DYNLL1 | ENSG00000088986 | NCBI 8655

Details for: DYNLL1

Gene ID: 8655

Symbol: DYNLL1

Ensembl ID: ENSG00000088986

Description: dynein light chain LC8-type 1

Associated with

Activation of bh3-only proteins
(R-HSA-114452)
Activation of bim and translocation to mitochondria
(R-HSA-111446)
Adaptive immune system
(R-HSA-1280218)
Aggrephagy
(R-HSA-9646399)
Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Anchoring of the basal body to the plasma membrane
(R-HSA-5620912)
Apoptosis
(R-HSA-109581)
Asparagine n-linked glycosylation
(R-HSA-446203)
Aurka activation by tpx2
(R-HSA-8854518)
Autophagy
(R-HSA-9612973)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Centrosome maturation
(R-HSA-380287)
Cilium assembly
(R-HSA-5617833)
Copi-independent golgi-to-er retrograde traffic
(R-HSA-6811436)
Copi-mediated anterograde transport
(R-HSA-6807878)
Disease
(R-HSA-1643685)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Er to golgi anterograde transport
(R-HSA-199977)
G2/m transition
(R-HSA-69275)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-HSA-3371497)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Intraflagellar transport
(R-HSA-5620924)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Loss of nlp from mitotic centrosomes
(R-HSA-380259)
Loss of proteins required for interphase microtubule organization from the centrosome
(R-HSA-380284)
Macroautophagy
(R-HSA-1632852)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Mhc class ii antigen presentation
(R-HSA-2132295)
Mitotic anaphase
(R-HSA-68882)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Neutrophil degranulation
(R-HSA-6798695)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Recruitment of mitotic centrosome proteins and complexes
(R-HSA-380270)
Recruitment of numa to mitotic centrosomes
(R-HSA-380320)
Regulation of plk1 activity at g2/m transition
(R-HSA-2565942)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Selective autophagy
(R-HSA-9663891)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Apoptotic process
(GO:0006915)
Centrosome
(GO:0005813)
Cilium
(GO:0005929)
Cop9 signalosome
(GO:0008180)
Cytoplasm
(GO:0005737)
Cytoplasmic dynein complex
(GO:0005868)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Deoxyribonuclease inhibitor activity
(GO:0060703)
Dna damage response
(GO:0006974)
Dynein complex
(GO:0030286)
Dynein intermediate chain binding
(GO:0045505)
Enzyme binding
(GO:0019899)
Enzyme inhibitor activity
(GO:0004857)
Identical protein binding
(GO:0042802)
Intraciliary retrograde transport
(GO:0035721)
Kinetochore
(GO:0000776)
Membrane
(GO:0016020)
Microtubule
(GO:0005874)
Mitochondrion
(GO:0005739)
Motile cilium assembly
(GO:0044458)
Negative regulation of dna strand resection involved in replication fork processing
(GO:0110027)
Negative regulation of nitric oxide biosynthetic process
(GO:0045019)
Negative regulation of phosphorylation
(GO:0042326)
Nitric-oxide synthase inhibitor activity
(GO:0036487)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus
(GO:0035774)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Scaffold protein binding
(GO:0097110)
Site of double-strand break
(GO:0035861)
Spermatid development
(GO:0007286)
Substantia nigra development
(GO:0021762)
Tertiary granule membrane
(GO:0070821)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 821.6260
Cell Significance Index: -127.8000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 513.4374
Cell Significance Index: -130.2300
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 392.9869
Cell Significance Index: -161.8900
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 335.6861
Cell Significance Index: -158.4900
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 331.6373
Cell Significance Index: -134.7300
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 292.2907
Cell Significance Index: -150.3500
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 237.1233
Cell Significance Index: -159.1200
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 142.5724
Cell Significance Index: -136.1200
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 121.5210
Cell Significance Index: -149.8300
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 40.6635
Cell Significance Index: -160.4600
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 37.1127
Cell Significance Index: -113.9900
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 35.9556
Cell Significance Index: -96.3200
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 9.3402
Cell Significance Index: 80.2600
Cell Name: granulosa cell (CL0000501)
Fold Change: 7.6433
Cell Significance Index: 200.9800
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 6.3309
Cell Significance Index: 220.0000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 5.7626
Cell Significance Index: 120.6200
Cell Name: peg cell (CL4033014)
Fold Change: 5.3650
Cell Significance Index: 123.9500
Cell Name: cell in vitro (CL0001034)
Fold Change: 4.5803
Cell Significance Index: 2501.4000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 4.3972
Cell Significance Index: 603.8600
Cell Name: kidney cell (CL1000497)
Fold Change: 4.0943
Cell Significance Index: 32.6900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 4.0864
Cell Significance Index: 192.0600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 4.0759
