Details for: ST8SIA2

Gene ID: 8128

Symbol: ST8SIA2

Ensembl ID: ENSG00000140557

Description: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.8837
    Cell Significance Index: 85.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.3653
    Cell Significance Index: 83.9200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.0128
    Cell Significance Index: 24.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7094
    Cell Significance Index: 39.8100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.5098
    Cell Significance Index: 5.3100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3798
    Cell Significance Index: 9.2000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2570
    Cell Significance Index: 5.3800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1809
    Cell Significance Index: 125.1000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1470
    Cell Significance Index: 4.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0727
    Cell Significance Index: 26.0800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0354
    Cell Significance Index: 0.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0303
    Cell Significance Index: 46.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0272
    Cell Significance Index: 0.7000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0212
    Cell Significance Index: 0.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0015
    Cell Significance Index: 0.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0002
    Cell Significance Index: 0.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0054
    Cell Significance Index: -2.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0067
    Cell Significance Index: -12.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0131
    Cell Significance Index: -9.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0167
    Cell Significance Index: -3.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0174
    Cell Significance Index: -11.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0191
    Cell Significance Index: -10.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0210
    Cell Significance Index: -11.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0254
    Cell Significance Index: -7.3100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0287
    Cell Significance Index: -1.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0291
    Cell Significance Index: -13.2200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0408
    Cell Significance Index: -0.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0408
    Cell Significance Index: -3.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0494
    Cell Significance Index: -1.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0522
    Cell Significance Index: -10.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0524
    Cell Significance Index: -9.4400
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0551
    Cell Significance Index: -0.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0567
    Cell Significance Index: -7.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0604
    Cell Significance Index: -11.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0618
    Cell Significance Index: -10.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0637
    Cell Significance Index: -9.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0766
    Cell Significance Index: -9.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0855
    Cell Significance Index: -11.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0958
    Cell Significance Index: -11.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1131
    Cell Significance Index: -12.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1174
    Cell Significance Index: -11.9900
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1243
    Cell Significance Index: -1.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1250
    Cell Significance Index: -13.0200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1316
    Cell Significance Index: -2.2500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1378
    Cell Significance Index: -2.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1483
    Cell Significance Index: -11.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1505
    Cell Significance Index: -11.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1551
    Cell Significance Index: -5.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1666
    Cell Significance Index: -11.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1721
    Cell Significance Index: -2.8800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1806
    Cell Significance Index: -1.1800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1858
    Cell Significance Index: -9.6800
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1859
    Cell Significance Index: -1.6900
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1882
    Cell Significance Index: -2.1300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1950
    Cell Significance Index: -1.8800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.2010
    Cell Significance Index: -2.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2192
    Cell Significance Index: -10.3000
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.2193
    Cell Significance Index: -3.1200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2194
    Cell Significance Index: -2.5600
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.2246
    Cell Significance Index: -2.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2249
    Cell Significance Index: -7.8800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2390
    Cell Significance Index: -5.9600
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.2430
    Cell Significance Index: -3.1100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2532
    Cell Significance Index: -2.4000
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.2641
    Cell Significance Index: -1.5500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2674
    Cell Significance Index: -3.8000
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.2707
