Details for: LTBP4

Gene ID: 8425

Symbol: LTBP4

Ensembl ID: ENSG00000090006

Description: latent transforming growth factor beta binding protein 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 205.2136
    Cell Significance Index: -31.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 118.9465
    Cell Significance Index: -30.1700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 66.1904
    Cell Significance Index: -31.2500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 64.7250
    Cell Significance Index: -26.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.0999
    Cell Significance Index: -32.1800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.5870
    Cell Significance Index: -31.0400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 8.7122
    Cell Significance Index: 59.0300
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 8.4625
    Cell Significance Index: 52.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.1955
    Cell Significance Index: -32.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.1651
    Cell Significance Index: -17.8700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 7.2931
    Cell Significance Index: 93.4000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.4399
    Cell Significance Index: -19.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.4058
    Cell Significance Index: 467.7100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.3540
    Cell Significance Index: 65.4600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 3.0501
    Cell Significance Index: 43.8000
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.4800
    Cell Significance Index: 14.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.4494
    Cell Significance Index: 70.2200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.7700
    Cell Significance Index: 28.0800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.4313
    Cell Significance Index: 15.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.4263
    Cell Significance Index: 39.8600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.3931
    Cell Significance Index: 48.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.3444
    Cell Significance Index: 28.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2609
    Cell Significance Index: 1138.4600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9786
    Cell Significance Index: 58.7500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9114
    Cell Significance Index: 99.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8141
    Cell Significance Index: 132.4100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.7596
    Cell Significance Index: 7.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7223
    Cell Significance Index: 19.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7103
    Cell Significance Index: 20.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5226
    Cell Significance Index: 231.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4920
    Cell Significance Index: 22.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4615
    Cell Significance Index: 31.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4488
    Cell Significance Index: 55.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4417
    Cell Significance Index: 9.5700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4315
    Cell Significance Index: 9.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4009
    Cell Significance Index: 143.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3676
    Cell Significance Index: 73.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3127
    Cell Significance Index: 30.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2888
    Cell Significance Index: 37.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1938
    Cell Significance Index: 14.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1905
    Cell Significance Index: 37.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1239
    Cell Significance Index: 168.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1224
    Cell Significance Index: 22.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1083
    Cell Significance Index: 5.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1080
    Cell Significance Index: 7.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1025
    Cell Significance Index: 1.7200
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.0797
    Cell Significance Index: 0.8800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0764
    Cell Significance Index: 52.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0597
    Cell Significance Index: 91.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0424
    Cell Significance Index: 1.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0421
    Cell Significance Index: 22.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0224
    Cell Significance Index: 4.2600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0189
    Cell Significance Index: 0.9500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0156
    Cell Significance Index: 28.7500
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: 0.0129
    Cell Significance Index: 0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0075
    Cell Significance Index: 14.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0169
    Cell Significance Index: -1.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0240
    Cell Significance Index: -0.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0264
    Cell Significance Index: -3.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0269
    Cell Significance Index: -20.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0288
    Cell Significance Index: -18.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0379
    Cell Significance Index: -27.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0428
    Cell Significance Index: -31.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0451
    Cell Significance Index: -2.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0492
    Cell Significance Index: -22.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0555
    Cell Significance Index: -31.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0557
    Cell Significance Index: -34.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0561