Cell Significance Index: 662.9100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 3.8452
Cell Significance Index: 200.2900
Cell Name: odontoblast (CL0000060)
Fold Change: 3.7960
Cell Significance Index: 486.6200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 3.4688
Cell Significance Index: 1533.6400
Cell Name: theca cell (CL0000503)
Fold Change: 3.4553
Cell Significance Index: 20.3000
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 3.3719
Cell Significance Index: 414.6000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 3.1134
Cell Significance Index: 561.2400
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.8886
Cell Significance Index: 26.6000
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 2.7908
Cell Significance Index: 30.3400
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 2.6844
Cell Significance Index: 189.8500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.6635
Cell Significance Index: 314.1100
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 2.4788
Cell Significance Index: 28.1600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.0620
Cell Significance Index: 413.6400
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.0236
Cell Significance Index: 25.9200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.8632
Cell Significance Index: 86.8700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.7625
Cell Significance Index: 131.3600
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.7423
Cell Significance Index: 112.4100
Cell Name: lactocyte (CL0002325)
Fold Change: 1.7240
Cell Significance Index: 222.7300
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.6936
Cell Significance Index: 49.7400
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.6106
Cell Significance Index: 319.6300
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.5576
Cell Significance Index: 81.7800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.1548
Cell Significance Index: 59.9900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.6971
Cell Significance Index: 250.0200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.5654
Cell Significance Index: 15.3900
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.5382
Cell Significance Index: 9.5100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5167
Cell Significance Index: 98.3300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4636
Cell Significance Index: 12.3800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.4494
Cell Significance Index: 76.7400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.3163
Cell Significance Index: 239.4200
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.2968
Cell Significance Index: 18.2400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2653
Cell Significance Index: 26.2500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.2307
Cell Significance Index: 169.1300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1845
Cell Significance Index: 5.3200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1652
Cell Significance Index: 2.7700
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0279
Cell Significance Index: -0.8000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0528
Cell Significance Index: -99.4100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0703
Cell Significance Index: -52.0800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0785
Cell Significance Index: -8.0200
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0857
Cell Significance Index: -157.9700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.1031
Cell Significance Index: -158.7600
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.1247
Cell Significance Index: -169.5500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1306
Cell Significance Index: -81.5300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1789
Cell Significance Index: -113.6200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1867
Cell Significance Index: -105.2900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2760
Cell Significance Index: -125.2900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3284
Cell Significance Index: -69.1800
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3891
Cell Significance Index: -10.8800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.4315
Cell Significance Index: -124.1600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.4902
Cell Significance Index: -22.2200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.5335
Cell Significance Index: -9.8600
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.6524
Cell Significance Index: -43.8700
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.7310
Cell Significance Index: -57.9000
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.7492
Cell Significance Index: -47.2200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.7579
Cell Significance Index: -86.8300
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.8462
Cell Significance Index: -98.6100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.9257
Cell Significance Index: -134.5600
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.9516
Cell Significance Index: -24.3100
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.9859
