Details for: OGT

Gene ID: 8473

Symbol: OGT

Ensembl ID: ENSG00000147162

Description: O-linked N-acetylglucosamine (GlcNAc) transferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 385.7399
    Cell Significance Index: -60.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 227.4650
    Cell Significance Index: -57.7000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 151.4998
    Cell Significance Index: -62.4100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 135.4097
    Cell Significance Index: -63.9300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 130.7300
    Cell Significance Index: -53.1100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 120.5711
    Cell Significance Index: -62.0200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 55.7742
    Cell Significance Index: -53.2500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 49.3692
    Cell Significance Index: -60.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 21.9235
    Cell Significance Index: -58.7300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.0343
    Cell Significance Index: -52.3200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.7360
    Cell Significance Index: -62.1000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.0136
    Cell Significance Index: -30.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.4595
    Cell Significance Index: 96.6800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.3146
    Cell Significance Index: 45.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1768
    Cell Significance Index: 436.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.9852
    Cell Significance Index: 51.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.7765
    Cell Significance Index: 136.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.7258
    Cell Significance Index: 111.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7048
    Cell Significance Index: 338.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.6315
    Cell Significance Index: 100.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5282
    Cell Significance Index: 548.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4646
    Cell Significance Index: 159.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.2590
    Cell Significance Index: 55.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.2174
    Cell Significance Index: 46.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.1138
    Cell Significance Index: 62.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0048
    Cell Significance Index: 60.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8310
    Cell Significance Index: 574.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8091
    Cell Significance Index: 730.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7986
    Cell Significance Index: 143.9700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.7701
    Cell Significance Index: 18.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7648
    Cell Significance Index: 94.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7516
    Cell Significance Index: 50.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7072
    Cell Significance Index: 33.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6032
    Cell Significance Index: 82.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5803
    Cell Significance Index: 94.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5458
    Cell Significance Index: 24.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5416
    Cell Significance Index: 1019.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.5200
    Cell Significance Index: 236.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4221
    Cell Significance Index: 11.4900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.4158
    Cell Significance Index: 10.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4060
    Cell Significance Index: 221.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3823
    Cell Significance Index: 519.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3706
    Cell Significance Index: 163.8400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3627
    Cell Significance Index: 42.7800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3229
    Cell Significance Index: 9.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2864
    Cell Significance Index: 181.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1881
    Cell Significance Index: 18.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1788
    Cell Significance Index: 275.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1731
    Cell Significance Index: 8.0700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1126
    Cell Significance Index: 1.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1014
    Cell Significance Index: 187.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0896
    Cell Significance Index: 15.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0816
    Cell Significance Index: 15.5300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0689
    Cell Significance Index: 0.9900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0165
    Cell Significance Index: 1.1700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0191
    Cell Significance Index: -0.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0225
    Cell Significance Index: -0.6000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0278
    Cell Significance Index: -0.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0300
    Cell Significance Index: -4.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0386
    Cell Significance Index: -28.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0404
    Cell Significance Index: -5.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0427
    Cell Significance Index: -31.3000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0505
    Cell Significance Index: -6.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0519
    Cell Significance Index: -39.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0561
    Cell Significance Index: -35.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0571
    Cell Significance Index: -4.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0886
    Cell Significance Index: -49.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0972
    Cell Significance Index: -5.0500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1054
    Cell Significance Index: -2.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1178
    Cell Significance Index: -4.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1366
    Cell Significance Index: -3.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1530
    Cell Significance Index: -15.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1580
    Cell Significance Index: -4.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1636
    Cell Significance Index: -34.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1880
    Cell Significance Index: -54.0900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2405
    Cell Significance Index: -3.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2901
    Cell Significance Index: -15.1100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3147
    Cell Significance Index: -35.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3299
    Cell Significance Index: -37.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3517
    Cell Significance Index: -36.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3756
    Cell Significance Index: -43.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3800
    Cell Significance Index: -9.5000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5366
    Cell Significance Index: -15.7600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5520
    Cell Significance Index: -11.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5633
    Cell Significance Index: -35.5000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5950
    Cell Significance Index: -3.6000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.6051
    Cell Significance Index: -4.1000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6479
    Cell Significance Index: -8.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6747
    Cell Significance Index: -21.6100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6952
    Cell Significance Index: -55.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7410
    Cell Significance Index: -38.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7831
    Cell Significance Index: -48.0100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.9004
    Cell Significance Index: -12.9500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.9302
    Cell Significance Index: -21.4900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.9415
    Cell Significance Index: -47.5800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.9447
    Cell Significance Index: -24.8400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.9458
    Cell Significance Index: -17.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9630
    Cell Significance Index: -25.7600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.9796
    Cell Significance Index: -21.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.0098
    Cell Significance Index: -35.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **O-GlcNAcylation**: OGT catalyzes the transfer of a GlcNAc moiety from UDP-GlcNAc to specific serine or threonine residues on proteins, resulting in the formation of O-GlcNAcylated proteins. 2. **Cellular localization**: OGT is primarily localized to the cytosol and nucleus, where it interacts with various proteins and regulates cellular processes. 3. **Subcellular localization**: OGT is also found in the nucleus, where it interacts with chromatin-modifying enzymes and regulates gene expression. 4. **Regulatory mechanisms**: OGT is regulated by various mechanisms, including phosphorylation, ubiquitination, and interaction with other proteins. **Pathways and Functions:** 1. **Metabolism**: OGT regulates glucose metabolism by phosphorylating and activating key enzymes involved in glycolysis, gluconeogenesis, and glycogen synthesis. 2. **Cell signaling**: OGT modulates signaling pathways involved in cell growth, differentiation, and survival, including the insulin receptor signaling pathway and the MAPK/ERK pathway. 3. **Epigenetic regulation**: OGT interacts with chromatin-modifying enzymes to regulate gene expression, including the regulation of transcription by RNA polymerase II and the modification of histones. 4. **Cell migration and adhesion**: OGT regulates cell migration and adhesion by phosphorylating and activating key proteins involved in these processes. 5. **Stem cell maintenance**: OGT maintains stem cell populations by regulating the expression of key transcription factors and the activity of stem cell-specific proteins. **Clinical Significance:** 1. **Cancer**: OGT has been implicated in the development and progression of various cancers, including breast, lung, and colon cancer. 2. **Neurological disorders**: OGT has been linked to neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 3. **Metabolic disorders**: OGT regulates glucose and lipid metabolism, making it a potential target for the treatment of metabolic disorders, such as type 2 diabetes and obesity. 4. **Cardiovascular disease**: OGT has been implicated in the development of cardiovascular disease, including atherosclerosis and heart failure. In conclusion, OGT is a crucial enzyme that regulates various cellular processes through O-GlcNAcylation. Its dysregulation has been implicated in various diseases, making it a potential target for therapeutic interventions. Further research is needed to fully elucidate the mechanisms of OGT and its role in human disease.