    Cell Significance Index: -3.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0761
    Cell Significance Index: -11.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0787
    Cell Significance Index: -5.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0855
    Cell Significance Index: -1.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0902
    Cell Significance Index: -25.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0997
    Cell Significance Index: -10.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1004
    Cell Significance Index: -11.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1417
    Cell Significance Index: -24.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1477
    Cell Significance Index: -8.2900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1488
    Cell Significance Index: -2.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1533
    Cell Significance Index: -17.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1633
    Cell Significance Index: -34.4000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1956
    Cell Significance Index: -2.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2019
    Cell Significance Index: -5.9300
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -0.2079
    Cell Significance Index: -0.4800
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.2190
    Cell Significance Index: -2.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2298
    Cell Significance Index: -17.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2317
    Cell Significance Index: -12.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2826
    Cell Significance Index: -32.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3021
    Cell Significance Index: -31.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3211
    Cell Significance Index: -14.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3226
    Cell Significance Index: -19.7800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3462
    Cell Significance Index: -7.5800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3638
    Cell Significance Index: -28.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3796
    Cell Significance Index: -16.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4037
    Cell Significance Index: -12.9300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4223
    Cell Significance Index: -15.9900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4532
    Cell Significance Index: -13.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4640
    Cell Significance Index: -12.2000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4752
    Cell Significance Index: -13.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4763
    Cell Significance Index: -30.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5235
    Cell Significance Index: -27.2000
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.5337
    Cell Significance Index: -5.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **ECM Organization:** LTBP4 is significantly expressed in various cell types, including fibroblasts, neural progenitor cells, and mesodermal cells, which are all involved in ECM production and remodeling. Its presence in these cells suggests a critical role in maintaining the integrity and organization of the ECM. 2. **TGF-β Signaling Regulation:** LTBP4 is a key regulator of TGF-β signaling by binding to latent TGF-β and facilitating its activation. This interaction enables TGF-β to signal through Smad proteins, leading to various cellular responses, including cell growth, differentiation, and ECM remodeling. 3. **Cellular Expression:** LTBP4 is expressed in multiple cell types, including fibroblasts, neural progenitor cells, and mesodermal cells, indicating its broad involvement in ECM regulation and TGF-β signaling. 4. **Protein-Protein Interactions:** LTBP4 interacts with various ECM components, including collagen, glycosaminoglycans, and elastic fibers, to modulate their organization and function. **Pathways and Functions:** 1. **Calcium Ion Binding:** LTBP4 interacts with calcium ions, which are essential for ECM organization and function. 2. **Collagen-Containing Extracellular Matrix:** LTBP4 is involved in regulating the organization of collagen-containing ECM components, which is critical for maintaining tissue structure and function. 3. **Elastic Fibre Formation:** LTBP4 plays a role in the formation and organization of elastic fibers, which are essential for maintaining tissue elasticity and resilience. 4. **Extracellular Matrix Organization:** LTBP4 is involved in regulating the organization of the ECM, including the arrangement of ECM components and the formation of microfibrils. 5. **Protein Binding:** LTBP4 interacts with various ECM components and signaling molecules, including TGF-β, to modulate their function and signaling. 6. **Signaling by TGF-β Receptor Complex:** LTBP4 is involved in regulating TGF-β signaling through the TGF-β receptor complex, which is critical for various cellular responses. **Clinical Significance:** 1. **Cancer Progression:** Alterations in LTBP4 expression and function have been linked to cancer progression, including tumor growth, invasion, and metastasis. 2. **Fibrotic Diseases:** LTBP4 is involved in regulating ECM organization and function, which is critical for maintaining tissue health. Alterations in LTBP4 expression and function have been linked to fibrotic diseases, including pulmonary fibrosis and liver fibrosis. 3. **Regenerative Medicine:** LTBP4 plays a critical role in regulating ECM organization and function, making it a potential target for regenerative medicine applications, including tissue engineering and wound healing. 4. **Inflammatory Diseases:** LTBP4 is involved in regulating TGF-β signaling, which is critical for maintaining tissue homeostasis. Alterations in LTBP4 expression and function have been linked to inflammatory diseases, including rheumatoid arthritis and atherosclerosis. In conclusion, LTBP4 is a multifunctional protein that plays a critical role in regulating ECM organization and TGF-β signaling. Its involvement in various cellular processes and diseases highlights the importance of LTBP4 in maintaining tissue health and homeostasis. Further research is needed to fully elucidate the mechanisms of LTBP4 and its clinical significance.

