Details for: SLC25A11

Gene ID: 8402

Symbol: SLC25A11

Ensembl ID: ENSG00000108528

Description: solute carrier family 25 member 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 179.2405
    Cell Significance Index: -27.8800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 117.7243
    Cell Significance Index: -29.8600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 89.2104
    Cell Significance Index: -36.7500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 79.4325
    Cell Significance Index: -32.2700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 68.7617
    Cell Significance Index: -35.3700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 54.5437
    Cell Significance Index: -36.6000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.8206
    Cell Significance Index: -32.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.3627
    Cell Significance Index: -34.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.2143
    Cell Significance Index: -36.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.9241
    Cell Significance Index: -27.4100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.7794
    Cell Significance Index: -20.8400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6857
    Cell Significance Index: -10.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.2822
    Cell Significance Index: 226.9800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.8850
    Cell Significance Index: 15.0500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.3715
    Cell Significance Index: 11.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.2955
    Cell Significance Index: 68.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0937
    Cell Significance Index: 70.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0619
    Cell Significance Index: 36.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0312
    Cell Significance Index: 48.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9843
    Cell Significance Index: 13.4300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.8541
    Cell Significance Index: 9.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8345
    Cell Significance Index: 102.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8183
    Cell Significance Index: 446.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8105
    Cell Significance Index: 57.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7658
    Cell Significance Index: 138.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7491
    Cell Significance Index: 102.8700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7192
    Cell Significance Index: 317.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6335
    Cell Significance Index: 13.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5664
    Cell Significance Index: 35.7000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5290
    Cell Significance Index: 15.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5048
    Cell Significance Index: 59.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4944
    Cell Significance Index: 63.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4701
    Cell Significance Index: 24.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4692
    Cell Significance Index: 12.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4508
    Cell Significance Index: 11.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4460
    Cell Significance Index: 20.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3934
    Cell Significance Index: 11.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3708
    Cell Significance Index: 60.3100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2917
    Cell Significance Index: 7.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2680
    Cell Significance Index: 34.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2370
    Cell Significance Index: 17.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2342
    Cell Significance Index: 46.9800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2324
    Cell Significance Index: 2.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1814
    Cell Significance Index: 8.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1606
    Cell Significance Index: 4.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1596
    Cell Significance Index: 31.6800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1401
    Cell Significance Index: 1.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1363
    Cell Significance Index: 25.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1274
    Cell Significance Index: 4.0800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1056
    Cell Significance Index: 1.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0875
    Cell Significance Index: 31.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0644
    Cell Significance Index: 10.9900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0623
    Cell Significance Index: 1.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0521
    Cell Significance Index: 1.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0468
    Cell Significance Index: 34.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0430
    Cell Significance Index: 4.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0341
    Cell Significance Index: 0.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0170
    Cell Significance Index: 11.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0161
    Cell Significance Index: 12.1900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0098
    Cell Significance Index: 0.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0090
    Cell Significance Index: -6.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0100
    Cell Significance Index: -18.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0128
    Cell Significance Index: -7.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0218
    Cell Significance Index: -40.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0235
    Cell Significance Index: -2.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0246
    Cell Significance Index: -13.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0263
    Cell Significance Index: -40.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0319
    Cell Significance Index: -20.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0326
    Cell Significance Index: -44.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0555
    Cell Significance Index: -25.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0903
    Cell Significance Index: -19.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0961
    Cell Significance Index: -11.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1008
    Cell Significance Index: -29.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1485
    Cell Significance Index: -17.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1493
    Cell Significance Index: -21.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1571
    Cell Significance Index: -4.3900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1726
    Cell Significance Index: -4.4100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1849
    Cell Significance Index: -2.7700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2040
    Cell Significance Index: -3.7700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2092
    Cell Significance Index: -5.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2137
    Cell Significance Index: -4.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2222
    Cell Significance Index: -17.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2860
    Cell Significance Index: -17.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2979
    Cell Significance Index: -22.8600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3065
    Cell Significance Index: -34.9900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3192
    Cell Significance Index: -5.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3245
    Cell Significance Index: -21.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3443
    Cell Significance Index: -35.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4008
    Cell Significance Index: -11.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4280
    Cell Significance Index: -12.6100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4944
    Cell Significance Index: -14.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5606
    Cell Significance Index: -31.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5880
    Cell Significance Index: -30.6300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5883
    Cell Significance Index: -6.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5896
    Cell Significance Index: -36.1500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.6848
    Cell Significance Index: -8.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7235
    Cell Significance Index: -32.0000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8239
    Cell Significance Index: -30.2500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.8429
    Cell Significance Index: -13.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transporter Function:** SLC25A11 is a transporter protein that facilitates the movement of ions, glucose, and other molecules across cellular membranes. 2. **Antiporter Activity:** The protein exhibits antiporter activity, which involves the exchange of one ion or molecule for another across the membrane. 3. **Energy Metabolism:** SLC25A11 plays a crucial role in energy metabolism, particularly in the transport of oxaloacetate and alpha-ketoglutarate across the mitochondrial inner membrane. 4. **Neurotransmission:** The protein is also involved in neurotransmission, particularly in the GABAergic system, where it regulates the transport of thiosulfate and other molecules. 5. **Cellular Localization:** SLC25A11 is expressed in various cell types, including epithelial cells of the nephron, placental villous trophoblasts, and neurons. **Pathways and Functions:** 1. **Alpha-Ketoglutarate Transport:** SLC25A11 facilitates the transport of alpha-ketoglutarate across the mitochondrial inner membrane, playing a crucial role in energy metabolism. 2. **Gluconeogenesis:** The protein is involved in gluconeogenesis, the process by which glucose is synthesized from non-carbohydrate sources. 3. **Glucose Metabolism:** SLC25A11 regulates glucose metabolism by facilitating the transport of glucose across cellular membranes. 4. **Lipid Transport:** The protein is also involved in lipid transport, particularly in the transport of oxaloacetate and other molecules. 5. **Mitochondrial Function:** SLC25A11 plays a critical role in mitochondrial function, particularly in the regulation of energy metabolism. **Clinical Significance:** 1. **Metabolic Disorders:** SLC25A11 has been implicated in various metabolic disorders, including diabetes, obesity, and metabolic syndrome. 2. **Neurological Conditions:** The protein has been associated with neurological conditions, including epilepsy, Alzheimer's disease, and Parkinson's disease. 3. **Hematological Disorders:** SLC25A11 has been linked to hematological disorders, including anemia and leukemia. 4. **Cancer:** The protein has been implicated in cancer, particularly in the regulation of energy metabolism and cell proliferation. 5. **Therapeutic Potential:** SLC25A11 has potential therapeutic applications in the treatment of various diseases, including metabolic disorders, neurological conditions, and hematological disorders. In conclusion, SLC25A11 is a multifaceted gene that plays a crucial role in energy metabolism, neurotransmission, and other cellular processes. Its clinical significance has been implicated in various diseases, and further research is needed to fully understand its functions and therapeutic potential.

