H4C11 | ENSG00000197238 | NCBI 8363

Details for: H4C11

Gene ID: 8363

Symbol: H4C11

Ensembl ID: ENSG00000197238

Description: H4 clustered histone 11

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdms demethylate histones
(R-HSA-3214842)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Pkmts methylate histone lysines
(R-HSA-3214841)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 16.0462
Cell Significance Index: -4.0700
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 9.0019
Cell Significance Index: -4.2500
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 6.3187
Cell Significance Index: -4.2400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 3.1875
Cell Significance Index: -3.9300
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.2151
Cell Significance Index: 30.3000
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 1.1705
Cell Significance Index: 16.2400
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 1.0745
Cell Significance Index: -4.2400
Cell Name: decidual cell (CL2000002)
Fold Change: 0.9253
Cell Significance Index: 14.8500
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.6400
Cell Significance Index: 9.2100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5413
Cell Significance Index: 488.7800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5126
Cell Significance Index: 14.7700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4337
Cell Significance Index: 47.1700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4304
Cell Significance Index: 25.8400
Cell Name: kidney cell (CL1000497)
Fold Change: 0.3720
Cell Significance Index: 2.9700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3682
Cell Significance Index: 16.6900
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3610
Cell Significance Index: 58.7200
Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 0.3214
Cell Significance Index: -0.0500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3033
Cell Significance Index: 6.5700
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.2790
Cell Significance Index: 4.1800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2790
Cell Significance Index: 53.0900
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.2763
Cell Significance Index: 2.7700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2392
Cell Significance Index: 16.5500
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.2369
Cell Significance Index: 4.9200
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2363
Cell Significance Index: 23.3800
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 0.1939
Cell Significance Index: 2.0600
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.1730
Cell Significance Index: 1.0700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1588
Cell Significance Index: 8.2500
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.1557
Cell Significance Index: 3.2600
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1497
Cell Significance Index: 9.6600
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.1495
Cell Significance Index: 0.9200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.1306
Cell Significance Index: 4.5400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1282
Cell Significance Index: 4.5100
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.1233
Cell Significance Index: 1.7300
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.1148
Cell Significance Index: 1.1900
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1029
Cell Significance Index: 56.1900
Cell Name: keratocyte (CL0002363)
Fold Change: 0.0958
Cell Significance Index: 1.5200
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.0941
Cell Significance Index: 1.3400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0929
Cell Significance Index: 2.4900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0853
Cell Significance Index: 6.3600
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.0552
Cell Significance Index: 0.6000
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0471
Cell Significance Index: 0.7100
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0268
Cell Significance Index: 0.6700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0250
Cell Significance Index: 0.8000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0213
Cell Significance Index: 2.9200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0184
Cell Significance Index: 2.1700
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0179
Cell Significance Index: 0.4700
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.0128
Cell Significance Index: 0.0800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0126
Cell Significance Index: 5.5600
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0107
Cell Significance Index: 1.3700
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0094
Cell Significance Index: 0.2000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0028
Cell Significance Index: 0.5000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0006
Cell Significance Index: 0.0100
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0001
Cell Significance Index: 0.0000
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0021
Cell Significance Index: -0.2600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0022
Cell Significance Index: -4.2300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0026
Cell Significance Index: -1.9900
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0051
Cell Significance Index: -3.7300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0053
Cell Significance Index: -3.9400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0061
Cell Significance Index: -3.4300
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0067
Cell Significance Index: -0.8600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0093
Cell Significance Index: -0.2600
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0096
Cell Significance Index: -1.9100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0097
Cell Significance Index: -4.4200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0105
Cell Significance Index: -3.7800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0114
Cell Significance Index: -1.1700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0148
Cell Significance Index: -4.2500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0149
Cell Significance Index: -2.5500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0156
Cell Significance Index: -1.7900
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0167
Cell Significance Index: -0.1900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0186
Cell Significance Index: -3.7300
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0208
Cell Significance Index: -1.4700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0239
Cell Significance Index: -5.0400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0243
Cell Significance Index: -3.5300
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0262
Cell Significance Index: -0.6700
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0307
Cell Significance Index: -0.4400
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.0338
Cell Significance Index: -0.3500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0406
Cell Significance Index: -4.2300
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0418
Cell Significance Index: -0.5700
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -0.0440
Cell Significance Index: -0.2400
Cell Name: slow muscle cell (CL0000189)
Fold Change: -0.0455
Cell Significance Index: -0.6800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0504
Cell Significance Index: -3.9900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0506
Cell Significance Index: -2.3800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0554
Cell Significance Index: -2.9100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0558
Cell Significance Index: -4.2800
Cell Name: immature alpha-beta T cell (CL0000790)
Fold Change: -0.0591
Cell Significance Index: -0.4400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0613
Cell Significance Index: -3.7600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0613
Cell Significance Index: -3.4400
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.0747
Cell Significance Index: -1.5200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0749
Cell Significance Index: -2.0400
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0805
Cell Significance Index: -2.3700
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0844
Cell Significance Index: -1.2100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0845
Cell Significance Index: -3.9400
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.0906
Cell Significance Index: -0.7700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0954
Cell Significance Index: -4.2200
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0961
Cell Significance Index: -1.0000
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0978
Cell Significance Index: -3.5900
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.0999
Cell Significance Index: -1.2800
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: -0.1008
Cell Significance Index: -1.2000
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.1032
Cell Significance Index: -3.0300
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: -0.1043
Cell Significance Index: -0.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** H4C11 is a histone H4 variant that exhibits distinct characteristics compared to other histone variants. Some of its key features include: * **Chromatin assembly**: H4C11 plays a crucial role in the assembly of chromatin structures, including the origin of replication and the pre-replicative complex. * **DNA repair**: H4C11 is involved in the repair of DNA damage, particularly at the site of damaged purines and pyrimidines. * **Cell cycle regulation**: H4C11 is involved in the regulation of the cell cycle, particularly during the G2/M phase. * **Transcriptional regulation**: H4C11 is involved in the regulation of gene expression, particularly through its interaction with transcription factors and chromatin-modifying enzymes. **Pathways and Functions** H4C11 is involved in various cellular pathways, including: * **Activation of anterior hox genes in hindbrain development during early embryogenesis**: H4C11 is involved in the regulation of anterior hox gene expression during hindbrain development. * **Assembly of the orc complex at the origin of replication**: H4C11 is involved in the assembly of the orc complex, which is essential for origin of replication. * **Base-excision repair**: H4C11 is involved in the repair of DNA damage at the site of damaged purines and pyrimidines. * **Cell cycle checkpoints**: H4C11 is involved in the regulation of cell cycle checkpoints, particularly during the G2/M phase. * **Epigenetic regulation of gene expression**: H4C11 is involved in the regulation of gene expression through its interaction with transcription factors and chromatin-modifying enzymes. **Clinical Significance** The dysregulation of H4C11 has been implicated in various diseases, including: * **Neurodegenerative diseases**: H4C11 has been implicated in the regulation of gene expression in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. * **Cancer**: H4C11 has been implicated in the regulation of gene expression in cancer, particularly in the development of leukemia and lymphoma. * **Neurodevelopmental disorders**: H4C11 has been implicated in the regulation of gene expression in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. In conclusion, H4C11 is a critical gene that plays a significant role in various cellular processes, including development, differentiation, DNA repair, and cell cycle regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining genome stability and cellular homeostasis.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.