Details for: EIF3F
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 502.3619
Cell Significance Index: -78.1400 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 251.1970
Cell Significance Index: -103.4800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 229.9283
Cell Significance Index: -93.4100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 221.5118
Cell Significance Index: -56.1900 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 210.0937
Cell Significance Index: -99.1900 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 204.8659
Cell Significance Index: -105.3800 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 148.2216
Cell Significance Index: -99.4600 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 99.9536
Cell Significance Index: -95.4300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 75.3717
Cell Significance Index: -92.9300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 25.1239
Cell Significance Index: -99.1400 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 24.1644
Cell Significance Index: -74.2200 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 18.8998
Cell Significance Index: -50.6300 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 13.6572
Cell Significance Index: -29.8900 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 7.3630
Cell Significance Index: 94.3000 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 7.2192
Cell Significance Index: 151.1100 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 6.5374
Cell Significance Index: 71.0700 - Cell Name: kidney cell (CL1000497)
Fold Change: 5.6311
Cell Significance Index: 44.9600 - Cell Name: granulosa cell (CL0000501)
Fold Change: 4.8732
Cell Significance Index: 128.1400 - Cell Name: theca cell (CL0000503)
Fold Change: 4.5515
Cell Significance Index: 26.7400 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 4.2971
Cell Significance Index: 126.2000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 4.2685
Cell Significance Index: 275.3900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 3.9714
Cell Significance Index: 545.3900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 3.7964
Cell Significance Index: 466.8000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 3.7367
Cell Significance Index: 440.6800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 3.4709
Cell Significance Index: 245.4800 - Cell Name: lactocyte (CL0002325)
Fold Change: 3.4117
Cell Significance Index: 440.7700 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 3.2813
Cell Significance Index: 57.9900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.2691
Cell Significance Index: 152.4200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 3.2113
Cell Significance Index: 150.9300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 3.0650
Cell Significance Index: 552.5200 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 3.0472
Cell Significance Index: 105.8900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.7710
Cell Significance Index: 206.5200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.6309
Cell Significance Index: 71.6100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 2.5657
Cell Significance Index: 1401.2100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.5601
Cell Significance Index: 1131.8700 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 2.5078
Cell Significance Index: 28.4900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.4105
Cell Significance Index: 69.1000 - Cell Name: peg cell (CL4033014)
Fold Change: 2.0337
Cell Significance Index: 46.9900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.7835
Cell Significance Index: 304.5500 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.7511
Cell Significance Index: 16.1300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.4571
Cell Significance Index: 75.6900 - Cell Name: odontoblast (CL0000060)
Fold Change: 1.4175
Cell Significance Index: 181.7200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.3380
Cell Significance Index: 92.5300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1860
Cell Significance Index: 192.8900 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.9906
Cell Significance Index: 97.9900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.9067
Cell Significance Index: 24.2100 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8386
Cell Significance Index: 757.2000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.8087
Cell Significance Index: 42.4600 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.7134
Cell Significance Index: 37.1600 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.4729
Cell Significance Index: 8.7400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3976
Cell Significance Index: 78.9200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3395
Cell Significance Index: 68.1100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1990
Cell Significance Index: 71.3700 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1660
Cell Significance Index: 31.6000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1365
Cell Significance Index: 2.2900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0916
Cell Significance Index: 69.3400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0249
Cell Significance Index: 18.2700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0018
Cell Significance Index: 0.0700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0164
Cell Significance Index: -1.6800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0284
Cell Significance Index: -53.3900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0365
Cell Significance Index: -27.0700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0500
Cell Significance Index: -92.2600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0616
Cell Significance Index: -38.4600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0640