    Cell Significance Index: -1.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2810
    Cell Significance Index: -12.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2830
    Cell Significance Index: -14.8600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2859
    Cell Significance Index: -8.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2923
    Cell Significance Index: -9.5700
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.2925
    Cell Significance Index: -2.8000
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.3054
    Cell Significance Index: -3.1400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3058
    Cell Significance Index: -6.1400
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.3069
    Cell Significance Index: -1.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3243
    Cell Significance Index: -12.2800
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.3246
    Cell Significance Index: -2.3600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3460
    Cell Significance Index: -7.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3520
    Cell Significance Index: -11.2100
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.3608
    Cell Significance Index: -2.2500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3684
    Cell Significance Index: -7.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3712
    Cell Significance Index: -10.6400
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.3838
    Cell Significance Index: -2.0100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3883
    Cell Significance Index: -6.6600
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.4041
    Cell Significance Index: -2.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4258
    Cell Significance Index: -11.3700
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.4288
    Cell Significance Index: -4.8700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4332
    Cell Significance Index: -13.7000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4343
    Cell Significance Index: -11.4200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4478
    Cell Significance Index: -11.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4523
    Cell Significance Index: -12.1200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4566
    Cell Significance Index: -12.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4585
    Cell Significance Index: -16.1100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4679
    Cell Significance Index: -9.7700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4684
    Cell Significance Index: -12.7500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4744
    Cell Significance Index: -12.1200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4781
    Cell Significance Index: -12.1800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.4869
    Cell Significance Index: -6.5700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4966
    Cell Significance Index: -9.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ST8SIA2 is a member of the alpha-2,8-sialyltransferase family, which is responsible for catalyzing the transfer of sialic acid residues to the O-6 position of galactose residues in N-glycans. The enzyme has a molecular weight of approximately 55 kDa and is characterized by its ability to accept sialic acid residues from UDP-sialic acid and transfer them to the growing glycan chain. ST8SIA2 has a high degree of specificity for alpha-2,8-sialylation, and its products are involved in the formation of gangliosides, which are important for neuronal development, axon guidance, and immune function. **Pathways and Functions** ST8SIA2 is involved in several cellular pathways, including: 1. **Axon Guidance**: ST8SIA2 is essential for the formation of gangliosides, which are important for axon guidance and neuronal development. The enzyme helps to regulate the expression of sialylated glycoproteins and glycolipids, which are involved in the formation of the growth cone and the guidance of axons during neuronal development. 2. **Neuronal Development**: ST8SIA2 is involved in the regulation of neuronal development, including the formation of synapses and the regulation of neuronal apoptosis. The enzyme helps to regulate the expression of sialylated glycoproteins and glycolipids, which are involved in the formation of the synapse and the regulation of neuronal survival. 3. **Immune Function**: ST8SIA2 is involved in the regulation of immune function, including the regulation of dendritic cell maturation and the activation of T cells. The enzyme helps to regulate the expression of sialylated glycoproteins and glycolipids, which are involved in the recognition of pathogens and the activation of immune responses. 4. **Protein Glycosylation**: ST8SIA2 is involved in the regulation of protein glycosylation, including the elongation of N-glycan antennae and the transfer of sialic acid residues to the growing glycan chain. **Clinical Significance** Dysregulation of ST8SIA2 has been implicated in several diseases, including: 1. **Neurodegenerative Disorders**: ST8SIA2 has been implicated in the regulation of neuronal development and function, and its dysregulation has been linked to neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. 2. **Immune Disorders**: ST8SIA2 has been implicated in the regulation of immune function, and its dysregulation has been linked to immune disorders such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer**: ST8SIA2 has been implicated in the regulation of cancer cell behavior, including the regulation of cell proliferation and migration. Its dysregulation has been linked to an increased risk of cancer. In conclusion, ST8SIA2 is an enzyme that plays a crucial role in various cellular processes, including axon guidance, neuronal development, and immune function. Its dysregulation has been implicated in several diseases, including neurodegenerative disorders, immune disorders, and cancer. Further research is needed to fully understand the role of ST8SIA2 in human disease and to develop therapeutic strategies to target this enzyme in the treatment of disease.

