Details for: DENR

Gene ID: 8562

Symbol: DENR

Ensembl ID: ENSG00000139726

Description: density regulated re-initiation and release factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 264.6819
    Cell Significance Index: -41.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 139.0141
    Cell Significance Index: -35.2600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 116.9809
    Cell Significance Index: -48.1900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 99.5504
    Cell Significance Index: -47.0000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 89.6410
    Cell Significance Index: -46.1100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 70.1914
    Cell Significance Index: -47.1000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.6518
    Cell Significance Index: -45.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.7936
    Cell Significance Index: -39.6300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.7155
    Cell Significance Index: -46.2300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.3529
    Cell Significance Index: -34.8700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.4399
    Cell Significance Index: -20.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.0043
    Cell Significance Index: 40.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.5607
    Cell Significance Index: 69.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.8211
    Cell Significance Index: 198.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.5007
    Cell Significance Index: 40.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4856
    Cell Significance Index: 294.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4762
    Cell Significance Index: 266.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4500
    Cell Significance Index: 178.3000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4452
    Cell Significance Index: 235.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3767
    Cell Significance Index: 88.8200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2272
    Cell Significance Index: 246.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0890
    Cell Significance Index: 594.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9941
    Cell Significance Index: 46.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9375
    Cell Significance Index: 128.7500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.9263
    Cell Significance Index: 8.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8912
    Cell Significance Index: 30.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8423
    Cell Significance Index: 99.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7496
    Cell Significance Index: 38.9400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7366
    Cell Significance Index: 325.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6951
    Cell Significance Index: 49.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6670
    Cell Significance Index: 18.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6224
    Cell Significance Index: 29.0200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6029
    Cell Significance Index: 12.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5834
    Cell Significance Index: 15.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5786
    Cell Significance Index: 207.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5715
    Cell Significance Index: 16.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5074
    Cell Significance Index: 65.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4598
    Cell Significance Index: 20.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4095
    Cell Significance Index: 25.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4046
    Cell Significance Index: 365.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3923
    Cell Significance Index: 8.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3202
    Cell Significance Index: 20.1800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3089
    Cell Significance Index: 30.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3054
    Cell Significance Index: 8.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1582
    Cell Significance Index: 8.8800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1273
    Cell Significance Index: 24.2300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1251
    Cell Significance Index: 2.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1218
    Cell Significance Index: 15.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1181
    Cell Significance Index: 20.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0797
    Cell Significance Index: 55.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0538
    Cell Significance Index: 4.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0498
    Cell Significance Index: 1.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0364
    Cell Significance Index: 1.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0276
    Cell Significance Index: 51.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0254
    Cell Significance Index: 0.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0208
    Cell Significance Index: 1.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0190
    Cell Significance Index: 35.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0184
    Cell Significance Index: 28.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0146
    Cell Significance Index: 0.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0070
    Cell Significance Index: 4.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0057
    Cell Significance Index: 0.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0017
    Cell Significance Index: 1.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0016
    Cell Significance Index: -2.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0055
    Cell Significance Index: -4.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0095
    Cell Significance Index: -5.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0116
    Cell Significance Index: -8.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0392
    Cell Significance Index: -17.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0568
    Cell Significance Index: -32.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0634
    Cell Significance Index: -6.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0732
    Cell Significance Index: -4.9200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0864
    Cell Significance Index: -0.6900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0957
    Cell Significance Index: -1.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0989
    Cell Significance Index: -20.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1306
    Cell Significance Index: -37.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1310
    Cell Significance Index: -15.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1690
    Cell Significance Index: -24.5700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1692
    Cell Significance Index: -1.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1719
    Cell Significance Index: -20.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1775
    Cell Significance Index: -7.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1867
    Cell Significance Index: -3.2000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1908
    Cell Significance Index: -21.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2425
    Cell Significance Index: -9.1800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2468
    Cell Significance Index: -5.9200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2931
    Cell Significance Index: -5.7200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3364
    Cell Significance Index: -5.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3415
    Cell Significance Index: -9.7900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3445
    Cell Significance Index: -8.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4102
    Cell Significance Index: -42.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4148
    Cell Significance Index: -32.8500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4279
    Cell Significance Index: -2.5900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5205
    Cell Significance Index: -9.6200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.5427
    Cell Significance Index: -3.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5650
    Cell Significance Index: -34.6400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6120
    Cell Significance Index: -19.6000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.6130
    Cell Significance Index: -7.8500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6294
    Cell Significance Index: -17.9600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7277
    Cell Significance Index: -21.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7634
    Cell Significance Index: -20.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8310
    Cell Significance Index: -21.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8868
    Cell Significance Index: -29.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** DENR is a small, RNA-binding protein that interacts with ribosomes and mRNA to regulate translation initiation. 2. **Function:** DENR facilitates the re-initiation of translation and the release of ribosomes from mRNA, allowing for the regulation of protein synthesis. 3. **Binding Specificity:** DENR binds to specific sequences on mRNA, including Ires (Internal Ribosome Entry Site) elements, which are involved in viral translation initiation. 4. **Regulation:** DENR is regulated by post-translational modifications, such as phosphorylation, which can affect its activity and interaction with other proteins. **Pathways and Functions:** 1. **Translation Initiation:** DENR is involved in the formation of the translation preinitiation complex (PIC) and the re-initiation of translation. 2. **Ribosome Disassembly:** DENR regulates the release of ribosomes from mRNA, allowing for the regulation of protein synthesis. 3. **Ires-dependent Viral Translational Initiation:** DENR interacts with Ires elements on viral mRNA, facilitating the initiation of translation. 4. **Cellular Regulation:** DENR plays a role in regulating protein synthesis in response to changes in cellular conditions, such as growth and differentiation. **Clinical Significance:** 1. **Cancer:** DENR has been implicated in the regulation of protein synthesis in cancer cells, where it may contribute to tumorigenesis and progression. 2. **Neurological Disorders:** DENR is expressed in neurons and has been linked to neurological disorders, such as Parkinson's disease and Alzheimer's disease. 3. **Immunological Disorders:** DENR is expressed in hematopoietic cells and has been implicated in immunological disorders, such as B-cell development and function. 4. **Infectious Diseases:** DENR's interaction with Ires elements on viral mRNA suggests its potential role in regulating viral translation and infection. In conclusion, DENR is a critical protein that regulates translation initiation and ribosome disassembly, with implications for cellular regulation, cancer, neurological disorders, immunological disorders, and infectious diseases. Further research is needed to fully understand the mechanisms of DENR and its role in these diseases.

