Details for: ST7

Gene ID: 7982

Symbol: ST7

Ensembl ID: ENSG00000004866

Description: suppression of tumorigenicity 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 204.2493
    Cell Significance Index: -31.7700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 128.9606
    Cell Significance Index: -32.7100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 62.6697
    Cell Significance Index: -25.4600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.3367
    Cell Significance Index: -33.7100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 26.7166
    Cell Significance Index: -25.5100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.7284
    Cell Significance Index: -23.4800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.3213
    Cell Significance Index: -28.6300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.6821
    Cell Significance Index: -34.2600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 4.8168
    Cell Significance Index: 115.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 3.8666
    Cell Significance Index: 237.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.8763
    Cell Significance Index: 82.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.7634
    Cell Significance Index: 554.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 2.6895
    Cell Significance Index: 46.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.3920
    Cell Significance Index: 160.8400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 2.3399
    Cell Significance Index: 32.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.1046
    Cell Significance Index: 161.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9155
    Cell Significance Index: 380.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.9108
    Cell Significance Index: 51.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.8711
    Cell Significance Index: 40.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3664
    Cell Significance Index: 490.1100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 1.3024
    Cell Significance Index: 16.8900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.2524
    Cell Significance Index: 26.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.2309
    Cell Significance Index: 34.4000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.1732
    Cell Significance Index: 15.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0878
    Cell Significance Index: 107.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0870
    Cell Significance Index: 48.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0574
    Cell Significance Index: 40.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8688
    Cell Significance Index: 784.4900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.8163
    Cell Significance Index: 13.7500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.6517
    Cell Significance Index: 15.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5914
    Cell Significance Index: 96.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5645
    Cell Significance Index: 61.4100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.5104
    Cell Significance Index: 8.4100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4544
    Cell Significance Index: 27.2800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4479
    Cell Significance Index: 5.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3698
    Cell Significance Index: 20.7500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.3353
    Cell Significance Index: 4.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3159
    Cell Significance Index: 36.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2608
    Cell Significance Index: 6.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2246
    Cell Significance Index: 15.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1976
    Cell Significance Index: 4.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1765
    Cell Significance Index: 8.2300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.1596
    Cell Significance Index: 2.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0926
    Cell Significance Index: 50.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0885
    Cell Significance Index: 15.9600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0756
    Cell Significance Index: 142.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0699
    Cell Significance Index: 107.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0680
    Cell Significance Index: 11.6100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0571
    Cell Significance Index: 0.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0556
    Cell Significance Index: 10.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0477
    Cell Significance Index: 87.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0423
    Cell Significance Index: 18.6800
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.0410
    Cell Significance Index: 0.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0404
    Cell Significance Index: 4.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0286
    Cell Significance Index: 38.8900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0266
    Cell Significance Index: 0.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0088
    Cell Significance Index: 5.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0081
    Cell Significance Index: -3.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0114
    Cell Significance Index: -8.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0258
    Cell Significance Index: -18.9100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0274
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0298
    Cell Significance Index: -22.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0325
    Cell Significance Index: -0.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0459
    Cell Significance Index: -6.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0501
    Cell Significance Index: -2.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0544
    Cell Significance Index: -30.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0556
    Cell Significance Index: -34.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0730
    Cell Significance Index: -3.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0975
    Cell Significance Index: -28.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0987
    Cell Significance Index: -12.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0991
    Cell Significance Index: -10.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1035
    Cell Significance Index: -14.2200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.1059
    Cell Significance Index: -0.9400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1278
    Cell Significance Index: -1.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1343
    Cell Significance Index: -2.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1594
    Cell Significance Index: -33.5700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1625
    Cell Significance Index: -3.3700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1734
    Cell Significance Index: -2.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1793
    Cell Significance Index: -22.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1975
    Cell Significance Index: -22.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1999
    Cell Significance Index: -23.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2234
    Cell Significance Index: -16.6500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2370
    Cell Significance Index: -7.7600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2417
    Cell Significance Index: -5.1300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2635
    Cell Significance Index: -5.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2698
    Cell Significance Index: -12.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2764
    Cell Significance Index: -28.7800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2801
    Cell Significance Index: -7.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2803
    Cell Significance Index: -9.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2869
    Cell Significance Index: -17.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2880
    Cell Significance Index: -15.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2895
    Cell Significance Index: -9.2200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.2962
    Cell Significance Index: -4.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3376
    Cell Significance Index: -23.8800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3416
    Cell Significance Index: -27.0600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3426
    Cell Significance Index: -4.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3809
    Cell Significance Index: -19.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3907
    Cell Significance Index: -10.6400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3956
    Cell Significance Index: -4.3100
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.4459
    Cell Significance Index: -3.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** ST7 is significantly expressed in regular ventricular cardiac myocytes, syncytiotrophoblast cells, neurons, and their associated cells, including Purkinje cells, stellate neurons, and inhibitory interneurons. 2. **Cellular Functions:** ST7 is involved in the regulation of cell differentiation, extracellular matrix organization, and protein binding, which are critical processes for maintaining tissue integrity and function. 3. **Gene Ontology:** ST7 is associated with the following gene ontology terms: Extracellular matrix organization, Membrane, and Protein binding. **Pathways and Functions:** The ST7 gene is implicated in various signaling pathways that regulate cellular processes. Some of the key pathways and functions associated with ST7 include: 1. **Extracellular Matrix Organization:** ST7 is involved in the regulation of extracellular matrix components, which is essential for maintaining tissue structure and function. 2. **Cell Differentiation:** ST7 plays a crucial role in regulating cell differentiation, particularly in cardiac and neural tissues. 3. **Protein Binding:** ST7 interacts with various proteins, including those involved in cell signaling and transcriptional regulation. 4. **Membrane Organization:** ST7 is associated with membrane organization and dynamics, which is critical for maintaining cellular homeostasis. **Clinical Significance:** The ST7 gene has implications for various diseases, particularly those affecting the heart and nervous system. Some potential clinical applications of ST7 include: 1. **Cardiac Disease:** Dysregulation of ST7 expression has been linked to various cardiac diseases, including heart failure and arrhythmias. 2. **Neurological Disorders:** ST7 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Cancer:** ST7 has been shown to have tumor-suppressive properties, and its dysregulation has been linked to various types of cancer. 4. **Neurodevelopmental Disorders:** ST7 expression has been linked to neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. In conclusion, the ST7 gene is a critical component of the human genome that plays a pivotal role in regulating cellular processes in cardiac and neural tissues. Its dysregulation has significant implications for various diseases, highlighting the importance of further research into the molecular mechanisms underlying ST7 function and its potential therapeutic applications.

