Details for: SSNA1

Gene ID: 8636

Symbol: SSNA1

Ensembl ID: ENSG00000176101

Description: SS nuclear autoantigen 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 231.4439
    Cell Significance Index: -36.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 168.8788
    Cell Significance Index: -42.8400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 121.8359
    Cell Significance Index: -50.1900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 108.3617
    Cell Significance Index: -51.1600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 99.0892
    Cell Significance Index: -50.9700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 76.5101
    Cell Significance Index: -51.3400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 39.3607
    Cell Significance Index: -48.5300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.3247
    Cell Significance Index: -52.5800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.9780
    Cell Significance Index: -36.7900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.5264
    Cell Significance Index: -25.5200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.5659
    Cell Significance Index: -14.3700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.4941
    Cell Significance Index: 20.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.1257
    Cell Significance Index: 99.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.0115
    Cell Significance Index: 1816.2200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.8172
    Cell Significance Index: 53.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4751
    Cell Significance Index: 95.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.4128
    Cell Significance Index: 66.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3599
    Cell Significance Index: 742.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3521
    Cell Significance Index: 243.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3342
    Cell Significance Index: 164.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2965
    Cell Significance Index: 67.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2947
    Cell Significance Index: 17.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2534
    Cell Significance Index: 147.8100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1446
    Cell Significance Index: 80.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1349
    Cell Significance Index: 51.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1169
    Cell Significance Index: 493.8300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1066
    Cell Significance Index: 10.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9003
    Cell Significance Index: 146.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8895
    Cell Significance Index: 122.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8706
    Cell Significance Index: 60.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7838
    Cell Significance Index: 20.6100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.7746
    Cell Significance Index: 8.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7481
    Cell Significance Index: 74.0000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7047
    Cell Significance Index: 14.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6956
    Cell Significance Index: 15.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5770
    Cell Significance Index: 16.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4481
    Cell Significance Index: 15.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4383
    Cell Significance Index: 11.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4365
    Cell Significance Index: 22.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3271
    Cell Significance Index: 42.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3252
    Cell Significance Index: 65.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3176
    Cell Significance Index: 8.4800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3137
    Cell Significance Index: 4.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2820
    Cell Significance Index: 21.0200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2569
    Cell Significance Index: 5.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2492
    Cell Significance Index: 31.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2301
    Cell Significance Index: 14.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2238
    Cell Significance Index: 42.5900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1720
    Cell Significance Index: 1.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1677
    Cell Significance Index: 33.2900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1060
    Cell Significance Index: 1.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0911
    Cell Significance Index: 2.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0903
    Cell Significance Index: 68.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0832
    Cell Significance Index: 29.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0528
    Cell Significance Index: 1.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0265
    Cell Significance Index: 4.5200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0096
    Cell Significance Index: 0.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0083
    Cell Significance Index: -6.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0125
    Cell Significance Index: -23.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0143
    Cell Significance Index: -9.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0215
    Cell Significance Index: -2.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0263
    Cell Significance Index: -1.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0305
    Cell Significance Index: -56.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0338
    Cell Significance Index: -52.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0360
    Cell Significance Index: -48.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0514
    Cell Significance Index: -38.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0559
    Cell Significance Index: -35.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0603
    Cell Significance Index: -1.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0833
    Cell Significance Index: -46.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0919
    Cell Significance Index: -57.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1030
    Cell Significance Index: -46.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1393
    Cell Significance Index: -40.1000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1660
    Cell Significance Index: -4.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2161
    Cell Significance Index: -25.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2659
    Cell Significance Index: -30.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2749
    Cell Significance Index: -57.9000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2766
    Cell Significance Index: -4.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2786
    Cell Significance Index: -9.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2841
    Cell Significance Index: -41.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4224
    Cell Significance Index: -11.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4836
    Cell Significance Index: -38.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4966
    Cell Significance Index: -51.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5118
    Cell Significance Index: -39.2800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5470
    Cell Significance Index: -7.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5586
    Cell Significance Index: -37.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5782
    Cell Significance Index: -35.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5790
    Cell Significance Index: -15.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6532
    Cell Significance Index: -19.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6733
    Cell Significance Index: -37.7800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6844
    Cell Significance Index: -7.0900
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.7410
    Cell Significance Index: -5.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7772
    Cell Significance Index: -22.2800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7785
    Cell Significance Index: -9.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7833
    Cell Significance Index: -19.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8084
    Cell Significance Index: -49.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.8789
    Cell Significance Index: -45.7800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9476
    Cell Significance Index: -5.7300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.0115
    Cell Significance Index: -17.8800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.0117
    Cell Significance Index: -14.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.0794
    Cell Significance Index: -47.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Centrosome Function:** SSNA1 is involved in the anchoring of the basal body to the plasma membrane, which is essential for the proper formation and function of cilia and flagella. 2. **Cell Cycle Regulation:** SSNA1 is also involved in the regulation of the cell cycle, particularly in the G2/M transition, where it interacts with proteins such as Plk1. 3. **Immune Response:** SSNA1 is expressed in immune cells, including CD4-positive and CD45RO-positive T cells, suggesting its involvement in immune response and possibly autoimmunity. 4. **Expression in Multiple Cell Types:** SSNA1 is expressed in a wide range of cell types, including epithelial cells, pancreatic acinar cells, and oogonial cells. **Pathways and Functions:** 1. **Anchoring of the Basal Body to the Plasma Membrane:** SSNA1 interacts with proteins such as Tpx2 to anchor the basal body to the plasma membrane, which is essential for the proper formation and function of cilia and flagella. 2. **Aurka Activation:** SSNA1 is involved in the activation of Aurka, a kinase that is essential for the proper formation and function of the mitotic spindle. 3. **Cell Cycle Regulation:** SSNA1 interacts with proteins such as Plk1 to regulate the G2/M transition, which is critical for cell cycle progression. 4. **Intraciliary Transport:** SSNA1 is involved in the transport of proteins and lipids within cilia, which is essential for the proper function of cilia. 5. **Immune Response:** SSNA1 is expressed in immune cells and may play a role in the regulation of immune responses, possibly through interactions with other immune-related proteins. **Clinical Significance:** SSNA1 has been implicated in several diseases, including Sjoegren's syndrome, a chronic autoimmune disorder characterized by inflammation of the exocrine glands. The gene's involvement in immune response and centrosome function may contribute to the development of autoimmune diseases. Additionally, SSNA1 may play a role in other diseases, such as cancer, where centrosome dysfunction is a common feature. In conclusion, SSNA1 is a multifunctional gene that plays a crucial role in centrosome function, cell cycle regulation, and immune response. Further studies are needed to fully understand the gene's function and its implications for human disease.

