Details for: FOSL1

Gene ID: 8061

Symbol: FOSL1

Ensembl ID: ENSG00000175592

Description: FOS like 1, AP-1 transcription factor subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 81.2625
    Cell Significance Index: -12.6400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 48.1976
    Cell Significance Index: -12.2300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 29.8582
    Cell Significance Index: -12.3000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 24.9349
    Cell Significance Index: -10.1300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 17.8087
    Cell Significance Index: -11.9500
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 15.5783
    Cell Significance Index: 46.3300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 10.6154
    Cell Significance Index: -10.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.3086
    Cell Significance Index: -12.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 4.0074
    Cell Significance Index: 208.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.5666
    Cell Significance Index: 102.2400
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.2720
    Cell Significance Index: 20.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2083
    Cell Significance Index: -12.6600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.0357
    Cell Significance Index: 53.6500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.2849
    Cell Significance Index: 16.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.1198
    Cell Significance Index: 57.7000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.9775
    Cell Significance Index: 28.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9335
    Cell Significance Index: 26.3800
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.7364
    Cell Significance Index: 20.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.6153
    Cell Significance Index: 208.6900
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.5455
    Cell Significance Index: 7.3600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.2703
    Cell Significance Index: 20.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2056
    Cell Significance Index: 34.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1716
    Cell Significance Index: 87.3200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.9181
    Cell Significance Index: 5.6500
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.8214
    Cell Significance Index: 4.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8154
    Cell Significance Index: 17.6700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5813
    Cell Significance Index: 8.7100
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.5604
    Cell Significance Index: 6.1900
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 0.4280
    Cell Significance Index: 3.0800
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.4077
    Cell Significance Index: 4.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3280
    Cell Significance Index: 14.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2922
    Cell Significance Index: 13.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2897
    Cell Significance Index: 10.1800
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.2213
    Cell Significance Index: 1.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2097
    Cell Significance Index: 24.4400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1764
    Cell Significance Index: 4.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1477
    Cell Significance Index: 65.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1185
    Cell Significance Index: 14.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1118
    Cell Significance Index: 21.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1050
    Cell Significance Index: 94.7900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0889
    Cell Significance Index: 1.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0773
    Cell Significance Index: 2.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0750
    Cell Significance Index: 7.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0696
    Cell Significance Index: 4.9200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0671
    Cell Significance Index: 4.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0671
    Cell Significance Index: 36.6700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0469
    Cell Significance Index: 5.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0456
    Cell Significance Index: 7.4200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0364
    Cell Significance Index: 0.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0342
    Cell Significance Index: 6.1700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0288
    Cell Significance Index: 0.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0276
    Cell Significance Index: 0.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0065
    Cell Significance Index: 0.7500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0044
    Cell Significance Index: 0.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0047
    Cell Significance Index: -0.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0052
    Cell Significance Index: -0.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0054
    Cell Significance Index: -10.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0089
    Cell Significance Index: -16.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0099
    Cell Significance Index: -15.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0124
    Cell Significance Index: -16.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0132
    Cell Significance Index: -10.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0146
    Cell Significance Index: -10.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0154
    Cell Significance Index: -11.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0161
    Cell Significance Index: -10.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0229
    Cell Significance Index: -12.9200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0239
    Cell Significance Index: -0.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0271
    Cell Significance Index: -9.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0278
    Cell Significance Index: -12.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0278
    Cell Significance Index: -17.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0318
    Cell Significance Index: -9.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0340
    Cell Significance Index: -4.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0358
    Cell Significance Index: -7.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0362
    Cell Significance Index: -5.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0364
    Cell Significance Index: -7.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0435
    Cell Significance Index: -7.4300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0450
    Cell Significance Index: -2.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0497
    Cell Significance Index: -2.3200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0558
    Cell Significance Index: -2.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0621
    Cell Significance Index: -1.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0625
    Cell Significance Index: -3.8300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.0640
    Cell Significance Index: -0.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0652
    Cell Significance Index: -6.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0668
    Cell Significance Index: -14.0700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0673
    Cell Significance Index: -0.6200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0748
    Cell Significance Index: -1.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1055
    Cell Significance Index: -12.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1139
    Cell Significance Index: -7.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1149
    Cell Significance Index: -11.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1228
    Cell Significance Index: -7.9200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1317
    Cell Significance Index: -2.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1432
    Cell Significance Index: -3.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1603
    Cell Significance Index: -12.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1678
    Cell Significance Index: -11.2900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1689
    Cell Significance Index: -2.4000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1733
    Cell Significance Index: -1.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1774
    Cell Significance Index: -4.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1831
    Cell Significance Index: -9.5400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.1971
    Cell Significance Index: -0.9100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.2044
    Cell Significance Index: -1.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** FOSL1 acts as a transcriptional regulator, influencing the expression of genes involved in cell growth, differentiation, and survival. 2. **Cellular Defense Response:** FOSL1 is involved in the cellular defense response, particularly in response to extracellular stimuli, such as oxidative stress and mechanical forces. 3. **Inflammation and Immunity:** FOSL1 is also implicated in the regulation of inflammatory responses and immune cell function, highlighting its potential role in autoimmune and inflammatory disorders. 4. **Cancer and Tumor Suppression:** FOSL1 has been shown to act as a tumor suppressor, inhibiting cell proliferation and promoting apoptosis in certain cancer cell types. 5. **Developmental and Regenerative Processes:** FOSL1 is involved in the regulation of developmental and regenerative processes, such as embryonic development, learning, and tissue repair. **Pathways and Functions:** FOSL1 is involved in numerous signaling pathways, including: 1. **MAPK/ERK pathway:** FOSL1 regulates the expression of genes involved in cell proliferation and differentiation in response to extracellular stimuli. 2. **NF-κB pathway:** FOSL1 modulates the activity of NF-κB, a transcription factor involved in inflammation and immune responses. 3. **Wnt/β-catenin pathway:** FOSL1 regulates the expression of genes involved in cell proliferation and differentiation in response to Wnt/β-catenin signaling. 4. **PI3K/Akt pathway:** FOSL1 modulates the activity of PI3K/Akt, a signaling pathway involved in cell survival and proliferation. **Clinical Significance:** FOSL1's involvement in various diseases has significant clinical implications: 1. **Cancer:** FOSL1's role as a tumor suppressor makes it a potential target for cancer therapy. 2. **Inflammatory Disorders:** FOSL1's involvement in inflammation and immune responses highlights its potential as a therapeutic target for autoimmune and inflammatory disorders. 3. **Neurological Disorders:** FOSL1's role in learning and memory suggests its potential involvement in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Developmental Disorders:** FOSL1's involvement in embryonic development and tissue repair highlights its potential as a therapeutic target for developmental disorders, such as Down syndrome and muscular dystrophy. In conclusion, FOSL1 is a multifaceted gene that plays a critical role in various cellular processes, including cell proliferation, differentiation, and survival. Its involvement in disease has significant clinical implications, making it a potential target for therapy in various conditions. Further research is needed to fully elucidate the mechanisms by which FOSL1 regulates cellular processes and to explore its therapeutic potential.

