Details for: ZXDA

Gene ID: 7789

Symbol: ZXDA

Ensembl ID: ENSG00000198205

Description: zinc finger X-linked duplicated A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 52.2035
    Cell Significance Index: -8.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 31.3432
    Cell Significance Index: -7.9500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.6101
    Cell Significance Index: -8.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2379
    Cell Significance Index: 235.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6595
    Cell Significance Index: 14.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6237
    Cell Significance Index: 61.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4650
    Cell Significance Index: 419.8800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3863
    Cell Significance Index: 23.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3717
    Cell Significance Index: 40.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3108
    Cell Significance Index: 50.5600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.2611
    Cell Significance Index: 3.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2376
    Cell Significance Index: 10.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2074
    Cell Significance Index: 10.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1826
    Cell Significance Index: 12.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1616
    Cell Significance Index: 3.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1579
    Cell Significance Index: 45.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1065
    Cell Significance Index: 2.9000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0954
    Cell Significance Index: 6.0100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0880
    Cell Significance Index: 1.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0809
    Cell Significance Index: 2.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0669
    Cell Significance Index: 7.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0622
    Cell Significance Index: 12.4800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0580
    Cell Significance Index: 1.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0442
    Cell Significance Index: 15.8600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0357
    Cell Significance Index: 15.7700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0287
    Cell Significance Index: 0.4600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0079
    Cell Significance Index: 0.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0038
    Cell Significance Index: 0.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0017
    Cell Significance Index: 0.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0007
    Cell Significance Index: 0.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0030
    Cell Significance Index: -5.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0038
    Cell Significance Index: -0.6900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0060
    Cell Significance Index: -4.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0070
    Cell Significance Index: -4.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0098
    Cell Significance Index: -7.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0114
    Cell Significance Index: -1.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0123
    Cell Significance Index: -22.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0141
    Cell Significance Index: -21.7100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0157
    Cell Significance Index: -8.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0161
    Cell Significance Index: -21.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0163
    Cell Significance Index: -12.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0172
    Cell Significance Index: -2.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0180
    Cell Significance Index: -0.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0184
    Cell Significance Index: -8.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0202
    Cell Significance Index: -2.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0208
    Cell Significance Index: -1.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0254
    Cell Significance Index: -3.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0262
    Cell Significance Index: -2.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0295
    Cell Significance Index: -3.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0296
    Cell Significance Index: -1.0400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0345
    Cell Significance Index: -0.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0348
    Cell Significance Index: -6.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0416
    Cell Significance Index: -4.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0455
    Cell Significance Index: -7.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0462
    Cell Significance Index: -9.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0471
    Cell Significance Index: -1.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0488
    Cell Significance Index: -3.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0511
    Cell Significance Index: -3.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0511
    Cell Significance Index: -3.8100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0537
    Cell Significance Index: -2.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0541
    Cell Significance Index: -1.4500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0612
    Cell Significance Index: -0.8700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0643
    Cell Significance Index: -2.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0712
    Cell Significance Index: -5.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0723
    Cell Significance Index: -2.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0812
    Cell Significance Index: -8.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0848
    Cell Significance Index: -6.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0855
    Cell Significance Index: -5.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0857
    Cell Significance Index: -4.0300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0956
    Cell Significance Index: -2.7400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1045
    Cell Significance Index: -1.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1046
    Cell Significance Index: -2.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1085
    Cell Significance Index: -2.2500
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.1103
    Cell Significance Index: -1.2700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1143
    Cell Significance Index: -4.9700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1148
    Cell Significance Index: -4.7000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1188
    Cell Significance Index: -1.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1232
    Cell Significance Index: -6.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1239
    Cell Significance Index: -6.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1328
    Cell Significance Index: -4.6200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1654
    Cell Significance Index: -4.1300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1696
    Cell Significance Index: -3.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1716
    Cell Significance Index: -7.5900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1724
    Cell Significance Index: -6.0400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1757
    Cell Significance Index: -4.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1800
    Cell Significance Index: -4.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1802
    Cell Significance Index: -5.7400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1853
    Cell Significance Index: -2.9400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1891
    Cell Significance Index: -3.2400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1893
    Cell Significance Index: -2.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1961
    Cell Significance Index: -5.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2002
    Cell Significance Index: -5.8800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2016
    Cell Significance Index: -2.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2037
    Cell Significance Index: -6.6700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2049
    Cell Significance Index: -3.6200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2056
    Cell Significance Index: -4.9300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2068
    Cell Significance Index: -7.8300
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.2085
    Cell Significance Index: -2.1000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2142
    Cell Significance Index: -6.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc Finger Domain:** The ZXDA protein contains a C2h2 zinc finger domain, a conserved structural motif involved in DNA binding and protein-protein interactions. 2. **Transcriptional Regulation:** ZXDA acts as a transcriptional coactivator, facilitating the positive regulation of DNA-templated transcription by RNA polymerase II. 3. **Cell-Type Specificity:** The gene is expressed in various cell types, including respiratory basal cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, and intestinal epithelial cells. 4. **Developmental Processes:** ZXDA plays a role in developmental processes, including cell proliferation and differentiation, particularly in the gastrointestinal tract. **Pathways and Functions:** 1. **Transcriptional Coactivation:** ZXDA interacts with transcriptional machinery, enhancing the activity of RNA polymerase II and promoting the expression of target genes. 2. **DNA Binding:** The zinc finger domain of ZXDA enables it to bind to specific DNA sequences, regulating gene expression and transcriptional processes. 3. **Cell Signaling:** ZXDA may participate in cell signaling pathways, influencing cell growth, differentiation, and survival. 4. **Epithelial Development:** In the gastrointestinal tract, ZXDA is involved in the development and maintenance of epithelial tissues, including the intestinal crypt stem cells. **Clinical Significance:** 1. **Gastrointestinal Disorders:** Alterations in ZXDA expression or function may contribute to gastrointestinal disorders, such as inflammatory bowel disease (IBD) or cancer. 2. **Neurological Disorders:** Dysregulation of ZXDA in the brain may be associated with neurological disorders, including autism spectrum disorder (ASD) or schizophrenia. 3. **Cancer Research:** Understanding the role of ZXDA in transcriptional regulation and cellular development may provide insights into the development of cancer and the identification of potential therapeutic targets. 4. **Gene Therapy:** Targeting ZXDA expression or function may offer a novel approach to treating genetic disorders or diseases associated with dysregulated transcriptional regulation. In conclusion, the ZXDA gene plays a crucial role in transcriptional regulation and developmental processes, with significant implications for our understanding of cellular functions and disease mechanisms. Further research is necessary to fully elucidate the functions of ZXDA and its potential applications in medicine.