Genular Protein ID: 3341748416

Symbol: SSNA1_HUMAN

Name: Sjoegren syndrome nuclear autoantigen 1

UniProtKB Accession Codes:

O43805 Q5VSG0 Q6FG70 Q9BVW8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 21 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9430706

Title: NA14 is a novel nuclear autoantigen with a coiled-coil domain.

PubMed ID: 9430706

DOI: 10.1074/jbc.273.3.1634

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12640030

Title: Chlamydomonas DIP13 and human NA14: a new class of proteins associated with microtubule structures is involved in cell division.

PubMed ID: 12640030

DOI: 10.1242/jcs.00337

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15269182

Title: Spastin interacts with the centrosomal protein NA14, and is enriched in the spindle pole, the midbody and the distal axon.

PubMed ID: 15269182

DOI: 10.1093/hmg/ddh223

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22008182

Title: Characterization of the structure and self-recognition of the human centrosomal protein NA14: implications for stability and function.

PubMed ID: 22008182

DOI: 10.1093/protein/gzr050

PubMed ID: 25390646

Title: Spastin-interacting protein NA14/SSNA1 functions in cytokinesis and axon development.

PubMed ID: 25390646

DOI: 10.1371/journal.pone.0112428

PubMed ID: 34970964

Title: SSNA1 stabilizes dynamic microtubules and detects microtubule damage.

PubMed ID: 34970964

DOI: 10.7554/elife.67282

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 119
  • Mass: 13596
  • Checksum: 6BB9BB96580DB807
  • Sequence:
    • MTQQGAALQN YNNELVKCIE ELCQKREELC RQIQEEEDEK QRLQNEVRQL TEKLARVNEN 
LARKIASRNE FDRTIAETEA AYLKILESSQ TLLSVLKREA GNLTKATAPD QKSSGGRDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.