Details for: EIF3F

Gene ID: 8665

Symbol: EIF3F

Ensembl ID: ENSG00000175390

Description: eukaryotic translation initiation factor 3 subunit F

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 502.3619
    Cell Significance Index: -78.1400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 251.1970
    Cell Significance Index: -103.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 229.9283
    Cell Significance Index: -93.4100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 221.5118
    Cell Significance Index: -56.1900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 210.0937
    Cell Significance Index: -99.1900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 204.8659
    Cell Significance Index: -105.3800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 148.2216
    Cell Significance Index: -99.4600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 99.9536
    Cell Significance Index: -95.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 75.3717
    Cell Significance Index: -92.9300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 25.1239
    Cell Significance Index: -99.1400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 24.1644
    Cell Significance Index: -74.2200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.8998
    Cell Significance Index: -50.6300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.6572
    Cell Significance Index: -29.8900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 7.3630
    Cell Significance Index: 94.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 7.2192
    Cell Significance Index: 151.1100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 6.5374
    Cell Significance Index: 71.0700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.6311
    Cell Significance Index: 44.9600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.8732
    Cell Significance Index: 128.1400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.5515
    Cell Significance Index: 26.7400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.2971
    Cell Significance Index: 126.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.2685
    Cell Significance Index: 275.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.9714
    Cell Significance Index: 545.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.7964
    Cell Significance Index: 466.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.7367
    Cell Significance Index: 440.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.4709
    Cell Significance Index: 245.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.4117
    Cell Significance Index: 440.7700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.2813
    Cell Significance Index: 57.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.2691
    Cell Significance Index: 152.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.2113
    Cell Significance Index: 150.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.0650
    Cell Significance Index: 552.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.0472
    Cell Significance Index: 105.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.7710
    Cell Significance Index: 206.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.6309
    Cell Significance Index: 71.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.5657
    Cell Significance Index: 1401.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.5601
    Cell Significance Index: 1131.8700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.5078
    Cell Significance Index: 28.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.4105
    Cell Significance Index: 69.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.0337
    Cell Significance Index: 46.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.7835
    Cell Significance Index: 304.5500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.7511
    Cell Significance Index: 16.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4571
    Cell Significance Index: 75.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.4175
    Cell Significance Index: 181.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.3380
    Cell Significance Index: 92.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1860
    Cell Significance Index: 192.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9906
    Cell Significance Index: 97.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9067
    Cell Significance Index: 24.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8386
    Cell Significance Index: 757.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8087
    Cell Significance Index: 42.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7134
    Cell Significance Index: 37.1600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4729
    Cell Significance Index: 8.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3976
    Cell Significance Index: 78.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3395
    Cell Significance Index: 68.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1990
    Cell Significance Index: 71.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1660
    Cell Significance Index: 31.6000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1365
    Cell Significance Index: 2.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0916
    Cell Significance Index: 69.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0249
    Cell Significance Index: 18.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0018
    Cell Significance Index: 0.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0164
    Cell Significance Index: -1.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0284
    Cell Significance Index: -53.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0365
    Cell Significance Index: -27.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0500
    Cell Significance Index: -92.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0616
    Cell Significance Index: -38.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0640
    Cell Significance Index: -98.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0717
    Cell Significance Index: -97.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1104
    Cell Significance Index: -62.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1168
    Cell Significance Index: -7.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1265
    Cell Significance Index: -80.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1943
    Cell Significance Index: -88.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1966
    Cell Significance Index: -11.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2253
    Cell Significance Index: -47.4600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2901
    Cell Significance Index: -7.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2971
    Cell Significance Index: -85.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4287
    Cell Significance Index: -11.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4986
    Cell Significance Index: -57.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5670
    Cell Significance Index: -66.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5714
    Cell Significance Index: -15.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5901
    Cell Significance Index: -85.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6324
    Cell Significance Index: -38.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.6744
    Cell Significance Index: -73.3600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.7893
    Cell Significance Index: -90.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8612
    Cell Significance Index: -57.9100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8761
    Cell Significance Index: -21.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8890
    Cell Significance Index: -70.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9377
    Cell Significance Index: -97.6400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.9525
    Cell Significance Index: -16.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0150
    Cell Significance Index: -32.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.0272
    Cell Significance Index: -22.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.0556
    Cell Significance Index: -81.0100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.0994
    Cell Significance Index: -15.0000
  • Cell Name: germ cell (CL0000586)
    Fold Change: -1.1290
    Cell Significance Index: -8.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.3407
    Cell Significance Index: -60.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3483
    Cell Significance Index: -82.6700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.7841
    Cell Significance Index: -52.5500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.7892
    Cell Significance Index: -26.8100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.8524
    Cell Significance Index: -15.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.9963
    Cell Significance Index: -88.3000
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -2.0068
    Cell Significance Index: -10.5600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.0466
    Cell Significance Index: -12.3700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -2.1548
    Cell Significance Index: -11.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EIF3F is a 40-kDa protein that belongs to the eIF3 complex, which is a heterohexamer composed of six subunits (eIF3a, eIF3b, eIF3c, eIF3d, eIF3e, and eIF3f). EIF3F is characterized by its ability to bind to the mRNA cap and facilitate the recruitment of the 40S ribosomal subunit, thereby initiating translation. This subunit also possesses cysteine-type deubiquitinase activity, which is essential for the regulation of protein degradation. **Pathways and Functions:** EIF3F is involved in various cellular processes, including: 1. **Cap-dependent translation initiation:** EIF3F recognizes the mRNA cap and recruits the 40S ribosomal subunit, initiating translation. 2. **Cysteine-type deubiquitinase activity:** EIF3F regulates protein degradation by removing ubiquitin from target proteins. 3. **Translation initiation complex formation:** EIF3F forms a complex with other eIF3 subunits and the 40S ribosomal subunit, facilitating translation initiation. 4. **Ribosomal scanning and start codon recognition:** EIF3F is involved in the recognition of the start codon and the recruitment of the 40S ribosomal subunit. **Clinical Significance:** EIF3F has been implicated in various diseases, including: 1. **Cancer:** Alterations in EIF3F expression have been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative diseases:** EIF3F has been linked to neurodegenerative diseases such as Alzheimer's and Parkinson's disease. 3. **Autoimmune disorders:** EIF3F has been implicated in autoimmune disorders, including multiple sclerosis and rheumatoid arthritis. 4. **Immunological disorders:** EIF3F has been shown to play a critical role in the regulation of immune responses, including the activation of T cells and the production of cytokines. **Significantly Expressed Cells:** EIF3F is highly expressed in various cell types, including: 1. **Mesodermal cells:** EIF3F is expressed in mesodermal cells, which are involved in the development of various tissues and organs. 2. **Immune cells:** EIF3F is expressed in immune cells, including T cells, B cells, and dendritic cells. 3. **Blood cells:** EIF3F is expressed in blood cells, including red blood cells, white blood cells, and platelets. In conclusion, EIF3F is a critical component of eukaryotic translation initiation, playing a pivotal role in the recognition of the mRNA cap and the recruitment of the 40S ribosomal subunit. Its dysregulation has been implicated in various diseases, highlighting the importance of EIF3F in maintaining cellular homeostasis. Further research is needed to fully elucidate the molecular mechanisms of EIF3F and its clinical significance in various diseases.

