Details for: NAA10

Gene ID: 8260

Symbol: NAA10

Ensembl ID: ENSG00000102030

Description: N-alpha-acetyltransferase 10, NatA catalytic subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 217.0430
    Cell Significance Index: -33.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 138.5410
    Cell Significance Index: -35.1400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 131.6187
    Cell Significance Index: -54.2200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 103.4583
    Cell Significance Index: -48.8500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 97.9921
    Cell Significance Index: -39.8100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 89.4271
    Cell Significance Index: -46.0000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 73.1347
    Cell Significance Index: -49.0800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 42.4722
    Cell Significance Index: -40.5500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.0564
    Cell Significance Index: -41.9900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.6232
    Cell Significance Index: -35.7000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.5198
    Cell Significance Index: -30.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.3607
    Cell Significance Index: -44.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.1346
    Cell Significance Index: 137.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.0214
    Cell Significance Index: 105.2900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.7737
    Cell Significance Index: 20.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.6026
    Cell Significance Index: 75.3200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.5286
    Cell Significance Index: 40.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.5020
    Cell Significance Index: 70.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.3382
    Cell Significance Index: 39.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2922
    Cell Significance Index: 1166.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1194
    Cell Significance Index: 611.3400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.0679
    Cell Significance Index: 11.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0556
    Cell Significance Index: 144.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0261
    Cell Significance Index: 132.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8700
    Cell Significance Index: 106.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8232
    Cell Significance Index: 148.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7533
    Cell Significance Index: 53.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7328
    Cell Significance Index: 54.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7069
    Cell Significance Index: 19.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6910
    Cell Significance Index: 305.5100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6598
    Cell Significance Index: 13.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6405
    Cell Significance Index: 33.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5522
    Cell Significance Index: 25.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5459
    Cell Significance Index: 93.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4966
    Cell Significance Index: 34.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4719
    Cell Significance Index: 16.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4371
    Cell Significance Index: 9.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4302
    Cell Significance Index: 86.3000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4258
    Cell Significance Index: 7.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3880
    Cell Significance Index: 63.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3695
    Cell Significance Index: 43.5800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2389
    Cell Significance Index: 2.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2279
    Cell Significance Index: 29.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1946
    Cell Significance Index: 37.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1684
    Cell Significance Index: 8.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1237
    Cell Significance Index: 44.3800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0949
    Cell Significance Index: 65.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0812
    Cell Significance Index: 5.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0621
    Cell Significance Index: 1.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0493
    Cell Significance Index: 37.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0041
    Cell Significance Index: 0.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0037
    Cell Significance Index: 0.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0053
    Cell Significance Index: -3.8800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0212
    Cell Significance Index: -39.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0266
    Cell Significance Index: -2.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0354
    Cell Significance Index: -65.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0401
    Cell Significance Index: -1.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0432
    Cell Significance Index: -66.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0500
    Cell Significance Index: -68.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0625
    Cell Significance Index: -46.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0628
    Cell Significance Index: -39.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0659
    Cell Significance Index: -6.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0768
    Cell Significance Index: -43.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0970