Cell Significance Index: -112.5400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.0960
Cell Significance Index: -61.5000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.2982
Cell Significance Index: -41.5800
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.3187
Cell Significance Index: -28.5700
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.3921
Cell Significance Index: -20.8600
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.4300
Cell Significance Index: -30.4600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.5298
Cell Significance Index: -159.2900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.7958
Cell Significance Index: -137.8100
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -1.8183
Cell Significance Index: -31.1600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -2.0123
Cell Significance Index: -27.4600
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -2.2778
Cell Significance Index: -65.0000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -2.5440
Cell Significance Index: -155.9700
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -2.6465
Cell Significance Index: -77.9500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -2.7746
Cell Significance Index: -74.2200
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -3.1076
Cell Significance Index: -137.4600
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -3.1683
Cell Significance Index: -84.9000
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -3.4004
Cell Significance Index: -111.3300
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -3.4899
Cell Significance Index: -128.1100
Cell Name: retinal rod cell (CL0000604)
Fold Change: -3.4965
Cell Significance Index: -41.6800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -3.5490
Cell Significance Index: -113.0300
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -3.6001
Cell Significance Index: -30.2400
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -3.6375
Cell Significance Index: -127.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Dynein complex component**: DYNLL1 is a light chain of the dynein complex, a motor protein responsible for transporting cargo along microtubules. 2. **Microtubule-associated protein**: DYNLL1 interacts with microtubules and other proteins to regulate cellular processes. 3. **Regulator of cell cycle and apoptosis**: DYNLL1 is involved in regulating the cell cycle, particularly during mitosis, and is also a component of the apoptotic process. 4. **Signaling protein**: DYNLL1 is a signaling protein that interacts with other proteins to regulate cellular responses to stimuli and stress. 5. **Expression in various cell types**: DYNLL1 is significantly expressed in various cell types, including uterine smooth muscle cells, mesenchymal stem cells, and skeletal muscle satellite stem cells. **Pathways and Functions** 1. **Activation of Bim and translocation to mitochondria**: DYNLL1 interacts with Bim, a pro-apoptotic protein, to regulate apoptosis. 2. **Activation of bh3-only proteins**: DYNLL1 interacts with bh3-only proteins to regulate apoptosis. 3. **Adaptive immune system**: DYNLL1 is involved in regulating the adaptive immune system, particularly during the activation of T cells. 4. **Aggrephagy**: DYNLL1 is involved in regulating aggrephagy, a process by which cells recognize and eliminate damaged or aggregated proteins. 5. **Amplification of signal from kinetochores**: DYNLL1 interacts with kinetochores to amplify signals during mitosis. 6. **Apoptosis**: DYNLL1 is a component of the apoptotic process, regulating the activation of pro-apoptotic proteins. 7. **Cell cycle**: DYNLL1 is involved in regulating the cell cycle, particularly during mitosis. 8. **Mitotic spindle checkpoint**: DYNLL1 interacts with proteins involved in the mitotic spindle checkpoint to regulate cell cycle progression. 9. **Neutrophil degranulation**: DYNLL1 is involved in regulating neutrophil degranulation, a process by which neutrophils release granules to fight infection. 10. **Programmed cell death**: DYNLL1 is involved in regulating programmed cell death, particularly during apoptosis. **Clinical Significance** 1. **Cancer**: DYNLL1 is overexpressed in various types of cancer, including breast cancer and lung cancer, and is associated with poor prognosis. 2. **Neurodegenerative diseases**: DYNLL1 is involved in regulating the progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Infectious diseases**: DYNLL1 is involved in regulating the immune response to infectious diseases, such as HIV and influenza. 4. **Autoimmune diseases**: DYNLL1 is involved in regulating the immune response to autoimmune diseases, such as rheumatoid arthritis and lupus. 5. **Regenerative medicine**: DYNLL1 is involved in regulating the process of tissue regeneration, particularly during wound healing and embryonic development. In conclusion, DYNLL1 is a gene that plays a crucial role in regulating various cellular processes, including cell cycle, apoptosis, and immune response. Its dysregulation is associated with various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Further research is needed to fully understand the role of DYNLL1 in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Dynein light chain 1, cytoplasmic