Genular Protein ID: 724795436

Symbol: M2OM_HUMAN

Name: Solute carrier family 25 member 11

UniProtKB Accession Codes:

Q02978 F5GY65 O75537 Q969P7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 CarbonylDB 1 ChEBI 10 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 5 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1457818

Title: Sequences of the human and bovine genes for the mitochondrial 2-oxoglutarate carrier.

PubMed ID: 1457818

DOI: 10.3109/10425179209034000

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21448454

Title: MISC-1/OGC links mitochondrial metabolism, apoptosis and insulin secretion.

PubMed ID: 21448454

DOI: 10.1371/journal.pone.0017827

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 37009826

Title: LINC00493-encoded microprotein SMIM26 exerts anti-metastatic activity in renal cell carcinoma.

PubMed ID: 37009826

DOI: 10.15252/embr.202256282

PubMed ID: 29431636

Title: Germline Mutations in the Mitochondrial 2-Oxoglutarate/Malate Carrier SLC25A11 Gene Confer a Predisposition to Metastatic Paragangliomas.

PubMed ID: 29431636

DOI: 10.1158/0008-5472.can-17-2463

Sequence Information:

  • Length: 314
  • Mass: 34062
  • Checksum: 9D61F817089FF5AA
  • Sequence:
    • MAATASAGAG GIDGKPRTSP KSVKFLFGGL AGMGATVFVQ PLDLVKNRMQ LSGEGAKTRE 
YKTSFHALTS ILKAEGLRGI YTGLSAGLLR QATYTTTRLG IYTVLFERLT GADGTPPGFL 
LKAVIGMTAG ATGAFVGTPA EVALIRMTAD GRLPADQRRG YKNVFNALIR ITREEGVLTL 
WRGCIPTMAR AVVVNAAQLA SYSQSKQFLL DSGYFSDNIL CHFCASMISG LVTTAASMPV 
DIAKTRIQNM RMIDGKPEYK NGLDVLFKVV RYEGFFSLWK GFTPYYARLG PHTVLTFIFL 
EQMNKAYKRL FLSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.