Details for: LAMTOR3

Gene ID: 8649

Symbol: LAMTOR3

Ensembl ID: ENSG00000109270

Description: late endosomal/lysosomal adaptor, MAPK and MTOR activator 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 194.8629
    Cell Significance Index: -30.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 117.6061
    Cell Significance Index: -29.8300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 76.1019
    Cell Significance Index: -31.3500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 71.3162
    Cell Significance Index: -33.6700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 70.5834
    Cell Significance Index: -28.6800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 62.5796
    Cell Significance Index: -32.1900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 50.4305
    Cell Significance Index: -33.8400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 30.2176
    Cell Significance Index: -28.8500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.2053
    Cell Significance Index: -32.3100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.6669
    Cell Significance Index: -28.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.5275
    Cell Significance Index: -33.6500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.0292
    Cell Significance Index: -21.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.2275
    Cell Significance Index: 376.1300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.2030
    Cell Significance Index: -7.0100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6308
    Cell Significance Index: 22.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3904
    Cell Significance Index: 226.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1194
    Cell Significance Index: 30.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9272
    Cell Significance Index: 114.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8369
    Cell Significance Index: 755.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8264
    Cell Significance Index: 42.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7592
    Cell Significance Index: 414.6100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7477
    Cell Significance Index: 6.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7358
    Cell Significance Index: 132.6500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.6463
    Cell Significance Index: 5.1600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6206
    Cell Significance Index: 12.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5990
    Cell Significance Index: 264.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5854
    Cell Significance Index: 16.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5783
    Cell Significance Index: 27.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5689
    Cell Significance Index: 35.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5467
    Cell Significance Index: 25.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5130
    Cell Significance Index: 102.9200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4988
    Cell Significance Index: 13.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4903
    Cell Significance Index: 67.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4743
    Cell Significance Index: 35.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4614
    Cell Significance Index: 32.6300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.4567
    Cell Significance Index: 3.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4541
    Cell Significance Index: 20.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3826
    Cell Significance Index: 49.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3469
    Cell Significance Index: 40.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2703
    Cell Significance Index: 14.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2685
    Cell Significance Index: 7.1700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2643
    Cell Significance Index: 3.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2437
    Cell Significance Index: 31.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2265
    Cell Significance Index: 6.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2225
    Cell Significance Index: 79.8100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2203
    Cell Significance Index: 6.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2178
    Cell Significance Index: 7.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2043
    Cell Significance Index: 38.8700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1643
    Cell Significance Index: 1.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1258
    Cell Significance Index: 12.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1220
    Cell Significance Index: 20.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1048
    Cell Significance Index: 20.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0989
    Cell Significance Index: 68.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0962
    Cell Significance Index: 5.0100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.0747
    Cell Significance Index: 0.4600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0728
    Cell Significance Index: 1.3500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0603
    Cell Significance Index: 0.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0100
    Cell Significance Index: 0.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0071
    Cell Significance Index: 0.4600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0071
    Cell Significance Index: 0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0047
    Cell Significance Index: 8.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0022
    Cell Significance Index: 1.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0028
    Cell Significance Index: -2.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0035
    Cell Significance Index: -2.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0050
    Cell Significance Index: -3.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0151
    Cell Significance Index: -27.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0155
    Cell Significance Index: -0.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0172
    Cell Significance Index: -26.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0235
    Cell Significance Index: -0.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0258
    Cell Significance Index: -16.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0263
    Cell Significance Index: -35.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0286
    Cell Significance Index: -2.9200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0337
    Cell Significance Index: -3.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0359
    Cell Significance Index: -20.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0485
    Cell Significance Index: -22.0300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0554
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0635
    Cell Significance Index: -13.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0816
    Cell Significance Index: -23.4800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0867
    Cell Significance Index: -1.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0915
    Cell Significance Index: -5.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1114
    Cell Significance Index: -16.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1295
    Cell Significance Index: -14.8400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1393
    Cell Significance Index: -1.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1585
    Cell Significance Index: -4.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1858
    Cell Significance Index: -10.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2140
    Cell Significance Index: -14.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2141
    Cell Significance Index: -16.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2559
    Cell Significance Index: -5.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2837
    Cell Significance Index: -22.4700
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.2841
    Cell Significance Index: -2.1500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3081
    Cell Significance Index: -3.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3115
    Cell Significance Index: -32.4400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3192
    Cell Significance Index: -7.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3846
    Cell Significance Index: -8.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4284
    Cell Significance Index: -18.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4433
    Cell Significance Index: -27.1800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4546
    Cell Significance Index: -13.3900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4592
    Cell Significance Index: -11.7300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.4680
    Cell Significance Index: -6.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4830
    Cell Significance Index: -12.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** LAMTOR3 is a multifunctional gene that exhibits characteristics of both autophagy-related and MAPK/MTOR signaling pathways. It is involved in the regulation of: 1. **Autophagy**: LAMTOR3 interacts with the autophagy-related protein ATG14L to regulate the formation of autophagosomes. 2. **MAPK/MTOR signaling**: LAMTOR3 activates the MAPK/MTOR pathway by interacting with the mTORC1 complex, leading to the activation of downstream targets. 3. **Energy regulation**: LAMTOR3 is involved in the regulation of energy metabolism by interacting with the AMPK/ATF6 pathway. 4. **Immune response**: LAMTOR3 is expressed in immune cells, such as macrophages and epithelial cells, and plays a role in regulating immune responses to pathogens and stress. **Pathways and Functions** LAMTOR3 is involved in various signaling pathways, including: 1. **Amino acid regulate mTORC1**: LAMTOR3 interacts with the amino acid-regulated mTORC1 complex to regulate protein synthesis and cell growth. 2. **Autophagy**: LAMTOR3 interacts with ATG14L to regulate autophagy and maintain cellular homeostasis. 3. **Cellular responses to stimuli**: LAMTOR3 regulates cellular responses to stress, nutrient availability, and energy status by interacting with multiple signaling pathways. 4. **Innate immune system**: LAMTOR3 is expressed in immune cells and plays a role in regulating innate immune responses to pathogens. **Clinical Significance** The dysregulation of LAMTOR3 has been implicated in various diseases, including: 1. **Cancer**: LAMTOR3 is overexpressed in certain types of cancer, including breast and lung cancer, and is associated with poor prognosis. 2. **Metabolic disorders**: LAMTOR3 is involved in the regulation of energy metabolism, and dysregulation of LAMTOR3 has been implicated in metabolic disorders, such as obesity and type 2 diabetes. 3. **Neurodegenerative diseases**: LAMTOR3 is involved in the regulation of autophagy and energy metabolism, and dysregulation of LAMTOR3 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. In conclusion, LAMTOR3 is a multifaceted gene that plays a crucial role in regulating cellular processes, including immune response, autophagy, and energy regulation. The dysregulation of LAMTOR3 has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 1565129323