Genular Protein ID: 3131286244

Symbol: LTBP4_HUMAN

Name: Latent-transforming growth factor beta-binding protein 4

UniProtKB Accession Codes:

Q8N2S1 O00508 O75412 O75413

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 2 RefSeq 3 SMART 2 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9271198

Title: Sequence and expression of a novel member (LTBP-4) of the family of latent transforming growth factor-beta binding proteins.

PubMed ID: 9271198

DOI: 10.1016/s0014-5793(97)00685-6

PubMed ID: 9660815

Title: Identification and characterization of a new latent transforming growth factor-beta-binding protein, LTBP-4.

PubMed ID: 9660815

DOI: 10.1074/jbc.273.29.18459

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 16157329

Title: Sequential deposition of latent TGF-beta binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts.

PubMed ID: 16157329

DOI: 10.1016/j.yexcr.2005.08.008

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27339457

Title: Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa.

PubMed ID: 27339457

DOI: 10.1016/j.matbio.2016.06.003

PubMed ID: 19836010

Title: Mutations in LTBP4 cause a syndrome of impaired pulmonary, gastrointestinal, genitourinary, musculoskeletal, and dermal development.

PubMed ID: 19836010

DOI: 10.1016/j.ajhg.2009.09.013

PubMed ID: 23440719

Title: LTBP4 genotype predicts age of ambulatory loss in Duchenne muscular dystrophy.

PubMed ID: 23440719

DOI: 10.1002/ana.23819

PubMed ID: 25641372

Title: Genetic modifiers of ambulation in the Cooperative International Neuromuscular Research Group Duchenne Natural History Study.

PubMed ID: 25641372

DOI: 10.1002/ana.24370

Sequence Information:

  • Length: 1624
  • Mass: 173435
  • Checksum: 75682D1F6E40657A
  • Sequence:
    • MPRPGTSGRR PLLLVLLLPL FAAATSAASP SPSPSQVVEV PGVPSRPASV AVCRCCPGQT 
SRRSRCIRAF CRVRSCQPKK CAGPQRCLNP VPAVPSPSPS VRKRQVSLNW QPLTLQEARA 
LLKRRRPRGP GGRGLLRRRP PQRAPAGKAP VLCPLICHNG GVCVKPDRCL CPPDFAGKFC 
QLHSSGARPP APAVPGLTRS VYTMPLANHR DDEHGVASMV SVHVEHPQEA SVVVHQVERV 
SGPWEEADAE AVARAEAAAR AEAAAPYTVL AQSAPREDGY SDASGFGYCF RELRGGECAS 
PLPGLRTQEV CCRGAGLAWG VHDCQLCSER LGNSERVSAP DGPCPTGFER VNGSCEDVDE 
CATGGRCQHG ECANTRGGYT CVCPDGFLLD SSRSSCISQH VISEAKGPCF RVLRDGGCSL 
PILRNITKQI CCCSRVGKAW GRGCQLCPPF GSEGFREICP AGPGYHYSAS DLRYNTRPLG 
QEPPRVSLSQ PRTLPATSRP SAGFLPTHRL EPRPEPRPDP RPGPELPLPS IPAWTGPEIP 
ESGPSSGMCQ RNPQVCGPGR CISRPSGYTC ACDSGFRLSP QGTRCIDVDE CRRVPPPCAP 
GRCENSPGSF RCVCGPGFRA GPRAAECLDV DECHRVPPPC DLGRCENTPG SFLCVCPAGY 
QAAPHGASCQ DVDECTQSPG LCGRGACKNL PGSFRCVCPA GFRGSACEED VDECAQEPPP 
CGPGRCDNTA GSFHCACPAG FRSRGPGAPC QDVDECARSP PPCTYGRCEN TEGSFQCVCP 
MGFQPNTAGS ECEDVDECEN HLACPGQECV NSPGSFQCRT CPSGHHLHRG RCTDVDECSS 
GAPPCGPHGH CTNTEGSFRC SCAPGYRAPS GRPGPCADVN ECLEGDFCFP HGECLNTDGS 
FACTCAPGYR PGPRGASCLD VDECSEEDLC QSGICTNTDG SFECICPPGH RAGPDLASCL 
DVDECRERGP ALCGSQRCEN SPGSYRCVRD CDPGYHAGPE GTCDDVDECQ EYGPEICGAQ 
RCENTPGSYR CTPACDPGYQ PTPGGGCQDV DECRNRSFCG AHAVCQNLPG SFQCLCDQGY 
EGARDGRHCV DVNECETLQG VCGAALCENV EGSFLCVCPN SPEEFDPMTG RCVPPRTSAG 
TFPGSQPQAP ASPVLPARPP PPPLPRRPST PRQGPVGSGR RECYFDTAAP DACDNILARN 
VTWQECCCTV GEGWGSGCRI QQCPGTETAE YQSLCPHGRG YLAPSGDLSL RRDVDECQLF 
RDQVCKSGVC VNTAPGYSCY CSNGYYYHTQ RLECIDNDEC ADEEPACEGG RCVNTVGSYH 
CTCEPPLVLD GSQRRCVSNE SQSLDDNLGV CWQEVGADLV CSHPRLDRQA TYTECCCLYG 
EAWGMDCALC PAQDSDDFEA LCNVLRPPAY SPPRPGGFGL PYEYGPDLGP PYQGLPYGPE 
LYPPPALPYD PYPPPPGPFA RREAPYGAPR FDMPDFEDDG GPYGESEAPA PPGPGTRWPY 
RSRDTRRSFP EPEEPPEGGS YAGSLAEPYE ELEAEECGIL DGCTNGRCVR VPEGFTCRCF 
DGYRLDMTRM ACVDINECDE AEAASPLCVN ARCLNTDGSF RCICRPGFAP THQPHHCAPA 
RPRA