Genular Protein ID: 2880944346

Symbol: ZXDA_HUMAN

Name: Zinc finger X-linked protein ZXDA

UniProtKB Accession Codes:

P98168 Q9UJP7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8268913

Title: Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies.

PubMed ID: 8268913

DOI: 10.1093/hmg/2.10.1611

PubMed ID: 17493635

Title: The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription.

PubMed ID: 17493635

DOI: 10.1016/j.jmb.2007.04.033

PubMed ID: 26566883

Title: Homozygous missense mutation in the LMAN2L gene segregates with intellectual disability in a large consanguineous Pakistani family.

PubMed ID: 26566883

DOI: 10.1136/jmedgenet-2015-103179

Sequence Information:

  • Length: 799
  • Mass: 84771
  • Checksum: 112BF6C6D0CAA670
  • Sequence:
    • MEIPKLLPAR GTLQGGGGGG IPAGGGRVHR GPDSPAGQVP TRRLLLPRGP QDGGPGRRRE 
EASTASRGPG PSLFAPRPHQ PSGGGDDFFL VLLDPVGGDV ETAGSGQAAG PVLREEAKAG 
PGLQGDESGA NPAGCSAQGP HCLSAVPTPA PISAPGPAAA FAGTVTIHNQ DLLLRFENGV 
LTLATPPPHA WEPGAAPAQQ PRCLIAPQAG FPQAAHPGDC PELRSDLLLA EPAEPAPAPA 
PQEEAEGLAA ALGPRGLLGS GPGVVLYLCP EALCGQTFAK KHQLKMHLLT HSSSQGQRPF 
KCPLGGCGWT FTTSYKLKRH LQSHDKLRPF GCPAEGCGKS FTTVYNLKAH MKGHEQENSF 
KCEVCEESFP TQAKLGAHQR SHFEPERPYQ CAFSGCKKTF ITVSALFSHN RAHFREQELF 
SCSFPGCSKQ YDKACRLKIH LRSHTGERPF LCDFDGCGWN FTSMSKLLRH KRKHDDDRRF 
MCPVEGCGKS FTRAEHLKGH SITHLGTKPF VCPVAGCCAR FSARSSLYIH SKKHLQDVDT 
WKSRCPISSC NKLFTSKHSM KTHMVKRHKV GQDLLAQLEA ANSLTPSSEL TSQRQNDLSD 
AEIVSLFSDV PDSTSAALLD TALVNSGILT IDVASVSSTL AGHLPANNNN SVGQAVDPPS 
LMATSDPPQS LDTSLFFGTA ATGFQQSSLN MDEVSSVSVG PLGSLDSLAM KNSSPEPQAL 
TPSSKLTVDT DTLTPSSTLC ENSVSELLTP AKAEWSVHPN SDFFGQEGET QFGFPNAAGN 
HGSQKERNLI TVTGSSFLV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.