Genular Protein ID: 1704524164

Symbol: OGT1_HUMAN

Name: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9083068

Title: O-linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats.

PubMed ID: 9083068

DOI: 10.1074/jbc.272.14.9316

PubMed ID: 11773972

Title: Human O-GlcNAc transferase (OGT): genomic structure, analysis of splice variants, fine mapping in Xq13.1.

PubMed ID: 11773972

DOI: 10.1007/s00335-001-2108-9

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12150998

Title: Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression.

PubMed ID: 12150998

DOI: 10.1016/s0092-8674(02)00810-3

PubMed ID: 12670868

Title: Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.

PubMed ID: 12670868

DOI: 10.1101/gad.252103

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19451179

Title: Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease.

PubMed ID: 19451179

DOI: 10.1093/brain/awp099

PubMed ID: 19073609

Title: Up-regulation of O-GlcNAc transferase with glucose deprivation in HepG2 cells is mediated by decreased hexosamine pathway flux.

PubMed ID: 19073609

DOI: 10.1074/jbc.m803198200

PubMed ID: 19377461

Title: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.

PubMed ID: 19377461

DOI: 10.1038/nature07954

PubMed ID: 24336203

Title: Retraction: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.

PubMed ID: 24336203

DOI: 10.1038/nature12896

PubMed ID: 20018852

Title: Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex.

PubMed ID: 20018852

DOI: 10.1074/jbc.c109.087981

PubMed ID: 20018868

Title: Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes.