Cell Significance Index: -98.4500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0717
Cell Significance Index: -97.5100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1104
Cell Significance Index: -62.2400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1168
Cell Significance Index: -7.3600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1265
Cell Significance Index: -80.3600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1943
Cell Significance Index: -88.1800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1966
Cell Significance Index: -11.0300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2253
Cell Significance Index: -47.4600 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2901
Cell Significance Index: -7.4100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2971
Cell Significance Index: -85.4900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.4287
Cell Significance Index: -11.9800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4986
Cell Significance Index: -57.1200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.5670
Cell Significance Index: -66.0800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.5714
Cell Significance Index: -15.2900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.5901
Cell Significance Index: -85.7800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.6324
Cell Significance Index: -38.8700 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.6744
Cell Significance Index: -73.3600 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.7893
Cell Significance Index: -90.1000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.8612
Cell Significance Index: -57.9100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.8761
Cell Significance Index: -21.9000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.8890
Cell Significance Index: -70.4100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.9377
Cell Significance Index: -97.6400 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.9525
Cell Significance Index: -16.4200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.0150
Cell Significance Index: -32.5100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.0272
Cell Significance Index: -22.2600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.0556
Cell Significance Index: -81.0100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.0994
Cell Significance Index: -15.0000 - Cell Name: germ cell (CL0000586)
Fold Change: -1.1290
Cell Significance Index: -8.5200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -1.3407
Cell Significance Index: -60.7700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.3483
Cell Significance Index: -82.6700 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.7841
Cell Significance Index: -52.5500 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.7892
Cell Significance Index: -26.8100 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -1.8524
Cell Significance Index: -15.5600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.9963
Cell Significance Index: -88.3000 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: -2.0068
Cell Significance Index: -10.5600 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -2.0466
Cell Significance Index: -12.3700 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -2.1548
Cell Significance Index: -11.7500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4093691514
Symbol: EIF3F_HUMAN
Name: Deubiquitinating enzyme eIF3f
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9341143
Title: Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly.
PubMed ID: 9341143
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12446680
Title: The p34cdc2-related cyclin-dependent kinase 11 interacts with the p47 subunit of eukaryotic initiation factor 3 during apoptosis.
PubMed ID: 12446680
PubMed ID: 16286006
Title: mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.
PubMed ID: 16286006
PubMed ID: 15703437
Title: Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association.
PubMed ID: 15703437
DOI: 10.1261/rna.7215305
PubMed ID: 16766523
Title: Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit.
PubMed ID: 16766523
PubMed ID: 17581632
Title: Reconstitution reveals the functional core of mammalian eIF3.
PubMed ID: 17581632
PubMed ID: 17322308
Title: Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry.
PubMed ID: 17322308
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068067
Title: The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways.
PubMed ID: 20068067
PubMed ID: 18599441
Title: Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3.
PubMed ID: 18599441
PubMed ID: 21124883
Title: The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation.
PubMed ID: 21124883
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25849773
Title: eIF3 targets cell-proliferation messenger RNAs for translational activation or repression.
PubMed ID: 25849773
DOI: 10.1038/nature14267
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27462815
Title: eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.
PubMed ID: 27462815
DOI: 10.1038/nature18954
PubMed ID: 16322461
Title: Structural roles for human translation factor eIF3 in initiation of protein synthesis.
PubMed ID: 16322461
PubMed ID: 30409806
Title: Quantifying the contribution of recessive coding variation to developmental disorders.
PubMed ID: 30409806
Sequence Information:
- Length: 357
- Mass: 37564
- Checksum: 8A70FC6E2BF07737
- Sequence:
MATPAVPVSA PPATPTPVPA AAPASVPAPT PAPAAAPVPA AAPASSSDPA AAAAATAAPG QTPASAQAPA QTPAPALPGP ALPGPFPGGR VVRLHPVILA SIVDSYERRN EGAARVIGTL LGTVDKHSVE VTNCFSVPHN ESEDEVAVDM EFAKNMYELH KKVSPNELIL GWYATGHDIT EHSVLIHEYY SREAPNPIHL TVDTSLQNGR MSIKAYVSTL MGVPGRTMGV MFTPLTVKYA YYDTERIGVD LIMKTCFSPN RVIGLSSDLQ QVGGASARIQ DALSTVLQYA EDVLSGKVSA DNTVGRFLMS LVNQVPKIVP DDFETMLNSN INDLLMVTYL ANLTQSQIAL NEKLVNL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.