Genular Protein ID: 983695057

Symbol: DENR_HUMAN

Name: Density-regulated protein

UniProtKB Accession Codes:

O43583 Q9H3U6 Q9UKZ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9628587

Title: Drp, a novel protein expressed at high cell density but not during growth arrest.

PubMed ID: 9628587

DOI: 10.1089/dna.1998.17.437

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10497265

Title: Identification of differentially expressed genes associated with HER-2/neu overexpression in human breast cancer cells.

PubMed ID: 10497265

DOI: 10.1093/nar/27.20.4008

PubMed ID: 16982740

Title: MCT-1 protein interacts with the cap complex and modulates messenger RNA translational profiles.

PubMed ID: 16982740

DOI: 10.1158/0008-5472.can-06-1999

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17878526

Title: Post-transcriptional control of the MCT-1-associated protein DENR/DRP by RNA-binding protein AUF1.

PubMed ID: 17878526

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20713520

Title: Activities of ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling.

PubMed ID: 20713520

DOI: 10.1101/gad.1957510

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 37875108

Title: Human MCTS1-dependent translation of JAK2 is essential for IFN-gamma immunity to mycobacteria.

PubMed ID: 37875108

DOI: 10.1016/j.cell.2023.09.024

Sequence Information:

  • Length: 198
  • Mass: 22092
  • Checksum: 023F70E0C6C0B25D
  • Sequence:
    • MAADISESSG ADCKGDPRNS AKLDADYPLR VLYCGVCSLP TEYCEYMPDV AKCRQWLEKN 
FPNEFAKLTV ENSPKQEAGI SEGQGTAGEE EEKKKQKRGG RGQIKQKKKT VPQKVTIAKI 
PRAKKKYVTR VCGLATFEID LKEAQRFFAQ KFSCGASVTG EDEIIIQGDF TDDIIDVIQE 
KWPEVDDDSI EDLGEVKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.