H3C11 | ENSG00000275379 | NCBI 8354

Details for: H3C11

Gene ID: 8354

Symbol: H3C11

Ensembl ID: ENSG00000275379

Description: H3 clustered histone 11

Associated with

Activated pkn1 stimulates transcription of ar (androgen receptor) regulated genes klk2 and klk3
(R-HSA-5625886)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Condensation of prophase chromosomes
(R-HSA-2299718)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective pyroptosis
(R-HSA-9710421)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna methylation
(R-HSA-5334118)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of adipogenesis genes by mll3 and mll4 complexes
(R-HSA-9851695)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hcmv late events
(R-HSA-9610379)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdms demethylate histones
(R-HSA-3214842)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interleukin-7 signaling
(R-HSA-1266695)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
Mll4 and mll3 complexes regulate expression of pparg target genes in adipogenesis and hepatic steatosis
(R-HSA-9841922)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Oxidative stress induced senescence
(R-HSA-2559580)
Pkmts methylate histone lysines
(R-HSA-3214841)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Viral infection pathways
(R-HSA-9824446)
Cadherin binding
(GO:0045296)
Chromatin organization
(GO:0006325)
Dna binding
(GO:0003677)
Gene expression
(GO:0010467)
Nucleosome assembly
(GO:0006334)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Structural constituent of chromatin
(GO:0030527)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: embryonic stem cell (CL0002322)
Fold Change: 4.9521
Cell Significance Index: -2.0400
Cell Name: proerythroblast (CL0000547)
Fold Change: 2.1095
Cell Significance Index: 30.2300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.1714
Cell Significance Index: 33.7500
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.7922
Cell Significance Index: 11.8700
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.7467
Cell Significance Index: 18.6200
Cell Name: thymocyte (CL0000893)
Fold Change: 0.6616
Cell Significance Index: 8.3600
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5350
Cell Significance Index: 11.5900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.4975
Cell Significance Index: 10.6000
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.4748
Cell Significance Index: 9.8500
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.4221
Cell Significance Index: 3.6900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.4095
Cell Significance Index: 14.3900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3879
Cell Significance Index: 73.8100
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2703
Cell Significance Index: 17.4400
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2686
Cell Significance Index: 16.1300
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2516
Cell Significance Index: 27.3700
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.2354
Cell Significance Index: 2.3600
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.2233
Cell Significance Index: 2.4200
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2128
Cell Significance Index: 21.0500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1890
Cell Significance Index: 30.7500
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.1747
Cell Significance Index: 1.2700
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.1548
Cell Significance Index: 0.8800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1464
Cell Significance Index: 132.2200
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.1419
Cell Significance Index: 3.7300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1175
Cell Significance Index: 8.1300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1057
Cell Significance Index: 4.7900
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.0869
Cell Significance Index: 0.9300
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.0868
Cell Significance Index: 1.1000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0859
Cell Significance Index: 10.1400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0626
Cell Significance Index: 3.2500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0617
Cell Significance Index: 1.6500
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.0591
Cell Significance Index: 0.8300
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0565
Cell Significance Index: 0.5900
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0372
Cell Significance Index: 0.5600
Cell Name: salivary gland cell (CL0009005)
Fold Change: 0.0370
Cell Significance Index: 0.4600
Cell Name: paneth cell (CL0000510)
Fold Change: 0.0333
Cell Significance Index: 0.3500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0216
Cell Significance Index: 0.5400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0194
Cell Significance Index: 0.6200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0148
Cell Significance Index: 2.6700
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.0040
Cell Significance Index: 0.0400
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0034
Cell Significance Index: 1.8800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0008
Cell Significance Index: 0.3500
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.0000
Cell Significance Index: 0.0000
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0001
Cell Significance Index: -0.0100
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0018
Cell Significance Index: -0.0800
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: -0.0019
Cell Significance Index: -0.0200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0023
Cell Significance Index: -0.1300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0028
Cell Significance Index: -2.1100
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0038
Cell Significance Index: -0.0800
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0044
Cell Significance Index: -0.5600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0050
Cell Significance Index: -1.7900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0051
Cell Significance Index: -0.3100
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.0055
Cell Significance Index: -0.0700
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.0065
Cell Significance Index: -0.0900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0075
Cell Significance Index: -0.8600
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0083
Cell Significance Index: -1.6500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0091