    Cell Significance Index: -11.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1037
    Cell Significance Index: -47.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1136
    Cell Significance Index: -70.9600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1350
    Cell Significance Index: -3.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1357
    Cell Significance Index: -2.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1525
    Cell Significance Index: -5.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1557
    Cell Significance Index: -4.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1586
    Cell Significance Index: -6.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1638
    Cell Significance Index: -47.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1942
    Cell Significance Index: -38.5300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2360
    Cell Significance Index: -6.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2700
    Cell Significance Index: -31.4700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2750
    Cell Significance Index: -4.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2871
    Cell Significance Index: -60.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3081
    Cell Significance Index: -44.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4093
    Cell Significance Index: -25.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4425
    Cell Significance Index: -46.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4492
    Cell Significance Index: -35.5800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.4571
    Cell Significance Index: -3.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4711
    Cell Significance Index: -36.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4756
    Cell Significance Index: -7.9600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5216
    Cell Significance Index: -5.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5935
    Cell Significance Index: -36.3900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6152
    Cell Significance Index: -18.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6629
    Cell Significance Index: -37.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7158
    Cell Significance Index: -48.1300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.0167
    Cell Significance Index: -8.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.0437
    Cell Significance Index: -46.1700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1049
    Cell Significance Index: -40.5600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.1134
    Cell Significance Index: -39.0100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.1378
    Cell Significance Index: -21.0300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.1588
    Cell Significance Index: -37.9400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1613
    Cell Significance Index: -36.9900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.1697
    Cell Significance Index: -20.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.2122
    Cell Significance Index: -31.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.2219
    Cell Significance Index: -46.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.2621
    Cell Significance Index: -33.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The NAA10 gene is a human gene encoding a catalytic subunit of the N-acetyltransferase complex. This complex is composed of multiple subunits, with NAA10 being a key component responsible for transferring an acetyl group to lysine residues on target proteins. The NAA10 gene is highly expressed in various cell types, including extravillous trophoblast, myeloid dendritic cells, and pancreatic acinar cells. Notably, NAA10 is also expressed in malignant cells, suggesting its potential role in cancer progression. **Pathways and Functions:** NAA10 is involved in various cellular processes, including: 1. **Protein Acetylation:** NAA10 catalyzes the transfer of an acetyl group to lysine residues on target proteins, which can alter their stability, localization, and interactions. 2. **Chromosome Organization:** NAA10 is involved in the regulation of centromeric cohesion and the maintenance of mitotic sister chromatid cohesion. 3. **Negative Regulation of Cell Cycle:** NAA10 has been shown to inhibit the G2/M phase transition, thereby regulating cell cycle progression. 4. **Immune Response:** NAA10 is expressed in myeloid dendritic cells and plays a role in the regulation of immune responses. **Clinical Significance:** The NAA10 gene has potential implications in various diseases, including: 1. **Cancer:** NAA10 overexpression has been observed in malignant cells, suggesting its potential role in cancer progression. 2. **Autoimmune Diseases:** Alterations in NAA10 expression and activity may contribute to the development of autoimmune diseases, such as rheumatoid arthritis. 3. **Neurological Disorders:** NAA10 may play a role in the regulation of protein acetylation in the central nervous system, which could contribute to the pathogenesis of neurological disorders, such as Alzheimer's disease. In conclusion, the NAA10 gene is a critical regulator of protein acetylation, with far-reaching implications for various cellular processes. Further research is needed to fully elucidate the role of NAA10 in disease pathology and to explore its potential as a therapeutic target. **Recommendations:** 1. **Further Research:** Investigate the role of NAA10 in specific disease models, including cancer and autoimmune diseases. 2. **Therapeutic Targeting:** Explore the potential of NAA10 as a therapeutic target for the treatment of diseases associated with protein acetylation dysregulation. 3. **Functional Validation:** Validate the functional significance of NAA10 in cellular processes, including protein acetylation and chromosome organization.

