Details for: SOCS1

Gene ID: 8651

Symbol: SOCS1

Ensembl ID: ENSG00000185338

Description: suppressor of cytokine signaling 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 153.2030
    Cell Significance Index: -23.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 92.5315
    Cell Significance Index: -23.4700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 52.8975
    Cell Significance Index: -21.4900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 50.8978
    Cell Significance Index: -24.0300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.1740
    Cell Significance Index: -23.0800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.3924
    Cell Significance Index: -23.9100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 10.9374
    Cell Significance Index: 29.3000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.0516
    Cell Significance Index: -23.8800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.7660
    Cell Significance Index: -17.7100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.4965
    Cell Significance Index: 15.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.9971
    Cell Significance Index: -5.3500
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.8516
    Cell Significance Index: 4.3200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.7942
    Cell Significance Index: 17.9900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.7432
    Cell Significance Index: 22.3300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.5086
    Cell Significance Index: 24.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4777
    Cell Significance Index: 66.9800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2752
    Cell Significance Index: 37.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1537
    Cell Significance Index: 30.9200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1291
    Cell Significance Index: 133.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0799
    Cell Significance Index: 106.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0512
    Cell Significance Index: 67.8200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9810
    Cell Significance Index: 885.8000
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.9806
    Cell Significance Index: 8.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9309
    Cell Significance Index: 151.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8833
    Cell Significance Index: 25.4500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7386
    Cell Significance Index: 15.4600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.6308
    Cell Significance Index: 9.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5474
    Cell Significance Index: 11.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5359
    Cell Significance Index: 58.2900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.4487
    Cell Significance Index: 3.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3824
    Cell Significance Index: 72.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3732
    Cell Significance Index: 51.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3590
    Cell Significance Index: 21.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2803
    Cell Significance Index: 153.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2495
    Cell Significance Index: 31.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2136
    Cell Significance Index: 10.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2069
    Cell Significance Index: 7.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1907
    Cell Significance Index: 84.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1608
    Cell Significance Index: 28.9900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1491
    Cell Significance Index: 2.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1231
    Cell Significance Index: 3.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1117
    Cell Significance Index: 7.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0878
    Cell Significance Index: 54.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0735
    Cell Significance Index: 2.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0507
    Cell Significance Index: 6.2400
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.0289
    Cell Significance Index: 0.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0180
    Cell Significance Index: 3.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0036
    Cell Significance Index: 0.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0011
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0092
    Cell Significance Index: -6.7900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0112
    Cell Significance Index: -21.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0146
    Cell Significance Index: -1.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0157
    Cell Significance Index: -29.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0167
    Cell Significance Index: -12.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0174
    Cell Significance Index: -12.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0182
    Cell Significance Index: -27.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0188
    Cell Significance Index: -10.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0211
    Cell Significance Index: -28.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0278
    Cell Significance Index: -0.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0323
    Cell Significance Index: -3.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0377
    Cell Significance Index: -23.9500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0382
    Cell Significance Index: -1.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0546
    Cell Significance Index: -24.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0571
    Cell Significance Index: -9.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0643
    Cell Significance Index: -23.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0676
    Cell Significance Index: -14.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0796
    Cell Significance Index: -9.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0831
    Cell Significance Index: -23.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1018
    Cell Significance Index: -11.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1182
    Cell Significance Index: -23.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1251
    Cell Significance Index: -6.5000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1377
    Cell Significance Index: -15.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1703
    Cell Significance Index: -24.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1716
    Cell Significance Index: -8.9400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1975
    Cell Significance Index: -2.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1986
    Cell Significance Index: -4.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2241
    Cell Significance Index: -10.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2246
    Cell Significance Index: -16.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2315
    Cell Significance Index: -24.1000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2623
    Cell Significance Index: -2.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2670
    Cell Significance Index: -14.0200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2732
    Cell Significance Index: -8.6400
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.2738
    Cell Significance Index: -1.9700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2764
    Cell Significance Index: -9.6100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2905
    Cell Significance Index: -23.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2995
    Cell Significance Index: -22.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3389
    Cell Significance Index: -21.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3396
    Cell Significance Index: -20.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3466
    Cell Significance Index: -11.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3639
    Cell Significance Index: -24.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3754
    Cell Significance Index: -10.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3807
    Cell Significance Index: -10.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4040
    Cell Significance Index: -24.8300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4071
    Cell Significance Index: -17.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4258
    Cell Significance Index: -11.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4287
    Cell Significance Index: -11.0200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.4540
    Cell Significance Index: -7.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4592
    Cell Significance Index: -25.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4745
    Cell Significance Index: -11.8600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4958
    Cell Significance Index: -5.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SOCS1 is a negative regulator of the JAK/STAT signaling pathway, which is a key signaling cascade involved in the regulation of immune responses. This gene is characterized by its ability to inhibit the phosphorylation and activation of STAT proteins, thereby modulating the transcription of genes involved in immune responses. SOCS1 is also involved in the regulation of other signaling pathways, including the PI3K/AKT pathway, the MAPK/ERK pathway, and the NF-κB pathway. Additionally, SOCS1 has been shown to interact with various proteins, including cytokines, growth factors, and transcription factors, to regulate immune responses. **Pathways and Functions:** SOCS1 is involved in the regulation of various immune-related pathways, including: 1. **Cytokine Signaling Pathway:** SOCS1 inhibits the JAK/STAT signaling pathway, which is a key signaling cascade involved in the regulation of immune responses. 2. **Adaptive Immune System:** SOCS1 regulates the differentiation and function of T cells and B cells, including the negative regulation of CD8+ and CD4+ T cell differentiation. 3. **Innate Immune System:** SOCS1 is involved in the regulation of innate immune responses, including the regulation of cytokine production and the activation of immune cells. 4. **Growth Hormone Signaling:** SOCS1 regulates the growth hormone signaling pathway, which is involved in the regulation of cell growth and differentiation. **Clinical Significance:** Dysregulation of SOCS1 has been implicated in various immune-related disorders, including: 1. **Autoimmune Diseases:** SOCS1 dysfunction has been linked to autoimmune diseases, such as rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Cancer:** SOCS1 has been shown to be a tumor suppressor gene, and its dysregulation has been implicated in various types of cancer, including leukemia, lymphoma, and breast cancer. 3. **Inflammatory Diseases:** SOCS1 has been shown to be involved in the regulation of inflammatory responses, and its dysregulation has been implicated in various inflammatory diseases, including asthma and rheumatoid arthritis. In conclusion, SOCS1 is a critical regulator of the immune system, and its dysregulation has been implicated in various immune-related disorders. Further research is needed to fully understand the molecular mechanisms underlying SOCS1 function and its role in immune regulation.