Genular Protein ID: 1835800846

Symbol: SIA8B_HUMAN

Name: Sialyltransferase 8B

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7559389

Title: A human STX cDNA confers polysialic acid expression in mammalian cells.

PubMed ID: 7559389

DOI: 10.1074/jbc.270.39.22685

PubMed ID: 9054414

Title: Human STX polysialyltransferase forms the embryonic form of the neural cell adhesion molecule. Tissue-specific expression, neurite outgrowth, and chromosomal localization in comparison with another polysialyltransferase, PST.

PubMed ID: 9054414

DOI: 10.1074/jbc.272.11.7182

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8027041

Title: Differential expression of five sialyltransferase genes in human tissues.

PubMed ID: 8027041

DOI: 10.1016/s0021-9258(17)32390-6

PubMed ID: 9774483

Title: Differential and cooperative polysialylation of the neural cell adhesion molecule by two polysialyltransferases, PST and STX.

PubMed ID: 9774483

DOI: 10.1074/jbc.273.43.28524

PubMed ID: 9852130

Title: In vivo autopolysialylation and localization of the polysialyltransferases PST and STX.

PubMed ID: 9852130

DOI: 10.1074/jbc.273.51.34586

PubMed ID: 10766765

Title: Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha2,8-Sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III.

PubMed ID: 10766765

DOI: 10.1074/jbc.m910204199

PubMed ID: 11744634

Title: The polysialyltransferase ST8Sia II/STX: posttranslational processing and role of autopolysialylation in the polysialylation of neural cell adhesion molecule.

PubMed ID: 11744634

DOI: 10.1093/glycob/11.11.997

PubMed ID: 28810663

Title: Different properties of polysialic acids synthesized by the polysialyltransferases ST8SIA2 and ST8SIA4.

PubMed ID: 28810663

DOI: 10.1093/glycob/cwx057

Sequence Information:

  • Length: 375
  • Mass: 42430
  • Checksum: 42F0BC5B33D62325
  • Sequence:
  • MQLQFRSWML AALTLLVVFL IFADISEIEE EIGNSGGRGT IRSAVNSLHS KSNRAEVVIN 
    GSSSPAVVDR SNESIKHNIQ PASSKWRHNQ TLSLRIRKQI LKFLDAEKDI SVLKGTLKPG 
    DIIHYIFDRD STMNVSQNLY ELLPRTSPLK NKHFGTCAIV GNSGVLLNSG CGQEIDAHSF 
    VIRCNLAPVQ EYARDVGLKT DLVTMNPSVI QRAFEDLVNA TWREKLLQRL HSLNGSILWI 
    PAFMARGGKE RVEWVNELIL KHHVNVRTAY PSLRLLHAVR GYWLTNKVHI KRPTTGLLMY 
    TLATRFCKQI YLYGFWPFPL DQNQNPVKYH YYDSLKYGYT SQASPHTMPL EFKALKSLHE 
    QGALKLTVGQ CDGAT

Genular Protein ID: 1499895440

Symbol: C6G488_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

Sequence Information:

  • Length: 354
  • Mass: 40250
  • Checksum: 49EFB8D188472CDA
  • Sequence:
  • MQLQFRSWML AALTLLVVFL IFADISEIEE EIGAEVVING SSSPAVVDRS NESIKHNIQP 
    ASSKWRHNQT LSLRIRKQIL KFLDAEKDIS VLKGTLKPGD IIHYIFDRDS TMNVSQNLYE 
    LLPRTSPLKN KHFGTCAIVG NSGVLLNSGC GQEIDAHSFV IRCNLAPVQE YARDVGLKTD 
    LVTMNPSVIQ RAFEDLVNAT WREKLLQRLH SLNGSILWIP AFMARGGKER VEWVNELILK 
    HHVNVRTAYP SLRLLHAVRG YWLTNKVHIK RPTTGLLMYT LATRFCKQIY LYGFWPFPLD 
    QNQNPVKYHY YDSLKYGYTS QASPHTMPLE FKALKSLHEQ GALKLTVGQC DGAT

Genular Protein ID: 3579016500

Symbol: Q4VAY9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 354
  • Mass: 40223
  • Checksum: 3D0428D915782CDC
  • Sequence:
  • MQLQFRSWML AALTLLVVFL IFADISEIEE EIGAEVVING SSSPAVVDRS NESIKHNIQP 
    ASSKWRHNQT LSLRIRKQIL KFSDAEKDIS VLKGTLKPGD IIHYIFDRDS TMNVSQNLYE 
    LLPRTSPLKN KHFGTCAIVG NSGVLLNSGC GQEIDAHSFV IRCNLAPVQE YARDVGLKTD 
    LVTMNPSVIQ RAFEDLVNAT WREKLLQRLH SLNGSILWIP AFMARGGKER VEWVNELILK 
    HHVNVRTAYP SLRLLHAVRG YWLTNKVHIK RPTTGLLMYT LATRFCKQIY LYGFWPFPLD 
    QNQNPVKYHY YDSLKYGYTS QASPHTMPLE FKALKSLHEQ GALKLTVGQC DGAT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.