expression and neuronal function. 4. **Gene Therapy**: The ZNF205 protein may serve as a target for gene therapy, particularly in the treatment of genetic disorders, such as inherited forms of cancer and immunological disorders. In conclusion, ZNF205 is a multifunctional transcription factor protein that plays a crucial role in regulating various cellular processes, including transcription, DNA binding, and protein-protein interactions. Its clinical significance lies in its potential as a biomarker for various types of cancer and immunological disorders, as well as its role in the pathogenesis of neurological disorders. Further research is needed to fully elucidate the functions and pathways of ZNF205 and its potential applications in human disease.

Genular Protein ID: 2119571685

Symbol: RHIT_HUMAN

Name: Zinc finger protein 205

UniProtKB Accession Codes:

O95201 A8MZK0 D3DUB4 I0J0A3 Q9BU95

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9787081

Title: Identification of two Kruppel-related zinc finger genes (ZNF200 and ZNF210) from human chromosome 16p13.3.

PubMed ID: 9787081

DOI: 10.1006/geno.1998.5430

PubMed ID: 22306510

Title: Identification of Rhit as a novel transcriptional repressor of human Mpv17-like protein with a mitigating effect on mitochondrial dysfunction, and its transcriptional regulation by FOXD3 and GABP.

PubMed ID: 22306510

DOI: 10.1016/j.freeradbiomed.2012.01.003

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 554
  • Mass: 60630
  • Checksum: B70DC15F0DFDC7FC
  • Sequence:
    • MSADGGGIQD TQDKETPPEV PDRGHPHQEM PSKLGEAVPS GDTQESLHIK MEPEEPHSEG 
ASQEDGAQGA WGWAPLSHGS KEKALFLPGG ALPSPRIPVL SREGRTRDRQ MAAALLTAWS 
QMPVTFEDVA LYLSREEWGR LDHTQQNFYR DVLQKKNGLS LGFPFSRPFW APQAHGKGEA 
SGSSRQAGDE KEWRGACTGA VEVGQRVQTS SVAALGNVKP FRTRAGRVQW GVPQCAQEAA 
CGRSSGPAKD SGQPAEPDRT PDAAPPDPSP TEPQEYRVPE KPNEEEKGAP ESGEEGLAPD 
SEVGRKSYRC EQCGKGFSWH SHLVTHRRTH TGEKPYACTD CGKRFGRSSH LIQHQIIHTG 
EKPYTCPACR KSFSHHSTLI QHQRIHTGEK PYVCDRCAKR FTRRSDLVTH QGTHTGAKPH 
KCPICAKCFT QSSALVTHQR THTGVKPYPC PECGKCFSQR SNLIAHNRTH TGEKPYHCLD 
CGKSFSHSSH LTAHQRTHRG VRPYACPLCG KSFSRRSNLH RHEKIHTTGP KALAMLMLGA 
AAAGALATPP PAPT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.