Genular Protein ID: 2272055890

Symbol: ST7_HUMAN

Name: Suppressor of tumorigenicity 7 protein

UniProtKB Accession Codes:

Q9NRC1 A4D0V2 Q5CZ72 Q7LE31 Q7LE32 Q8NA32 Q8NEJ8 Q8TDI9 Q9BWX3 Q9BWX4 Q9NRC2 Q9NXZ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 3 ExpressionAtlas 1 GO 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10889047

Title: Identification of a novel gene on chromosome 7q31 that is interrupted by a translocation breakpoint in an autistic individual.

PubMed ID: 10889047

DOI: 10.1086/303005

PubMed ID: 11279520

Title: Mutational and functional analyses reveal that ST7 is a highly conserved tumor-suppressor gene on human chromosome 7q31.

PubMed ID: 11279520

DOI: 10.1038/86891

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12213198

Title: The RAY1/ST7 tumor-suppressor locus on chromosome 7q31 represents a complex multi-transcript system.

PubMed ID: 12213198

DOI: 10.1006/geno.2002.6835

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16474848

Title: ST7-mediated suppression of tumorigenicity of prostate cancer cells is characterized by remodeling of the extracellular matrix.

PubMed ID: 16474848

DOI: 10.1038/sj.onc.1209418

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 11726923

Title: Mutation of the ST7 tumor suppressor gene on 7q31.1 is rare in breast, ovarian and colorectal cancers.

PubMed ID: 11726923

DOI: 10.1038/ng784

Sequence Information:

  • Length: 585
  • Mass: 67166
  • Checksum: 7BA8974E564B307F
  • Sequence:
    • MAEAATGFLE QLKSCIVWSW TYLWTVWFFI VLFLVYILRV PLKINDNLST VSMFLNTLTP 
KFYVALTGTS SLISGLILIF EWWYFRKYGT SFIEQVSVSH LRPLLGGVDN NSSNNSNSSN 
GDSDSNRQSV SECKVWRNPL NLFRGAEYNR YTWVTGREPL TYYDMNLSAQ DHQTFFTCDS 
DHLRPADAIM QKAWRERNPQ ARISAAHEAL EINEIRSRVE VPLIASSTIW EIKLLPKCAT 
AYILLAEEEA TTIAEAEKLF KQALKAGDGC YRRSQQLQHH GSQYEAQHRR DTNVLVYIKR 
RLAMCARRLG RTREAVKMMR DLMKEFPLLS MFNIHENLLE ALLELQAYAD VQAVLAKYDD 
ISLPKSATIC YTAALLKARA VSDKFSPEAA SRRGLSTAEM NAVEAIHRAV EFNPHVPKYL 
LEMKSLILPP EHILKRGDSE AIAYAFFHLA HWKRVEGALN LLHCTWEGTF RMIPYPLEKG 
HLFYPYPICT ETADRELLPS FHEVSVYPKK ELPFFILFTA GLCSFTAMLA LLTHQFPELM 
GVFAKAMIDI FCSAEFRDWN CKSIFMRVED ELEIPPAPQS QHFQN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.