Genular Protein ID: 1486026746

Symbol: FOSL1_HUMAN

Name: Fos-related antigen 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2107490

Title: Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation.

PubMed ID: 2107490

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8230424

Title: Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals.

PubMed ID: 8230424

DOI: 10.1128/jvi.67.12.7001-7007.1993

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

Sequence Information:

  • Length: 271
  • Mass: 29413
  • Checksum: 1B6492D709E66570
  • Sequence:
  • MFRDFGEPGP SSGNGGGYGG PAQPPAAAQA AQQKFHLVPS INTMSGSQEL QWMVQPHFLG 
    PSSYPRPLTY PQYSPPQPRP GVIRALGPPP GVRRRPCEQI SPEEEERRRV RRERNKLAAA 
    KCRNRRKELT DFLQAETDKL EDEKSGLQRE IEELQKQKER LELVLEAHRP ICKIPEGAKE 
    GDTGSTSGTS SPPAPCRPVP CISLSPGPVL EPEALHTPTL MTTPSLTPFT PSLVFTYPST 
    PEPCASAHRK SSSSSGDPSS DPLGSPTLLA L

Genular Protein ID: 4210451047

Symbol: E9PKL5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 135
  • Mass: 14151
  • Checksum: E8B1BCB8037FBAEC
  • Sequence:
  • MFRDFGEPGP SSGNGGGYGG PAQPPAAAQA AQQKFHLVPS INTMSGSQEL QWMVQPHFLG 
    PSSYPRPLTY PQYSPPQPRP GVIRALGPPP GVRRRPCEQP GGRGAPPSKA RAEQAGCGQV 
    QEPEEGTDRL PAGGD

Genular Protein ID: 2534857455

Symbol: E9PPX2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 235
  • Mass: 25005
  • Checksum: 514E4F227EE0B483
  • Sequence:
  • MFRDFGEPGP SSGNGGGYGG PAQPPAAAQA AQQKFHLVPS INTMSGSQEL QWMVQPHFLG 
    PSSYPRPLTY PQYSPPQPRP GVIRALGPPP GVRRRPCEQE TDKLEDEKSG LQREIEELQK 
    QKERLELVLE AHRPICKIPE GAKEGDTGST SGTSSPPAPC RPVPCISLSP GPVLEPEALH 
    TPTLMTTPSL TPFTPSLVFT YPSTPEPCAS AHRKSSSSSG DPSSDPLGSP TLLAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.