Genular Protein ID: 4093691514

Symbol: EIF3F_HUMAN

Name: Deubiquitinating enzyme eIF3f

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9341143

Title: Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly.

PubMed ID: 9341143

DOI: 10.1074/jbc.272.43.27042

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12446680

Title: The p34cdc2-related cyclin-dependent kinase 11 interacts with the p47 subunit of eukaryotic initiation factor 3 during apoptosis.

PubMed ID: 12446680

DOI: 10.1074/jbc.m206427200

PubMed ID: 16286006

Title: mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.

PubMed ID: 16286006

DOI: 10.1016/j.cell.2005.10.024

PubMed ID: 15703437

Title: Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association.

PubMed ID: 15703437

DOI: 10.1261/rna.7215305

PubMed ID: 16766523

Title: Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit.

PubMed ID: 16766523

DOI: 10.1074/jbc.m605418200

PubMed ID: 17581632

Title: Reconstitution reveals the functional core of mammalian eIF3.

PubMed ID: 17581632

DOI: 10.1038/sj.emboj.7601765

PubMed ID: 17322308

Title: Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry.

PubMed ID: 17322308

DOI: 10.1074/mcp.m600399-mcp200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068067

Title: The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways.

PubMed ID: 20068067

DOI: 10.1158/1541-7786.mcr-08-0491

PubMed ID: 18599441

Title: Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3.

PubMed ID: 18599441

DOI: 10.1073/pnas.0801313105

PubMed ID: 21124883

Title: The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation.

PubMed ID: 21124883

DOI: 10.1371/journal.pbio.1000545

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25849773

Title: eIF3 targets cell-proliferation messenger RNAs for translational activation or repression.

PubMed ID: 25849773

DOI: 10.1038/nature14267

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27462815

Title: eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.

PubMed ID: 27462815

DOI: 10.1038/nature18954

PubMed ID: 16322461

Title: Structural roles for human translation factor eIF3 in initiation of protein synthesis.

PubMed ID: 16322461

DOI: 10.1126/science.1118977

PubMed ID: 30409806

Title: Quantifying the contribution of recessive coding variation to developmental disorders.

PubMed ID: 30409806

DOI: 10.1126/science.aar6731

Sequence Information:

  • Length: 357
  • Mass: 37564
  • Checksum: 8A70FC6E2BF07737
  • Sequence:
  • MATPAVPVSA PPATPTPVPA AAPASVPAPT PAPAAAPVPA AAPASSSDPA AAAAATAAPG 
    QTPASAQAPA QTPAPALPGP ALPGPFPGGR VVRLHPVILA SIVDSYERRN EGAARVIGTL 
    LGTVDKHSVE VTNCFSVPHN ESEDEVAVDM EFAKNMYELH KKVSPNELIL GWYATGHDIT 
    EHSVLIHEYY SREAPNPIHL TVDTSLQNGR MSIKAYVSTL MGVPGRTMGV MFTPLTVKYA 
    YYDTERIGVD LIMKTCFSPN RVIGLSSDLQ QVGGASARIQ DALSTVLQYA EDVLSGKVSA 
    DNTVGRFLMS LVNQVPKIVP DDFETMLNSN INDLLMVTYL ANLTQSQIAL NEKLVNL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.