PubMed ID: 20018868

DOI: 10.1074/jbc.m109.077818

PubMed ID: 20200153

Title: The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias.

PubMed ID: 20200153

DOI: 10.1074/jbc.m109.072579

PubMed ID: 20824293

Title: Elevated O-GlcNAc-dependent signaling through inducible mOGT expression selectively triggers apoptosis.

PubMed ID: 20824293

DOI: 10.1007/s00726-010-0719-8

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22121020

Title: GlcNAcylation of histone H2B facilitates its monoubiquitination.

PubMed ID: 22121020

DOI: 10.1038/nature10656

PubMed ID: 21285374

Title: Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway.

PubMed ID: 21285374

DOI: 10.1073/pnas.1013822108

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 22923583

Title: Phosphofructokinase 1 glycosylation regulates cell growth and metabolism.

PubMed ID: 22923583

DOI: 10.1126/science.1222278

PubMed ID: 23353889

Title: TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS.

PubMed ID: 23353889

DOI: 10.1038/emboj.2012.357

PubMed ID: 23629655

Title: Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1).

PubMed ID: 23629655

DOI: 10.1074/jbc.m112.439729

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23222540

Title: TET2 promotes histone O-GlcNAcylation during gene transcription.

PubMed ID: 23222540

DOI: 10.1038/nature11742

PubMed ID: 24995978

Title: Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase.

PubMed ID: 24995978

DOI: 10.1016/j.cell.2014.06.007

PubMed ID: 24563466

Title: Cross-talk between two essential nutrient-sensitive enzymes: O-GlcNAc transferase (OGT) and AMP-activated protein kinase (AMPK).

PubMed ID: 24563466

DOI: 10.1074/jbc.m113.523068

PubMed ID: 24474760

Title: O-GlcNAcylation regulates EZH2 protein stability and function.

PubMed ID: 24474760

DOI: 10.1073/pnas.1323226111

PubMed ID: 26678539

Title: Mixed lineage leukemia 5 (MLL5) protein stability is cooperatively regulated by O-GlcNac transferase (OGT) and ubiquitin specific protease 7 (USP7).

PubMed ID: 26678539

DOI: 10.1371/journal.pone.0145023

PubMed ID: 26369908

Title: Identification and biological consequences of the O-GlcNAc modification of the human innate immune receptor, Nod2.

PubMed ID: 26369908

DOI: 10.1093/glycob/cwv076

PubMed ID: 27527864

Title: O-GlcNAcylation of ATG4B positively regulates autophagy by increasing its hydroxylase activity.

PubMed ID: 27527864

DOI: 10.18632/oncotarget.11083

PubMed ID: 27713473

Title: Identification of the nuclear localisation signal of O-GlcNAc transferase and its nuclear import regulation.

PubMed ID: 27713473

DOI: 10.1038/srep34614

PubMed ID: 28742148

Title: Hijacking of the O-GlcNAcZYME complex by the HTLV-1 Tax oncoprotein facilitates viral transcription.

PubMed ID: 28742148

DOI: 10.1371/journal.ppat.1006518

PubMed ID: 30699359

Title: Post-translational regulation of FNIP1 creates a rheostat for the molecular chaperone Hsp90.

PubMed ID: 30699359

DOI: 10.1016/j.celrep.2019.01.018

PubMed ID: 31527085

Title: O-GlcNAcylation of Thr12/Ser56 in short-form O-GlcNAc transferase (sOGT) regulates its substrate selectivity.

PubMed ID: 31527085

DOI: 10.1074/jbc.ra119.009085

PubMed ID: 34074792

Title: Interaction hot spots for phase separation revealed by NMR studies of a CAPRIN1 condensed phase.

PubMed ID: 34074792

DOI: 10.1073/pnas.2104897118

PubMed ID: 34667079

Title: PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands.

PubMed ID: 34667079

DOI: 10.26508/lsa.202101228

PubMed ID: 37541260

Title: O-GlcNAcylation of Raptor transduces glucose signals to mTORC1.

PubMed ID: 37541260

DOI: 10.1016/j.molcel.2023.07.011

PubMed ID: 37962578

Title: O-GlcNAc modification of GSDMD attenuates LPS-induced endothelial cells pyroptosis.

PubMed ID: 37962578

DOI: 10.1007/s00011-023-01812-1

PubMed ID: 15361863

Title: The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha.