Genular Protein ID: 2496524981

Symbol: DYL1_HUMAN

Name: Dynein light chain 1, cytoplasmic

UniProtKB Accession Codes:

P63167 Q15701

Database IDs:

Citations:

PubMed ID: 8628263

Title: Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster.

PubMed ID: 8628263

DOI: 10.1128/mcb.16.5.1966

PubMed ID: 10198631

Title: The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex.

PubMed ID: 10198631

DOI: 10.1016/s1097-2765(00)80456-6

PubMed ID: 12857789

Title: Targeting of incoming retroviral Gag to the centrosome involves a direct interaction with the dynein light chain 8.

PubMed ID: 12857789

DOI: 10.1242/jcs.00613

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15193260

Title: Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes.

PubMed ID: 15193260

DOI: 10.1016/j.ccr.2004.05.022

PubMed ID: 14607843

Title: Roles of TRP14, a thioredoxin-related protein in tumor necrosis factor-alpha signaling pathways.

PubMed ID: 14607843

DOI: 10.1074/jbc.m307959200

PubMed ID: 15891768

Title: Functional regulation of oestrogen receptor pathway by the dynein light chain 1.

PubMed ID: 15891768

DOI: 10.1038/sj.embor.7400417

PubMed ID: 16684779

Title: Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells.

PubMed ID: 16684779

DOI: 10.1074/jbc.m600021200

PubMed ID: 18084006

Title: Serine 88 phosphorylation of the 8-kDa dynein light chain 1 is a molecular switch for its dimerization status and functions.

PubMed ID: 18084006

DOI: 10.1074/jbc.m704512200

PubMed ID: 18650427

Title: Biochemical and structural characterization of the Pak1-LC8 interaction.

PubMed ID: 18650427

DOI: 10.1074/jbc.m800758200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 19380881

Title: Dynein light chain regulates axonal trafficking and synaptic levels of Bassoon.

PubMed ID: 19380881

DOI: 10.1083/jcb.200807155

PubMed ID: 20412299

Title: Structural basis for the interaction between dynein light chain 1 and the glutamate channel homolog GRINL1A.

PubMed ID: 20412299

DOI: 10.1111/j.1742-4658.2010.07649.x

PubMed ID: 20921139

Title: The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy.

PubMed ID: 20921139

DOI: 10.1083/jcb.201002100

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21402792

Title: The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment.

PubMed ID: 21402792

DOI: 10.1083/jcb.201008023

PubMed ID: 22167198

Title: ATM substrate Chk2-interacting Zn2+ finger (ASCIZ) Is a bi-functional transcriptional activator and feedback sensor in the regulation of dynein light chain (DYNLL1) expression.

PubMed ID: 22167198

DOI: 10.1074/jbc.m111.306019

PubMed ID: 22965910

Title: Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation.

PubMed ID: 22965910

DOI: 10.1083/jcb.201202112

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24682284

Title: Evolutionary and Molecular Facts Link the WWC Protein Family to Hippo Signaling.

PubMed ID: 24682284

DOI: 10.1093/molbev/msu115

PubMed ID: 25741013

Title: Ebola virus VP35 interaction with dynein LC8 regulates viral RNA synthesis.

PubMed ID: 25741013

DOI: 10.1128/jvi.03652-14

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31505170

Title: Interactions between two regulatory proteins of microtubule dynamics, HDAC6, TPPP/p25, and the hub protein, DYNLL/LC8.

PubMed ID: 31505170

DOI: 10.1016/j.bbamcr.2019.118556

PubMed ID: 30464262

Title: DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells.

PubMed ID: 30464262

DOI: 10.1038/s41586-018-0670-5

PubMed ID: 29955062

Title: Molecular basis of Tousled-Like Kinase 2 activation.