Genular Protein ID: 2307768341

Symbol: SOCS1_HUMAN

Name: Suppressor of cytokine signaling 1

UniProtKB Accession Codes:

O15524 O15097 Q9NSA7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 27 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 12 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9266833

Title: Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.

PubMed ID: 9266833

DOI: 10.1006/bbrc.1997.7080

PubMed ID: 9341160

Title: SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase.

PubMed ID: 9341160

DOI: 10.1074/jbc.272.43.27178

PubMed ID: 9202125

Title: A family of cytokine-inducible inhibitors of signaling.

PubMed ID: 9202125

DOI: 10.1038/43206

PubMed ID: 10512686

Title: Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively.

PubMed ID: 10512686

DOI: 10.1006/geno.1999.5937

PubMed ID: 9202126

Title: A new protein containing an SH2 domain that inhibits JAK kinases.

PubMed ID: 9202126

DOI: 10.1038/43213

PubMed ID: 9727029

Title: Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor.

PubMed ID: 9727029

DOI: 10.1074/jbc.273.37.24095

PubMed ID: 11278610

Title: The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.

PubMed ID: 11278610

DOI: 10.1074/jbc.m010074200

PubMed ID: 11313480

Title: Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation.

PubMed ID: 11313480

DOI: 10.1128/mcb.21.10.3547-3557.2001

PubMed ID: 11553846

Title: SOCS proteins: negative regulators of cytokine signaling.

PubMed ID: 11553846

DOI: 10.1634/stemcells.19-5-378

PubMed ID: 12470648

Title: Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin.

PubMed ID: 12470648

DOI: 10.1016/s0006-291x(02)02718-3

PubMed ID: 11835308

Title: Cytokine signaling in the brain: putting a SOCS in it?

PubMed ID: 11835308

DOI: 10.1002/jnr.10145

PubMed ID: 16410555

Title: Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling.

PubMed ID: 16410555

DOI: 10.1242/jcs.02740

PubMed ID: 12163497

Title: TRIM8/GERP RING finger protein interacts with SOCS-1.

PubMed ID: 12163497

DOI: 10.1074/jbc.m205900200

PubMed ID: 23401859

Title: DCNL1 functions as a substrate sensor and activator of cullin 2-RING ligase.

PubMed ID: 23401859

DOI: 10.1128/mcb.01342-12

PubMed ID: 32853638

Title: Immune dysregulation and multisystem inflammatory syndrome in children (MIS-C) in individuals with haploinsufficiency of SOCS1.

PubMed ID: 32853638

DOI: 10.1016/j.jaci.2020.07.033

PubMed ID: 32499645

Title: Whole-genome sequencing of a sporadic primary immunodeficiency cohort.

PubMed ID: 32499645

DOI: 10.1038/s41586-020-2265-1

PubMed ID: 33087723

Title: Early-onset autoimmunity associated with SOCS1 haploinsufficiency.

PubMed ID: 33087723

DOI: 10.1038/s41467-020-18925-4

Sequence Information:

  • Length: 211
  • Mass: 23551
  • Checksum: 7CC983533F78B127
  • Sequence:
    • MVAHNQVAAD NAVSTAAEPR RRPEPSSSSS SSPAAPARPR PCPAVPAPAP GDTHFRTFRS 
HADYRRITRA SALLDACGFY WGPLSVHGAH ERLRAEPVGT FLVRDSRQRN CFFALSVKMA 
SGPTSIRVHF QAGRFHLDGS RESFDCLFEL LEHYVAAPRR MLGAPLRQRR VRPLQELCRQ 
RIVATVGREN LARIPLNPVL RDYLSSFPFQ I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.