PubMed ID: 15361863

DOI: 10.1038/nsmb833

PubMed ID: 21240259

Title: Structure of human O-GlcNAc transferase and its complex with a peptide substrate.

PubMed ID: 21240259

DOI: 10.1038/nature09638

PubMed ID: 23103939

Title: Structural snapshots of the reaction coordinate for O-GlcNAc transferase.

PubMed ID: 23103939

DOI: 10.1038/nchembio.1109

PubMed ID: 26237509

Title: The active site of O-GlcNAc transferase imposes constraints on substrate sequence.

PubMed ID: 26237509

DOI: 10.1038/nsmb.3063

PubMed ID: 26273451

Title: Nonsyndromic X-linked intellectual deficiency in three brothers with a novel MED12 missense mutation [c.5922G>T (p.Glu1974His)].

PubMed ID: 26273451

DOI: 10.1002/ccr3.301

PubMed ID: 28302723

Title: Identification and characterization of a missense mutation in the O-linked beta-N-acetylglucosamine (O-GlcNAc) transferase gene that segregates with X-linked intellectual disability.

PubMed ID: 28302723

DOI: 10.1074/jbc.m116.771030

PubMed ID: 28584052

Title: Mutations in N-acetylglucosamine (O-GlcNAc) transferase in patients with X-linked intellectual disability.

PubMed ID: 28584052

DOI: 10.1074/jbc.m117.790097

Sequence Information:

  • Length: 1046
  • Mass: 116925
  • Checksum: 852ED68BDDE63363
  • Sequence:
  • MASSVGNVAD STEPTKRMLS FQGLAELAHR EYQAGDFEAA ERHCMQLWRQ EPDNTGVLLL 
    LSSIHFQCRR LDRSAHFSTL AIKQNPLLAE AYSNLGNVYK ERGQLQEAIE HYRHALRLKP 
    DFIDGYINLA AALVAAGDME GAVQAYVSAL QYNPDLYCVR SDLGNLLKAL GRLEEAKACY 
    LKAIETQPNF AVAWSNLGCV FNAQGEIWLA IHHFEKAVTL DPNFLDAYIN LGNVLKEARI 
    FDRAVAAYLR ALSLSPNHAV VHGNLACVYY EQGLIDLAID TYRRAIELQP HFPDAYCNLA 
    NALKEKGSVA EAEDCYNTAL RLCPTHADSL NNLANIKREQ GNIEEAVRLY RKALEVFPEF 
    AAAHSNLASV LQQQGKLQEA LMHYKEAIRI SPTFADAYSN MGNTLKEMQD VQGALQCYTR 
    AIQINPAFAD AHSNLASIHK DSGNIPEAIA SYRTALKLKP DFPDAYCNLA HCLQIVCDWT 
    DYDERMKKLV SIVADQLEKN RLPSVHPHHS MLYPLSHGFR KAIAERHGNL CLDKINVLHK 
    PPYEHPKDLK LSDGRLRVGY VSSDFGNHPT SHLMQSIPGM HNPDKFEVFC YALSPDDGTN 
    FRVKVMAEAN HFIDLSQIPC NGKAADRIHQ DGIHILVNMN GYTKGARNEL FALRPAPIQA 
    MWLGYPGTSG ALFMDYIITD QETSPAEVAE QYSEKLAYMP HTFFIGDHAN MFPHLKKKAV 
    IDFKSNGHIY DNRIVLNGID LKAFLDSLPD VKIVKMKCPD GGDNADSSNT ALNMPVIPMN 
    TIAEAVIEMI NRGQIQITIN GFSISNGLAT TQINNKAATG EEVPRTIIVT TRSQYGLPED 
    AIVYCNFNQL YKIDPSTLQM WANILKRVPN SVLWLLRFPA VGEPNIQQYA QNMGLPQNRI 
    IFSPVAPKEE HVRRGQLADV CLDTPLCNGH TTGMDVLWAG TPMVTMPGET LASRVAASQL 
    TCLGCLELIA KNRQEYEDIA VKLGTDLEYL KKVRGKVWKQ RISSPLFNTK QYTMELERLY 
    LQMWEHYAAG NKPDHMIKPV EVTESA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.