Genular Protein ID: 2769560684

Symbol: NAA10_HUMAN

Name: N-alpha-acetyltransferase 10

UniProtKB Accession Codes:

P41227 A6NM98

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 3 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 30 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EC 6 EMBL 5 EMDB 2 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 Rhea 18 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7981673

Title: Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae.

PubMed ID: 7981673

DOI: 10.1093/hmg/3.7.1061

PubMed ID: 15496142

Title: Identification and characterization of the human ARD1-NATH protein acetyltransferase complex.

PubMed ID: 15496142

DOI: 10.1042/bj20041071

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12464182

Title: Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation.

PubMed ID: 12464182

DOI: 10.1016/s0092-8674(02)01085-1

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16507339

Title: Cloning and characterization of hNAT5/hSAN: an evolutionarily conserved component of the NatA protein N-alpha-acetyltransferase complex.

PubMed ID: 16507339

DOI: 10.1016/j.gene.2005.12.008

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19480662

Title: A novel human NatA Nalpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1).

PubMed ID: 19480662

DOI: 10.1186/1471-2091-10-15

PubMed ID: 19660095

Title: A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates.

PubMed ID: 19660095

DOI: 10.1186/1753-6561-3-s6-s2

PubMed ID: 19716809

Title: Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation.

PubMed ID: 19716809

DOI: 10.1016/j.bbrc.2009.08.127

PubMed ID: 19826488

Title: Arrest defective-1 controls tumor cell behavior by acetylating myosin light chain kinase.

PubMed ID: 19826488

DOI: 10.1371/journal.pone.0007451

PubMed ID: 19420222

Title: Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans.

PubMed ID: 19420222

DOI: 10.1073/pnas.0901931106

PubMed ID: 20154145

Title: The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation.

PubMed ID: 20154145

DOI: 10.1128/mcb.01199-09

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 20145209

Title: ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway.

PubMed ID: 20145209

DOI: 10.1126/scisignal.2000590

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24431331

Title: A splice donor mutation in NAA10 results in the dysregulation of the retinoic acid signalling pathway and causes Lenz microphthalmia syndrome.

PubMed ID: 24431331

DOI: 10.1136/jmedgenet-2013-101660

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25732826

Title: An organellar nalpha-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity.

PubMed ID: 25732826

DOI: 10.1016/j.celrep.2015.01.053

PubMed ID: 27422821

Title: Opposing functions of the N-terminal acetyltransferases Naa50 and NatA in sister-chromatid cohesion.

PubMed ID: 27422821

DOI: 10.1074/jbc.m116.737585

PubMed ID: 27708256

Title: ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation.

PubMed ID: 27708256

DOI: 10.1038/ncomms12882

PubMed ID: 29754825

Title: Structure of Human NatA and Its Regulation by the Huntingtin Interacting Protein HYPK.

PubMed ID: 29754825

DOI: 10.1016/j.str.2018.04.003

PubMed ID: 32042062

Title: Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK.

PubMed ID: 32042062

DOI: 10.1038/s41467-020-14584-7

PubMed ID: 21700266

Title: Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency.

PubMed ID: 21700266

DOI: 10.1016/j.ajhg.2011.05.017

PubMed ID: 25489052

Title: Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.

PubMed ID: 25489052

DOI: 10.1093/hmg/ddu611

PubMed ID: 26522270

Title: NAA10 mutation causing a novel intellectual disability syndrome with Long QT due to N-terminal acetyltransferase impairment.

PubMed ID: 26522270

DOI: 10.1038/srep16022

PubMed ID: 31174490

Title: A novel NAA10 p.(R83H) variant with impaired acetyltransferase activity identified in two boys with ID and microcephaly.

PubMed ID: 31174490

DOI: 10.1186/s12881-019-0803-1

Sequence Information:

  • Length: 235
  • Mass: 26459
  • Checksum: 6393A907F5C2DDC4
  • Sequence:
    • MNIRNARPED LMNMQHCNLL CLPENYQMKY YFYHGLSWPQ LSYIAEDENG KIVGYVLAKM 
EEDPDDVPHG HITSLAVKRS HRRLGLAQKL MDQASRAMIE NFNAKYVSLH VRKSNRAALH 
LYSNTLNFQI SEVEPKYYAD GEDAYAMKRD LTQMADELRR HLELKEKGRH VVLGAIENKV 
ESKGNSPPSS GEACREEKGL AAEDSGGDSK DLSEVSETTE STDVKDSSEA SDSAS

Genular Protein ID: 2092140847

Symbol: B7Z9N2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z9N2

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 30 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 6 EMBL 4 GO 3 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 18 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 118
  • Mass: 13833
  • Checksum: F8354549FE370A1A
  • Sequence:
    • MNIRNARPED LMNMQHCNLL CLPENYQMKY YFYHGLSWPQ LSYIAEDENG KIVGYVLAKM 
EEDPDDVPHG HITSLAVKRS HRRLGLAQKL MDQASRAMIE NFNAKYVSLH VRKRWKPG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.