Symbol: LTOR3_HUMAN

Name: Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3

UniProtKB Accession Codes:

Q9UHA4 B2R4A1 J3KMX4 Q9H364

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 12 Ensembl 2 EvolutionaryTrace 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 23 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 9 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20381137

Title: Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

PubMed ID: 20381137

DOI: 10.1016/j.cell.2010.02.024

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22980980

Title: Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1.

PubMed ID: 22980980

DOI: 10.1016/j.cell.2012.07.032

PubMed ID: 25561175

Title: SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.

PubMed ID: 25561175

DOI: 10.1038/nature14107

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25567906

Title: Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.

PubMed ID: 25567906

DOI: 10.1126/science.1257132

PubMed ID: 15016825

Title: The structure of the MAPK scaffold, MP1, bound to its partner, p14. A complex with a critical role in endosomal MAP kinase signaling.

PubMed ID: 15016825

DOI: 10.1074/jbc.m401648200

PubMed ID: 30181260

Title: Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms.

PubMed ID: 30181260

DOI: 10.1073/pnas.1811727115

PubMed ID: 29285400

Title: Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane.

PubMed ID: 29285400

DOI: 10.1038/celldisc.2017.49

PubMed ID: 29107538

Title: Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.

PubMed ID: 29107538

DOI: 10.1016/j.molcel.2017.10.016

PubMed ID: 29123114

Title: Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1.

PubMed ID: 29123114

DOI: 10.1038/s41467-017-01567-4

PubMed ID: 29158492

Title: Structural basis for the assembly of the Ragulator-Rag GTPase complex.

PubMed ID: 29158492

DOI: 10.1038/s41467-017-01762-3

PubMed ID: 28935770

Title: Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.

PubMed ID: 28935770

DOI: 10.1126/science.aao1583

PubMed ID: 31704029

Title: Cryo-EM structure of the human FLCN-FNIP2-Rag-Ragulator complex.

PubMed ID: 31704029

DOI: 10.1016/j.cell.2019.10.036

PubMed ID: 31601708

Title: Structural basis for the docking of mTORC1 on the lysosomal surface.

PubMed ID: 31601708

DOI: 10.1126/science.aay0166

PubMed ID: 31672913

Title: Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.

PubMed ID: 31672913

DOI: 10.1126/science.aax0364

PubMed ID: 32868926

Title: Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9.

PubMed ID: 32868926

DOI: 10.1038/s41594-020-0490-9

PubMed ID: 35338845

Title: Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.

PubMed ID: 35338845

DOI: 10.1016/j.molcel.2022.03.002

PubMed ID: 36103527

Title: Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation.

PubMed ID: 36103527

DOI: 10.1126/sciadv.add2926

PubMed ID: 36697823

Title: Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.

PubMed ID: 36697823

DOI: 10.1038/s41586-022-05652-7

Sequence Information:

  • Length: 124
  • Mass: 13623
  • Checksum: 0A5196CF41D83D13
  • Sequence:
    • MADDLKRFLY KKLPSVEGLH AIVVSDRDGV PVIKVANDNA PEHALRPGFL STFALATDQG 
SKLGLSKNKS IICYYNTYQV VQFNRLPLVV SFIASSSANT GLIVSLEKEL APLFEELRQV 
VEVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.