Genular Protein ID: 3316994112

Symbol: A0A0C4DH07_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C4DH07

Database IDs:

ARBA 8 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 10 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 8 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 3 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1587
  • Mass: 169456
  • Checksum: C221635636D13889
  • Sequence:
    • MGDVKALLFV AAARARRLGG AAASESLAVS EAFCRVRSCQ PKKCAGPQRC LNPVPAVPSP 
SPSVRKRQVS LNWQPLTLQE ARALLKRRRP RGPGGRGLLR RRPPQRAPAG KAPVLCPLIC 
HNGGVCVKPD RCLCPPDFAG KFCQLHSSGA RPPAPAVPGL TRSVYTMPLA NHRDDEHGVA 
SMVSVHVEHP QEASVVVHQV ERVSGPWEEA DAEAVARAEA AARAEAAAPY TVLAQSAPRE 
DGYSDASGFG YCFRELRGGE CASPLPGLRT QEVCCRGAGL AWGVHDCQLC SERLGNSERV 
SAPDGPCPTG FERVNGSCED VDECATGGRC QHGECANTRG GYTCVCPDGF LLDSSRSSCI 
SQHVISEAKG PCFRVLRDGG CSLPILRNIT KQICCCSRVG KAWGRGCQLC PPFGSEGFRE 
ICPAGPGYHY SASDLRYNTR PLGQEPPRVS LSQPRTLPAT SRPSAGFLPT HRLEPRPEPR 
PDPRPGPELP LPSIPAWTGP EIPESGPSSG MCQRNPQVCG PGRCISRPSG YTCACDSGFR 
LSPQGTRCID VDECRRVPPP CAPGRCENSP GSFRCVCGPG FRAGPRAAEC LDVDECHRVP 
PPCDLGRCEN TPGSFLCVCP AGYQAAPHGA SCQDVDECTQ SPGLCGRGAC KNLPGSFRCV 
CPAGFRGSAC EEDVDECAQE PPPCGPGRCD NTAGSFHCAC PAGFRSRGPG APCQDVDECA 
RSPPPCTYGR CENTEGSFQC VCPMGFQPNT AGSECEDVDE CENHLACPGQ ECVNSPGSFQ 
CRTCPSGHHL HRGRCTDVDE CSSGAPPCGP HGHCTNTEGS FRCSCAPGYR APSGRPGPCA 
DVNECLEGDF CFPHGECLNT DGSFACTCAP GYRPGPRGAS CLDVDECSEE DLCQSGICTN 
TDGSFECICP PGHRAGPDLA SCLDVDECRE RGPALCGSQR CENSPGSYRC VRDCDPGYHA 
GPEGTCDDVD ECQEYGPEIC GAQRCENTPG SYRCTPACDP GYQPTPGGGC QDVDECRNRS 
FCGAHAVCQN LPGSFQCLCD QGYEGARDGR HCVDVNECET LQGVCGAALC ENVEGSFLCV 
CPNSPEEFDP MTGRCVPPRT SAGTFPGSQP QAPASPVLPA RPPPPPLPRR PSTPRQGPVG 
SGRRECYFDT AAPDACDNIL ARNVTWQECC CTVGEGWGSG CRIQQCPGTE TAEYQSLCPH 
GRGYLAPSGD LSLRRDVDEC QLFRDQVCKS GVCVNTAPGY SCYCSNGYYY HTQRLECIDN 
DECADEEPAC EGGRCVNTVG SYHCTCEPPL VLDGSQRRCV SNESQSLDDN LGVCWQEVGA 
DLVCSHPRLD RQATYTECCC LYGEAWGMDC ALCPAQDSDD FEALCNVLRP PAYSPPRPGG 
FGLPYEYGPD LGPPYQGLPY GPELYPPPAL PYDPYPPPPG PFARREAPYG APRFDMPDFE 
DDGGPYGESE APAPPGPGTR WPYRSRDTRR SFPEPEEPPE GGSYAGSLAE PYEELEAEEC 
GILDGCTNGR CVRVPEGFTC RCFDGYRLDM TRMACVDINE CDEAEAASPL CVNARCLNTD 
GSFRCICRPG FAPTHQPHHC APARPRA