PubMed ID: 29955062

DOI: 10.1038/s41467-018-04941-y

PubMed ID: 33323470

Title: Functional analysis of TLK2 variants and their proximal interactomes implicates impaired kinase activity and chromatin maintenance defects in their pathogenesis.

PubMed ID: 33323470

DOI: 10.1136/jmedgenet-2020-107281

PubMed ID: 37696958

Title: Dynamics of the DYNLL1-MRE11 complex regulate DNA end resection and recruitment of Shieldin to DSBs.

PubMed ID: 37696958

DOI: 10.1038/s41594-023-01074-9

PubMed ID: 10426949

Title: Structure of the PIN/LC8 dimer with a bound peptide.

PubMed ID: 10426949

DOI: 10.1038/11501

PubMed ID: 23482567

Title: Structural analysis of the regulation of the DYNLL/LC8 binding to Nek9 by phosphorylation.

PubMed ID: 23482567

DOI: 10.1074/jbc.m113.459149

Sequence Information:

Length: 89
Mass: 10366
Checksum: F5E7647D092BEB3A
Sequence:

MCDRKAVIKN ADMSEEMQQD SVECATQALE KYNIEKDIAA HIKKEFDKKY NPTWHCIVGR 
NFGSYVTHET KHFIYFYLGQ VAILLFKSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: DYNLL1

Associated with

Cells (max top 100)

Other Information

Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster. PubMed ID: 8628263

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. PubMed ID: 10198631

Targeting of incoming retroviral Gag to the centrosome involves a direct interaction with the dynein light chain 8. PubMed ID: 12857789

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes. PubMed ID: 15193260

Roles of TRP14, a thioredoxin-related protein in tumor necrosis factor-alpha signaling pathways. PubMed ID: 14607843

Functional regulation of oestrogen receptor pathway by the dynein light chain 1. PubMed ID: 15891768

Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells. PubMed ID: 16684779

Serine 88 phosphorylation of the 8-kDa dynein light chain 1 is a molecular switch for its dimerization status and functions. PubMed ID: 18084006

Biochemical and structural characterization of the Pak1-LC8 interaction. PubMed ID: 18650427

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Dynein light chain regulates axonal trafficking and synaptic levels of Bassoon. PubMed ID: 19380881

Structural basis for the interaction between dynein light chain 1 and the glutamate channel homolog GRINL1A. PubMed ID: 20412299

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy. PubMed ID: 20921139

Initial characterization of the human central proteome. PubMed ID: 21269460

The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment. PubMed ID: 21402792

ATM substrate Chk2-interacting Zn2+ finger (ASCIZ) Is a bi-functional transcriptional activator and feedback sensor in the regulation of dynein light chain (DYNLL1) expression. PubMed ID: 22167198

Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation. PubMed ID: 22965910

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Evolutionary and Molecular Facts Link the WWC Protein Family to Hippo Signaling. PubMed ID: 24682284

Ebola virus VP35 interaction with dynein LC8 regulates viral RNA synthesis. PubMed ID: 25741013

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Interactions between two regulatory proteins of microtubule dynamics, HDAC6, TPPP/p25, and the hub protein, DYNLL/LC8. PubMed ID: 31505170

DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells. PubMed ID: 30464262

Molecular basis of Tousled-Like Kinase 2 activation. PubMed ID: 29955062

Functional analysis of TLK2 variants and their proximal interactomes implicates impaired kinase activity and chromatin maintenance defects in their pathogenesis. PubMed ID: 33323470

Dynamics of the DYNLL1-MRE11 complex regulate DNA end resection and recruitment of Shieldin to DSBs. PubMed ID: 37696958

Structure of the PIN/LC8 dimer with a bound peptide. PubMed ID: 10426949

Structural analysis of the regulation of the DYNLL/LC8 binding to Nek9 by phosphorylation. PubMed ID: 23482567