Details for: TEAD2

Gene ID: 8463

Symbol: TEAD2

Ensembl ID: ENSG00000074219

Description: TEA domain transcription factor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 125.1405
    Cell Significance Index: -19.4700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 76.7613
    Cell Significance Index: -19.4700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 40.4026
    Cell Significance Index: -19.0800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 37.4640
    Cell Significance Index: -15.2200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.9310
    Cell Significance Index: -15.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.9112
    Cell Significance Index: -19.3800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 3.8470
    Cell Significance Index: 61.7200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.3701
    Cell Significance Index: 49.6100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.0641
    Cell Significance Index: 22.4400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.7298
    Cell Significance Index: 60.1100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.5804
    Cell Significance Index: 20.2400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.4892
    Cell Significance Index: 11.8900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2202
    Cell Significance Index: 232.2200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.1185
    Cell Significance Index: 6.9200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.0584
    Cell Significance Index: 8.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8885
    Cell Significance Index: 46.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8372
    Cell Significance Index: 82.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6384
    Cell Significance Index: 74.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5498
    Cell Significance Index: 496.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4767
    Cell Significance Index: 65.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4446
    Cell Significance Index: 72.3100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4176
    Cell Significance Index: 7.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3417
    Cell Significance Index: 186.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2709
    Cell Significance Index: 53.7600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2453
    Cell Significance Index: 6.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2002
    Cell Significance Index: 13.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1814
    Cell Significance Index: 23.2600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1430
    Cell Significance Index: 98.9300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1171
    Cell Significance Index: 1.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0930
    Cell Significance Index: 5.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0749
    Cell Significance Index: 3.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0742
    Cell Significance Index: 9.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0650
    Cell Significance Index: 28.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0576
    Cell Significance Index: 4.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0530
    Cell Significance Index: 2.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0524
    Cell Significance Index: 8.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0417
    Cell Significance Index: 26.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0350
    Cell Significance Index: 0.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0162
    Cell Significance Index: 0.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0139
    Cell Significance Index: 1.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0056
    Cell Significance Index: 0.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0051
    Cell Significance Index: 9.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0018
    Cell Significance Index: 2.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0012
    Cell Significance Index: 0.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0006
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0050
    Cell Significance Index: -6.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0101
    Cell Significance Index: -7.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0117
    Cell Significance Index: -8.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0133
    Cell Significance Index: -8.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0146
    Cell Significance Index: -0.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0162
    Cell Significance Index: -7.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0166
    Cell Significance Index: -2.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0190
    Cell Significance Index: -13.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0227
    Cell Significance Index: -12.8300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0371
    Cell Significance Index: -0.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0379
    Cell Significance Index: -6.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0426
    Cell Significance Index: -8.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0451
    Cell Significance Index: -5.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0517
    Cell Significance Index: -14.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0522
    Cell Significance Index: -18.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0628
    Cell Significance Index: -1.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0755
    Cell Significance Index: -8.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0845
    Cell Significance Index: -16.9600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0964
    Cell Significance Index: -4.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1002
    Cell Significance Index: -10.2400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1171
    Cell Significance Index: -2.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1405
    Cell Significance Index: -4.5000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1430
    Cell Significance Index: -16.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1562
    Cell Significance Index: -18.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1758
    Cell Significance Index: -18.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1769
    Cell Significance Index: -12.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1784
    Cell Significance Index: -10.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2068
    Cell Significance Index: -16.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2284
    Cell Significance Index: -14.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2501
    Cell Significance Index: -7.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2664
    Cell Significance Index: -7.2500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2736
    Cell Significance Index: -8.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2823
    Cell Significance Index: -7.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2863
    Cell Significance Index: -18.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2976
    Cell Significance Index: -20.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3157
    Cell Significance Index: -19.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4039
    Cell Significance Index: -20.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4063
    Cell Significance Index: -21.3300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.4067
    Cell Significance Index: -2.1400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4387
    Cell Significance Index: -6.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4447
    Cell Significance Index: -19.6700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4505
    Cell Significance Index: -18.4600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4763
    Cell Significance Index: -20.7100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5092
    Cell Significance Index: -13.0900
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: -0.5165
    Cell Significance Index: -3.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5188
    Cell Significance Index: -19.6500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5491
    Cell Significance Index: -19.2400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5685
    Cell Significance Index: -20.8700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5918
    Cell Significance Index: -12.6500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5974
    Cell Significance Index: -19.5600
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.6035
    Cell Significance Index: -3.7900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6121
    Cell Significance Index: -19.5000
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.6286
    Cell Significance Index: -3.6900
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.6318
    Cell Significance Index: -3.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** TEAD2 contains a TEA domain, a transcriptional activation domain, and a DNA-binding domain, enabling it to interact with coactivators and corepressors to modulate gene expression. 2. **Cellular localization:** TEAD2 is primarily localized in the nucleus, where it regulates transcription by interacting with RNA polymerase II and other transcription factors. 3. **Interactions:** TEAD2 interacts with various coactivators and corepressors, including YAP1 and WWTR1 (Taz), to modulate gene expression. 4. **Target genes:** TEAD2 regulates the transcription of genes involved in developmental processes, including embryonic heart tube morphogenesis, embryonic organ development, and gastrulation. **Pathways and Functions:** 1. **Cellular response to retinoic acid:** TEAD2 regulates the transcription of retinoic acid-responsive genes, influencing cell proliferation and differentiation. 2. **Chromatin remodeling:** TEAD2 interacts with chromatin remodeling complexes to modulate gene expression and regulate chromatin structure. 3. **Developmental biology:** TEAD2 plays a critical role in embryonic heart tube morphogenesis, embryonic organ development, and gastrulation, influencing the formation of axial mesoderm, paraxial mesoderm, and notochord. 4. **Stem cell differentiation:** TEAD2 regulates the transcription of genes involved in stem cell differentiation, influencing the fate of mesodermal cells and neural crest cells. **Clinical Significance:** 1. **Cancer:** TEAD2 is overexpressed in various cancers, including breast, lung, and colon cancer, suggesting its role in tumorigenesis and cancer progression. 2. **Cardiovascular disease:** TEAD2 regulates the transcription of genes involved in cardiovascular development and function, highlighting its potential role in cardiovascular disease. 3. **Neurological disorders:** TEAD2 interacts with transcription factors involved in neurological development and function, suggesting its potential involvement in neurological disorders, such as autism and schizophrenia. 4. **Regenerative medicine:** TEAD2 regulates the transcription of genes involved in tissue repair and regeneration, making it a potential target for regenerative therapies. In conclusion, TEAD2 is a key transcription factor involved in regulating gene expression during developmental processes and has significant implications for human disease. Further investigation into the molecular mechanisms of TEAD2 and its interactions with coactivators and corepressors is necessary to fully understand its role in human biology and disease.