Genular Protein ID: 1219416924

Symbol: B3KXY6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KXY6

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 2 InterPro 9 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 3 SAM 1 SMART 2 SUPFAM 3

Sequence Information:

  • Length: 844
  • Mass: 90751
  • Checksum: 05729D3A8F202D7A
  • Sequence:
    • MGFQPNTAGS ECEDVDECEN HLACPGQECV NSPGSFQCRT CPSGHHLHRG RCTDVDECSS 
GAPPCGPHGH CTNTEGSFRC SCAPGYRAPS GRPGPCADVN ECLEGDFCFP HGECLNTDGS 
FACTCAPGYR PGPRGASCLD VDECSEEDLC QSGICTNTDG SFECICPPGH RAGPDLASCL 
DVDECRERGP ALCGSQRCEN SPGSYRCVRD CDPGYHAGPE GTCDDVDECQ EYGPEICGAQ 
RCENTPGSYR CTPACDPGYQ PTPGGGCQDV DECRNRSFCG AHAVCQNLPG SFQCLCDQGY 
EGARDGRHCV DVNECETLQG VCGAALCENV EGSFLCVCPN SPEEFDPMTG RCVPPRTSAG 
TFPGSQPQAP ASPVLPARPP PPPLPRRPST PRQGPVGSGR RECYFDTAAP DACDNILARN 
VTWQECCCTV GEGWGSGCRI QQCPGTETAE YQSLCPHGRG YLAPSGDLSL RRDVDECQLF 
RDQVCKSGVC VNTAPGYSCY CSNGYYYHTQ RLECIDNDEC ADEEPACEGG RCVNTVGSYH 
CTCEPPLVLD GSQRRCVSNE SQSLDDNLGV CWQEVGADLV CSHPRLDRQA TYTECCCLYG 
EAWGMDCALC PAQDSDDFEA LCNVLRPPAY SPPRPGGFGL PYEYGPDLGP PYQGLPYGPE 
LYPPPALPYD PYPPPPGPFA RREAPYGAPR FDMPDFEDDG GPYGESEAPA PPGPGTRWPY 
RSRDTRRSFP EPEEPPEGGS YAGSLAEPYE ELEAEECGIL DGCTNGRCVR VPEGFTCRCF 
DGYRLDMTRM ACVDINECDE AEAASPLCVN ARCLNTDGSF RCICRPGFAP THQPHHCAPA 
RPRA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.