Cell Significance Index: -1.5500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0101
Cell Significance Index: -2.0300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0108
Cell Significance Index: -1.3300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0114
Cell Significance Index: -1.5700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0136
Cell Significance Index: -0.9600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0180
Cell Significance Index: -0.8400
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: -0.0185
Cell Significance Index: -0.0900
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0202
Cell Significance Index: -0.2200
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0211
Cell Significance Index: -0.5400
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0216
Cell Significance Index: -2.2100
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.0221
Cell Significance Index: -0.3100
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0241
Cell Significance Index: -0.7900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0265
Cell Significance Index: -0.7400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0340
Cell Significance Index: -1.6000
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0376
Cell Significance Index: -0.4100
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0396
Cell Significance Index: -0.5400
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: -0.0412
Cell Significance Index: -0.3200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0419
Cell Significance Index: -1.1200
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0430
Cell Significance Index: -1.3700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0445
Cell Significance Index: -0.7500
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0475
Cell Significance Index: -1.4000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0475
Cell Significance Index: -1.6500
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0523
Cell Significance Index: -0.7600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0536
Cell Significance Index: -1.4600
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0540
Cell Significance Index: -1.8900
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0548
Cell Significance Index: -2.0100
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0552
Cell Significance Index: -0.6300
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0601
Cell Significance Index: -0.8600
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0619
Cell Significance Index: -0.8100
Cell Name: macroglial cell (CL0000126)
Fold Change: -0.0622
Cell Significance Index: -0.7200
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0652
Cell Significance Index: -1.6600
Cell Name: muscle cell (CL0000187)
Fold Change: -0.0669
Cell Significance Index: -0.6400
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.0674
Cell Significance Index: -0.4000
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.0682
Cell Significance Index: -0.5800
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.0684
Cell Significance Index: -0.6900
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0693
Cell Significance Index: -1.7300
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0738
Cell Significance Index: -1.4600
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0786
Cell Significance Index: -1.9600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0792
Cell Significance Index: -2.2700
Cell Name: tendon cell (CL0000388)
Fold Change: -0.0802
Cell Significance Index: -1.0900
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.0807
Cell Significance Index: -1.1600
Cell Name: peg cell (CL4033014)
Fold Change: -0.0814
Cell Significance Index: -1.8800
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0822
Cell Significance Index: -1.6400
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0858
Cell Significance Index: -1.3900
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0861
Cell Significance Index: -2.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** H3C11 is a histone protein with a molecular weight of approximately 14 kDa. It is a member of the histone H3 family, which is characterized by a conserved histone H3 domain. H3C11 contains a unique N-terminal domain that is distinct from other histone H3 variants. This domain is thought to be involved in protein-protein interactions and chromatin remodeling. H3C11 is also known for its high degree of methylation, which can affect its ability to bind DNA and regulate gene expression. **Pathways and Functions** H3C11 is involved in various cellular processes, including: 1. **Cell cycle regulation**: H3C11 plays a role in regulating the cell cycle, particularly during the G2/M phase. It is involved in the assembly of the pre-replicative complex and the condensation of prophase chromosomes. 2. **Transcriptional control**: H3C11 is a transcriptional regulator that influences the expression of genes involved in cellular differentiation, development, and immune responses. 3. **Chromatin modifications**: H3C11 is involved in chromatin modifications, including DNA methylation, acetylation, and demethylation. These modifications can affect gene expression and chromatin structure. 4. **DNA replication**: H3C11 is involved in the assembly of the pre-replicative complex and the replication of DNA. 5. **Immune system regulation**: H3C11 is expressed in immune cells and is involved in the regulation of immune responses, including cytokine signaling and the activation of immune cells. **Clinical Significance** Dysregulation of H3C11 has been implicated in various diseases, including: 1. **Cancer**: H3C11 mutations have been found in certain types of cancer, including leukemia and lymphoma. 2. **Inflammatory disorders**: H3C11 is involved in the regulation of immune responses, and its dysregulation has been linked to inflammatory disorders, including rheumatoid arthritis and multiple sclerosis. 3. **Developmental abnormalities**: H3C11 is involved in the regulation of cellular differentiation and development. Its dysregulation has been linked to developmental abnormalities, including birth defects and genetic disorders. 4. **Neurological disorders**: H3C11 has been implicated in the regulation of neuronal function and has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, H3C11 is a critical component of chromatin structure and gene regulation. Its dysregulation has been linked to various diseases, and further research is needed to fully understand its role in human biology and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.