Genular Protein ID: 1204928876

Symbol: TEAD2_HUMAN

Name: Transcriptional enhancer factor TEF-4

UniProtKB Accession Codes:

Q15562 B4DTJ6 M0R1T9 Q8NA25 Q96IG3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 9 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 31 PDBsum 31 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8702974

Title: A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain.

PubMed ID: 8702974

DOI: 10.1074/jbc.271.36.21775

PubMed ID: 18579750

Title: TEAD mediates YAP-dependent gene induction and growth control.

PubMed ID: 18579750

DOI: 10.1101/gad.1664408

PubMed ID: 19324877

Title: TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition.

PubMed ID: 19324877

DOI: 10.1074/jbc.m900843200

Sequence Information:

  • Length: 447
  • Mass: 49243
  • Checksum: A9077F55638A3AC7
  • Sequence:
    • MGEPRAGAAL DDGSGWTGSE EGSEEGTGGS EGAGGDGGPD AEGVWSPDIE QSFQEALAIY 
PPCGRRKIIL SDEGKMYGRN ELIARYIKLR TGKTRTRKQV SSHIQVLARR KSREIQSKLK 
DQVSKDKAFQ TMATMSSAQL ISAPSLQAKL GPTGPQASEL FQFWSGGSGP PWNVPDVKPF 
SQTPFTLSLT PPSTDLPGYE PPQALSPLPP PTPSPPAWQA RGLGTARLQL VEFSAFVEPP 
DAVDSYQRHL FVHISQHCPS PGAPPLESVD VRQIYDKFPE KKGGLRELYD RGPPHAFFLV 
KFWADLNWGP SGEEAGAGGS ISSGGFYGVS SQYESLEHMT LTCSSKVCSF GKQVVEKVET 
ERAQLEDGRF VYRLLRSPMC EYLVNFLHKL RQLPERYMMN SVLENFTILQ VVTNRDTQEL 
LLCTAYVFEV STSERGAQHH IYRLVRD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.